Details for: FPR1

Gene ID: 2357

Symbol: FPR1

Ensembl ID: ENSG00000171051

Description: formyl peptide receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.2
    Marker Score: 179195
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.91
    Marker Score: 5672
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.63
    Marker Score: 6541
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.34
    Marker Score: 5653
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.11
    Marker Score: 8758
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.06
    Marker Score: 2360
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.01
    Marker Score: 821
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.93
    Marker Score: 49317
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.85
    Marker Score: 1852.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.74
    Marker Score: 20281
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.69
    Marker Score: 929
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.66
    Marker Score: 3383
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1163
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168767
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.36
    Marker Score: 1389
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.34
    Marker Score: 8119
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.27
    Marker Score: 3286
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.26
    Marker Score: 407
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4806
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 498
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14642
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.88
    Marker Score: 1146
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.81
    Marker Score: 416
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.8
    Marker Score: 967
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1199
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.72
    Marker Score: 720
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.7
    Marker Score: 293
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.66
    Marker Score: 240
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 397
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.61
    Marker Score: 209
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.53
    Marker Score: 1638
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.53
    Marker Score: 587.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.51
    Marker Score: 219.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.43
    Marker Score: 249
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.43
    Marker Score: 778
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 202
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 111
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.39
    Marker Score: 176.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.39
    Marker Score: 270
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.39
    Marker Score: 192
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.36
    Marker Score: 109
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.35
    Marker Score: 223
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.34
    Marker Score: 181
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.33
    Marker Score: 217
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.32
    Marker Score: 194
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 302
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.31
    Marker Score: 217
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.31
    Marker Score: 156
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.31
    Marker Score: 304.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.3
    Marker Score: 386
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.29
    Marker Score: 321
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 553
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.29
    Marker Score: 143.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 174
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.28
    Marker Score: 78
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.28
    Marker Score: 216
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.27
    Marker Score: 161
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.24
    Marker Score: 81
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.24
    Marker Score: 74
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 212
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.24
    Marker Score: 101.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.22
    Marker Score: 372
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 125
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.21
    Marker Score: 58
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.21
    Marker Score: 226
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.21
    Marker Score: 42
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.21
    Marker Score: 104
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2
    Marker Score: 130
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2
    Marker Score: 87.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 109
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.19
    Marker Score: 40
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.19
    Marker Score: 123
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.18
    Marker Score: 43

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Other Information

## Summary FPR1 is a G protein-coupled receptor (GPCR) that is expressed on a variety of immune cells, including monocytes, macrophages, and dendritic cells. It is a key regulator of innate immunity, and its expression and activity are involved in the regulation of inflammation, immune cell migration, and tissue repair. ## Key characteristics * FPR1 is a single-pass membrane protein with a molecular weight of approximately 130 kDa. * It is a member of the GPCR family of cell surface receptors. * FPR1 is expressed in high abundance in the blood and lymphoid tissues. * It is also expressed in the lungs, liver, and other tissues. * FPR1 is a ligand-gated ion channel, which means that it opens when a ligand binds to it. * When FPR1 is activated, it activates the G protein GPCR signaling pathway. * The activation of GPCRs leads to the phosphorylation of a variety of downstream proteins, which ultimately modulates the activity of immune cells. ## Pathways and functions FPR1 is involved in a variety of immune pathways, including: * The innate immune system: FPR1 is expressed on immune cells such as macrophages and dendritic cells, which are key players in the innate immune response. Activation of FPR1 by formyl peptides, a class of molecules that are produced by bacteria and fungi, triggers the inflammatory response. * The adaptive immune system: FPR1 is also expressed on activated T cells and B cells, which are important players in the adaptive immune response. Activation of FPR1 by formyl peptides can inhibit the activation of T cells and B cells, which can help to prevent the development of autoimmune diseases. ## Clinical significance FPR1 is a potential therapeutic target for a variety of inflammatory diseases. For example, FPR1 is expressed on immune cells in rheumatoid arthritis, where it is thought to contribute to the inflammatory response. Inhibition of FPR1 with antibodies or small molecules has been shown to be effective in reducing inflammation and pain in animal models of rheumatoid arthritis. FPR1 is also a potential therapeutic target for sepsis, a life-threatening condition that is characterized by a systemic inflammatory response. Sepsis is a major cause of death in the United States, and it is estimated to cost billions of dollars each year. FPR1 is expressed on immune cells in the blood and other body fluids, and it is thought to play a role in the inflammatory response to sepsis. Inhibition of FPR1 with antibodies or small molecules has been shown to be effective in reducing inflammation and mortality in animal models of sepsis.

Genular Protein ID: 3281554151

Symbol: FPR1_HUMAN

Name: fMet-Leu-Phe receptor

UniProtKB Accession Codes:

P21462 Q14939 Q7Z6A4 Q86U52 Q9NS48

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 4 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2161213

Title: Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA.

PubMed ID: 2161213

DOI: 10.1016/0006-291x(90)91143-g

PubMed ID: 2176894

Title: The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.

PubMed ID: 2176894

DOI: 10.1021/bi00502a016

PubMed ID: 1712023

Title: Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor.

PubMed ID: 1712023

DOI: 10.1016/s0021-9258(18)98935-0

PubMed ID: 1612600

Title: Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.

PubMed ID: 1612600

DOI: 10.1016/0888-7543(92)90265-t

PubMed ID: 8224916

Title: Sequence and organization of the human N-formyl peptide receptor-encoding gene.

PubMed ID: 8224916

DOI: 10.1016/0378-1119(93)90653-k

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1445895

Title: Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression.

PubMed ID: 1445895

DOI: 10.1021/bi00161a044

PubMed ID: 10514456

Title: Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor.

PubMed ID: 10514456

DOI: 10.1074/jbc.274.42.29791

PubMed ID: 15153520

Title: Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor.

PubMed ID: 15153520

DOI: 10.4049/jimmunol.172.11.6994

PubMed ID: 15210802

Title: Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor.

PubMed ID: 15210802

DOI: 10.4049/jimmunol.173.1.428

PubMed ID: 25109685

Title: FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages.

PubMed ID: 25109685

DOI: 10.1038/cmi.2014.61

Sequence Information:

  • Length: 350
  • Mass: 38446
  • Checksum: 06651DF820B1CBD1
  • Sequence:
    • METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV AGFRMTHTVT 
TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF VFTIVDINLF GSVFLIALIA 
LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW VMALLLTLPV IIRVTTVPGK TGTVACTFNF 
SPWTNDPKER INVAVAMLTV RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL 
RVLSFVAAAF FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML 
YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVELQAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.