Details for: ICAM4

Gene ID: 3386

Symbol: ICAM4

Ensembl ID: ENSG00000105371

Description: intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.97
    Marker Score: 2059
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.84
    Marker Score: 1246
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.1
    Marker Score: 825.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.09
    Marker Score: 351
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.81
    Marker Score: 569
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.74
    Marker Score: 1843
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 536
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.68
    Marker Score: 2840.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.68
    Marker Score: 493
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.61
    Marker Score: 391
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.58
    Marker Score: 3032.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.58
    Marker Score: 202
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.51
    Marker Score: 136
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.51
    Marker Score: 3309
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.49
    Marker Score: 296
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.47
    Marker Score: 890
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.46
    Marker Score: 208
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.46
    Marker Score: 368
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.46
    Marker Score: 552
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.44
    Marker Score: 219
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.43
    Marker Score: 1034
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.42
    Marker Score: 233
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 843
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.41
    Marker Score: 124
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 108
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 267
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4
    Marker Score: 255
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.39
    Marker Score: 218
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.38
    Marker Score: 1589
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.38
    Marker Score: 186.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.37
    Marker Score: 229.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.35
    Marker Score: 357
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 139
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.33
    Marker Score: 2435
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.32
    Marker Score: 1949
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.32
    Marker Score: 538
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.31
    Marker Score: 165
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.3
    Marker Score: 259
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.3
    Marker Score: 253
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.29
    Marker Score: 587
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 327
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.24
    Marker Score: 247
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.24
    Marker Score: 2802
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.24
    Marker Score: 393
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.22
    Marker Score: 629.5
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.22
    Marker Score: 61
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.21
    Marker Score: 68
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.21
    Marker Score: 208
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.2
    Marker Score: 532
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.2
    Marker Score: 123
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.2
    Marker Score: 309
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.2
    Marker Score: 56
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.2
    Marker Score: 151
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 95
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 113
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.19
    Marker Score: 2495
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.19
    Marker Score: 64
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.18
    Marker Score: 420
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 109
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.18
    Marker Score: 89
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.18
    Marker Score: 41
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.18
    Marker Score: 432
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.17
    Marker Score: 199
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 56
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.17
    Marker Score: 149
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.17
    Marker Score: 67
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 163
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.17
    Marker Score: 320
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 148
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.16
    Marker Score: 148
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 110
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.16
    Marker Score: 49
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.16
    Marker Score: 278
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.16
    Marker Score: 2484
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 91
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.16
    Marker Score: 31
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.15
    Marker Score: 390
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.15
    Marker Score: 86
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.15
    Marker Score: 3784
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.15
    Marker Score: 163
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.14
    Marker Score: 31

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Other Information

**Key characteristics:** - ICAM4 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in various cell types, including endothelial cells, epithelial cells, immune cells, and cancer cells. - It is a homophilic molecule, meaning it binds to other ICAMs. - It is involved in cell adhesion, cell signaling, and extracellular matrix organization. **Pathways and functions:** - ICAM4 is involved in cell-cell adhesion by binding to other ICAMs on neighboring cells. - It is also involved in cell signaling pathways, such as the integrin signaling pathway. - It plays a role in extracellular matrix organization by interacting with components of the extracellular matrix, such as collagen and elastin. - ICAM4 also regulates the migration and adhesion of immune cells to the cell surface. **Clinical significance:** - Mutations in ICAM4 have been linked to several human diseases, including cancer, autoimmune disorders, and vascular diseases. - ICAM4 is a potential therapeutic target for cancer and other diseases that are characterized by abnormal cell adhesion. - Blockade of ICAM4 signaling has been shown to inhibit cancer cell growth and metastasis. **Additional information:** - ICAM4 is a highly conserved protein with similar sequences in other species. - It is expressed in high levels in healthy tissues, but its expression is upregulated in cancer cells. - ICAM4 is a promising target for cancer immunotherapy.

Genular Protein ID: 3076699401

Symbol: ICAM4_HUMAN

Name: Intercellular adhesion molecule 4

UniProtKB Accession Codes:

Q14773 A0M8X2 Q14771 Q14772 Q16375 Q9BWR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 1 PRO 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8202485

Title: The LW blood group glycoprotein is homologous to intercellular adhesion molecules.

PubMed ID: 8202485

DOI: 10.1073/pnas.91.12.5306

PubMed ID: 8639917

Title: Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes.

PubMed ID: 8639917

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7632968

Title: Molecular basis and expression of the LWa/LWb blood group polymorphism.

PubMed ID: 7632968

PubMed ID: 11435317

Title: Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms.

PubMed ID: 11435317

DOI: 10.1182/blood.v98.2.458

Sequence Information:

  • Length: 271
  • Mass: 29265
  • Checksum: 2F6BC8BABD79E615
  • Sequence:
    • MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ 
PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK 
TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL 
ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSPAPTA 
LASGSIAALV GILLTVGAAY LCKCLAMKSQ A

Genular Protein ID: 2247155702

Symbol: U5U6P8_HUMAN

Name: N/A

UniProtKB Accession Codes:

U5U6P8

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 8 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 7632968

Title: Molecular basis and expression of the LWa/LWb blood group polymorphism.

PubMed ID: 7632968

PubMed ID: 24673173

Title: Genetic variation of the whole ICAM4 gene in Caucasians and African Americans.

PubMed ID: 24673173

DOI: 10.1111/trf.12615

Sequence Information:

  • Length: 272
  • Mass: 29649
  • Checksum: 991DE1707703CA19
  • Sequence:
    • MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ 
PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK 
TRWATSRITA YSVPGGLLGG DPEAWKPGHL FRKPGALHRP GSGQRDLDLR VCCWTPRLLA 
ARDLPRAPQS RRPGGPQQLG THYTDARLEP RAHSFGLRFH RCPCRDPPHC GRCVPMQVPS 
YEVPGVKGDV LCRLSEKKRN MKQSGEMAIH GG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.