Details for: HMOX1

Gene ID: 3162

Symbol: HMOX1

Ensembl ID: ENSG00000100292

Description: heme oxygenase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.6
    Marker Score: 5064
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.43
    Marker Score: 2435
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.14
    Marker Score: 2579
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.13
    Marker Score: 1173
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.95
    Marker Score: 813
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.82
    Marker Score: 101691
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.81
    Marker Score: 705
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.79
    Marker Score: 4313
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.78
    Marker Score: 2033
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.77
    Marker Score: 4344
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.74
    Marker Score: 712
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.62
    Marker Score: 3286
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.59
    Marker Score: 9634
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.56
    Marker Score: 40040
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.47
    Marker Score: 49850
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.46
    Marker Score: 834
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.38
    Marker Score: 490
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.38
    Marker Score: 1449
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.37
    Marker Score: 1396
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.31
    Marker Score: 15248
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.28
    Marker Score: 2166
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.25
    Marker Score: 5182
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.23
    Marker Score: 1215
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.2
    Marker Score: 2825
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.14
    Marker Score: 4031
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16844
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.08
    Marker Score: 1197
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.03
    Marker Score: 3240
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71768.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47997
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.99
    Marker Score: 1589
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.98
    Marker Score: 666
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.95
    Marker Score: 472
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.93
    Marker Score: 3639.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.92
    Marker Score: 2383
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.9
    Marker Score: 2233
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5038
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5265
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.82
    Marker Score: 5367
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.81
    Marker Score: 635
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 618
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.81
    Marker Score: 1049
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3155
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.75
    Marker Score: 518
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.75
    Marker Score: 473
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.74
    Marker Score: 185
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.74
    Marker Score: 814
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.74
    Marker Score: 185
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1176
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.73
    Marker Score: 500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.73
    Marker Score: 3495.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.71
    Marker Score: 163
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 638
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.69
    Marker Score: 861.5
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.69
    Marker Score: 218
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.66
    Marker Score: 411
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.63
    Marker Score: 217
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.63
    Marker Score: 310
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.62
    Marker Score: 485
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.61
    Marker Score: 222
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.61
    Marker Score: 407
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 292
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.6
    Marker Score: 432
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.58
    Marker Score: 1018
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.58
    Marker Score: 621
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.58
    Marker Score: 920
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 748
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.56
    Marker Score: 1023.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.54
    Marker Score: 838
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.53
    Marker Score: 531
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.53
    Marker Score: 448
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 167
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 309
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.51
    Marker Score: 894
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5
    Marker Score: 8091
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.5
    Marker Score: 775
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5
    Marker Score: 730.5
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.49
    Marker Score: 393
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.48
    Marker Score: 136
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.47
    Marker Score: 2305
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.47
    Marker Score: 113
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.45
    Marker Score: 144
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.45
    Marker Score: 439
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.45
    Marker Score: 125
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.45
    Marker Score: 139
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.44
    Marker Score: 215
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.44
    Marker Score: 234

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Other Information

**Key characteristics:** * HMOX1 is a protein of the cytochrome c superfamily. * It is a large protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including monocytes, macrophages, and endothelial cells. * It is a key regulator of inflammation. * It can be involved in both innate and adaptive immune responses. **Pathways and functions:** * HMOX1 is involved in the regulation of oxygen transport in the body. * It is a key regulator of inflammation. * It can be involved in both innate and adaptive immune responses. **Clinical significance:** * Mutations in the HMOX1 gene have been linked to a number of diseases, including rheumatoid arthritis, systemic sclerosis, and inflammatory bowel disease. * HMOX1 is a potential therapeutic target for these diseases. **Additional notes:** * HMOX1 is a highly conserved protein, with a similar protein found in other vertebrates. * It is a multi-functional protein that can interact with a variety of other proteins. * It is a key regulator of inflammation, and its expression is often upregulated in inflammatory diseases.

Genular Protein ID: 2356160291

Symbol: HMOX1_HUMAN

Name: Heme oxygenase 1

UniProtKB Accession Codes:

P09601

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 EC 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 53 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 26 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 10 RefSeq 1 Rhea 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3345742

Title: Human heme oxygenase cDNA and induction of its mRNA by hemin.

PubMed ID: 3345742

DOI: 10.1111/j.1432-1033.1988.tb13811.x

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 2911585

Title: Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

PubMed ID: 2911585

DOI: 10.1073/pnas.86.1.99

PubMed ID: 2537723

Title: Structural organization of the human heme oxygenase gene and the function of its promoter.

PubMed ID: 2537723

DOI: 10.1111/j.1432-1033.1989.tb14583.x

PubMed ID: 7703255

Title: Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase.

PubMed ID: 7703255

DOI: 10.1021/bi00013a034

PubMed ID: 9884342

Title: Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency.

PubMed ID: 9884342

DOI: 10.1172/jci4165

PubMed ID: 11121422

Title: Disruption of an active site hydrogen bond converts human heme oxygenase-1 into a peroxidase.

PubMed ID: 11121422

DOI: 10.1074/jbc.m010349200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19556236

Title: Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum.

PubMed ID: 19556236

DOI: 10.1074/jbc.m109.028001

PubMed ID: 20055707

Title: Mechanisms of cell protection by heme oxygenase-1.

PubMed ID: 20055707

DOI: 10.1146/annurev.pharmtox.010909.105600

PubMed ID: 20855888

Title: CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1.

PubMed ID: 20855888

DOI: 10.1074/jbc.m110.170324

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22419571

Title: Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol.

PubMed ID: 22419571

DOI: 10.3324/haematol.2012.063651

PubMed ID: 35239449

Title: SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection.

PubMed ID: 35239449

DOI: 10.1080/15548627.2022.2039992

PubMed ID: 27184847

Title: APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest.

PubMed ID: 27184847

DOI: 10.1016/j.celrep.2016.04.064

PubMed ID: 10467099

Title: Crystal structure of human heme oxygenase-1.

PubMed ID: 10467099

DOI: 10.1038/12319

PubMed ID: 12842469

Title: Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications.

PubMed ID: 12842469

DOI: 10.1016/s0022-2836(03)00578-3

Sequence Information:

  • Length: 288
  • Mass: 32819
  • Checksum: AB47827778694064
  • Sequence:
    • MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA 
LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE 
VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ 
LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA 
SNKVQDSAPV ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.