Details for: MNDA

Gene ID: 4332

Symbol: MNDA

Ensembl ID: ENSG00000163563

Description: myeloid cell nuclear differentiation antigen

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 89.4917
    Cell Significance Index: -13.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.1024
    Cell Significance Index: -14.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.6532
    Cell Significance Index: -13.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 11.7640
    Cell Significance Index: 217.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1764
    Cell Significance Index: -13.7800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.7176
    Cell Significance Index: 88.4600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 5.4853
    Cell Significance Index: 36.3900
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 4.2912
    Cell Significance Index: 17.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6137
    Cell Significance Index: -14.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3675
    Cell Significance Index: -7.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.0898
    Cell Significance Index: 82.6500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.5438
    Cell Significance Index: 4.4100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3553
    Cell Significance Index: 4.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0423
    Cell Significance Index: 6.1500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.0097
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.1800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0077
    Cell Significance Index: -0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0105
    Cell Significance Index: -16.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0124
    Cell Significance Index: -7.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0143
    Cell Significance Index: -10.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0157
    Cell Significance Index: -0.3800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0188
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0192
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.2600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0211
    Cell Significance Index: -0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0251
    Cell Significance Index: -14.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0305
    Cell Significance Index: -8.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0315
    Cell Significance Index: -14.2900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0335
    Cell Significance Index: -0.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0392
    Cell Significance Index: -14.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0482
    Cell Significance Index: -9.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0583
    Cell Significance Index: -12.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0681
    Cell Significance Index: -12.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0694
    Cell Significance Index: -13.9200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0806
    Cell Significance Index: -0.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0819
    Cell Significance Index: -4.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0822
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0856
    Cell Significance Index: -14.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0932
    Cell Significance Index: -11.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1000
    Cell Significance Index: -12.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1003
    Cell Significance Index: -13.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1060
    Cell Significance Index: -13.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1063
    Cell Significance Index: -12.5400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1171
    Cell Significance Index: -0.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1248
    Cell Significance Index: -5.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1308
    Cell Significance Index: -13.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1341
    Cell Significance Index: -15.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1360
    Cell Significance Index: -5.5700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1490
    Cell Significance Index: -2.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1644
    Cell Significance Index: -7.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1790
    Cell Significance Index: -13.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1836
    Cell Significance Index: -13.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2021
    Cell Significance Index: -12.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2029
    Cell Significance Index: -13.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2086
    Cell Significance Index: -13.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2176
    Cell Significance Index: -14.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2501
    Cell Significance Index: -13.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2718
    Cell Significance Index: -14.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2782
    Cell Significance Index: -15.6100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2938
    Cell Significance Index: -3.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3124
    Cell Significance Index: -8.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3136
    Cell Significance Index: -14.6200
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.3513
    Cell Significance Index: -3.3800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3523
    Cell Significance Index: -3.0800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3553
    Cell Significance Index: -3.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3588
    Cell Significance Index: -15.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3792
    Cell Significance Index: -13.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3962
    Cell Significance Index: -13.8800
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.4045
    Cell Significance Index: -3.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4047
    Cell Significance Index: -14.2200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4061
    Cell Significance Index: -5.7000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.4180
    Cell Significance Index: -4.3300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.4184
    Cell Significance Index: -4.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4212
    Cell Significance Index: -15.9500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4311
    Cell Significance Index: -4.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4352
    Cell Significance Index: -14.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4455
    Cell Significance Index: -14.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4577
    Cell Significance Index: -12.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4665
    Cell Significance Index: -13.7000
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4712
    Cell Significance Index: -4.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4765
    Cell Significance Index: -13.6600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4774
    Cell Significance Index: -4.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4812
    Cell Significance Index: -12.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4845
    Cell Significance Index: -14.2700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.4854
    Cell Significance Index: -5.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4921
    Cell Significance Index: -12.9400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5035
    Cell Significance Index: -7.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5103
    Cell Significance Index: -16.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5148
    Cell Significance Index: -14.6900
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.5253
    Cell Significance Index: -5.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5333
    Cell Significance Index: -14.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5405
    Cell Significance Index: -13.7700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5409
    Cell Significance Index: -13.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5535
    Cell Significance Index: -14.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5559
    Cell Significance Index: -10.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5586
    Cell Significance Index: -13.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5593
    Cell Significance Index: -11.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5787
    Cell Significance Index: -14.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** MNDA is predominantly expressed in myeloid cells, including CD14-positive, CD16-negative classical monocytes, CD14-positive monocytes, lung macrophages, blood cells, and non-classical monocytes. 2. **Cellular Localization:** MNDA is primarily localized in the nucleus and cytosol of myeloid cells, suggesting its involvement in transcriptional regulation and cytoskeletal dynamics. 3. **Protein Binding:** MNDA interacts with various proteins, including those involved in the regulation of apoptotic processes, DNA damage response, and immune system signaling pathways. **Pathways and Functions:** 1. **Activation of Innate Immune Response:** MNDA plays a crucial role in regulating the activation of innate immune responses, particularly in myeloid cells. Its expression is upregulated in response to pathogens and inflammatory stimuli, allowing for the rapid mobilization of immune cells. 2. **Negative Regulation of B Cell Proliferation:** MNDA inhibits B cell proliferation, thereby modulating the adaptive immune response and preventing autoimmune reactions. 3. **Regulation of Apoptotic Process:** MNDA promotes the apoptotic process, which is essential for eliminating infected cells and maintaining tissue homeostasis. 4. **DNA Damage Response:** MNDA interacts with proteins involved in the DNA damage response, ensuring the accurate repair of DNA lesions and preventing genomic instability. 5. **Intracellular Membrane-Bounded Organelle Regulation:** MNDA regulates the dynamics of intracellular membrane-bounded organelles, such as mitochondria and lysosomes, which are critical for maintaining cellular homeostasis. **Clinical Significance:** 1. **Infectious Diseases:** MNDA's role in regulating innate immune responses makes it an attractive target for the development of novel therapies for infectious diseases, such as sepsis and tuberculosis. 2. **Autoimmune Disorders:** The negative regulation of B cell proliferation by MNDA may hold promise for the treatment of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** MNDA's involvement in the regulation of apoptotic processes and DNA damage response suggests its potential as a biomarker for cancer diagnosis and treatment. 4. **Immunodeficiency Disorders:** The study of MNDA's expression and function in immunodeficiency disorders, such as primary immunodeficiency diseases, may provide insights into the development of novel therapeutic strategies. In conclusion, MNDA is a critical regulator of the innate immune response, and its dysregulation has been implicated in various diseases. Further research is necessary to fully elucidate the mechanisms underlying MNDA's functions and to explore its therapeutic potential.

Genular Protein ID: 727168332

Symbol: MNDA_HUMAN

Name: Myeloid cell nuclear differentiation antigen

UniProtKB Accession Codes:

P41218

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1644857

Title: Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha.

PubMed ID: 1644857

DOI: 10.1002/jcb.240490114

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1377701

Title: Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins.

PubMed ID: 1377701

DOI: 10.1002/jcb.240480210

PubMed ID: 7512843

Title: The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells.

PubMed ID: 7512843

PubMed ID: 8175894

Title: Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage.

PubMed ID: 8175894

DOI: 10.1002/jcb.240540208

PubMed ID: 7806273

Title: The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression.

PubMed ID: 7806273

DOI: 10.1007/bf00188431

PubMed ID: 9712147

Title: Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding.

PubMed ID: 9712147

DOI: 10.1002/(sici)1097-4644(19980915)70:4<489::aid-jcb6>3.3.co;2-n

Sequence Information:

  • Length: 407
  • Mass: 45836
  • Checksum: F4943C38033C5A83
  • Sequence:
    • MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD LMEKKFQGVA 
CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP VKKINQEEVG LAAPAPTARN 
KLTSEARGRI PVAQKRKTPN KEKTEAKRNK VSQEQSKPPG PSGASTSAAV DHPPLPQTSS 
STPSNTSFTP NQETQAQRQV DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV 
ASKTQYFHVK VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII 
EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV VGSGKWHNIK 
CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK EGPMNVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.