Details for: CL0000875

Cell ID: CL0000875

Cell Name: non-classical monocyte

Marker Score Threshold: 2414
(Derived using integrated single-cell and genomic data)

Description: A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair.

Synonyms: patrolling monocyte, resident monocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.69
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.35
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 3.3
    Ensembl ID: ENSG00000104763
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 3.24
    Ensembl ID: ENSG00000204472
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.24
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.15
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.06
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 3.01
    Ensembl ID: ENSG00000140379
  • Gene Symbol: C5AR1 (ENSG00000197405)
    Fold Change: 2.95
    Ensembl ID: ENSG00000197405
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.94
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.89
    Ensembl ID: ENSG00000182718
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.87
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.8
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.79
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.79
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.78
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.77
    Ensembl ID: ENSG00000143878
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 2.68
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.68
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.63
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.61
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.6
    Ensembl ID: ENSG00000005022
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.59
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.53
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 2.49
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 2.47
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.38
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 2.35
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.25
    Ensembl ID: ENSG00000152518
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.25
    Ensembl ID: ENSG00000084234
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.23
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.22
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.22
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 2.21
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CASP1 (ENSG00000137752)
    Fold Change: 2.12
    Ensembl ID: ENSG00000137752
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.09
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.09
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.08
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.03
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.01
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.99
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.97
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.88
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.83
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.79
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.76
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.74
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.74
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.72
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.69
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.68
    Ensembl ID: ENSG00000126247
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.67
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.67
    Ensembl ID: ENSG00000196954
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.63
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.62
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.6
    Ensembl ID: ENSG00000152234
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.6
    Ensembl ID: ENSG00000184922
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.59
    Ensembl ID: ENSG00000023445
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1.59
    Ensembl ID: ENSG00000173372
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.59
    Ensembl ID: ENSG00000147872
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.5
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.49
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.46
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.45
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.42
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.41
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.38
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.38
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.35
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.32
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.32
    Ensembl ID: ENSG00000137845
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.31
    Ensembl ID: ENSG00000173020
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 1.3
    Ensembl ID: ENSG00000136250
  • Gene Symbol: C3AR1 (ENSG00000171860)
    Fold Change: 1.28
    Ensembl ID: ENSG00000171860
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.27
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.26
    Ensembl ID: ENSG00000106605
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.26
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.23
    Ensembl ID: ENSG00000090013
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.22
    Ensembl ID: ENSG00000121691
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.19
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.19
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.17
    Ensembl ID: ENSG00000060971
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.12
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.08
    Ensembl ID: ENSG00000111275
  • Gene Symbol: C1QB (ENSG00000173369)
    Fold Change: 1.08
    Ensembl ID: ENSG00000173369
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.07
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.06
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.06
    Ensembl ID: ENSG00000162772
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.05
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.03
    Ensembl ID: ENSG00000012779
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.03
    Ensembl ID: ENSG00000131100
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.02
    Ensembl ID: ENSG00000183255
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.02
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.02
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.01
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072778
Hovered Details

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Hovered Details

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**Key Characteristics** The non-classical monocyte is characterized by the following key features: 1. **Low expression of CCR2**: Non-classical monocytes express low levels of CCR2, a receptor involved in the recruitment of monocytes to sites of inflammation. 2. **Low responsiveness to monocyte chemoattractant CCL2/MCP1**: Non-classical monocytes are less responsive to CCL2/MCP1, a chemokine that attracts monocytes to sites of inflammation. 3. **Low phagocytic activity**: Non-classical monocytes have reduced phagocytic activity compared to classical monocytes, which limits their ability to engulf and eliminate pathogens. 4. **Decreased size**: Non-classical monocytes are smaller than classical monocytes, which may reflect their reduced phagocytic activity and altered gene expression profile. 5. **Increased co-stimulatory activity**: Non-classical monocytes exhibit increased co-stimulatory activity, which enables them to interact with and activate T cells and other immune cells. **Clinical Significance** The non-classical monocyte has significant clinical implications, particularly in the context of infectious diseases, autoimmune disorders, and cancer. This cell type may: 1. **Contribute to the pathogenesis of infectious diseases**: Non-classical monocytes may play a role in the immune evasion of pathogens, such as Leishmania, by inhibiting the host's ability to mount an effective immune response. 2. **Influence the progression of autoimmune disorders**: Non-classical monocytes may contribute to the development and progression of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, by modulating the immune response and promoting inflammation. 3. **Support tumor growth and metastasis**: Non-classical monocytes may facilitate the growth and spread of cancer cells by promoting angiogenesis, suppressing immune responses, and modulating the tumor microenvironment. In conclusion, the non-classical monocyte is a distinct cell type that plays a significant role in the regulation of immune responses and tissue repair. Its altered gene expression profile and functional characteristics have significant clinical implications, particularly in the context of infectious diseases, autoimmune disorders, and cancer.