Details for: ICAM4

Gene ID: 3386

Symbol: ICAM4

Ensembl ID: ENSG00000105371

Description: intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 12.4065
    Cell Significance Index: 5.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.1377
    Cell Significance Index: -2.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 11.0229
    Cell Significance Index: -5.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6335
    Cell Significance Index: -4.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5002
    Cell Significance Index: -5.9200
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 1.2070
    Cell Significance Index: 8.7600
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.9928
    Cell Significance Index: 3.7000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1771
    Cell Significance Index: 3.1300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0875
    Cell Significance Index: 0.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0693
    Cell Significance Index: 3.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0579
    Cell Significance Index: 1.5500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0567
    Cell Significance Index: 0.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0314
    Cell Significance Index: 3.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0234
    Cell Significance Index: 3.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0220
    Cell Significance Index: 0.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0161
    Cell Significance Index: 2.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0145
    Cell Significance Index: 1.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0133
    Cell Significance Index: 0.6200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0065
    Cell Significance Index: 0.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0053
    Cell Significance Index: 0.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0025
    Cell Significance Index: 0.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0012
    Cell Significance Index: -0.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0060
    Cell Significance Index: -0.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0061
    Cell Significance Index: -0.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0064
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0071
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0108
    Cell Significance Index: -4.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0115
    Cell Significance Index: -6.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0125
    Cell Significance Index: -5.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0145
    Cell Significance Index: -1.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0175
    Cell Significance Index: -6.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0195
    Cell Significance Index: -5.6300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0247
    Cell Significance Index: -0.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0248
    Cell Significance Index: -4.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0258
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0308
    Cell Significance Index: -6.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0351
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0363
    Cell Significance Index: -6.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0364
    Cell Significance Index: -5.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0460
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0503
    Cell Significance Index: -5.7600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0504
    Cell Significance Index: -0.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0562
    Cell Significance Index: -2.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0565
    Cell Significance Index: -0.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0593
    Cell Significance Index: -4.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0606
    Cell Significance Index: -1.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0679
    Cell Significance Index: -2.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0705
    Cell Significance Index: -4.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0814
    Cell Significance Index: -6.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0869
    Cell Significance Index: -2.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0932
    Cell Significance Index: -0.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0996
    Cell Significance Index: -6.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1022
    Cell Significance Index: -6.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1073
    Cell Significance Index: -3.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1140
    Cell Significance Index: -5.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1153
    Cell Significance Index: -6.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1179
    Cell Significance Index: -3.3800
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1238
    Cell Significance Index: -0.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1270
    Cell Significance Index: -2.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1293
    Cell Significance Index: -5.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1321
    Cell Significance Index: -4.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1413
    Cell Significance Index: -6.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1422
    Cell Significance Index: -1.9400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1487
    Cell Significance Index: -1.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1510
    Cell Significance Index: -5.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1560
    Cell Significance Index: -5.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1605
    Cell Significance Index: -2.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1650
    Cell Significance Index: -6.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1655
    Cell Significance Index: -4.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1727
    Cell Significance Index: -5.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1745
    Cell Significance Index: -5.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1773
    Cell Significance Index: -5.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1922
    Cell Significance Index: -4.9100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1927
    Cell Significance Index: -4.9100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1965
    Cell Significance Index: -0.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2025
    Cell Significance Index: -5.4300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2034
    Cell Significance Index: -2.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2063
    Cell Significance Index: -5.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2069
    Cell Significance Index: -5.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2092
    Cell Significance Index: -4.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2166
    Cell Significance Index: -5.4100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2182
    Cell Significance Index: -4.4400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2256
    Cell Significance Index: -1.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2277
    Cell Significance Index: -6.0800
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.2286
    Cell Significance Index: -1.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2329
    Cell Significance Index: -5.8100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2344
    Cell Significance Index: -3.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2389
    Cell Significance Index: -5.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2393
    Cell Significance Index: -6.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2414
    Cell Significance Index: -3.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2429
    Cell Significance Index: -4.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2481
    Cell Significance Index: -3.9800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2552
    Cell Significance Index: -3.2200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2587
    Cell Significance Index: -3.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-cell adhesion:** ICAM4 is a transmembrane glycoprotein that mediates cell-cell adhesion, facilitating the interaction between adjacent cells. 2. **Immune regulation:** ICAM4 is involved in the regulation of immune responses, particularly in the interaction between lymphoid and non-lymphoid cells. 3. **Extracellular matrix organization:** ICAM4 contributes to the organization and maintenance of the extracellular matrix, which is essential for tissue structure and function. 4. **Expression in diverse cell types:** ICAM4 is expressed in a wide range of cell types, including erythroid progenitor cells, GABAergic interneurons, and immune cells such as monocytes. **Pathways and Functions:** 1. **Adaptive immune system:** ICAM4 is involved in the interaction between lymphoid and non-lymphoid cells, facilitating the coordination of immune responses. 2. **Cell-cell adhesion:** ICAM4 mediates cell-cell adhesion, which is essential for the formation and maintenance of tissue structure. 3. **Extracellular matrix organization:** ICAM4 contributes to the organization and maintenance of the extracellular matrix, which is critical for tissue function and integrity. 4. **Integrin binding:** ICAM4 interacts with integrins, which are cell surface receptors that mediate cell-cell and cell-extracellular matrix interactions. **Clinical Significance:** 1. **Blood transfusion reactions:** ICAM4 is involved in the recognition of ABO blood group antigens, which are critical in blood transfusion reactions. 2. **Immune-mediated diseases:** Dysregulation of ICAM4 has been implicated in various immune-mediated diseases, including autoimmune disorders and transplant rejection. 3. **Cancer:** ICAM4 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumor progression and metastasis. 4. **Neurological disorders:** ICAM4 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may contribute to the disruption of normal cell-cell adhesion and immune regulation. In conclusion, ICAM4 is a crucial component of intercellular adhesion and immune regulation, with significant implications for various biological processes and diseases. Further research is needed to fully elucidate the functions and clinical significance of ICAM4.

Genular Protein ID: 3076699401

Symbol: ICAM4_HUMAN

Name: Intercellular adhesion molecule 4

UniProtKB Accession Codes:

Q14773 A0M8X2 Q14771 Q14772 Q16375 Q9BWR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8202485

Title: The LW blood group glycoprotein is homologous to intercellular adhesion molecules.

PubMed ID: 8202485

DOI: 10.1073/pnas.91.12.5306

PubMed ID: 8639917

Title: Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes.

PubMed ID: 8639917

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7632968

Title: Molecular basis and expression of the LWa/LWb blood group polymorphism.

PubMed ID: 7632968

PubMed ID: 11435317

Title: Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms.

PubMed ID: 11435317

DOI: 10.1182/blood.v98.2.458

Sequence Information:

  • Length: 271
  • Mass: 29265
  • Checksum: 2F6BC8BABD79E615
  • Sequence:
    • MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ 
PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK 
TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL 
ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSPAPTA 
LASGSIAALV GILLTVGAAY LCKCLAMKSQ A

Genular Protein ID: 2247155702

Symbol: U5U6P8_HUMAN

Name: N/A

UniProtKB Accession Codes:

U5U6P8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 ExpressionAtlas 1 GO 2 Gene3D 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 7632968

Title: Molecular basis and expression of the LWa/LWb blood group polymorphism.

PubMed ID: 7632968

PubMed ID: 24673173

Title: Genetic variation of the whole ICAM4 gene in Caucasians and African Americans.

PubMed ID: 24673173

DOI: 10.1111/trf.12615

Sequence Information:

  • Length: 272
  • Mass: 29649
  • Checksum: 991DE1707703CA19
  • Sequence:
    • MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ 
PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK 
TRWATSRITA YSVPGGLLGG DPEAWKPGHL FRKPGALHRP GSGQRDLDLR VCCWTPRLLA 
ARDLPRAPQS RRPGGPQQLG THYTDARLEP RAHSFGLRFH RCPCRDPPHC GRCVPMQVPS 
YEVPGVKGDV LCRLSEKKRN MKQSGEMAIH GG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.