Details for: ZDHHC1

Gene ID: 29800

Symbol: ZDHHC1

Ensembl ID: ENSG00000159714

Description: zinc finger DHHC-type containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.1766
    Cell Significance Index: -12.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.7442
    Cell Significance Index: -12.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.0870
    Cell Significance Index: -12.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 18.5985
    Cell Significance Index: -12.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3224
    Cell Significance Index: -10.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8868
    Cell Significance Index: -12.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6587
    Cell Significance Index: -12.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0866
    Cell Significance Index: -12.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0945
    Cell Significance Index: 17.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8007
    Cell Significance Index: 21.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7788
    Cell Significance Index: 703.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6006
    Cell Significance Index: 65.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5535
    Cell Significance Index: 33.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5517
    Cell Significance Index: 89.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4741
    Cell Significance Index: 21.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4738
    Cell Significance Index: 95.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2989
    Cell Significance Index: 20.6700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2948
    Cell Significance Index: 4.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2763
    Cell Significance Index: 191.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2541
    Cell Significance Index: 138.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2300
    Cell Significance Index: 101.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2262
    Cell Significance Index: 4.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2230
    Cell Significance Index: 30.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2185
    Cell Significance Index: 6.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2151
    Cell Significance Index: 21.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2064
    Cell Significance Index: 4.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1970
    Cell Significance Index: 70.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1585
    Cell Significance Index: 30.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1505
    Cell Significance Index: 7.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1296
    Cell Significance Index: 16.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1286
    Cell Significance Index: 2.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1274
    Cell Significance Index: 5.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1228
    Cell Significance Index: 1.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1053
    Cell Significance Index: 1.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0989
    Cell Significance Index: 5.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0955
    Cell Significance Index: 3.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0928
    Cell Significance Index: 5.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0858
    Cell Significance Index: 1.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0856
    Cell Significance Index: 2.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0700
    Cell Significance Index: 1.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0679
    Cell Significance Index: 13.4800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0666
    Cell Significance Index: 0.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0634
    Cell Significance Index: 7.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0603
    Cell Significance Index: 10.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0330
    Cell Significance Index: 2.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0258
    Cell Significance Index: 0.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0199
    Cell Significance Index: 2.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0147
    Cell Significance Index: 27.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0137
    Cell Significance Index: 21.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0116
    Cell Significance Index: 21.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0076
    Cell Significance Index: 0.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0052
    Cell Significance Index: 3.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0022
    Cell Significance Index: 0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0014
    Cell Significance Index: 1.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0058
    Cell Significance Index: -0.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0117
    Cell Significance Index: -1.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0121
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0125
    Cell Significance Index: -9.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0138
    Cell Significance Index: -0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0209
    Cell Significance Index: -13.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0280
    Cell Significance Index: -1.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0353
    Cell Significance Index: -10.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0363
    Cell Significance Index: -3.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0387
    Cell Significance Index: -2.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0414
    Cell Significance Index: -1.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0522
    Cell Significance Index: -6.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0551
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0598
    Cell Significance Index: -12.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0742
    Cell Significance Index: -1.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0897
    Cell Significance Index: -5.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0991
    Cell Significance Index: -2.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1037
    Cell Significance Index: -4.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1054
    Cell Significance Index: -12.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1090
    Cell Significance Index: -11.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1176
    Cell Significance Index: -3.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1195
    Cell Significance Index: -7.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1235
    Cell Significance Index: -2.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1266
    Cell Significance Index: -2.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1303
    Cell Significance Index: -3.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1373
    Cell Significance Index: -3.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1489
    Cell Significance Index: -11.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1697
    Cell Significance Index: -8.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1711
    Cell Significance Index: -11.0400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1746
    Cell Significance Index: -1.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1752
    Cell Significance Index: -11.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1775
    Cell Significance Index: -2.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1890
    Cell Significance Index: -2.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1953
    Cell Significance Index: -6.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1980
    Cell Significance Index: -2.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2064
    Cell Significance Index: -4.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2117
    Cell Significance Index: -3.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2314
    Cell Significance Index: -3.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2379
    Cell Significance Index: -5.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2488
    Cell Significance Index: -2.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2505
    Cell Significance Index: -8.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2532
    Cell Significance Index: -8.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZDHHC1 is a 12-transmembrane domain protein that belongs to the DHHC-type palmitoyltransferase family. It is characterized by its ability to palmitoylate proteins, particularly cysteine residues, which is essential for protein localization, stability, and function. The gene is highly expressed in cells involved in immune response, including choroid plexus epithelial cells, ciliated columnar cells of the tracheobronchial tree, and pulmonary interstitial fibroblasts. ZDHHC1 also exhibits a high degree of tissue specificity, with expression restricted to specific cell types and tissues. **Pathways and Functions:** ZDHHC1 is involved in various signaling pathways, including the antiviral innate immune response, DNA binding, and protein targeting to membranes. Its palmitoylation activity is crucial for the proper localization of proteins to the endoplasmic reticulum (ER) and Golgi apparatus, where they can interact with other proteins and lipid molecules. ZDHHC1 also plays a role in the regulation of defense responses to viral infections by positive regulating the expression of defense genes. Furthermore, it is involved in the regulation of protein-protein interactions and protein stability, which is essential for maintaining cellular homeostasis. **Clinical Significance:** Dysregulation of ZDHHC1 has been implicated in various immune-mediated disorders, including viral infections, autoimmune diseases, and cancer. For instance, alterations in ZDHHC1 expression have been observed in patients with chronic viral hepatitis, where it is associated with impaired immune response and liver damage. Additionally, ZDHHC1 has been shown to play a role in the development and progression of certain types of cancer, including lung and breast cancer, where its expression is often downregulated. Furthermore, ZDHHC1 has been identified as a potential therapeutic target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where its dysregulation contributes to disease pathogenesis. In conclusion, ZDHHC1 is a multifaceted protein that plays a critical role in various cellular processes, including immune response, protein localization, and signaling pathways. Its dysregulation has been implicated in various immune-mediated disorders, making it a potential therapeutic target for the treatment of these diseases. Further research is necessary to fully elucidate the mechanisms by which ZDHHC1 regulates immune responses and to explore its therapeutic potential in human disease.

Genular Protein ID: 1917348077

Symbol: ZDHC1_HUMAN

Name: Zinc finger protein 377

UniProtKB Accession Codes:

Q8WTX9 O15461

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 Rhea 4 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10395086

Title: The DHHC domain: a new highly conserved cysteine-rich motif.

PubMed ID: 10395086

DOI: 10.1023/a:1006932522197

PubMed ID: 16647879

Title: Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.

PubMed ID: 16647879

DOI: 10.1016/j.bbalip.2006.03.010

PubMed ID: 25299331

Title: The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.

PubMed ID: 25299331

DOI: 10.1016/j.chom.2014.09.006

Sequence Information:

  • Length: 485
  • Mass: 54818
  • Checksum: 6B75B077D782F358
  • Sequence:
    • MYKMNICNKP SNKTAPEKSV WTAPAQPSGP SPELQGQRSR RNGWSWPPHP LQIVAWLLYL 
FFAVIGFGIL VPLLPHHWVP AGYACMGAIF AGHLVVHLTA VSIDPADANV RDKSYAGPLP 
IFNRSQHAHV IEDLHCNLCN VDVSARSKHC SACNKCVCGF DHHCKWLNNC VGERNYRLFL 
HSVASALLGV LLLVLVATYV FVEFFVNPMR LRTNRHFEVL KNHTDVWFVF LPAAPVETQA 
PAILALAALL ILLGLLSTAL LGHLLCFHIY LMWHKLTTYE YIVQHRPPQE AKGVHRELES 
CPPKMRPIQE MEFYMRTFRH MRPEPPGQAG PAAVNAKHSR PASPDPTPGR RDCAGPPVQV 
EWDRKKPLPW RSPLLLLAMW GPQAPPCLCR KRGRGACIKC ERLRPRIRRR GLGPPAAAPA 
RRRIPRTPAL CTPLALPAPT TRRRQSPWTR FQWRRRAWAA PLWPPRGAGA DSPRWRGRRV 
RPPFS

Genular Protein ID: 2138284842

Symbol: I3L202_HUMAN

Name: N/A

UniProtKB Accession Codes:

I3L202

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 4 RuleBase 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 482
  • Mass: 52869
  • Checksum: 87FA10E208B3A7B2
  • Sequence:
    • MYKMNICNKP SNKTAPEKSV WTAPAQPSGP SPELQGQRSR RNGWSWPPHP LQIVAWLLYL 
FFAVIGFGIL VPLLPHHWVP AGYACMGAIF AGHLVVHLTA VSIDPADANV RDKSYAGPLP 
IFNRSQHAHV IEDLHCNLCN VDVSARSKHC SACNKCVCGF DHHCKWLNNC VGERNYRLFL 
HSVASALLGV LLLVLVATYV FVEFFVNPMR LRTNRHFEVL KNHTDVWFVF LPAAPVETQA 
PAILALAALL ILLGLLSTAL LGHLLCFHIY LMWHKLTTYE YIVQHRPPQE AKGVHRELES 
CPPKMRPIQE MEFYMRTFRH MRPEPPGQAG PAAVNANPSQ FLATRGQAEP PPPSSPDTLA 
LPPRIRPQKK RKRRVYKVRT SETSDPASGP RAPSRRSSSS TDSADASPVH AAGPAGAYHS 
ASAESVDEIP VAQTRLGSAA LAAPRGRGRQ PTLARQARAP AVFVSPSSGE PRAPGGREAG 
LA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.