Details for: TYROBP
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.22
Marker Score: 4177 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.14
Marker Score: 14988 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.64
Marker Score: 259252 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.5
Marker Score: 12441 - Cell Name: lung macrophage (CL1001603)
Fold Change: 4.02
Marker Score: 4600 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 4
Marker Score: 4824 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.86
Marker Score: 7526 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.75
Marker Score: 9054 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.7
Marker Score: 4117 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.39
Marker Score: 3393 - Cell Name: basophil (CL0000767)
Fold Change: 3.36
Marker Score: 1596 - Cell Name: blood cell (CL0000081)
Fold Change: 3.2
Marker Score: 37187 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.19
Marker Score: 7942 - Cell Name: myelocyte (CL0002193)
Fold Change: 3.16
Marker Score: 1365 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 3.15
Marker Score: 8151 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 3.11
Marker Score: 1022 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 3.06
Marker Score: 78317 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 3.05
Marker Score: 18535 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 3.02
Marker Score: 1234 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.01
Marker Score: 754 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.9
Marker Score: 1210 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.9
Marker Score: 1251 - Cell Name: ILC1, human (CL0001077)
Fold Change: 2.82
Marker Score: 714 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.38
Marker Score: 1310 - Cell Name: classical monocyte (CL0000860)
Fold Change: 2.26
Marker Score: 9378 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.21
Marker Score: 3247 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 2.13
Marker Score: 1098 - Cell Name: granulocyte (CL0000094)
Fold Change: 1.97
Marker Score: 884.5 - Cell Name: osteoclast (CL0000092)
Fold Change: 1.93
Marker Score: 960 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.82
Marker Score: 1405 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.76
Marker Score: 5568 - Cell Name: macrophage (CL0000235)
Fold Change: 1.73
Marker Score: 1923 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.73
Marker Score: 1190 - Cell Name: promyelocyte (CL0000836)
Fold Change: 1.66
Marker Score: 819 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.65
Marker Score: 806 - Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 1.61
Marker Score: 886 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.56
Marker Score: 1131 - Cell Name: dendritic cell (CL0000451)
Fold Change: 1.53
Marker Score: 1047 - Cell Name: monocyte (CL0000576)
Fold Change: 1.52
Marker Score: 1974 - Cell Name: natural killer cell (CL0000623)
Fold Change: 1.51
Marker Score: 1958 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.49
Marker Score: 743 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.49
Marker Score: 1520 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167337 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.45
Marker Score: 1454 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.4
Marker Score: 505 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.39
Marker Score: 501 - Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 1.35
Marker Score: 305 - Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 1.28
Marker Score: 337 - Cell Name: Langerhans cell (CL0000453)
Fold Change: 1.28
Marker Score: 383.5 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.26
Marker Score: 5161 - Cell Name: mature T cell (CL0002419)
Fold Change: 1.25
Marker Score: 12384 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.22
Marker Score: 1177 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.19
Marker Score: 801 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.19
Marker Score: 302 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.18
Marker Score: 2251 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.14
Marker Score: 7411 - Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 1.12
Marker Score: 365 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.12
Marker Score: 387 - Cell Name: neutrophil (CL0000775)
Fold Change: 1.1
Marker Score: 672 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.08
Marker Score: 1491 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 1.07
Marker Score: 949 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 1.04
Marker Score: 359 - Cell Name: myeloid cell (CL0000763)
Fold Change: 1
Marker Score: 1606 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71712 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47940 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30398 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.98
Marker Score: 303 - Cell Name: mast cell (CL0000097)
Fold Change: 0.97
Marker Score: 564 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.96
Marker Score: 593 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 491 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2405 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.93
Marker Score: 1691 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.92
Marker Score: 482 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2719 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 362 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5145 - Cell Name: Unknown (CL0000548)
Fold Change: 0.89
Marker Score: 652 - Cell Name: phagocyte (CL0000234)
Fold Change: 0.89
Marker Score: 296 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.89
Marker Score: 730 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.88
Marker Score: 409 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.88
Marker Score: 474 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 317 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.88
Marker Score: 636 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.87
Marker Score: 427 - Cell Name: colon macrophage (CL0009038)
Fold Change: 0.87
Marker Score: 240 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5253 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.86
Marker Score: 517 - Cell Name: leukocyte (CL0000738)
Fold Change: 0.86
Marker Score: 491 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.84
Marker Score: 260 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.84
Marker Score: 570 - Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.83
Marker Score: 627 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.83
Marker Score: 651 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.83
Marker Score: 525 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.82
Marker Score: 340 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.81
Marker Score: 714 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.81
Marker Score: 3390 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 615.5 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.8
Marker Score: 686 - Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.8
Marker Score: 334.5
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Other Information
Genular Protein ID: 3786314690
Symbol: TYOBP_HUMAN
Name: Killer-activating receptor-associated protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9490415
Title: Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.
PubMed ID: 9490415
DOI: 10.1038/35642
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16344560
Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
PubMed ID: 16344560
DOI: 10.1101/gr.4039406
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9655483
Title: Association of DAP12 with activating CD94/NKG2C NK cell receptors.
PubMed ID: 9655483
PubMed ID: 10449773
Title: Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.
PubMed ID: 10449773
PubMed ID: 10604985
Title: Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.
PubMed ID: 10604985
PubMed ID: 10888890
Title: Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.
PubMed ID: 10888890
DOI: 10.1038/77153
PubMed ID: 10799849
Title: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.
PubMed ID: 10799849
PubMed ID: 11602640
Title: A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.
PubMed ID: 11602640
PubMed ID: 12370476
Title: Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms.
PubMed ID: 12370476
PubMed ID: 11922939
Title: TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.
PubMed ID: 11922939
PubMed ID: 15557162
Title: Molecular characterization of a novel immune receptor restricted to the monocytic lineage.
PubMed ID: 15557162
PubMed ID: 15940674
Title: The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.
PubMed ID: 15940674
PubMed ID: 17012248
Title: Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.
PubMed ID: 17012248
PubMed ID: 16920917
Title: Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways.
PubMed ID: 16920917
PubMed ID: 17928527
Title: Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.
PubMed ID: 17928527
PubMed ID: 18624290
Title: Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.
PubMed ID: 18624290
PubMed ID: 18957693
Title: Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.
PubMed ID: 18957693
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 21727189
Title: The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
PubMed ID: 21727189
DOI: 10.1084/jem.20101623
PubMed ID: 23715743
Title: DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells.
PubMed ID: 23715743
DOI: 10.1189/jlb.0213093
PubMed ID: 25957402
Title: DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response.
PubMed ID: 25957402
PubMed ID: 26221034
Title: Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.
PubMed ID: 26221034
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26358190
Title: Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.
PubMed ID: 26358190
DOI: 10.1038/cr.2015.108
PubMed ID: 20890284
Title: The structural basis for intramembrane assembly of an activating immunoreceptor complex.
PubMed ID: 20890284
DOI: 10.1038/ni.1943
PubMed ID: 25981043
Title: Transmembrane complexes of DAP12 crystallized in lipid membranes provide insights into control of oligomerization in immunoreceptor assembly.
PubMed ID: 25981043
PubMed ID: 27658901
Title: TYROBP genetic variants in early-onset Alzheimer's disease.
PubMed ID: 27658901
PubMed ID: 28716534
Title: Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.
PubMed ID: 28716534
Sequence Information:
- Length: 113
- Mass: 12179
- Checksum: 267CB1C1756F89F0
- Sequence:
MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD LVLTVLIALA VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD VYSDLNTQRP YYK
Genular Protein ID: 177418576
Symbol: X6RGC9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 101
- Mass: 10972
- Checksum: 63633932D40DCC95
- Sequence:
MGGLEPCSRL LLLPLLLAVS DCSCSTVSPG VLAGIVMGDL VLTVLIALAV YFLGRLVPRG RGAAEATRKQ RITETESPYQ ELQGQRSDVY SDLNTQRPYY K
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.