IGKV4 1 | ENSG00000211598 | NCBI 28908

Details for: IGKV4 1

Gene ID: 28908

Symbol: IGKV4 1

Ensembl ID: ENSG00000211598

Description: immunoglobulin kappa variable 4-1

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 4.0832
Cell Significance Index: 102.0700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 3.2675
Cell Significance Index: 49.2400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9505
Cell Significance Index: 180.8900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.9340
Cell Significance Index: 14.4500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6796
Cell Significance Index: 40.8000
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.5259
Cell Significance Index: 7.6400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5078
Cell Significance Index: 10.8200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4146
Cell Significance Index: 45.1000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2697
Cell Significance Index: 26.6800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2468
Cell Significance Index: 222.8700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2345
Cell Significance Index: 16.2200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1996
Cell Significance Index: 32.4600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0813
Cell Significance Index: 10.4200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0177
Cell Significance Index: 0.5100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0004
Cell Significance Index: -0.0200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0009
Cell Significance Index: -0.0200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0090
Cell Significance Index: -6.7800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0208
Cell Significance Index: -0.2400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0290
Cell Significance Index: -8.3500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0315
Cell Significance Index: -17.7500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0347
Cell Significance Index: -3.5400
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0358
Cell Significance Index: -7.1100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0378
Cell Significance Index: -1.2100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0453
Cell Significance Index: -0.9400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0576
Cell Significance Index: -0.9900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0840
Cell Significance Index: -5.1500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0875
Cell Significance Index: -11.3000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0896
Cell Significance Index: -15.3000
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.0975
Cell Significance Index: -1.0900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1058
Cell Significance Index: -8.1200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1189
Cell Significance Index: -3.1800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1446
Cell Significance Index: -10.7800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1446
Cell Significance Index: -16.5700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1557
Cell Significance Index: -7.2600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1769
Cell Significance Index: -9.1900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1814
Cell Significance Index: -11.7000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2494
Cell Significance Index: -9.1600
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2703
Cell Significance Index: -3.0200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2715
Cell Significance Index: -12.7600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2811
Cell Significance Index: -7.0100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2899
Cell Significance Index: -8.5400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3026
Cell Significance Index: -7.7300
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.3216
Cell Significance Index: -4.3800
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.3279
Cell Significance Index: -3.7200
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3876
Cell Significance Index: -6.5200
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.3904
Cell Significance Index: -2.6000
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.4139
Cell Significance Index: -5.1200
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.4205
Cell Significance Index: -4.9700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4225
Cell Significance Index: -12.1100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4376
Cell Significance Index: -10.9300
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.4482
Cell Significance Index: -5.6800
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.4589
Cell Significance Index: -6.4400
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4620
Cell Significance Index: -11.7700
Cell Name: peg cell (CL4033014)
Fold Change: -0.4640
Cell Significance Index: -10.7200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4669
Cell Significance Index: -11.3100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4777
Cell Significance Index: -8.0000
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.4781
Cell Significance Index: -6.9900
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: -0.5002
Cell Significance Index: -4.5000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5005
Cell Significance Index: -9.2500
Cell Name: enterocyte (CL0000584)
Fold Change: -0.5045
Cell Significance Index: -3.1300
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.5070
Cell Significance Index: -7.3900
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.5280
Cell Significance Index: -7.3000
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.5285
Cell Significance Index: -8.5600
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.5372
Cell Significance Index: -6.3200
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.5424
Cell Significance Index: -10.6100
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.5426
Cell Significance Index: -9.2800
Cell Name: naive B cell (CL0000788)
Fold Change: -0.5433
Cell Significance Index: -5.7200
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.5504
Cell Significance Index: -11.4800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.5514
Cell Significance Index: -7.9300
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.5574
Cell Significance Index: -7.2900
Cell Name: plasmablast (CL0000980)
Fold Change: -0.5689
Cell Significance Index: -5.2800
Cell Name: leukocyte (CL0000738)
Fold Change: -0.5752
Cell Significance Index: -9.7700
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.5812
Cell Significance Index: -4.0900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5818
Cell Significance Index: -8.5900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5860
Cell Significance Index: -8.4200
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.5881
Cell Significance Index: -7.6100
Cell Name: memory B cell (CL0000787)
Fold Change: -0.5931
Cell Significance Index: -6.3100
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.6058
Cell Significance Index: -6.1500
Cell Name: thymocyte (CL0000893)
Fold Change: -0.6102
Cell Significance Index: -7.7100
Cell Name: B cell (CL0000236)
Fold Change: -0.6165
Cell Significance Index: -7.2900
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.6303
Cell Significance Index: -7.1400
Cell Name: promonocyte (CL0000559)
Fold Change: -0.6343
Cell Significance Index: -6.7800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6364
Cell Significance Index: -10.7200
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.6625
Cell Significance Index: -8.5000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6644
Cell Significance Index: -11.7400
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.6702
Cell Significance Index: -7.0700
Cell Name: monocyte (CL0000576)
Fold Change: -0.6770
Cell Significance Index: -7.7900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.6855
Cell Significance Index: -9.4000
Cell Name: myelocyte (CL0002193)
Fold Change: -0.6860
Cell Significance Index: -7.3300
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.6933
Cell Significance Index: -6.8400
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.6948
Cell Significance Index: -7.5700
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.7008
Cell Significance Index: -8.3200
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.7044
Cell Significance Index: -7.7100
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.7057
Cell Significance Index: -9.2100
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.7083
Cell Significance Index: -10.4600
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.7145
Cell Significance Index: -7.5900
Cell Name: goblet cell (CL0000160)
Fold Change: -0.7187
Cell Significance Index: -6.5000
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.7210
Cell Significance Index: -10.7900
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.7234
Cell Significance Index: -7.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV4-1 is a single-copy gene that codes for a protein belonging to the immunoglobulin superfamily. The protein is a member of the kappa light chain family and is involved in the regulation of B cell receptor signaling. IGKV4-1 is expressed in various cell types, including B cells, natural killer cells, and T cells, and is significantly expressed in the plasma membrane of these cells. The protein has multiple functional domains, including a binding domain for antigens and a signaling domain that regulates the activation of B cell receptors. **Pathways and Functions** IGKV4-1 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Antigen binding**: IGKV4-1 binds to antigens, which triggers the activation of B cell receptors and the subsequent signaling cascade that regulates immune responses. 2. **Complement activation**: IGKV4-1 is involved in the regulation of the complement cascade, which is a critical component of the innate immune response. The protein regulates the activation of complement proteins, including C4 and C2, which are involved in the clearance of pathogens from the body. 3. **Phagocytosis**: IGKV4-1 is involved in the regulation of phagocytosis, which is the process by which cells engulf and clear pathogens from the body. The protein regulates the activation of scavenger receptors, which are involved in the recognition and uptake of pathogens. 4. **Immune response regulation**: IGKV4-1 regulates the immune response to Leishmania parasite infection, which involves the activation of B cells and the production of antibodies. The protein also regulates the immune response to SARS-CoV, which involves the activation of T cells and the production of cytokines. **Clinical Significance** IGKV4-1 has significant clinical relevance, particularly in the context of Leishmaniasis and SARS-CoV infections. Dysregulation of IGKV4-1 has been implicated in the development of these diseases, and the protein may serve as a potential therapeutic target. Additionally, IGKV4-1 has been implicated in the regulation of immune responses to other pathogens, including viruses and bacteria, and may serve as a potential target for the development of vaccines and immunotherapies. In conclusion, IGKV4-1 is a critical component of the adaptive immune response and plays a significant role in the regulation of immune responses to Leishmania parasite infection and SARS-CoV. Further research is needed to fully understand the function and clinical significance of IGKV4-1, but it is clear that this protein is an important regulator of the immune system.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.