Details for: HRH2

Gene ID: 3274

Symbol: HRH2

Ensembl ID: ENSG00000113749

Description: histamine receptor H2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.6284
    Cell Significance Index: -16.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.1452
    Cell Significance Index: -16.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.7132
    Cell Significance Index: -14.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.6518
    Cell Significance Index: -17.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.8679
    Cell Significance Index: -14.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3338
    Cell Significance Index: -16.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.6058
    Cell Significance Index: 115.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.3344
    Cell Significance Index: 147.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8756
    Cell Significance Index: 108.8900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.9895
    Cell Significance Index: 30.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.9072
    Cell Significance Index: 16.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.8642
    Cell Significance Index: -4.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8346
    Cell Significance Index: 368.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7576
    Cell Significance Index: 47.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2772
    Cell Significance Index: 243.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2672
    Cell Significance Index: 57.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.9295
    Cell Significance Index: 17.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7694
    Cell Significance Index: 59.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6968
    Cell Significance Index: 41.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5988
    Cell Significance Index: 414.1300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5956
    Cell Significance Index: 7.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4719
    Cell Significance Index: 46.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4487
    Cell Significance Index: 48.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4442
    Cell Significance Index: 401.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4187
    Cell Significance Index: 150.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3205
    Cell Significance Index: 19.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3188
    Cell Significance Index: 6.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2786
    Cell Significance Index: 45.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2454
    Cell Significance Index: 7.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2429
    Cell Significance Index: 16.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1798
    Cell Significance Index: 11.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1648
    Cell Significance Index: 4.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1374
    Cell Significance Index: 3.9200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1302
    Cell Significance Index: 1.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0624
    Cell Significance Index: 1.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0324
    Cell Significance Index: 6.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0208
    Cell Significance Index: 0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0188
    Cell Significance Index: 8.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0042
    Cell Significance Index: 0.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0041
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0116
    Cell Significance Index: -17.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0142
    Cell Significance Index: -1.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0166
    Cell Significance Index: -0.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0187
    Cell Significance Index: -13.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0192
    Cell Significance Index: -8.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0237
    Cell Significance Index: -15.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0238
    Cell Significance Index: -18.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0253
    Cell Significance Index: -18.7700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0270
    Cell Significance Index: -0.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0283
    Cell Significance Index: -15.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0293
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0320
    Cell Significance Index: -20.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0330
    Cell Significance Index: -18.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0364
    Cell Significance Index: -2.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0519
    Cell Significance Index: -14.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0628
    Cell Significance Index: -1.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0736
    Cell Significance Index: -13.2600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0743
    Cell Significance Index: -0.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0754
    Cell Significance Index: -1.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0788
    Cell Significance Index: -5.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0798
    Cell Significance Index: -2.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0821
    Cell Significance Index: -11.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0870
    Cell Significance Index: -11.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0888
    Cell Significance Index: -18.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0889
    Cell Significance Index: -2.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0907
    Cell Significance Index: -13.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1082
    Cell Significance Index: -13.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1117
    Cell Significance Index: -19.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1205
    Cell Significance Index: -5.2400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1248
    Cell Significance Index: -1.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1345
    Cell Significance Index: -2.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1350
    Cell Significance Index: -17.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1399
    Cell Significance Index: -16.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1454
    Cell Significance Index: -10.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1457
    Cell Significance Index: -17.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1564
    Cell Significance Index: -16.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1609
    Cell Significance Index: -18.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1844
    Cell Significance Index: -9.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1850
    Cell Significance Index: -3.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1914
    Cell Significance Index: -10.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1997
    Cell Significance Index: -2.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2005
    Cell Significance Index: -15.8800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2166
    Cell Significance Index: -4.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2232
    Cell Significance Index: -7.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2315
    Cell Significance Index: -17.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2436
    Cell Significance Index: -13.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2502
    Cell Significance Index: -13.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2575
    Cell Significance Index: -12.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2674
    Cell Significance Index: -4.0300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2677
    Cell Significance Index: -3.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2758
    Cell Significance Index: -17.3800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2974
    Cell Significance Index: -3.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3443
    Cell Significance Index: -8.8500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3610
    Cell Significance Index: -3.6200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3628
    Cell Significance Index: -7.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3647
    Cell Significance Index: -7.1300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3743
    Cell Significance Index: -4.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HRH2 gene is a single copy gene located on chromosome 22q13.1. It encodes for a 445-amino acid protein, Histamine H2 receptor (HRH2_HUMAN), which belongs to the family of G protein-coupled receptors (GPCRs). The HRH2 receptor is a ligand-activated receptor that binds to histamine, a biogenic amine involved in various physiological processes. The receptor is characterized by its high affinity for histamine, with a Kd value of 10-9 M. **Pathways and Functions** The HRH2 receptor is involved in several signaling pathways, including: 1. **Gastric acid secretion**: The HRH2 receptor is expressed in the parietal cells of the stomach and plays a crucial role in regulating gastric acid secretion in response to histamine. 2. **Immune response**: The HRH2 receptor is expressed on various immune cells, including classical monocytes and immature innate lymphoid cells, and modulates immune responses. 3. **Neurotransmission**: The HRH2 receptor is expressed in the brain and plays a role in regulating neurotransmission, particularly in the regulation of glutamatergic neurons. 4. **Histamine receptors**: The HRH2 receptor is part of the histamine receptor family and is involved in regulating histamine-mediated responses. **Clinical Significance** The HRH2 receptor plays a crucial role in various diseases and disorders, including: 1. **Gastroesophageal reflux disease (GERD)**: The HRH2 receptor is involved in regulating gastric acid secretion, and its dysregulation can contribute to GERD. 2. **Allergic disorders**: The HRH2 receptor is involved in regulating immune responses, and its dysregulation can contribute to allergic disorders, such as asthma and allergic rhinitis. 3. **Neurological disorders**: The HRH2 receptor is involved in regulating neurotransmission, and its dysregulation can contribute to neurological disorders, such as Parkinson's disease and epilepsy. 4. **Cancer**: The HRH2 receptor has been implicated in various types of cancer, including gastric cancer and lymphoma. In conclusion, the HRH2 gene encodes for a critical receptor involved in regulating various physiological processes, including gastric acid secretion, immune response, and neurotransmission. Its dysregulation can contribute to various diseases and disorders, highlighting the importance of further research into the HRH2 gene and its role in human health and disease. **Proteins and Variants** The HRH2 gene encodes for a single protein, Histamine H2 receptor (HRH2_HUMAN). Variants of the HRH2 gene have been associated with various diseases and disorders, including GERD and allergic disorders. Further research is needed to fully understand the role of HRH2 variants in human health and disease. **Signaling by HRH2** The HRH2 receptor is a G protein-coupled receptor that signals through a G protein-coupled signaling pathway. The receptor activates a G protein, which in turn activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. cAMP then activates various downstream targets, including protein kinase A (PKA), which regulates various cellular processes. **Regulation of HRH2** The expression and activity of the HRH2 receptor are regulated by various factors, including histamine, calcium, and protein kinase C (PKC). Histamine is the primary ligand for the HRH2 receptor, and its binding to the receptor activates the receptor and triggers a signaling cascade. **Conclusion** In conclusion, the HRH2 gene encodes for a critical receptor involved in regulating various physiological processes, including gastric acid secretion, immune response, and neurotransmission. Further research is needed to fully understand the role of the HRH2 gene in human health and disease, as well as its potential as a therapeutic target for various diseases and disorders.

Genular Protein ID: 2963209348

Symbol: HRH2_HUMAN

Name: Histamine H2 receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1714721

Title: Molecular cloning of the human histamine H2 receptor.

PubMed ID: 1714721

DOI: 10.1016/0006-291x(91)91047-g

PubMed ID: 7755641

Title: Identification of the promoter region of the human histamine H2-receptor gene.

PubMed ID: 7755641

DOI: 10.1006/bbrc.1995.1703

PubMed ID: 10371214

Title: Human histamine H2 receptor gene: multiple transcription initiation and tissue-specific expression.

PubMed ID: 10371214

DOI: 10.1016/s0014-5793(99)00618-3

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8817552

Title: Allelic variations of the human histamine H2 receptor gene.

PubMed ID: 8817552

DOI: 10.1097/00001756-199605170-00015

PubMed ID: 9374694

Title: Novel insights into histamine H2 receptor biology.

PubMed ID: 9374694

DOI: 10.1152/ajpgi.1997.273.5.g987

Sequence Information:

  • Length: 359
  • Mass: 40098
  • Checksum: 9835AE2BA60B9B0F
  • Sequence:
  • MAPNGTASSF CLDSTACKIT ITVVLAVLIL ITVAGNVVVC LAVGLNRRLR NLTNCFIVSL 
    AITDLLLGLL VLPFSAIYQL SCKWSFGKVF CNIYTSLDVM LCTASILNLF MISLDRYCAV 
    MDPLRYPVLV TPVRVAISLV LIWVISITLS FLSIHLGWNS RNETSKGNHT TSKCKVQVNE 
    VYGLVDGLVT FYLPLLIMCI TYYRIFKVAR DQAKRINHIS SWKAATIREH KATVTLAAVM 
    GAFIICWFPY FTAFVYRGLR GDDAINEVLE AIVLWLGYAN SALNPILYAA LNRDFRTGYQ 
    QLFCCRLANR NSHKTSLRSN ASQLSRTQSR EPRQQEEKPL KLQVWSGTEV TAPQGATDR

Genular Protein ID: 2166581906

Symbol: A0A1B0GTK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 422
  • Mass: 46948
  • Checksum: 838678E91AB412D1
  • Sequence:
  • MAPNGTASSF CLDSTACKIT ITVVLAVLIL ITVAGNVVVC LAVGLNRRLR NLTNCFIVSL 
    AITDLLLGLL VLPFSAIYQL SCKWSFGKVF CNIYTSLDVM LCTASILNLF MISLDRYCAV 
    MDPLRYPVLV TPVRVAISLV LIWVISITLS FLSIHLGWNS RNETSKGNHT TSKCKVQVNE 
    VYGLVDGLVT FYLPLLIMCI TYYRIFKVAR DQAKRINHIS SWKAATIREH KATVTLAAVM 
    GAFIICWFPY FTAFVYRGLR GDDAINEVLE AIVLWLGYAN SALNPILYAA LNRDFRTGYQ 
    QLFCCRLANR NSHKTSLRSN ASQLSRTQSR EPRQQEEKPL KLQVWSGTEV TAPQGATDRK 
    PALSCTTCSS NLLSCCKSLW GLRFLQRHMG GPSEELSGEP LSEEPQKRPP QKAVRTLPSE 
    AV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.