Details for: FCER1G

Gene ID: 2207

Symbol: FCER1G

Ensembl ID: ENSG00000158869

Description: Fc epsilon receptor Ig

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.53
    Marker Score: 253231
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.5
    Marker Score: 13129.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.47
    Marker Score: 12361.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.21
    Marker Score: 4680
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 4.01
    Marker Score: 4583
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.89
    Marker Score: 7587
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.75
    Marker Score: 9051
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.52
    Marker Score: 1673
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.3
    Marker Score: 3296.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.12
    Marker Score: 7781
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.1
    Marker Score: 1339
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 3.03
    Marker Score: 77486
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.99
    Marker Score: 18183.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.94
    Marker Score: 7622
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.9
    Marker Score: 33757
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.83
    Marker Score: 931
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.81
    Marker Score: 1170
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.75
    Marker Score: 1187
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.74
    Marker Score: 1120
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.58
    Marker Score: 646
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.51
    Marker Score: 637
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.38
    Marker Score: 1312
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.33
    Marker Score: 1863
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.22
    Marker Score: 9234
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.89
    Marker Score: 2276
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.7
    Marker Score: 847
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.63
    Marker Score: 1814
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.6
    Marker Score: 791
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.6
    Marker Score: 1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1136
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.56
    Marker Score: 2021
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.41
    Marker Score: 1438
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.4
    Marker Score: 1821
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.34
    Marker Score: 562
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.34
    Marker Score: 1344
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.32
    Marker Score: 1000
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.3
    Marker Score: 294
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.29
    Marker Score: 665
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.27
    Marker Score: 324
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.22
    Marker Score: 546
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.13
    Marker Score: 407
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4744
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.12
    Marker Score: 11076
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.11
    Marker Score: 857
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.09
    Marker Score: 667
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.06
    Marker Score: 325
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.04
    Marker Score: 602
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71723
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47950
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.98
    Marker Score: 257
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.97
    Marker Score: 336.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.96
    Marker Score: 661
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.96
    Marker Score: 286
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.93
    Marker Score: 1762
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.92
    Marker Score: 284
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.91
    Marker Score: 981
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2725
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5183.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.9
    Marker Score: 484
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.89
    Marker Score: 1430
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.89
    Marker Score: 306
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.88
    Marker Score: 247
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5260
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.85
    Marker Score: 234
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.85
    Marker Score: 383.5
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.84
    Marker Score: 279
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.84
    Marker Score: 410
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.84
    Marker Score: 288
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.83
    Marker Score: 1335
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.83
    Marker Score: 1503
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.81
    Marker Score: 667
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 618
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.81
    Marker Score: 402
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.8
    Marker Score: 289
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.79
    Marker Score: 454
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.79
    Marker Score: 326
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.78
    Marker Score: 567
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.78
    Marker Score: 492
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.77
    Marker Score: 1111
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.71
    Marker Score: 476
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.7
    Marker Score: 2872
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.69
    Marker Score: 653
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.69
    Marker Score: 320
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.68
    Marker Score: 219
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.68
    Marker Score: 4421
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.65
    Marker Score: 1702
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.64
    Marker Score: 269
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.63
    Marker Score: 128
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.63
    Marker Score: 425
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.62
    Marker Score: 306

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Other Information

**Key characteristics:** * The FCER1G gene is located on chromosome 15q21.1. * It is a member of the Fc epsilon receptor family of cell surface receptors. * The protein is a type I transmembrane protein with a single extracellular domain and a single transmembrane domain. * The extracellular domain is responsible for binding to its ligand, which is a glycoprotein called Ige. * The transmembrane domain is responsible for signaling through the intracellular pathway. **Pathways and functions:** * The FCER1G protein is involved in the regulation of inflammation. It is expressed in high levels in inflammatory cells, and its expression is increased in response to inflammation. * The FCER1G protein is also involved in cell migration. It is expressed in cells that are migrating through the tissue, and its expression is increased in response to growth factors. * The FCER1G protein is also involved in signal transduction. It is a downstream target for a variety of cytokines and growth factors, and its expression is increased in response to these signals. **Clinical significance:** * Mutations in the FCER1G gene have been linked to a number of human diseases, including rheumatoid arthritis, inflammatory bowel disease, and psoriasis. * The FCER1G gene is a promising target for the treatment of these diseases. By blocking the activity of the FCER1G protein, it is possible to inhibit inflammation and cell migration. **Additional information:** * The FCER1G protein is a highly conserved protein, with a similar protein found in mice. * The FCER1G protein is a member of the C-type lectin receptors (clrs) family of cell surface receptors. * The clrs family of receptors are involved in a variety of cellular processes, including inflammation, cell migration, and adhesion.

Genular Protein ID: 1824569880

Symbol: FCERG_HUMAN

Name: High affinity immunoglobulin epsilon receptor subunit gamma

UniProtKB Accession Codes:

P30273 Q5VTW4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 ELM 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 29 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 10 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2138619

Title: Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family.

PubMed ID: 2138619

DOI: 10.1016/s0021-9258(19)39347-0

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8611682

Title: FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.

PubMed ID: 8611682

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18776906

Title: Mincle is an ITAM-coupled activating receptor that senses damaged cells.

PubMed ID: 18776906

DOI: 10.1038/ni.1651

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26311901

Title: TARM1 is a novel leukocyte receptor complex-encoded ITAM receptor that costimulates proinflammatory cytokine secretion by macrophages and neutrophils.

PubMed ID: 26311901

DOI: 10.4049/jimmunol.1401847

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28652325

Title: Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules.

PubMed ID: 28652325

DOI: 10.1073/pnas.1706483114

Sequence Information:

  • Length: 86
  • Mass: 9667
  • Checksum: 2F2C7536513D6165
  • Sequence:
    • MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV RKAAITSYEK 
SDGVYTGLST RNQETYETLK HEKPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.