Details for: TNFSF13

Gene ID: 8741

Symbol: TNFSF13

Ensembl ID: ENSG00000161955

Description: TNF superfamily member 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.7625
    Cell Significance Index: -8.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 17.9243
    Cell Significance Index: -9.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2410
    Cell Significance Index: 41.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5053
    Cell Significance Index: 90.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7064
    Cell Significance Index: 16.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6237
    Cell Significance Index: 67.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4030
    Cell Significance Index: 11.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3538
    Cell Significance Index: 24.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1959
    Cell Significance Index: 8.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1836
    Cell Significance Index: 3.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1209
    Cell Significance Index: 21.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1205
    Cell Significance Index: 22.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1000
    Cell Significance Index: 12.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0908
    Cell Significance Index: 1.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0663
    Cell Significance Index: 59.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0640
    Cell Significance Index: 1.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0636
    Cell Significance Index: 1.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0595
    Cell Significance Index: 9.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0519
    Cell Significance Index: 1.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0446
    Cell Significance Index: 5.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0343
    Cell Significance Index: 1.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0093
    Cell Significance Index: 0.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0088
    Cell Significance Index: 0.4100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0073
    Cell Significance Index: 0.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0005
    Cell Significance Index: 0.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0039
    Cell Significance Index: -0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0109
    Cell Significance Index: -5.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0131
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0133
    Cell Significance Index: -8.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0155
    Cell Significance Index: -8.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0164
    Cell Significance Index: -7.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0201
    Cell Significance Index: -7.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0227
    Cell Significance Index: -0.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0230
    Cell Significance Index: -1.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0238
    Cell Significance Index: -6.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0252
    Cell Significance Index: -2.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0264
    Cell Significance Index: -1.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0277
    Cell Significance Index: -5.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0299
    Cell Significance Index: -4.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0318
    Cell Significance Index: -1.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0362
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0396
    Cell Significance Index: -8.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0401
    Cell Significance Index: -6.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0524
    Cell Significance Index: -6.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0594
    Cell Significance Index: -8.6400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0598
    Cell Significance Index: -0.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0722
    Cell Significance Index: -9.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0811
    Cell Significance Index: -6.2200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0839
    Cell Significance Index: -1.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0869
    Cell Significance Index: -1.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1005
    Cell Significance Index: -4.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1034
    Cell Significance Index: -2.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1095
    Cell Significance Index: -8.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1101
    Cell Significance Index: -5.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1232
    Cell Significance Index: -5.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1249
    Cell Significance Index: -9.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1409
    Cell Significance Index: -9.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1466
    Cell Significance Index: -1.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1489
    Cell Significance Index: -9.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1517
    Cell Significance Index: -3.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1593
    Cell Significance Index: -8.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1638
    Cell Significance Index: -8.6000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1668
    Cell Significance Index: -1.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1811
    Cell Significance Index: -6.3500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1812
    Cell Significance Index: -2.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1885
    Cell Significance Index: -8.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1939
    Cell Significance Index: -5.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2051
    Cell Significance Index: -5.8800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2121
    Cell Significance Index: -3.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2221
    Cell Significance Index: -5.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2224
    Cell Significance Index: -8.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2321
    Cell Significance Index: -8.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2448
    Cell Significance Index: -3.3400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2551
    Cell Significance Index: -2.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2654
    Cell Significance Index: -8.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2685
    Cell Significance Index: -8.5500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2708
    Cell Significance Index: -3.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2942
    Cell Significance Index: -3.9100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2985
    Cell Significance Index: -2.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3038
    Cell Significance Index: -8.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3056
    Cell Significance Index: -8.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3112
    Cell Significance Index: -9.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3199
    Cell Significance Index: -4.9500
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.3250
    Cell Significance Index: -2.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3315
    Cell Significance Index: -8.2700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3389
    Cell Significance Index: -8.4500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3424
    Cell Significance Index: -3.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3450
    Cell Significance Index: -8.7900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3499
    Cell Significance Index: -7.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3503
    Cell Significance Index: -8.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3558
    Cell Significance Index: -9.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3568
    Cell Significance Index: -5.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3595
    Cell Significance Index: -5.2200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3734
    Cell Significance Index: -5.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFSF13 is characterized by its ability to bind to TNFR2, a non-canonical NF-κB pathway receptor. This interaction triggers a signaling cascade that regulates the activation and proliferation of immune cells, including monocytes and dendritic cells. The gene's expression profile is notable for its presence in cells that are involved in the innate and adaptive immune responses, such as CD14-low, CD16-positive monocytes and transitional stage B cells. Additionally, TNFSF13 is expressed in epithelial cells, suggesting its involvement in non-immune functions, such as regulation of cell proliferation and differentiation. **Pathways and Functions** TNFSF13 is involved in several signaling pathways, including: 1. **TNFR2 non-canonical NF-κB pathway**: The binding of TNFSF13 to TNFR2 triggers a signaling cascade that regulates the activation and proliferation of immune cells. 2. **Cytokine signaling in immune system**: TNFSF13 is involved in the regulation of cytokine signaling, which is essential for the coordination of immune responses. 3. **Immune response**: TNFSF13 plays a crucial role in the regulation of immune cell populations, including the activation and proliferation of monocytes and dendritic cells. 4. **Positive regulation of cell population proliferation**: TNFSF13 is involved in the regulation of cell proliferation, particularly in epithelial cells. 5. **Signaling receptor binding**: TNFSF13 binds to its physiological receptors, TNFR2, to trigger signaling cascades that regulate immune responses. **Clinical Significance** The clinical significance of TNFSF13 is multifaceted: 1. **Immune-mediated diseases**: TNFSF13 is involved in the regulation of immune cell populations, making it a potential target for the treatment of immune-mediated diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: TNFSF13 is expressed in epithelial cells, suggesting its involvement in the regulation of cell proliferation and differentiation, which may contribute to tumorigenesis. 3. **Infectious diseases**: TNFSF13 is involved in the regulation of immune responses, making it a potential target for the treatment of infectious diseases, such as tuberculosis and HIV. 4. **Regenerative medicine**: TNFSF13 may play a role in the regulation of tissue repair and regeneration, particularly in epithelial cells. In conclusion, TNFSF13 is a multifunctional gene that plays a crucial role in the regulation of immune responses, cell proliferation, and differentiation. Its clinical significance is vast, and further research is necessary to fully understand its role in human disease and to develop therapeutic strategies that target this gene.

Genular Protein ID: 3074093586

Symbol: TNF13_HUMAN

Name: Tumor necrosis factor ligand superfamily member 13

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9743536

Title: APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.

PubMed ID: 9743536

DOI: 10.1084/jem.188.6.1185

PubMed ID: 10331498

Title: TALL-1 is a novel member of the TNF family that is down-regulated by mitogens.

PubMed ID: 10331498

DOI: 10.1002/jlb.65.5.680

PubMed ID: 10706119

Title: APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death.

PubMed ID: 10706119

PubMed ID: 12411489

Title: An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein.

PubMed ID: 12411489

DOI: 10.1093/emboj/cdf565

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10973284

Title: APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.

PubMed ID: 10973284

DOI: 10.1038/79802

PubMed ID: 11571266

Title: Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.

PubMed ID: 11571266

DOI: 10.1093/embo-reports/kve198

Sequence Information:

  • Length: 250
  • Mass: 27433
  • Checksum: AE1A6B9457F6E298
  • Sequence:
  • MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT QQTELQSLRR 
    EVSRLQGTGG PSQNGEGYPW QSLPEQSSDA LEAWENGERS RKRRAVLTQK QKKQHSVLHL 
    VPINATSKDD SDVTEVMWQP ALRRGRGLQA QGYGVRIQDA GVYLLYSQVL FQDVTFTMGQ 
    VVSREGQGRQ ETLFRCIRSM PSHPDRAYNS CYSAGVFHLH QGDILSVIIP RARAKLNLSP 
    HGTFLGFVKL

Genular Protein ID: 4067869535

Symbol: Q2QBA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21687682

Title: Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival.

PubMed ID: 21687682

DOI: 10.1371/journal.pone.0020787

Sequence Information:

  • Length: 223
  • Mass: 24279
  • Checksum: 341F54179B86F2C4
  • Sequence:
  • MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT QQTELQSLRR 
    EVSRLQGTGG PSQNGEGYPW QSLPEQQHSV LHLVPINATS KDDSDVTEVM WQPALRRGRG 
    LQAQGYGVRI QDAGVYLLYS QVLFQDVTFT MGQVVSREGQ GRQETLFRCI RSMPSHPDRA 
    YNSCYSAGVF HLHQGDILSV IIPRARAKLN LSPHGTFLGF VKL

Genular Protein ID: 4080008743

Symbol: B3KR02_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 234
  • Mass: 25651
  • Checksum: 8ADA2D1114950780
  • Sequence:
  • MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT QQTELQSLRR 
    EVSRLQGTGG PSQNGEGYPW QSLPEQSSDA LEAWESGERS RKRRAVLTQK QKNDSDVTEV 
    MWQPALRRGR GLQAQGYGVR IQDAGVYLLY SQVLFQDVTF TMGQVVSREG QGRQETLFRC 
    IRSMPSHPDR AYNSCYSAGV FHLHQGDILS VIIPRARAKL NLSPHGTFLG FVKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.