Details for: TPPP3

Gene ID: 51673

Symbol: TPPP3

Ensembl ID: ENSG00000159713

Description: tubulin polymerization promoting protein family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 121.5724
    Cell Significance Index: -18.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.2381
    Cell Significance Index: -18.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 44.5202
    Cell Significance Index: -18.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 38.5493
    Cell Significance Index: -18.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.2958
    Cell Significance Index: -18.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3452
    Cell Significance Index: -18.9200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 12.5689
    Cell Significance Index: 37.3800
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 8.8197
    Cell Significance Index: 50.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.9034
    Cell Significance Index: 39.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7592
    Cell Significance Index: -18.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.3429
    Cell Significance Index: 28.0800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 2.2809
    Cell Significance Index: 22.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2161
    Cell Significance Index: 51.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1426
    Cell Significance Index: 623.9900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.0253
    Cell Significance Index: 8.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7821
    Cell Significance Index: 35.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6334
    Cell Significance Index: 571.9400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.5367
    Cell Significance Index: 4.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4544
    Cell Significance Index: 23.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4379
    Cell Significance Index: 47.6400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.4089
    Cell Significance Index: 4.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4049
    Cell Significance Index: 65.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3745
    Cell Significance Index: 22.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3630
    Cell Significance Index: 69.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3077
    Cell Significance Index: 22.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2692
    Cell Significance Index: 26.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2229
    Cell Significance Index: 168.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1931
    Cell Significance Index: 13.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1741
    Cell Significance Index: 20.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1556
    Cell Significance Index: 4.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1369
    Cell Significance Index: 3.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1353
    Cell Significance Index: 59.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1218
    Cell Significance Index: 15.6100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1143
    Cell Significance Index: 2.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0916
    Cell Significance Index: 3.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0840
    Cell Significance Index: 1.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0379
    Cell Significance Index: 0.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0304
    Cell Significance Index: 6.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0261
    Cell Significance Index: 3.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0199
    Cell Significance Index: 3.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0010
    Cell Significance Index: 0.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0057
    Cell Significance Index: -3.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0079
    Cell Significance Index: -0.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0080
    Cell Significance Index: -15.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0136
    Cell Significance Index: -2.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0145
    Cell Significance Index: -22.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0166
    Cell Significance Index: -22.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0175
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0189
    Cell Significance Index: -10.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0233
    Cell Significance Index: -17.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0240
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0277
    Cell Significance Index: -17.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0318
    Cell Significance Index: -11.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0440
    Cell Significance Index: -19.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0455
    Cell Significance Index: -13.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0466
    Cell Significance Index: -9.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0554
    Cell Significance Index: -3.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0595
    Cell Significance Index: -1.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0597
    Cell Significance Index: -7.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0631
    Cell Significance Index: -11.3700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0730
    Cell Significance Index: -0.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0781
    Cell Significance Index: -1.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0786
    Cell Significance Index: -2.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0981
    Cell Significance Index: -11.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0988
    Cell Significance Index: -12.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1001
    Cell Significance Index: -10.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1280
    Cell Significance Index: -18.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1550
    Cell Significance Index: -9.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1818
    Cell Significance Index: -5.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1819
    Cell Significance Index: -18.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1845
    Cell Significance Index: -11.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1867
    Cell Significance Index: -5.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1975
    Cell Significance Index: -13.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2140
    Cell Significance Index: -13.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2229
    Cell Significance Index: -17.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2419
    Cell Significance Index: -11.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2626
    Cell Significance Index: -20.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2641
    Cell Significance Index: -17.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2728
    Cell Significance Index: -16.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2771
    Cell Significance Index: -14.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2786
    Cell Significance Index: -12.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2988
    Cell Significance Index: -8.8000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3054
    Cell Significance Index: -1.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3197
    Cell Significance Index: -8.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3207
    Cell Significance Index: -13.1400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3392
    Cell Significance Index: -4.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3463
    Cell Significance Index: -17.9900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3937
    Cell Significance Index: -4.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4073
    Cell Significance Index: -14.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4332
    Cell Significance Index: -4.7100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4436
    Cell Significance Index: -1.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4713
    Cell Significance Index: -16.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4766
    Cell Significance Index: -12.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4777
    Cell Significance Index: -8.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4806
    Cell Significance Index: -5.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4925
    Cell Significance Index: -18.6500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5299
    Cell Significance Index: -13.2400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5449
    Cell Significance Index: -7.5600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.5629
    Cell Significance Index: -4.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule polymerization promoting function:** TPPP3 is involved in promoting microtubule polymerization, which is essential for various cellular processes, including cell division, migration, and intracellular transport. 2. **Expression in diverse cell types:** TPPP3 is expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, embryonic stem cell, smooth muscle fiber of ileum, peripheral blood mononuclear cell, orthochromatic erythroblast, stem cell of epidermis, inflammatory cell, kidney cell, and stromal cell of bone marrow. 3. **Regulation of protein polymerization:** TPPP3 is involved in the regulation of protein polymerization, which is essential for maintaining cellular homeostasis and responding to environmental changes. **Pathways and Functions:** 1. **Microtubule dynamics:** TPPP3 regulates microtubule dynamics by promoting microtubule polymerization, which is essential for maintaining cellular homeostasis. 2. **Cell division:** TPPP3 is involved in regulating cell division by promoting microtubule polymerization, which is essential for the proper segregation of chromosomes. 3. **Intracellular transport:** TPPP3 regulates intracellular transport by promoting microtubule polymerization, which is essential for the movement of organelles and vesicles within the cell. 4. **Decidualization and embryo implantation:** TPPP3 is involved in regulating decidualization and embryo implantation by promoting microtubule polymerization, which is essential for the proper establishment of the implantation site. 5. **Perinuclear region of cytoplasm:** TPPP3 regulates the perinuclear region of cytoplasm by promoting microtubule polymerization, which is essential for maintaining cellular homeostasis. **Clinical Significance:** 1. **Cancer:** Alterations in TPPP3 expression have been observed in various types of cancer, including breast, lung, and colon cancer. TPPP3 may play a role in promoting microtubule polymerization, which can contribute to cancer progression. 2. **Neurodegenerative diseases:** TPPP3 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where microtubule dynamics are disrupted. 3. **Reproductive disorders:** TPPP3 may play a role in regulating decidualization and embryo implantation, which can contribute to reproductive disorders, including infertility and miscarriage. 4. **Inflammatory diseases:** TPPP3 may be involved in regulating inflammation by promoting microtubule polymerization, which can contribute to inflammatory diseases, including arthritis and atherosclerosis. In conclusion, TPPP3 is a gene that plays a significant role in regulating microtubule dynamics, which is essential for maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, reproductive disorders, and inflammatory diseases. Further research is needed to fully understand the role of TPPP3 in human disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 1065697314

Symbol: TPPP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BW30 Q49AH9 Q9Y326 Q9Y6H0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17105200

Title: Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.

PubMed ID: 17105200

DOI: 10.1021/bi061305e

PubMed ID: 19633818

Title: Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation.

PubMed ID: 19633818

DOI: 10.1007/s11010-009-0208-0

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 30667362

Title: Inhibition of TPPP3 attenuates beta-catenin/NF-kappaB/COX-2 signaling in endometrial stromal cells and impairs decidualization.

PubMed ID: 30667362

DOI: 10.1530/joe-18-0459

Sequence Information:

  • Length: 176
  • Mass: 18985
  • Checksum: 20EA146E93FB1ADF
  • Sequence:
    • MAASTDMAGL EESFRKFAIH GDPKASGQEM NGKNWAKLCK DCKVADGKSV TGTDVDIVFS 
KVKGKSARVI NYEEFKKALE ELATKRFKGK SKEEAFDAIC QLVAGKEPAN VGVTKAKTGG 
AVDRLTDTSR YTGSHKERFD ESGKGKGIAG RQDILDDSGY VSAYKNAGTY DAKVKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.