IGKV4 1 | ENSG00000211598 | NCBI 28908

Details for: IGKV4 1

Gene ID: 28908

Symbol: IGKV4 1

Ensembl ID: ENSG00000211598

Description: immunoglobulin kappa variable 4-1

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin production
(GO:0002377)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 4.9
Marker Score: 3,793
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.84
Marker Score: 1,988
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.67
Marker Score: 4,169
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1,158
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 843
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.16
Marker Score: 986
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7,555
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,788
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 784
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.98
Marker Score: 619
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 498
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.94
Marker Score: 389
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,290
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 365
Cell Name: blood cell (CL0000081)
Fold Change: 0.91
Marker Score: 10,545
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,294
Cell Name: plasmablast (CL0000980)
Fold Change: 0.86
Marker Score: 1,149
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.85
Marker Score: 389
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.81
Marker Score: 3,383
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,269
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.78
Marker Score: 272
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 700
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.72
Marker Score: 700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 454
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.66
Marker Score: 288
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.55
Marker Score: 228
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.54
Marker Score: 285
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.52
Marker Score: 1,028
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.52
Marker Score: 462
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.46
Marker Score: 270
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.45
Marker Score: 254
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.45
Marker Score: 935
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.37
Marker Score: 350
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.33
Marker Score: 104
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.32
Marker Score: 577
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.31
Marker Score: 334
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.31
Marker Score: 367
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.3
Marker Score: 252
Cell Name: plasma cell (CL0000786)
Fold Change: 0.3
Marker Score: 331
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.29
Marker Score: 81
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.29
Marker Score: 76
Cell Name: B cell (CL0000236)
Fold Change: 0.28
Marker Score: 264
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.27
Marker Score: 222
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.25
Marker Score: 429
Cell Name: naive B cell (CL0000788)
Fold Change: 0.24
Marker Score: 217
Cell Name: memory B cell (CL0000787)
Fold Change: 0.24
Marker Score: 179
Cell Name: glial cell (CL0000125)
Fold Change: 0.23
Marker Score: 255
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.22
Marker Score: 365
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.22
Marker Score: 501
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.21
Marker Score: 151
Cell Name: T cell (CL0000084)
Fold Change: 0.21
Marker Score: 361
Cell Name: platelet (CL0000233)
Fold Change: 0.2
Marker Score: 92
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.2
Marker Score: 69
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.2
Marker Score: 177
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.2
Marker Score: 148
Cell Name: immature B cell (CL0000816)
Fold Change: 0.19
Marker Score: 128
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.19
Marker Score: 42
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.19
Marker Score: 154
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.18
Marker Score: 294
Cell Name: mast cell (CL0000097)
Fold Change: 0.18
Marker Score: 106
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.18
Marker Score: 143
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.18
Marker Score: 41
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.18
Marker Score: 217
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.17
Marker Score: 52
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.17
Marker Score: 45
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.17
Marker Score: 113
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.17
Marker Score: 168
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.17
Marker Score: 42
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.16
Marker Score: 62
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.16
Marker Score: 9,052
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.16
Marker Score: 42
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.16
Marker Score: 44
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.16
Marker Score: 42
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.16
Marker Score: 88
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.15
Marker Score: 37
Cell Name: fibroblast (CL0000057)
Fold Change: 0.15
Marker Score: 149
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.15
Marker Score: 111
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.15
Marker Score: 44
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.15
Marker Score: 108
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.15
Marker Score: 75
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.15
Marker Score: 90
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.15
Marker Score: 42
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.15
Marker Score: 45
Cell Name: leukocyte (CL0000738)
Fold Change: 0.14
Marker Score: 83
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.14
Marker Score: 143
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.14
Marker Score: 88
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.14
Marker Score: 41
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.14
Marker Score: 39
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.14
Marker Score: 93

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** IGKV4-1 is a single-copy gene that codes for a protein belonging to the immunoglobulin superfamily. The protein is a member of the kappa light chain family and is involved in the regulation of B cell receptor signaling. IGKV4-1 is expressed in various cell types, including B cells, natural killer cells, and T cells, and is significantly expressed in the plasma membrane of these cells. The protein has multiple functional domains, including a binding domain for antigens and a signaling domain that regulates the activation of B cell receptors. **Pathways and Functions** IGKV4-1 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Antigen binding**: IGKV4-1 binds to antigens, which triggers the activation of B cell receptors and the subsequent signaling cascade that regulates immune responses. 2. **Complement activation**: IGKV4-1 is involved in the regulation of the complement cascade, which is a critical component of the innate immune response. The protein regulates the activation of complement proteins, including C4 and C2, which are involved in the clearance of pathogens from the body. 3. **Phagocytosis**: IGKV4-1 is involved in the regulation of phagocytosis, which is the process by which cells engulf and clear pathogens from the body. The protein regulates the activation of scavenger receptors, which are involved in the recognition and uptake of pathogens. 4. **Immune response regulation**: IGKV4-1 regulates the immune response to Leishmania parasite infection, which involves the activation of B cells and the production of antibodies. The protein also regulates the immune response to SARS-CoV, which involves the activation of T cells and the production of cytokines. **Clinical Significance** IGKV4-1 has significant clinical relevance, particularly in the context of Leishmaniasis and SARS-CoV infections. Dysregulation of IGKV4-1 has been implicated in the development of these diseases, and the protein may serve as a potential therapeutic target. Additionally, IGKV4-1 has been implicated in the regulation of immune responses to other pathogens, including viruses and bacteria, and may serve as a potential target for the development of vaccines and immunotherapies. In conclusion, IGKV4-1 is a critical component of the adaptive immune response and plays a significant role in the regulation of immune responses to Leishmania parasite infection and SARS-CoV. Further research is needed to fully understand the function and clinical significance of IGKV4-1, but it is clear that this protein is an important regulator of the immune system.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.