Details for: FPR1

Gene ID: 2357

Symbol: FPR1

Ensembl ID: ENSG00000171051

Description: formyl peptide receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.1269
    Cell Significance Index: -12.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.7656
    Cell Significance Index: -13.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.5318
    Cell Significance Index: -12.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.5341
    Cell Significance Index: -12.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4627
    Cell Significance Index: -12.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.9500
    Cell Significance Index: 128.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.1328
    Cell Significance Index: 48.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5176
    Cell Significance Index: -5.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2801
    Cell Significance Index: 78.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2637
    Cell Significance Index: 50.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2204
    Cell Significance Index: 199.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2084
    Cell Significance Index: 20.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1858
    Cell Significance Index: 4.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0434
    Cell Significance Index: 7.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0164
    Cell Significance Index: 0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0032
    Cell Significance Index: -0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0050
    Cell Significance Index: -9.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0090
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0102
    Cell Significance Index: -18.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0119
    Cell Significance Index: -18.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0143
    Cell Significance Index: -19.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0163
    Cell Significance Index: -12.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0166
    Cell Significance Index: -12.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0180
    Cell Significance Index: -11.4600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0183
    Cell Significance Index: -0.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0183
    Cell Significance Index: -5.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0228
    Cell Significance Index: -2.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0231
    Cell Significance Index: -8.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0312
    Cell Significance Index: -14.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0335
    Cell Significance Index: -6.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0379
    Cell Significance Index: -7.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0395
    Cell Significance Index: -1.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0420
    Cell Significance Index: -1.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0448
    Cell Significance Index: -1.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0533
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0573
    Cell Significance Index: -9.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0639
    Cell Significance Index: -13.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0667
    Cell Significance Index: -9.7000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0839
    Cell Significance Index: -1.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0872
    Cell Significance Index: -10.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1030
    Cell Significance Index: -13.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1045
    Cell Significance Index: -13.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1067
    Cell Significance Index: -12.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1077
    Cell Significance Index: -12.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1087
    Cell Significance Index: -5.4900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1104
    Cell Significance Index: -4.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1107
    Cell Significance Index: -15.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1116
    Cell Significance Index: -12.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1145
    Cell Significance Index: -7.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1202
    Cell Significance Index: -0.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1232
    Cell Significance Index: -12.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1490
    Cell Significance Index: -1.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1518
    Cell Significance Index: -4.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1643
    Cell Significance Index: -12.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1743
    Cell Significance Index: -4.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1789
    Cell Significance Index: -13.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1838
    Cell Significance Index: -12.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1938
    Cell Significance Index: -12.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1986
    Cell Significance Index: -4.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2018
    Cell Significance Index: -8.2700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2025
    Cell Significance Index: -3.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2090
    Cell Significance Index: -5.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2144
    Cell Significance Index: -13.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2209
    Cell Significance Index: -10.3800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2241
    Cell Significance Index: -2.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2325
    Cell Significance Index: -12.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2536
    Cell Significance Index: -14.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2592
    Cell Significance Index: -6.9200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2773
    Cell Significance Index: -3.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2791
    Cell Significance Index: -14.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2835
    Cell Significance Index: -12.5400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2934
    Cell Significance Index: -2.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2977
    Cell Significance Index: -15.6300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3065
    Cell Significance Index: -4.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3073
    Cell Significance Index: -19.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3169
    Cell Significance Index: -11.1000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3291
    Cell Significance Index: -2.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3324
    Cell Significance Index: -7.0800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3340
    Cell Significance Index: -2.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3412
    Cell Significance Index: -12.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3552
    Cell Significance Index: -16.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3703
    Cell Significance Index: -12.1300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.3802
    Cell Significance Index: -3.0800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3889
    Cell Significance Index: -3.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3961
    Cell Significance Index: -14.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3966
    Cell Significance Index: -12.6300
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.4158
    Cell Significance Index: -4.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4315
    Cell Significance Index: -12.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4382
    Cell Significance Index: -12.8700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4447
    Cell Significance Index: -4.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4523
    Cell Significance Index: -12.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4538
    Cell Significance Index: -12.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4678
    Cell Significance Index: -13.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4699
    Cell Significance Index: -10.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4783
    Cell Significance Index: -11.9300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4940
    Cell Significance Index: -7.0200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4943
    Cell Significance Index: -12.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5018
    Cell Significance Index: -12.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GPCR structure and function:** FPR1 is a member of the GPCR family, characterized by its seven transmembrane helices and the presence of a G protein-coupled binding site. 2. **Ligand specificity:** FPR1 is activated by formyl peptides, which are derived from bacterial cell walls, as well as other ligands, such as N-formyl peptides and certain amino acids. 3. **Cellular expression:** FPR1 is expressed on various immune cells, including CD14-positive and CD16-positive classical monocytes, non-classical monocytes, lung macrophages, alveolar macrophages, and Kupffer cells. 4. **Signaling pathways:** FPR1 activates several signaling pathways, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, and nitric oxide-mediated signal transduction. **Pathways and Functions:** 1. **Chemotaxis:** FPR1 activation promotes chemotaxis, the movement of immune cells towards chemokines, which is essential for the recruitment of immune cells to sites of infection or inflammation. 2. **Degranulation:** FPR1 activation leads to degranulation, the release of granules containing antimicrobial peptides and other immune molecules, which is crucial for the elimination of pathogens. 3. **Cytokine production:** FPR1 activation modulates cytokine production, including the release of pro-inflammatory cytokines, such as IL-1β and TNF-α, and anti-inflammatory cytokines, such as IL-10. 4. **Immune cell activation:** FPR1 activation enhances the activation of immune cells, including the upregulation of surface receptors, such as CD14 and CD16, and the production of cytokines and chemokines. **Clinical Significance:** 1. **Inflammatory disorders:** Dysregulation of FPR1 has been implicated in various inflammatory and immune-mediated disorders, including asthma, chronic obstructive pulmonary disease (COPD), and sepsis. 2. **Infectious diseases:** FPR1 plays a crucial role in the recognition and elimination of pathogens, particularly Gram-negative bacteria, and its dysregulation can contribute to the development of infections. 3. **Cancer:** FPR1 has been shown to promote tumor progression and metastasis, highlighting its potential as a therapeutic target in cancer. 4. **Therapeutic targets:** FPR1 is a potential therapeutic target for the treatment of inflammatory and immune-mediated disorders, as well as infectious diseases. In conclusion, FPR1 is a key player in the regulation of immune responses and inflammation, and its dysregulation has been implicated in various clinical disorders. Further research is needed to fully elucidate the mechanisms of FPR1 and its potential therapeutic applications.

Genular Protein ID: 3281554151

Symbol: FPR1_HUMAN

Name: fMet-Leu-Phe receptor

UniProtKB Accession Codes:

P21462 Q14939 Q7Z6A4 Q86U52 Q9NS48

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 4 Ensembl 4 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2161213

Title: Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA.

PubMed ID: 2161213

DOI: 10.1016/0006-291x(90)91143-g

PubMed ID: 2176894

Title: The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.

PubMed ID: 2176894

DOI: 10.1021/bi00502a016

PubMed ID: 1712023

Title: Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor.

PubMed ID: 1712023

DOI: 10.1016/s0021-9258(18)98935-0

PubMed ID: 1612600

Title: Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.

PubMed ID: 1612600

DOI: 10.1016/0888-7543(92)90265-t

PubMed ID: 8224916

Title: Sequence and organization of the human N-formyl peptide receptor-encoding gene.

PubMed ID: 8224916

DOI: 10.1016/0378-1119(93)90653-k

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1445895

Title: Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression.

PubMed ID: 1445895

DOI: 10.1021/bi00161a044

PubMed ID: 10514456

Title: Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor.

PubMed ID: 10514456

DOI: 10.1074/jbc.274.42.29791

PubMed ID: 15153520

Title: Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor.

PubMed ID: 15153520

DOI: 10.4049/jimmunol.172.11.6994

PubMed ID: 15210802

Title: Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor.

PubMed ID: 15210802

DOI: 10.4049/jimmunol.173.1.428

PubMed ID: 25109685

Title: FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages.

PubMed ID: 25109685

DOI: 10.1038/cmi.2014.61

Sequence Information:

  • Length: 350
  • Mass: 38446
  • Checksum: 06651DF820B1CBD1
  • Sequence:
    • METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV AGFRMTHTVT 
TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF VFTIVDINLF GSVFLIALIA 
LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW VMALLLTLPV IIRVTTVPGK TGTVACTFNF 
SPWTNDPKER INVAVAMLTV RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL 
RVLSFVAAAF FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML 
YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVELQAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.