Details for: CL0000767

Cell ID: CL0000767

Cell Name: basophil

Marker Score Threshold: 475
(Derived using integrated single-cell and genomic data)

Description: Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.

Synonyms: polymorphonuclear leucocyte, polymorphonuclear leukocyte, basophilic leucocyte, basophilic leukocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.56
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.54
    Ensembl ID: ENSG00000135046
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.54
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.42
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 3.42
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 3.39
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 3.34
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.34
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 3.31
    Ensembl ID: ENSG00000110848
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.26
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.26
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.22
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 3.2
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.98
    Ensembl ID: ENSG00000104894
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.94
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.87
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.73
    Ensembl ID: ENSG00000100300
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 2.7
    Ensembl ID: ENSG00000147872
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.45
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.44
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.41
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.38
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.36
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CALB2 (ENSG00000172137)
    Fold Change: 2.32
    Ensembl ID: ENSG00000172137
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 2.3
    Ensembl ID: ENSG00000161203
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.28
    Ensembl ID: ENSG00000168421
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.28
    Ensembl ID: ENSG00000067560
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 2.25
    Ensembl ID: ENSG00000109321
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.24
    Ensembl ID: ENSG00000153113
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.24
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.2
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.18
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.15
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 2.09
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 2.03
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.03
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.01
    Ensembl ID: ENSG00000165527
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 2.01
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.99
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.93
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.85
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.83
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.8
    Ensembl ID: ENSG00000165092
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.8
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.74
    Ensembl ID: ENSG00000127022
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.71
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.71
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.68
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.64
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.62
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.6
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 1.59
    Ensembl ID: ENSG00000169252
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.56
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.53
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.52
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.52
    Ensembl ID: ENSG00000213465
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.49
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.47
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.47
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.44
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.44
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.44
    Ensembl ID: ENSG00000106605
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.43
    Ensembl ID: ENSG00000105254
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.43
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.41
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.38
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.38
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.37
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.36
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.36
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.35
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.31
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.26
    Ensembl ID: ENSG00000141480
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.25
    Ensembl ID: ENSG00000106546
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.21
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.17
    Ensembl ID: ENSG00000099624
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143669
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.15
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.13
    Ensembl ID: ENSG00000169020
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.13
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CD33 (ENSG00000105383)
    Fold Change: 1.12
    Ensembl ID: ENSG00000105383
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.12
    Ensembl ID: ENSG00000113328
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.08
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.07
    Ensembl ID: ENSG00000196776
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.07
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110955
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.04
    Ensembl ID: ENSG00000085662
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.03
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.02
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.01
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.01
    Ensembl ID: ENSG00000152234
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1
    Ensembl ID: ENSG00000173372
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: N/A
    Ensembl ID: ENSG00000084234
  • Gene Symbol: C1QB (ENSG00000173369)
    Fold Change: N/A
    Ensembl ID: ENSG00000173369
Hovered Details

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Hovered Details

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**Key Characteristics** * Irregularly shaped nucleus with partially constricted lobes * Pale-staining cytoplasm containing coarse, bluish-black granules * Express CD123, CD193, CD203c, and FceRIa surface markers * Release vasoactive amines (histamine and serotonin) upon activation * Involved in regulation of inflammation and allergic responses * Play a role in immune system, particularly in innate immunity **Clinical Significance** Basophils have been implicated in various diseases and conditions, including: 1. **Allergic reactions**: Basophils are key players in the development of allergic reactions, including anaphylaxis, asthma, and atopic dermatitis. 2. **Inflammatory diseases**: Basophils contribute to the pathogenesis of inflammatory diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 3. **Autoimmune disorders**: Basophils may play a role in autoimmune disorders, such as type 1 diabetes and rheumatoid arthritis. 4. **Cancer**: Basophils have been implicated in the development and progression of certain cancers, including leukemia and lymphoma. 5. **Neurological disorders**: Basophils may contribute to the pathogenesis of neurological disorders, such as Parkinson's disease and Alzheimer's disease. Understanding the role of basophils in the immune system and their involvement in various diseases is essential for the development of effective therapeutic strategies.