Details for: TMEM176A
Gene ID: 55365
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TMEM176A
Ensembl ID: ENSG00000002933
Description: transmembrane protein 176A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 45.44rCSI 47.5%PRS 89.45
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CSI 40.95rCSI 42.9%PRS 93.3
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CSI 38.1rCSI 39.91%PRS 89.67
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CSI 31.02rCSI 44.46%PRS 89.78
-
CSI 23.84rCSI 36.43%PRS 93.16
-
CSI 21.72rCSI 35.77%PRS 93.3
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CSI 18.23rCSI 39.37%PRS 89.88
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CSI 17.55rCSI 38.64%PRS 93.8
-
CSI 16.94rCSI 13.76%PRS 91.1
-
CSI 16.75rCSI 48.49%PRS 90.97
-
CSI 16.34rCSI 26.19%PRS 95.54
-
CSI 15.95rCSI 51.75%PRS 89.99
-
CSI 15.67rCSI 25.27%PRS 89
-
CSI 15.43rCSI 29.46%PRS 97.66
-
CSI 14.94rCSI 18.59%PRS 91.4
-
CSI 14.46rCSI 15.37%PRS 93.71
-
CSI 13.98rCSI 12.05%PRS 91.21
-
CSI 13.36rCSI 62.3%PRS 94.6
-
CSI 13.27rCSI 20.29%PRS 94.84
-
CSI 13.1rCSI 19.38%PRS 92.97
-
CSI 12.97rCSI 12.5%PRS 87.94
-
CSI 12.37rCSI 11.51%PRS 93.02
-
CSI 12rCSI 15.09%PRS 96.07
-
CSI 12rCSI 47.78%PRS 94.38
-
CSI 11.93rCSI 33.91%PRS 88.47
-
CSI 11.51rCSI 14.33%PRS 96.37
-
CSI 10.9rCSI 15.1%PRS 88.66
-
CSI 10.83rCSI 8.4%PRS 93.7
-
CSI 10.38rCSI 10.21%PRS 93.24
-
CSI 10.26rCSI 19.26%PRS 93.3
-
CSI 9.98rCSI 13.08%PRS 96.69
-
CSI 9.94rCSI 15.26%PRS 96.18
-
CSI 9.82rCSI 17.74%PRS 92.63
-
CSI 9.68rCSI 8.93%PRS 92.71
-
CSI 9.66rCSI 8.57%PRS 89.43
-
CSI 9.39rCSI 8.62%PRS 95.37
-
CSI 9.32rCSI 20.92%PRS 97.24
-
CSI 9.11rCSI 13.92%PRS 96.49
-
CSI 9.05rCSI 8.55%PRS 89.74
-
CSI 9.04rCSI 12.36%PRS 89.99
-
CSI 8.49rCSI 17.97%PRS 95.58
-
CSI 8.31rCSI 16.45%PRS 94.02
-
CSI 8.23rCSI 14.73%PRS 90.31
-
CSI 8.02rCSI 6.18%PRS 94.35
-
CSI 7.98rCSI 29.88%PRS 87.9
-
CSI 7.97rCSI 22.41%PRS 88.16
-
CSI 7.83rCSI 27.79%PRS 92.86
-
CSI 7.62rCSI 32.03%PRS 93.29
-
CSI 7.45rCSI 17.88%PRS 91.6
-
CSI 7.29rCSI 18.84%PRS 89.48
-
CSI 6.75rCSI 9.19%PRS 63.98
-
CSI 6.74rCSI 9.21%PRS 90.08
-
CSI 6.64rCSI 25.83%PRS 88.71
-
CSI 6.5rCSI 10.27%PRS 92.63
-
CSI 6.15rCSI 7.43%PRS 95.51
-
CSI 6.03rCSI 10.83%PRS 87.19
-
CSI 5.87rCSI 8.01%PRS 85.76
-
CSI 5.64rCSI 55.44%PRS 94.43
-
CSI 5.52rCSI 33.1%PRS 90.75
-
CSI 5.5rCSI 12.91%PRS 89.27
-
CSI 5.32rCSI 28.99%PRS 93.77
-
CSI 5.21rCSI 27.37%PRS 91.44
-
CSI 5.03rCSI 11.07%PRS 94.04
-
CSI 4.95rCSI 11.31%PRS 92.63
-
CSI 4.85rCSI 7.21%PRS 90.47
-
CSI 4.75rCSI 11.61%PRS 85.84
-
CSI 4.49rCSI 11.67%PRS 91.1
-
CSI 4.37rCSI 10.5%PRS 92.65
-
CSI 4.28rCSI 9.56%PRS 95.44
-
CSI 4.26rCSI 10.81%PRS 86.33
-
CSI 4.26rCSI 8.45%PRS 88.63
-
CSI 4.22rCSI 5.98%PRS 89.88
-
CSI 4.2rCSI 4.6%PRS 93.2
-
CSI 4.2rCSI 4.93%PRS 91.68
-
CSI 4.08rCSI 5.19%PRS 94.7
-
CSI 3.82rCSI 6.53%PRS 97.63
-
CSI 3.75rCSI 4.8%PRS 94.98
-
CSI 3.71rCSI 16.33%PRS 81.79
-
CSI 3.6rCSI 13.7%PRS 85.79
-
CSI 3.32rCSI 5.86%PRS 94.13
-
CSI 3.21rCSI 7.31%PRS 85.21
-
CSI 3.11rCSI 5.88%PRS 95.52
-
CSI 3.02rCSI 3.62%PRS 90.66
-
CSI 2.76rCSI 11.09%PRS 90.31
-
CSI 2.7rCSI 3.99%PRS 96.05
-
CSI 2.69rCSI 6.4%PRS 93.2
-
CSI 2.5rCSI 5.53%PRS 91.69
-
CSI 2.35rCSI 11.03%PRS 93.49
-
CSI 2.35rCSI 9.07%PRS 94.13
-
CSI 2.26rCSI 5.41%PRS 93.66
-
CSI 2.19rCSI 5.09%PRS 93.09
-
CSI 2.14rCSI 3.66%PRS 93.28
-
CSI 2.11rCSI 3.18%PRS 95.18
-
CSI 2.01rCSI 15.12%PRS 95.54
-
CSI 1.99rCSI 12.04%PRS 96.02
-
CSI 1.97rCSI 1.97%PRS 86.55
-
CSI 1.83rCSI 48.09%PRS 94.81
-
CSI 1.76rCSI 2.34%PRS 94.13
-
CSI 1.51rCSI 3.94%PRS 87.83
-
CSI 1.5rCSI 23.17%PRS 93.99
-
CSI 0.6rCSI 9.1%PRS 94.9%
-
CSI 0.6rCSI 6.1%PRS 88.3%
-
CSI 0.7rCSI 4.0%PRS 93.1%
-
CSI 0.8rCSI 3.0%PRS 94.4%
-
CSI 1.0rCSI 8.4%PRS 89.6%
-
CSI 1.1rCSI 3.0%PRS 94.3%
-
CSI 1.1rCSI 3.0%PRS 93.6%
-
CSI 1.2rCSI 6.6%PRS 97.5%
-
CSI 1.2rCSI 5.7%PRS 96.8%
-
CSI 1.2rCSI 2.4%PRS 92.9%
-
CSI 1.3rCSI 3.5%PRS 94.3%
-
CSI 1.3rCSI 1.9%PRS 97.7%
-
CSI 1.3rCSI 6.8%PRS 93.3%
-
CSI 1.3rCSI 2.9%PRS 93.6%
-
CSI 1.4rCSI 3.5%PRS 87.2%
-
CSI 1.4rCSI 11.3%PRS 87.9%
-
CSI 1.4rCSI 6.3%PRS 94.6%
-
CSI 1.5rCSI 23.2%PRS 94.0%
-
CSI 1.5rCSI 3.9%PRS 87.8%
-
CSI 1.8rCSI 2.3%PRS 94.1%
-
CSI 1.8rCSI 48.1%PRS 94.8%
-
CSI 2.0rCSI 2.0%PRS 86.6%
-
CSI 2.0rCSI 12.0%PRS 96.0%
-
CSI 2.0rCSI 15.1%PRS 95.5%
-
CSI 2.1rCSI 3.2%PRS 95.2%
-
CSI 2.1rCSI 3.7%PRS 93.3%
-
CSI 2.2rCSI 5.1%PRS 93.1%
-
CSI 2.3rCSI 5.4%PRS 93.7%
-
CSI 2.4rCSI 9.1%PRS 94.1%
-
CSI 2.4rCSI 11.0%PRS 93.5%
-
CSI 2.5rCSI 5.5%PRS 91.7%
-
CSI 2.7rCSI 6.4%PRS 93.2%
-
CSI 2.7rCSI 4.0%PRS 96.1%
-
CSI 2.8rCSI 11.1%PRS 90.3%
-
CSI 3.0rCSI 3.6%PRS 90.7%
-
CSI 3.1rCSI 5.9%PRS 95.5%
-
CSI 3.2rCSI 7.3%PRS 85.2%
-
CSI 3.3rCSI 5.9%PRS 94.1%
-
CSI 3.6rCSI 13.7%PRS 85.8%
-
CSI 3.7rCSI 16.3%PRS 81.8%
-
CSI 3.8rCSI 4.8%PRS 95.0%
-
CSI 3.8rCSI 6.5%PRS 97.6%
-
CSI 4.1rCSI 5.2%PRS 94.7%
-
CSI 4.2rCSI 4.9%PRS 91.7%
-
CSI 4.2rCSI 4.6%PRS 93.2%
-
CSI 4.2rCSI 6.0%PRS 89.9%
-
CSI 4.3rCSI 8.5%PRS 88.6%
-
CSI 4.3rCSI 10.8%PRS 86.3%
-
CSI 4.3rCSI 9.6%PRS 95.4%
-
CSI 4.4rCSI 10.5%PRS 92.7%
-
CSI 4.5rCSI 11.7%PRS 91.1%
-
CSI 4.8rCSI 11.6%PRS 85.8%
-
CSI 4.9rCSI 7.2%PRS 90.5%
-
CSI 5.0rCSI 11.3%PRS 92.6%
-
CSI 5.0rCSI 11.1%PRS 94.0%
-
CSI 5.2rCSI 27.4%PRS 91.4%
-
CSI 5.3rCSI 29.0%PRS 93.8%
-
CSI 5.5rCSI 12.9%PRS 89.3%
-
CSI 5.5rCSI 33.1%PRS 90.8%
-
CSI 5.6rCSI 55.4%PRS 94.4%
-
CSI 5.9rCSI 8.0%PRS 85.8%
-
CSI 6.0rCSI 10.8%PRS 87.2%
-
CSI 6.2rCSI 7.4%PRS 95.5%
-
CSI 6.5rCSI 10.3%PRS 92.6%
-
CSI 6.6rCSI 25.8%PRS 88.7%
-
CSI 6.7rCSI 9.2%PRS 90.1%
-
CSI 6.8rCSI 9.2%PRS 64.0%
-
CSI 7.3rCSI 18.8%PRS 89.5%
-
CSI 7.5rCSI 17.9%PRS 91.6%
-
CSI 7.6rCSI 32.0%PRS 93.3%
-
CSI 7.8rCSI 27.8%PRS 92.9%
-
CSI 8.0rCSI 22.4%PRS 88.2%
-
CSI 8.0rCSI 29.9%PRS 87.9%
-
CSI 8.0rCSI 6.2%PRS 94.4%
-
CSI 8.2rCSI 14.7%PRS 90.3%
-
CSI 8.3rCSI 16.5%PRS 94.0%
-
CSI 8.5rCSI 18.0%PRS 95.6%
-
CSI 9.0rCSI 12.4%PRS 90.0%
-
CSI 9.1rCSI 8.6%PRS 89.7%
-
CSI 9.1rCSI 13.9%PRS 96.5%
-
CSI 9.3rCSI 20.9%PRS 97.2%
-
CSI 9.4rCSI 8.6%PRS 95.4%
-
CSI 9.7rCSI 8.6%PRS 89.4%
-
CSI 9.7rCSI 8.9%PRS 92.7%
-
CSI 9.8rCSI 17.7%PRS 92.6%
-
CSI 9.9rCSI 15.3%PRS 96.2%
-
CSI 10.0rCSI 13.1%PRS 96.7%
-
CSI 10.3rCSI 19.3%PRS 93.3%
-
CSI 10.4rCSI 10.2%PRS 93.2%
-
CSI 10.8rCSI 8.4%PRS 93.7%
-
CSI 10.9rCSI 15.1%PRS 88.7%
-
CSI 11.5rCSI 14.3%PRS 96.4%
-
CSI 11.9rCSI 33.9%PRS 88.5%
-
CSI 12.0rCSI 47.8%PRS 94.4%
-
CSI 12.0rCSI 15.1%PRS 96.1%
-
CSI 12.4rCSI 11.5%PRS 93.0%
-
CSI 13.0rCSI 12.5%PRS 87.9%
-
CSI 13.1rCSI 19.4%PRS 93.0%
-
CSI 13.3rCSI 20.3%PRS 94.8%
-
CSI 13.4rCSI 62.3%PRS 94.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 1215285788
Symbol: T176A_HUMAN
Name: Transmembrane protein 176A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12097419
Title: Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.
PubMed ID: 12097419
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 25130899
Title: Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.
PubMed ID: 25130899
DOI: 10.1111/tra.12205
Sequence Information:
- Length: 235
- Mass: 26116
- Checksum: F44045DC0FEA5C82
- Sequence:
MGTADSDEMA PEAPQHTHID VHIHQESALA KLLLTCCSAL RPRATQARGS SRLLVASWVM QIVLGILSAV LGGFFYIRDY TLLVTSGAAI WTGAVAVLAG AAAFIYEKRG GTYWALLRTL LTLAAFSTAI AALKLWNEDF RYGYSYYNSA CRISSSSDWN TPAPTQSPEE VRRLHLCTSF MDMLKALFRT LQAMLLGVWI LLLLASLTPL WLYCWRMFPT KGKRDQKEML EVSGI