Details for: LSP1

Gene ID: 4046

Symbol: LSP1

Ensembl ID: ENSG00000130592

Description: lymphocyte specific protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 10.23
    Marker Score: 14693
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.86
    Marker Score: 2950
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.57
    Marker Score: 3228
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.16
    Marker Score: 41202.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.11
    Marker Score: 12985
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.04
    Marker Score: 11167
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 3.97
    Marker Score: 11216
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.76
    Marker Score: 43752
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.74
    Marker Score: 209332.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.73
    Marker Score: 10878
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.61
    Marker Score: 5309
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.59
    Marker Score: 3992.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.48
    Marker Score: 3272
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.45
    Marker Score: 14814
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 3.44
    Marker Score: 4134
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.41
    Marker Score: 3300.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.25
    Marker Score: 6323
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.22
    Marker Score: 170356.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.2
    Marker Score: 2715
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.2
    Marker Score: 2807
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.19
    Marker Score: 7774
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.14
    Marker Score: 13059
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.09
    Marker Score: 3736
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.08
    Marker Score: 7660
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.03
    Marker Score: 8487.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.92
    Marker Score: 5093.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.87
    Marker Score: 1922
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.82
    Marker Score: 1392
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.81
    Marker Score: 17995.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.8
    Marker Score: 11468
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.77
    Marker Score: 2332
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.75
    Marker Score: 5391
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.7
    Marker Score: 1553
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.67
    Marker Score: 1610
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.66
    Marker Score: 584
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.62
    Marker Score: 2455
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6
    Marker Score: 7706.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.59
    Marker Score: 1119
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.59
    Marker Score: 5419
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.57
    Marker Score: 2286.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.53
    Marker Score: 1839
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.48
    Marker Score: 4254
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.48
    Marker Score: 877
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.48
    Marker Score: 4426
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.45
    Marker Score: 621
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.39
    Marker Score: 1812
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.38
    Marker Score: 6170
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.37
    Marker Score: 1733
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.28
    Marker Score: 2248
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.28
    Marker Score: 1387
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.25
    Marker Score: 741
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.25
    Marker Score: 2007
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.24
    Marker Score: 1376
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.21
    Marker Score: 508
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.2
    Marker Score: 765
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.17
    Marker Score: 1569
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.17
    Marker Score: 5234
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.17
    Marker Score: 667
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.16
    Marker Score: 1632
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.15
    Marker Score: 1690
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.15
    Marker Score: 1104
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.11
    Marker Score: 1801
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.05
    Marker Score: 668
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.05
    Marker Score: 637
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.04
    Marker Score: 1196
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.03
    Marker Score: 5830
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 2.02
    Marker Score: 457
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.01
    Marker Score: 1337
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.99
    Marker Score: 1629
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.99
    Marker Score: 993
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.98
    Marker Score: 5393
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.94
    Marker Score: 1252
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.92
    Marker Score: 2076
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.91
    Marker Score: 667
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.91
    Marker Score: 1392.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.9
    Marker Score: 2103
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.88
    Marker Score: 571
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.87
    Marker Score: 1292
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.87
    Marker Score: 805
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.85
    Marker Score: 2181
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.84
    Marker Score: 1329
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.83
    Marker Score: 1209
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.82
    Marker Score: 1016
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.81
    Marker Score: 2406
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.8
    Marker Score: 478
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.78
    Marker Score: 1083.5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.78
    Marker Score: 4000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.74
    Marker Score: 1441
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.68
    Marker Score: 1709
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.66
    Marker Score: 396
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.64
    Marker Score: 2327
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.63
    Marker Score: 564
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.62
    Marker Score: 568
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.61
    Marker Score: 694.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6
    Marker Score: 1689
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.6
    Marker Score: 40962
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.59
    Marker Score: 780
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.58
    Marker Score: 359
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.54
    Marker Score: 2074
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.53
    Marker Score: 1043

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Other Information

**Key characteristics:** * LSP1 is a member of the immunoglobulin superfamily. * It is expressed in high levels in cells of the immune system, including lymphocytes, macrophages, and dendritic cells. * It is involved in the regulation of the actin cytoskeleton, cell migration, and signaling pathways. * It is also involved in the regulation of inflammation and cell death. **Pathways and functions:** * LSP1 is a key regulator of innate immunity. It is expressed in high levels in cells of the immune system, including lymphocytes, macrophages, and dendritic cells. * It is involved in the regulation of inflammation by binding to the actin cytoskeleton and promoting the formation of microfilaments. * It is also involved in the regulation of cell migration by binding to specific receptors on immune cells and promoting their migration. * It is involved in the regulation of cell death by binding to phosphatidylserine on the surface of dying cells and promoting their phagocytosis. **Clinical significance:** * Mutations in the LSP1 gene have been linked to a number of human diseases, including systemic sclerosis, rheumatoid arthritis, and cancer. * LSP1 is a potential target for therapeutic intervention in these diseases. **Additional information:** * The LSP1 gene is located on chromosome 15q21.1. * It is a highly conserved gene, with a similar gene found in other mammals. * It is expressed in humans at an estimated transcript level of 1,000,000 copies per cell.

Genular Protein ID: 1827040711

Symbol: LSP1_HUMAN

Name: Lymphocyte-specific protein 1

UniProtKB Accession Codes:

P33241 B3KPP1 B3KRR6 E9PBV6 E9PFP3 Q16096 Q53H48 Q6FHM3 Q9BUY8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2295815

Title: Human and mouse LSP1 genes code for highly conserved phosphoproteins.

PubMed ID: 2295815

PubMed ID: 2174784

Title: Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen.

PubMed ID: 2174784

DOI: 10.1002/eji.1830201109

PubMed ID: 8274738

Title: The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein.

PubMed ID: 8274738

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17481585

Title: MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization.

PubMed ID: 17481585

DOI: 10.1016/j.bbrc.2007.04.104

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 339
  • Mass: 37192
  • Checksum: F2A18533500611D9
  • Sequence:
    • MAEASSDPGA EEREELLGPT AQWSVEDEEE AVHEQCQHER DRQLQAQDEE GGGHVPERPK 
QEMLLSLKPS EAPELDEDEG FGDWSQRPEQ RQQHEGAQGA LDSGEPPQCR SPEGEQEDRP 
GLHAYEKEDS DEVHLEELSL SKEGPGPEDT VQDNLGAAGA EEEQEEHQKC QQPRTPSPLV 
LEGTIEQSSP PLSPTTKLID RTESLNRSIE KSNSVKKSQP DLPISKIDQW LEQYTQAIET 
AGRTPKLARQ ASIELPSMAV ASTKSRWETG EVQAQSAAKT PSCKDIVAGD MSKKSLWEQK 
GGSKTSSTIK STPSGKRYKF VATGHGKYEK VLVEGGPAP

Genular Protein ID: 2369080759

Symbol: A8K7L8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K7L8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 277
  • Mass: 30184
  • Checksum: 3A823DF3EF7B6972
  • Sequence:
    • MLLSLKPSEA PELDEDEGFG DWSQRPEQRQ QHEGAQGALD SGEPPQCRSP EGEQEDRPGL 
HAYEKEDSDE VHLEELSLSK EGPGPEDTVQ DNLGAAGAEE EQEEHQKCQQ PRTPSPLVLE 
GTIEQSSPPL SPTTKLIDRT ESLNRSIEKS NSVKKSQPDL PISEIDQWLE QYTQAIETAG 
RTPKLARQAS IELPSMAVAS TKSRWETGEV QAQSAAKAPS CKDIVAGDMS KKSLWEQKGG 
SKTSSTIKST PSGKRYKFVA TGHGKYEKVL VEGGPAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.