TREX1 | ENSG00000213689 | NCBI 11277

Details for: TREX1

Gene ID: 11277

Symbol: TREX1

Ensembl ID: ENSG00000213689

Description: three prime repair exonuclease 1

Associated with

Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Irf3-mediated induction of type i ifn
(R-HSA-3270619)
Regulation by trex1
(R-HSA-3248023)
Regulation of innate immune responses to cytosolic dna
(R-HSA-3134975)
Sting mediated induction of host immune responses
(R-HSA-1834941)
3'-5'-dna exonuclease activity
(GO:0008296)
3'-5' exonuclease activity
(GO:0008408)
Activation of immune response
(GO:0002253)
Adenyl deoxyribonucleotide binding
(GO:0032558)
Apoptotic cell clearance
(GO:0043277)
Atrial cardiac muscle tissue development
(GO:0003228)
Blood vessel development
(GO:0001568)
Cd86 biosynthetic process
(GO:0035781)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to hydroxyurea
(GO:0072711)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to reactive oxygen species
(GO:0034614)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Determination of adult lifespan
(GO:0008340)
Dna binding, bending
(GO:0008301)
Dna catabolic process
(GO:0006308)
Dna duplex unwinding
(GO:0032508)
Dna metabolic process
(GO:0006259)
Dna modification
(GO:0006304)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Dna replication
(GO:0006260)
Dna synthesis involved in uv-damage excision repair
(GO:1904161)
Double-stranded dna 3'-5' dna exonuclease activity
(GO:0008311)
Double-stranded dna binding
(GO:0003690)
Endoplasmic reticulum membrane
(GO:0005789)
Establishment of protein localization
(GO:0045184)
Generation of precursor metabolites and energy
(GO:0006091)
Heart morphogenesis
(GO:0003007)
Heart process
(GO:0003015)
Immune complex formation
(GO:0097281)
Immune response in brain or nervous system
(GO:0002383)
Inflammatory response to antigenic stimulus
(GO:0002437)
Kidney development
(GO:0001822)
Lymphoid progenitor cell differentiation
(GO:0002320)
Macrophage activation involved in immune response
(GO:0002281)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Mismatch repair
(GO:0006298)
Mitotic g1 dna damage checkpoint signaling
(GO:0031571)
Mutlalpha complex binding
(GO:0032405)
Mutsalpha complex binding
(GO:0032407)
Negative regulation of cgas/sting signaling pathway
(GO:0160049)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of type i interferon-mediated signaling pathway
(GO:0060339)
Nuclear envelope
(GO:0005635)
Nuclear replication fork
(GO:0043596)
Oligosaccharyltransferase complex
(GO:0008250)
Protein-dna complex
(GO:0032993)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein stabilization
(GO:0050821)
Regulation of cellular respiration
(GO:0043457)
Regulation of fatty acid metabolic process
(GO:0019217)
Regulation of glycolytic process
(GO:0006110)
Regulation of immunoglobulin production
(GO:0002637)
Regulation of inflammatory response
(GO:0050727)
Regulation of lipid biosynthetic process
(GO:0046890)
Regulation of lysosome organization
(GO:1905671)
Regulation of protein complex stability
(GO:0061635)
Regulation of t cell activation
(GO:0050863)
Regulation of tumor necrosis factor production
(GO:0032680)
Regulation of type i interferon production
(GO:0032479)
Retrotransposition
(GO:0032197)
Single-stranded dna binding
(GO:0003697)
T cell antigen processing and presentation
(GO:0002457)
Type i interferon-mediated signaling pathway
(GO:0060337)
Ww domain binding
(GO:0050699)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 18.8612
Cell Significance Index: -7.6600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 8.0283
Cell Significance Index: -7.6700
Cell Name: lung secretory cell (CL1000272)
Fold Change: 4.6851
Cell Significance Index: 35.6700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.5510
Cell Significance Index: -4.1600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.4635
Cell Significance Index: 42.9800
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.6022
Cell Significance Index: 5.7200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5208
Cell Significance Index: 13.9600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.3573
Cell Significance Index: 11.4500
Cell Name: precursor cell (CL0011115)
Fold Change: 0.3376
Cell Significance Index: 2.5600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2600
Cell Significance Index: 13.5500
Cell Name: helper T cell (CL0000912)
Fold Change: 0.0514
Cell Significance Index: 0.7300
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.0367
Cell Significance Index: 0.4200
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.0217
Cell Significance Index: 0.0500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0170
Cell Significance Index: 2.0100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0009
Cell Significance Index: -0.6400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0014
Cell Significance Index: -0.1400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0014
Cell Significance Index: -0.0200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0083
Cell Significance Index: -2.3900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0104
Cell Significance Index: -7.7300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0109
Cell Significance Index: -6.1600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0110
Cell Significance Index: -2.2100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0133
Cell Significance Index: -8.3200
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0142
Cell Significance Index: -7.7700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0232
Cell Significance Index: -3.9600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0386
Cell Significance Index: -8.1400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0412
Cell Significance Index: -7.4300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0436
Cell Significance Index: -0.7300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0437
Cell Significance Index: -1.1700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0535
Cell Significance Index: -6.1300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0573
Cell Significance Index: -1.2000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0609
Cell Significance Index: -7.4900
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.0927
Cell Significance Index: -1.2700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0948
Cell Significance Index: -4.4200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1039
Cell Significance Index: -1.1300
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1093
Cell Significance Index: -0.8900
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: -0.1189
Cell Significance Index: -1.2300
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1388
Cell Significance Index: -4.4200
Cell Name: group 3 innate lymphoid cell, human (CL0001078)
Fold Change: -0.1494
Cell Significance Index: -1.4000
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: -0.1511
Cell Significance Index: -1.2000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1596
Cell Significance Index: -5.5900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1597
Cell Significance Index: -5.2300
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.1605
Cell Significance Index: -1.5700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1634
Cell Significance Index: -6.0000
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1705
Cell Significance Index: -1.3900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1736
Cell Significance Index: -8.1600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1820
Cell Significance Index: -5.3600
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2098
Cell Significance Index: -2.6000
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.2123
Cell Significance Index: -3.1000
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2203
Cell Significance Index: -4.7600
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: -0.2220
Cell Significance Index: -1.3900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2262
Cell Significance Index: -5.6500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2317
Cell Significance Index: -5.0700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2317
Cell Significance Index: -1.4000
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2389
Cell Significance Index: -5.9600
Cell Name: goblet cell (CL0000160)
Fold Change: -0.2399
Cell Significance Index: -2.1700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2401
Cell Significance Index: -4.7000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2437
Cell Significance Index: -4.5100
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2531
Cell Significance Index: -5.1500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2564
Cell Significance Index: -5.0700
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.2590
Cell Significance Index: -3.7600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2599
Cell Significance Index: -7.0800
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.2607
Cell Significance Index: -4.3900
Cell Name: neuron (CL0000540)
Fold Change: -0.2616
Cell Significance Index: -2.4800
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2621
Cell Significance Index: -3.8700
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2650
Cell Significance Index: -5.3200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2719
Cell Significance Index: -5.7700
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.2738
Cell Significance Index: -2.2600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2766
Cell Significance Index: -7.9700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2840
Cell Significance Index: -8.1400
Cell Name: enterocyte (CL0000584)
Fold Change: -0.2845
Cell Significance Index: -1.7700
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.2873
Cell Significance Index: -3.0900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.3034
Cell Significance Index: -7.7300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3036
Cell Significance Index: -7.5700
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.3069
Cell Significance Index: -6.1200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3139
Cell Significance Index: -6.7100
Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.3178
Cell Significance Index: -2.5900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3187
Cell Significance Index: -8.3800
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.3229
Cell Significance Index: -6.3600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3244
Cell Significance Index: -7.8600
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.3288
Cell Significance Index: -6.8600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3333
Cell Significance Index: -3.4500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3347
Cell Significance Index: -3.9900
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.3470
Cell Significance Index: -6.0000
Cell Name: microglial cell (CL0000129)
Fold Change: -0.3487
Cell Significance Index: -4.1000
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3531
Cell Significance Index: -5.0700
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.3633
Cell Significance Index: -3.2000
Cell Name: stem cell (CL0000034)
Fold Change: -0.3687
Cell Significance Index: -2.6800
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.3819
Cell Significance Index: -5.8000
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.3994
Cell Significance Index: -5.9800
Cell Name: glioblast (CL0000030)
Fold Change: -0.4013
Cell Significance Index: -2.5200
Cell Name: thymocyte (CL0000893)
Fold Change: -0.4084
Cell Significance Index: -5.1600
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.4085
Cell Significance Index: -5.9800
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.4196
Cell Significance Index: -2.4900
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.4285
Cell Significance Index: -3.2700
Cell Name: astrocyte (CL0000127)
Fold Change: -0.4308
Cell Significance Index: -4.9300
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.4332
Cell Significance Index: -6.9700
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.4540
Cell Significance Index: -7.7600
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.4545
Cell Significance Index: -6.3700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4552
Cell Significance Index: -6.2100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.4648
Cell Significance Index: -7.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TREX1 is a 3'-5' exonuclease enzyme that is highly specific for single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) substrates. Its primary function is to remove damaged or mismatched DNA bases, thereby preventing mutations and maintaining genetic integrity. TREX1 is also involved in the regulation of various cellular processes, including: * Immune response: TREX1 is highly expressed in immune cells, particularly T-helper 17 cells, and is involved in the activation of innate immunity and the production of type I interferons. * DNA repair: TREX1 is a key player in the repair of damaged DNA, including the removal of mismatched bases and the correction of DNA lesions. * Metabolism: TREX1 is involved in the regulation of cellular respiration and metabolism, including the regulation of glycolytic and fatty acid metabolic processes. * Development: TREX1 is implicated in the development of the heart and blood vessels, as well as the regulation of cellular differentiation and proliferation. **Pathways and Functions** TREX1 is involved in several cellular pathways, including: * Activation of immune response: TREX1 is highly expressed in immune cells and is involved in the activation of innate immunity and the production of type I interferons. * Apoptotic cell clearance: TREX1 is involved in the removal of apoptotic cells, which helps to prevent the spread of disease. * DNA repair: TREX1 is a key player in the repair of damaged DNA, including the removal of mismatched bases and the correction of DNA lesions. * Metabolism: TREX1 is involved in the regulation of cellular respiration and metabolism, including the regulation of glycolytic and fatty acid metabolic processes. * Development: TREX1 is implicated in the development of the heart and blood vessels, as well as the regulation of cellular differentiation and proliferation. **Clinical Significance** Dysregulation of TREX1 has been implicated in several diseases, including: * Atherosclerosis: TREX1 is involved in the regulation of lipid metabolism, and dysregulation of TREX1 has been implicated in the development of atherosclerosis. * Cancer: TREX1 is involved in the regulation of DNA repair, and dysregulation of TREX1 has been implicated in the development of cancer. * Neurodegenerative diseases: TREX1 is involved in the regulation of cellular differentiation and proliferation, and dysregulation of TREX1 has been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * Autoimmune diseases: TREX1 is involved in the regulation of immune responses, and dysregulation of TREX1 has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, TREX1 is a critical gene that plays a key role in maintaining genome stability and regulating various cellular processes. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

TREX1_HUMAN
Q5TZT0_HUMAN

Genular Protein ID: 518114896

Symbol: TREX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NSU2 B2RCN9 Q8TEU2 Q9BPW1 Q9Y4X2

Database IDs:

Citations:

PubMed ID: 10393201

Title: A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein.

PubMed ID: 10393201

DOI: 10.1093/emboj/18.13.3868

PubMed ID: 10391904

Title: Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.

PubMed ID: 10391904

DOI: 10.1074/jbc.274.28.19655

PubMed ID: 11278605

Title: Structure and expression of the TREX1 and TREX2 3'-->5' exonuclease genes.

PubMed ID: 11278605

DOI: 10.1074/jbc.m010051200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16818237

Title: The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

PubMed ID: 16818237

DOI: 10.1016/j.molcel.2006.06.005

PubMed ID: 18045533

Title: Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.

PubMed ID: 18045533

DOI: 10.1016/j.cell.2007.10.017

PubMed ID: 17293595

Title: The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.

PubMed ID: 17293595

DOI: 10.1074/jbc.m700039200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23993650

Title: Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

PubMed ID: 23993650

DOI: 10.1016/j.immuni.2013.08.004

PubMed ID: 23979357

Title: The TREX1 C-terminal region controls cellular localization through ubiquitination.

PubMed ID: 23979357

DOI: 10.1074/jbc.m113.503391

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33476576

Title: ER-directed TREX1 limits cGAS activation at micronuclei.

PubMed ID: 33476576

DOI: 10.1016/j.molcel.2020.12.037

PubMed ID: 16845398

Title: Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus.

PubMed ID: 16845398

DOI: 10.1038/ng1845

PubMed ID: 17357087

Title: Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.

PubMed ID: 17357087

DOI: 10.1086/513443

PubMed ID: 17846997

Title: Clinical and molecular phenotype of Aicardi-Goutieres syndrome.

PubMed ID: 17846997

DOI: 10.1086/521373

PubMed ID: 17440703

Title: A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.

PubMed ID: 17440703

DOI: 10.1007/s00109-007-0199-9

PubMed ID: 17660818

Title: Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

PubMed ID: 17660818

DOI: 10.1038/ng2091

PubMed ID: 17660820

Title: C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy.

PubMed ID: 17660820

DOI: 10.1038/ng2082

PubMed ID: 20799324

Title: A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutieres syndrome.

PubMed ID: 20799324

DOI: 10.1002/ajmg.a.33620

PubMed ID: 20131292

Title: Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome.

PubMed ID: 20131292

DOI: 10.1002/art.27367

Sequence Information:

Length: 314
Mass: 33212
Checksum: EE8F63B6496D72F4
Sequence:

MGSQALPPGP MQTLIFFDME ATGLPFSQPK VTELCLLAVH RCALESPPTS QGPPPTVPPP 
PRVVDKLSLC VAPGKACSPA ASEITGLSTA VLAAHGRQCF DDNLANLLLA FLRRQPQPWC 
LVAHNGDRYD FPLLQAELAM LGLTSALDGA FCVDSITALK ALERASSPSE HGPRKSYSLG 
SIYTRLYGQS PPDSHTAEGD VLALLSICQW RPQALLRWVD AHARPFGTIR PMYGVTASAR 
TKPRPSAVTT TAHLATTRNT SPSLGESRGT KDLPPVKDPG ALSREGLLAP LGLLAILTLA 
VATLYGLSLA TPGE

Genular Protein ID: 3214235001

Symbol: Q5TZT0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TZT0

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 304
Mass: 32276
Checksum: 922048DCC4122124
Sequence:

MQTLIFFDME ATGLPFSQPK VTELCLLAVH RCALESPPTS QGPPPTVPPP PRVVDKLSLC 
VAPGKACSPA ASEITGLSTA VLAAHGRQCF DDNLANLLLA FLRRQPQPWC LVAHNGDRYD 
FPLLQAELAM LGLTSALDGA FCVDSITALK ALERASSPSE HGPRKSYSLG SIYTRLYGQS 
PPDSHTAEGD VLALLSICQW RPQALLRWVD AHARPFGTIR PMYGVTASAR TKPRPSAVTT 
TAHLATTRNT SPSLGESRGT KDLPPVKDPG ALSREGLLAP LGLLAILTLA VATLYGLSLA 
TPGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TREX1

Associated with

Cells (max top 100)

Other Information

A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. PubMed ID: 10393201

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'--&gt;5' exonucleases. PubMed ID: 10391904

Structure and expression of the TREX1 and TREX2 3'--&gt;5' exonuclease genes. PubMed ID: 11278605

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. PubMed ID: 16818237

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. PubMed ID: 18045533

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. PubMed ID: 17293595

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. PubMed ID: 23993650

The TREX1 C-terminal region controls cellular localization through ubiquitination. PubMed ID: 23979357

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

ER-directed TREX1 limits cGAS activation at micronuclei. PubMed ID: 33476576

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. PubMed ID: 16845398

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. PubMed ID: 17357087

Clinical and molecular phenotype of Aicardi-Goutieres syndrome. PubMed ID: 17846997

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. PubMed ID: 17440703

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. PubMed ID: 17660818

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. PubMed ID: 17660820

A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutieres syndrome. PubMed ID: 20799324

Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome. PubMed ID: 20131292

The sequence of the human genome. PubMed ID: 11181995

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Database document:

PubMed ID: 10393201

PubMed ID: 10391904

PubMed ID: 11278605

PubMed ID: 14702039

PubMed ID: 17974005

PubMed ID: 16641997

PubMed ID: 15489334

PubMed ID: 16818237

PubMed ID: 18045533

PubMed ID: 17293595

PubMed ID: 18669648

PubMed ID: 23993650

PubMed ID: 23979357

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 25944712

PubMed ID: 33476576

PubMed ID: 16845398

PubMed ID: 17357087

PubMed ID: 17846997

PubMed ID: 17440703

PubMed ID: 17660818

PubMed ID: 17660820

PubMed ID: 20799324

PubMed ID: 20131292

PubMed ID: 11181995

PubMed ID: 18669648

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 25944712