Details for: LSP1

Gene ID: 4046

Symbol: LSP1

Ensembl ID: ENSG00000130592

Description: lymphocyte specific protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 193.8986
    Cell Significance Index: -30.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.3213
    Cell Significance Index: -40.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.0397
    Cell Significance Index: -42.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.9471
    Cell Significance Index: -34.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.3396
    Cell Significance Index: -34.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.6298
    Cell Significance Index: -42.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.2731
    Cell Significance Index: -10.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.2182
    Cell Significance Index: -29.8600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 17.5745
    Cell Significance Index: 47.0800
  • Cell Name: centroblast (CL0009112)
    Fold Change: 16.9691
    Cell Significance Index: 39.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0474
    Cell Significance Index: -30.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1373
    Cell Significance Index: -32.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.8620
    Cell Significance Index: 145.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.2403
    Cell Significance Index: 212.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1781
    Cell Significance Index: -15.7100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 3.3682
    Cell Significance Index: 57.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.3097
    Cell Significance Index: 390.3100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.7607
    Cell Significance Index: 11.4900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.4526
    Cell Significance Index: 7.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.7057
    Cell Significance Index: 86.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.6555
    Cell Significance Index: 32.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7696
    Cell Significance Index: 20.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6803
    Cell Significance Index: 67.3000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.6657
    Cell Significance Index: 6.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5866
    Cell Significance Index: 529.6800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.5216
    Cell Significance Index: 3.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4587
    Cell Significance Index: 13.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4312
    Cell Significance Index: 12.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3495
    Cell Significance Index: 56.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1951
    Cell Significance Index: 23.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1618
    Cell Significance Index: 30.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1545
    Cell Significance Index: 9.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1380
    Cell Significance Index: 15.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1165
    Cell Significance Index: 214.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0215
    Cell Significance Index: 3.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0205
    Cell Significance Index: 0.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0179
    Cell Significance Index: 0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0117
    Cell Significance Index: 17.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0112
    Cell Significance Index: -21.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0156
    Cell Significance Index: -21.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0246
    Cell Significance Index: -3.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0321
    Cell Significance Index: -24.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0327
    Cell Significance Index: -17.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0453
    Cell Significance Index: -33.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0488
    Cell Significance Index: -21.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0571
    Cell Significance Index: -32.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0588
    Cell Significance Index: -43.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0653
    Cell Significance Index: -41.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0685
    Cell Significance Index: -4.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0689
    Cell Significance Index: -1.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0699
    Cell Significance Index: -1.4500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0724
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0787
    Cell Significance Index: -35.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0850
    Cell Significance Index: -30.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0949
    Cell Significance Index: -4.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1107
    Cell Significance Index: -11.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1113
    Cell Significance Index: -14.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1195
    Cell Significance Index: -23.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1368
    Cell Significance Index: -27.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1437
    Cell Significance Index: -7.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1566
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1610
    Cell Significance Index: -33.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1664
    Cell Significance Index: -19.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1847
    Cell Significance Index: -31.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1953
    Cell Significance Index: -6.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2104
    Cell Significance Index: -2.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2365
    Cell Significance Index: -14.2000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2407
    Cell Significance Index: -3.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2444
    Cell Significance Index: -6.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2610
    Cell Significance Index: -33.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2738
    Cell Significance Index: -39.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2767
    Cell Significance Index: -31.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2785
    Cell Significance Index: -12.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2814
    Cell Significance Index: -29.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2819
    Cell Significance Index: -1.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3075
    Cell Significance Index: -14.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3518
    Cell Significance Index: -21.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3648
    Cell Significance Index: -7.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3792
    Cell Significance Index: -29.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4048
    Cell Significance Index: -8.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4691
    Cell Significance Index: -34.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4800
    Cell Significance Index: -33.9500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4840
    Cell Significance Index: -8.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4939
    Cell Significance Index: -31.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5076
    Cell Significance Index: -7.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5501
    Cell Significance Index: -43.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5679
    Cell Significance Index: -26.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5693
    Cell Significance Index: -29.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5954
    Cell Significance Index: -33.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6255
    Cell Significance Index: -12.2300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.6740
    Cell Significance Index: -5.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6980
    Cell Significance Index: -36.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7185
    Cell Significance Index: -31.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.8173
    Cell Significance Index: -8.2000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.8252
    Cell Significance Index: -6.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8295
    Cell Significance Index: -31.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8351
    Cell Significance Index: -29.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8810
    Cell Significance Index: -32.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.8900
    Cell Significance Index: -13.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8971
    Cell Significance Index: -28.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Specific expression in lymphoid cells**: LSP1 is specifically expressed in lymphoid cells, including T cells, B cells, and natural killer cells, highlighting its importance in immune cell function and regulation. 2. **Cell surface localization**: LSP1 is localized to the cell surface, where it can interact with other proteins and receptors to regulate immune cell function. 3. **Multiple isoforms**: The LSP1 gene encodes multiple isoforms, which may have distinct functions and expression patterns. 4. **Conserved across species**: LSP1 is conserved across species, suggesting an evolutionary conserved role in immune function. **Pathways and Functions** 1. **Actin cytoskeleton regulation**: LSP1 interacts with actin-binding proteins to regulate the actin cytoskeleton, which is essential for immune cell migration, adhesion, and signaling. 2. **Cell adhesion and migration**: LSP1 regulates cell adhesion and migration through interactions with integrins and other adhesion molecules. 3. **Signaling pathways**: LSP1 modulates signaling pathways, including those involved in immune cell activation, proliferation, and differentiation. 4. **Extracellular exosome regulation**: LSP1 is involved in the regulation of extracellular exosomes, which play a critical role in immune system development and maintenance. **Signaling and Function** LSP1 plays a critical role in regulating immune cell function, including: 1. **T cell activation and proliferation**: LSP1 modulates T cell activation and proliferation through interactions with T cell receptors and co-receptors. 2. **Natural killer cell function**: LSP1 regulates natural killer cell function, including cytotoxicity and cytokine production. 3. **Dendritic cell maturation**: LSP1 is involved in the maturation of dendritic cells, which is essential for immune system development and maintenance. **Clinical Significance** Dysregulation of LSP1 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: Altered LSP1 expression has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: LSP1 is overexpressed in certain types of cancer, including lung and breast cancer, suggesting a potential role in tumorigenesis. 3. **Immunodeficiency disorders**: Mutations in the LSP1 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, LSP1 is a critical component of the immune system that plays a significant role in regulating immune cell function and signaling. Further research is needed to fully elucidate the mechanisms of LSP1 and its role in immune-related disorders.

Genular Protein ID: 1827040711

Symbol: LSP1_HUMAN

Name: Lymphocyte-specific protein 1

UniProtKB Accession Codes:

P33241 B3KPP1 B3KRR6 E9PBV6 E9PFP3 Q16096 Q53H48 Q6FHM3 Q9BUY8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2295815

Title: Human and mouse LSP1 genes code for highly conserved phosphoproteins.

PubMed ID: 2295815

PubMed ID: 2174784

Title: Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen.

PubMed ID: 2174784

DOI: 10.1002/eji.1830201109

PubMed ID: 8274738

Title: The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein.

PubMed ID: 8274738

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17481585

Title: MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization.

PubMed ID: 17481585

DOI: 10.1016/j.bbrc.2007.04.104

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 339
  • Mass: 37192
  • Checksum: F2A18533500611D9
  • Sequence:
    • MAEASSDPGA EEREELLGPT AQWSVEDEEE AVHEQCQHER DRQLQAQDEE GGGHVPERPK 
QEMLLSLKPS EAPELDEDEG FGDWSQRPEQ RQQHEGAQGA LDSGEPPQCR SPEGEQEDRP 
GLHAYEKEDS DEVHLEELSL SKEGPGPEDT VQDNLGAAGA EEEQEEHQKC QQPRTPSPLV 
LEGTIEQSSP PLSPTTKLID RTESLNRSIE KSNSVKKSQP DLPISKIDQW LEQYTQAIET 
AGRTPKLARQ ASIELPSMAV ASTKSRWETG EVQAQSAAKT PSCKDIVAGD MSKKSLWEQK 
GGSKTSSTIK STPSGKRYKF VATGHGKYEK VLVEGGPAP

Genular Protein ID: 2369080759

Symbol: A8K7L8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K7L8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 277
  • Mass: 30184
  • Checksum: 3A823DF3EF7B6972
  • Sequence:
    • MLLSLKPSEA PELDEDEGFG DWSQRPEQRQ QHEGAQGALD SGEPPQCRSP EGEQEDRPGL 
HAYEKEDSDE VHLEELSLSK EGPGPEDTVQ DNLGAAGAEE EQEEHQKCQQ PRTPSPLVLE 
GTIEQSSPPL SPTTKLIDRT ESLNRSIEKS NSVKKSQPDL PISEIDQWLE QYTQAIETAG 
RTPKLARQAS IELPSMAVAS TKSRWETGEV QAQSAAKAPS CKDIVAGDMS KKSLWEQKGG 
SKTSSTIKST PSGKRYKFVA TGHGKYEKVL VEGGPAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.