Details for: HRH2

Gene ID: 3274

Symbol: HRH2

Ensembl ID: ENSG00000113749

Description: histamine receptor H2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.82
    Marker Score: 17122
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.73
    Marker Score: 96784
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.67
    Marker Score: 3405
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.67
    Marker Score: 14313
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.56
    Marker Score: 2412
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.55
    Marker Score: 3025
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.52
    Marker Score: 14400
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169053
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.46
    Marker Score: 89975
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.43
    Marker Score: 1426
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.43
    Marker Score: 2707
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.39
    Marker Score: 10666
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20469
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.29
    Marker Score: 589
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.22
    Marker Score: 27344
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.16
    Marker Score: 13428
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.14
    Marker Score: 1164
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.14
    Marker Score: 17023
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.09
    Marker Score: 2721.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.05
    Marker Score: 390
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251782
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.04
    Marker Score: 20615
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48025.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.97
    Marker Score: 36759
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5334
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.91
    Marker Score: 2007
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.91
    Marker Score: 292
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 503
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.79
    Marker Score: 3053
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3274
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.75
    Marker Score: 360
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.73
    Marker Score: 366
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.71
    Marker Score: 450
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.68
    Marker Score: 1643
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.68
    Marker Score: 1398
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.66
    Marker Score: 218
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.63
    Marker Score: 1059
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.63
    Marker Score: 2233.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.62
    Marker Score: 307
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.6
    Marker Score: 569
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.59
    Marker Score: 2449.5
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.58
    Marker Score: 249
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.57
    Marker Score: 292.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.57
    Marker Score: 648
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.55
    Marker Score: 1037
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.55
    Marker Score: 229.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.53
    Marker Score: 853
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.52
    Marker Score: 357
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.5
    Marker Score: 292
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.48
    Marker Score: 1951
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.47
    Marker Score: 288
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.46
    Marker Score: 187
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 299
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.45
    Marker Score: 155
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 253
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.43
    Marker Score: 109
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.43
    Marker Score: 2622
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.42
    Marker Score: 1729
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.42
    Marker Score: 4213.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.41
    Marker Score: 411
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.4
    Marker Score: 287
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.4
    Marker Score: 113
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.4
    Marker Score: 166
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.39
    Marker Score: 473
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.39
    Marker Score: 1012
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.38
    Marker Score: 592
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.38
    Marker Score: 696
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.38
    Marker Score: 132
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.38
    Marker Score: 113
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.38
    Marker Score: 258
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.38
    Marker Score: 113
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.37
    Marker Score: 487
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.37
    Marker Score: 108
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 360
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.36
    Marker Score: 101
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.36
    Marker Score: 13167
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 158
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.35
    Marker Score: 177
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.34
    Marker Score: 104
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.34
    Marker Score: 168

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Other Information

**Key characteristics** - HRH2 is a G protein-coupled receptor. - It is expressed in various cell types, including neurons, macrophages, and epithelial cells. - It is a ligand for the G protein-coupled receptor 5-HT2A. **Pathways and functions** - Activation of HRH2 by its ligand, histamine, leads to the closure of G protein-coupled receptors on the cell surface. - This closure inhibits the activity of downstream signaling pathways, including those involving the G protein GPCR 5-HT2A. - Inhibition of 5-HT2A signaling leads to a decrease in blood pressure and inflammation. **Clinical significance** - Mutations in HRH2 have been linked to several human diseases, including asthma, migraines, and inflammatory bowel disease. - Histamine is a potent inflammatory mediator, and HRH2 signaling is involved in the regulation of inflammation. - Therefore, HRH2 mutations may contribute to the development of these diseases. **Additional information** - The HRH2 gene is located on chromosome 15q21.1. - It is a single-exon gene with a size of approximately 2.2 kb. - It encodes a protein of 371 amino acids.

Genular Protein ID: 2963209348

Symbol: HRH2_HUMAN

Name: Histamine H2 receptor

UniProtKB Accession Codes:

P25021 B5BUP7 Q14464 Q7Z5R9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 23 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1714721

Title: Molecular cloning of the human histamine H2 receptor.

PubMed ID: 1714721

DOI: 10.1016/0006-291x(91)91047-g

PubMed ID: 7755641

Title: Identification of the promoter region of the human histamine H2-receptor gene.

PubMed ID: 7755641

DOI: 10.1006/bbrc.1995.1703

PubMed ID: 10371214

Title: Human histamine H2 receptor gene: multiple transcription initiation and tissue-specific expression.

PubMed ID: 10371214

DOI: 10.1016/s0014-5793(99)00618-3

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8817552

Title: Allelic variations of the human histamine H2 receptor gene.

PubMed ID: 8817552

DOI: 10.1097/00001756-199605170-00015

PubMed ID: 9374694

Title: Novel insights into histamine H2 receptor biology.

PubMed ID: 9374694

DOI: 10.1152/ajpgi.1997.273.5.g987

Sequence Information:

  • Length: 359
  • Mass: 40098
  • Checksum: 9835AE2BA60B9B0F
  • Sequence:
    • MAPNGTASSF CLDSTACKIT ITVVLAVLIL ITVAGNVVVC LAVGLNRRLR NLTNCFIVSL 
AITDLLLGLL VLPFSAIYQL SCKWSFGKVF CNIYTSLDVM LCTASILNLF MISLDRYCAV 
MDPLRYPVLV TPVRVAISLV LIWVISITLS FLSIHLGWNS RNETSKGNHT TSKCKVQVNE 
VYGLVDGLVT FYLPLLIMCI TYYRIFKVAR DQAKRINHIS SWKAATIREH KATVTLAAVM 
GAFIICWFPY FTAFVYRGLR GDDAINEVLE AIVLWLGYAN SALNPILYAA LNRDFRTGYQ 
QLFCCRLANR NSHKTSLRSN ASQLSRTQSR EPRQQEEKPL KLQVWSGTEV TAPQGATDR

Genular Protein ID: 2166581906

Symbol: A0A1B0GTK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B0GTK7

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MANE-Select 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 5 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 422
  • Mass: 46948
  • Checksum: 838678E91AB412D1
  • Sequence:
    • MAPNGTASSF CLDSTACKIT ITVVLAVLIL ITVAGNVVVC LAVGLNRRLR NLTNCFIVSL 
AITDLLLGLL VLPFSAIYQL SCKWSFGKVF CNIYTSLDVM LCTASILNLF MISLDRYCAV 
MDPLRYPVLV TPVRVAISLV LIWVISITLS FLSIHLGWNS RNETSKGNHT TSKCKVQVNE 
VYGLVDGLVT FYLPLLIMCI TYYRIFKVAR DQAKRINHIS SWKAATIREH KATVTLAAVM 
GAFIICWFPY FTAFVYRGLR GDDAINEVLE AIVLWLGYAN SALNPILYAA LNRDFRTGYQ 
QLFCCRLANR NSHKTSLRSN ASQLSRTQSR EPRQQEEKPL KLQVWSGTEV TAPQGATDRK 
PALSCTTCSS NLLSCCKSLW GLRFLQRHMG GPSEELSGEP LSEEPQKRPP QKAVRTLPSE 
AV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.