Details for: TYROBP

Gene ID: 7305

Symbol: TYROBP

Ensembl ID: ENSG00000011600

Description: transmembrane immune signaling adaptor TYROBP

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.22
    Marker Score: 4177
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.14
    Marker Score: 14988
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.64
    Marker Score: 259252
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.5
    Marker Score: 12441
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 4.02
    Marker Score: 4600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 4
    Marker Score: 4824
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.86
    Marker Score: 7526
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.75
    Marker Score: 9054
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.7
    Marker Score: 4117
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.39
    Marker Score: 3393
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.36
    Marker Score: 1596
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.2
    Marker Score: 37187
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.19
    Marker Score: 7942
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.16
    Marker Score: 1365
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 3.15
    Marker Score: 8151
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 3.11
    Marker Score: 1022
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 3.06
    Marker Score: 78317
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.05
    Marker Score: 18535
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 3.02
    Marker Score: 1234
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.01
    Marker Score: 754
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.9
    Marker Score: 1210
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.9
    Marker Score: 1251
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.82
    Marker Score: 714
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.38
    Marker Score: 1310
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.26
    Marker Score: 9378
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.21
    Marker Score: 3247
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.13
    Marker Score: 1098
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.97
    Marker Score: 884.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.93
    Marker Score: 960
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.82
    Marker Score: 1405
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.76
    Marker Score: 5568
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.73
    Marker Score: 1923
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.73
    Marker Score: 1190
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.66
    Marker Score: 819
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.65
    Marker Score: 806
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.61
    Marker Score: 886
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1131
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.53
    Marker Score: 1047
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.52
    Marker Score: 1974
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.51
    Marker Score: 1958
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.49
    Marker Score: 743
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.49
    Marker Score: 1520
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167337
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.45
    Marker Score: 1454
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.4
    Marker Score: 505
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.39
    Marker Score: 501
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.35
    Marker Score: 305
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.28
    Marker Score: 337
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 1.28
    Marker Score: 383.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.26
    Marker Score: 5161
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.25
    Marker Score: 12384
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.22
    Marker Score: 1177
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.19
    Marker Score: 801
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.19
    Marker Score: 302
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.18
    Marker Score: 2251
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.14
    Marker Score: 7411
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.12
    Marker Score: 365
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.12
    Marker Score: 387
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.1
    Marker Score: 672
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.08
    Marker Score: 1491
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.07
    Marker Score: 949
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.04
    Marker Score: 359
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 1
    Marker Score: 1606
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71712
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47940
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.98
    Marker Score: 303
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.97
    Marker Score: 564
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.96
    Marker Score: 593
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.93
    Marker Score: 1691
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.92
    Marker Score: 482
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5145
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.89
    Marker Score: 652
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.89
    Marker Score: 296
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.89
    Marker Score: 730
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.88
    Marker Score: 409
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.88
    Marker Score: 474
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.88
    Marker Score: 636
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.87
    Marker Score: 427
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.87
    Marker Score: 240
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5253
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 517
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.86
    Marker Score: 491
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.84
    Marker Score: 260
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.84
    Marker Score: 570
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.83
    Marker Score: 627
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.83
    Marker Score: 651
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.83
    Marker Score: 525
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.82
    Marker Score: 340
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.81
    Marker Score: 714
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.81
    Marker Score: 3390
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 615.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.8
    Marker Score: 686
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.8
    Marker Score: 334.5

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Other Information

**Key Characteristics:** 1. **Transmembrane Adaptor Function:** TYROBP acts as a transmembrane adaptor protein, bridging signaling pathways and facilitating the interaction between immune cells and their microenvironment. 2. **Immune Cell Regulation:** TYROBP modulates the activation, proliferation, and function of various immune cells, including natural killer cells, macrophages, and T cells. 3. **Signaling Pathway Modulation:** TYROBP interacts with multiple signaling receptors and molecules, influencing the activation of downstream pathways involved in immune responses. 4. **Protein Localization:** TYROBP regulates the localization of proteins to the cell surface, influencing cell-cell communication and immune cell function. 5. **Diverse Tissue Expression:** TYROBP is expressed in various tissues, including immune cells, neurons, and epithelial cells, highlighting its broad functional scope. **Pathways and Functions:** 1. **Adaptive Immune Response:** TYROBP modulates the activation and proliferation of T cells, B cells, and natural killer cells, influencing the adaptive immune response. 2. **Innate Immune Response:** TYROBP interacts with pattern recognition receptors and Toll-like receptors, activating innate immune responses and modulating the production of cytokines and chemokines. 3. **Cellular Defense Response:** TYROBP regulates the activation of immune cells, such as macrophages and neutrophils, and modulates the production of antimicrobial peptides and proteins. 4. **Nervous System Development:** TYROBP plays a role in the development and function of the nervous system, influencing axon guidance, neuronal survival, and synaptic plasticity. 5. **Cancer and Autoimmune Diseases:** TYROBP dysregulation has been implicated in various cancers, autoimmune disorders, and inflammatory diseases, highlighting its potential as a therapeutic target. **Clinical Significance:** 1. **Autoimmune Diseases:** TYROBP dysregulation has been linked to autoimmune disorders, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** TYROBP expression is altered in various cancers, including leukemia, lymphoma, and breast cancer, suggesting its potential as a diagnostic or therapeutic biomarker. 3. **Neurological Disorders:** TYROBP dysregulation has been implicated in neurological conditions, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Infectious Diseases:** TYROBP modulates the immune response to infections, influencing the production of cytokines and chemokines, and the activation of immune cells. In conclusion, TYROBP is a multifunctional protein that plays a critical role in regulating immune responses, cellular defense, and nervous system development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and therapeutic potential.

Genular Protein ID: 3786314690

Symbol: TYOBP_HUMAN

Name: Killer-activating receptor-associated protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9490415

Title: Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.

PubMed ID: 9490415

DOI: 10.1038/35642

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9655483

Title: Association of DAP12 with activating CD94/NKG2C NK cell receptors.

PubMed ID: 9655483

DOI: 10.1016/s1074-7613(00)80574-9

PubMed ID: 10449773

Title: Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.

PubMed ID: 10449773

DOI: 10.1073/pnas.96.17.9792

PubMed ID: 10604985

Title: Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.

PubMed ID: 10604985

DOI: 10.4049/jimmunol.164.1.9

PubMed ID: 10888890

Title: Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

PubMed ID: 10888890

DOI: 10.1038/77153

PubMed ID: 10799849

Title: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.

PubMed ID: 10799849

DOI: 10.4049/jimmunol.164.10.4991

PubMed ID: 11602640

Title: A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.

PubMed ID: 11602640

DOI: 10.1084/jem.194.8.1111

PubMed ID: 12370476

Title: Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms.

PubMed ID: 12370476

DOI: 10.1212/wnl.59.7.1105

PubMed ID: 11922939

Title: TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.

PubMed ID: 11922939

DOI: 10.1016/s0161-5890(02)00004-4

PubMed ID: 15557162

Title: Molecular characterization of a novel immune receptor restricted to the monocytic lineage.

PubMed ID: 15557162

DOI: 10.4049/jimmunol.173.11.6703

PubMed ID: 15940674

Title: The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.

PubMed ID: 15940674

DOI: 10.1002/eji.200425843

PubMed ID: 17012248

Title: Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

PubMed ID: 17012248

DOI: 10.1096/fj.06-5800com

PubMed ID: 16920917

Title: Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways.

PubMed ID: 16920917

DOI: 10.4049/jimmunol.177.5.2819

PubMed ID: 17928527

Title: Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

PubMed ID: 17928527

DOI: 10.1182/blood-2007-04-085787

PubMed ID: 18624290

Title: Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.

PubMed ID: 18624290

DOI: 10.1002/eji.200838434

PubMed ID: 18957693

Title: Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.

PubMed ID: 18957693

DOI: 10.1126/scisignal.1159665

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21727189

Title: The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.

PubMed ID: 21727189

DOI: 10.1084/jem.20101623

PubMed ID: 23715743

Title: DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells.

PubMed ID: 23715743

DOI: 10.1189/jlb.0213093

PubMed ID: 25957402

Title: DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response.

PubMed ID: 25957402

DOI: 10.1074/jbc.m115.645986

PubMed ID: 26221034

Title: Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.

PubMed ID: 26221034

DOI: 10.1074/jbc.m115.643361

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26358190

Title: Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.

PubMed ID: 26358190

DOI: 10.1038/cr.2015.108

PubMed ID: 20890284

Title: The structural basis for intramembrane assembly of an activating immunoreceptor complex.

PubMed ID: 20890284

DOI: 10.1038/ni.1943

PubMed ID: 25981043

Title: Transmembrane complexes of DAP12 crystallized in lipid membranes provide insights into control of oligomerization in immunoreceptor assembly.

PubMed ID: 25981043

DOI: 10.1016/j.celrep.2015.04.045

PubMed ID: 27658901

Title: TYROBP genetic variants in early-onset Alzheimer's disease.

PubMed ID: 27658901

DOI: 10.1016/j.neurobiolaging.2016.07.028

PubMed ID: 28716534

Title: Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.

PubMed ID: 28716534

DOI: 10.1016/j.neurobiolaging.2017.06.019

Sequence Information:

  • Length: 113
  • Mass: 12179
  • Checksum: 267CB1C1756F89F0
  • Sequence:
  • MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD LVLTVLIALA 
    VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD VYSDLNTQRP YYK

Genular Protein ID: 177418576

Symbol: X6RGC9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 101
  • Mass: 10972
  • Checksum: 63633932D40DCC95
  • Sequence:
  • MGGLEPCSRL LLLPLLLAVS DCSCSTVSPG VLAGIVMGDL VLTVLIALAV YFLGRLVPRG 
    RGAAEATRKQ RITETESPYQ ELQGQRSDVY SDLNTQRPYY K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.