Details for: FCER1G

Gene ID: 2207

Symbol: FCER1G

Ensembl ID: ENSG00000158869

Description: Fc epsilon receptor Ig

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.5315
    Cell Significance Index: -23.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.5672
    Cell Significance Index: -24.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.0786
    Cell Significance Index: -33.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 63.0656
    Cell Significance Index: -32.4400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 20.2771
    Cell Significance Index: 54.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8409
    Cell Significance Index: -23.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 16.0854
    Cell Significance Index: 297.3000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 13.0780
    Cell Significance Index: 54.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6320
    Cell Significance Index: -26.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.9659
    Cell Significance Index: 76.8300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.8445
    Cell Significance Index: 25.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.1490
    Cell Significance Index: 366.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.9301
    Cell Significance Index: 51.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7099
    Cell Significance Index: 37.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0109
    Cell Significance Index: 192.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7703
    Cell Significance Index: 76.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6331
    Cell Significance Index: 571.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3699
    Cell Significance Index: 60.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1761
    Cell Significance Index: 19.1500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.1397
    Cell Significance Index: 2.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1216
    Cell Significance Index: 12.4200
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.0508
    Cell Significance Index: 0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0373
    Cell Significance Index: 7.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0271
    Cell Significance Index: 20.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0094
    Cell Significance Index: -0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0123
    Cell Significance Index: -23.1800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0137
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0194
    Cell Significance Index: -35.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0201
    Cell Significance Index: -12.5700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0219
    Cell Significance Index: -0.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0220
    Cell Significance Index: -0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0230
    Cell Significance Index: -35.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0268
    Cell Significance Index: -36.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0279
    Cell Significance Index: -15.7500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0309
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0418
    Cell Significance Index: -12.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0443
    Cell Significance Index: -32.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0458
    Cell Significance Index: -25.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0492
    Cell Significance Index: -31.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0528
    Cell Significance Index: -23.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0576
    Cell Significance Index: -1.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0694
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0700
    Cell Significance Index: -14.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0713
    Cell Significance Index: -25.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0718
    Cell Significance Index: -32.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0724
    Cell Significance Index: -5.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0737
    Cell Significance Index: -3.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0870
    Cell Significance Index: -4.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0982
    Cell Significance Index: -16.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1232
    Cell Significance Index: -22.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1280
    Cell Significance Index: -25.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1292
    Cell Significance Index: -3.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1520
    Cell Significance Index: -20.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1538
    Cell Significance Index: -17.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1550
    Cell Significance Index: -2.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1559
    Cell Significance Index: -9.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1566
    Cell Significance Index: -6.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1591
    Cell Significance Index: -20.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1717
    Cell Significance Index: -5.5000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1890
    Cell Significance Index: -1.7600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1923
    Cell Significance Index: -3.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2033
    Cell Significance Index: -29.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2127
    Cell Significance Index: -26.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2155
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2203
    Cell Significance Index: -25.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2296
    Cell Significance Index: -29.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2438
    Cell Significance Index: -25.3900
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.2448
    Cell Significance Index: -2.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2450
    Cell Significance Index: -14.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2484
    Cell Significance Index: -29.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2524
    Cell Significance Index: -6.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2653
    Cell Significance Index: -12.4700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2752
    Cell Significance Index: -2.8100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2808
    Cell Significance Index: -2.2900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3262
    Cell Significance Index: -5.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3360
    Cell Significance Index: -8.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3526
    Cell Significance Index: -27.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3533
    Cell Significance Index: -24.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3785
    Cell Significance Index: -8.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3958
    Cell Significance Index: -29.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4116
    Cell Significance Index: -32.6000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4256
    Cell Significance Index: -3.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4304
    Cell Significance Index: -28.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4389
    Cell Significance Index: -22.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4624
    Cell Significance Index: -28.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4749
    Cell Significance Index: -29.9300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.5206
    Cell Significance Index: -4.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5341
    Cell Significance Index: -29.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5717
    Cell Significance Index: -8.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5837
    Cell Significance Index: -25.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5965
    Cell Significance Index: -27.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5981
    Cell Significance Index: -31.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6025
    Cell Significance Index: -3.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6372
    Cell Significance Index: -33.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6477
    Cell Significance Index: -18.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -0.6495
    Cell Significance Index: 1.7400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.6922
    Cell Significance Index: -7.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7160
    Cell Significance Index: -31.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7502
    Cell Significance Index: -27.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Receptor Structure**: The FcεRIγ subunit is a transmembrane protein that spans the plasma membrane, with an extracellular domain that interacts with IgE antibodies and an intracellular domain that interacts with signaling molecules. 2. **Expression**: The gene is primarily expressed on mast cells, basophils, and a subset of classical monocytes, with expression levels varying among different cell types. 3. **Function**: The FcεRIγ subunit is essential for the high-affinity binding of IgE antibodies to the FcεRI receptor complex, which is critical for mediating IgE-dependent allergic responses. 4. **Signaling**: Upon cross-linking, the FcεRIγ subunit triggers a signaling cascade that activates various kinases, including Syk and JAK, leading to the activation of downstream transcription factors and the release of inflammatory mediators. **Pathways and Functions** 1. **FcεRI Signaling Pathway**: The FcεRIγ subunit is integral to the FcεRI signaling pathway, which involves the activation of Syk and JAK kinases, leading to the activation of downstream transcription factors and the release of inflammatory mediators. 2. **Antigen Processing and Presentation**: The FcεRIγ subunit is also involved in the processing and presentation of exogenous peptide antigens via MHC class I and II molecules. 3. **Innate Immune Response**: The FcεRIγ subunit plays a role in the innate immune response, particularly in the activation of neutrophils and the regulation of platelet activation. 4. **Immunoglobulin Mediated Immune Response**: The FcεRIγ subunit is critical for the immunoglobulin-mediated immune response, particularly in the mediation of IgE-dependent allergic responses. **Clinical Significance** 1. **Allergic Diseases**: The FcεRIγ subunit is implicated in the pathogenesis of various allergic diseases, including atopic dermatitis, asthma, and allergic rhinitis. 2. **Immunotherapy**: The FcεRIγ subunit is a target for immunotherapy, with therapies aimed at blocking the FcεRIγ subunit to prevent IgE-dependent allergic responses. 3. **Cancer**: The FcεRIγ subunit has been implicated in the development and progression of certain types of cancer, including melanoma and lung cancer. 4. **Infectious Diseases**: The FcεRIγ subunit plays a role in the innate immune response to infections, particularly in the activation of neutrophils and the regulation of platelet activation. In conclusion, the FCER1G gene encodes for the high-affinity immunoglobulin epsilon receptor subunit gamma, a critical component of the FcεRI receptor complex involved in IgE-dependent allergic responses. The FcεRIγ subunit plays a pivotal role in the FcεRI signaling pathway, antigen processing and presentation, and the innate immune response. Its dysregulation has been implicated in various diseases, including allergic diseases, cancer, and infectious diseases, making it a promising target for therapeutic interventions.

Genular Protein ID: 1824569880

Symbol: FCERG_HUMAN

Name: High affinity immunoglobulin epsilon receptor subunit gamma

UniProtKB Accession Codes:

P30273 Q5VTW4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 ELM 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 29 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 10 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2138619

Title: Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family.

PubMed ID: 2138619

DOI: 10.1016/s0021-9258(19)39347-0

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8611682

Title: FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.

PubMed ID: 8611682

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18776906

Title: Mincle is an ITAM-coupled activating receptor that senses damaged cells.

PubMed ID: 18776906

DOI: 10.1038/ni.1651

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26311901

Title: TARM1 is a novel leukocyte receptor complex-encoded ITAM receptor that costimulates proinflammatory cytokine secretion by macrophages and neutrophils.

PubMed ID: 26311901

DOI: 10.4049/jimmunol.1401847

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28652325

Title: Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules.

PubMed ID: 28652325

DOI: 10.1073/pnas.1706483114

Sequence Information:

  • Length: 86
  • Mass: 9667
  • Checksum: 2F2C7536513D6165
  • Sequence:
    • MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV RKAAITSYEK 
SDGVYTGLST RNQETYETLK HEKPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.