Details for: TYROBP

Gene ID: 7305

Symbol: TYROBP

Ensembl ID: ENSG00000011600

Description: transmembrane immune signaling adaptor TYROBP

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 186.0552
    Cell Significance Index: -28.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.4594
    Cell Significance Index: -27.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 95.6537
    Cell Significance Index: -38.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.0884
    Cell Significance Index: -38.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.4876
    Cell Significance Index: -39.6100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 36.2129
    Cell Significance Index: 97.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 23.1368
    Cell Significance Index: 427.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.9611
    Cell Significance Index: -28.3100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 13.9285
    Cell Significance Index: 57.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.7799
    Cell Significance Index: -27.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3366
    Cell Significance Index: -34.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2817
    Cell Significance Index: -32.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.4196
    Cell Significance Index: 83.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3302
    Cell Significance Index: -11.6000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 4.0970
    Cell Significance Index: 27.1800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 3.8359
    Cell Significance Index: 65.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.1210
    Cell Significance Index: 83.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1684
    Cell Significance Index: 222.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9545
    Cell Significance Index: 94.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7929
    Cell Significance Index: 715.9100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.7578
    Cell Significance Index: 1.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3919
    Cell Significance Index: 63.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3643
    Cell Significance Index: 23.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1889
    Cell Significance Index: 20.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1783
    Cell Significance Index: 18.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0254
    Cell Significance Index: 15.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0154
    Cell Significance Index: 11.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0123
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0165
    Cell Significance Index: -31.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0233
    Cell Significance Index: -43.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0244
    Cell Significance Index: -13.7400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0247
    Cell Significance Index: -0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0276
    Cell Significance Index: -42.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0301
    Cell Significance Index: -8.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0308
    Cell Significance Index: -6.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0318
    Cell Significance Index: -43.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0368
    Cell Significance Index: -0.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0528
    Cell Significance Index: -1.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0539
    Cell Significance Index: -39.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0600
    Cell Significance Index: -38.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0722
    Cell Significance Index: -31.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0809
    Cell Significance Index: -2.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0847
    Cell Significance Index: -38.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0896
    Cell Significance Index: -11.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0919
    Cell Significance Index: -32.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0924
    Cell Significance Index: -4.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0969
    Cell Significance Index: -20.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1182
    Cell Significance Index: -5.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1230
    Cell Significance Index: -21.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1243
    Cell Significance Index: -7.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1324
    Cell Significance Index: -1.7600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1350
    Cell Significance Index: -1.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1358
    Cell Significance Index: -9.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1445
    Cell Significance Index: -3.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1459
    Cell Significance Index: -26.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1644
    Cell Significance Index: -32.9700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1869
    Cell Significance Index: -1.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2152
    Cell Significance Index: -29.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2304
    Cell Significance Index: -7.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2337
    Cell Significance Index: -9.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2428
    Cell Significance Index: -29.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2551
    Cell Significance Index: -37.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2637
    Cell Significance Index: -34.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2731
    Cell Significance Index: -5.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2732
    Cell Significance Index: -31.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2779
    Cell Significance Index: -7.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2896
    Cell Significance Index: -34.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3027
    Cell Significance Index: -6.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3094
    Cell Significance Index: -14.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3110
    Cell Significance Index: -32.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3201
    Cell Significance Index: -2.6100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3267
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3399
    Cell Significance Index: -38.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3621
    Cell Significance Index: -6.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3895
    Cell Significance Index: -23.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4302
    Cell Significance Index: -33.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4543
    Cell Significance Index: -33.8600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.4934
    Cell Significance Index: -4.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5177
    Cell Significance Index: -12.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5197
    Cell Significance Index: -34.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5227
    Cell Significance Index: -32.1300
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.5305
    Cell Significance Index: -5.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5613
    Cell Significance Index: -29.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5639
    Cell Significance Index: -35.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6099
    Cell Significance Index: -31.7700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.6492
    Cell Significance Index: -5.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6513
    Cell Significance Index: -36.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7112
    Cell Significance Index: -37.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7125
    Cell Significance Index: -33.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7663
    Cell Significance Index: -33.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8175
    Cell Significance Index: -17.4100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.8201
    Cell Significance Index: -8.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8733
    Cell Significance Index: -38.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9537
    Cell Significance Index: -35.0100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.9604
    Cell Significance Index: -8.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9663
    Cell Significance Index: -33.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0154
    Cell Significance Index: -38.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0379
    Cell Significance Index: -33.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Adaptor Function:** TYROBP acts as a transmembrane adaptor protein, bridging signaling pathways and facilitating the interaction between immune cells and their microenvironment. 2. **Immune Cell Regulation:** TYROBP modulates the activation, proliferation, and function of various immune cells, including natural killer cells, macrophages, and T cells. 3. **Signaling Pathway Modulation:** TYROBP interacts with multiple signaling receptors and molecules, influencing the activation of downstream pathways involved in immune responses. 4. **Protein Localization:** TYROBP regulates the localization of proteins to the cell surface, influencing cell-cell communication and immune cell function. 5. **Diverse Tissue Expression:** TYROBP is expressed in various tissues, including immune cells, neurons, and epithelial cells, highlighting its broad functional scope. **Pathways and Functions:** 1. **Adaptive Immune Response:** TYROBP modulates the activation and proliferation of T cells, B cells, and natural killer cells, influencing the adaptive immune response. 2. **Innate Immune Response:** TYROBP interacts with pattern recognition receptors and Toll-like receptors, activating innate immune responses and modulating the production of cytokines and chemokines. 3. **Cellular Defense Response:** TYROBP regulates the activation of immune cells, such as macrophages and neutrophils, and modulates the production of antimicrobial peptides and proteins. 4. **Nervous System Development:** TYROBP plays a role in the development and function of the nervous system, influencing axon guidance, neuronal survival, and synaptic plasticity. 5. **Cancer and Autoimmune Diseases:** TYROBP dysregulation has been implicated in various cancers, autoimmune disorders, and inflammatory diseases, highlighting its potential as a therapeutic target. **Clinical Significance:** 1. **Autoimmune Diseases:** TYROBP dysregulation has been linked to autoimmune disorders, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** TYROBP expression is altered in various cancers, including leukemia, lymphoma, and breast cancer, suggesting its potential as a diagnostic or therapeutic biomarker. 3. **Neurological Disorders:** TYROBP dysregulation has been implicated in neurological conditions, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Infectious Diseases:** TYROBP modulates the immune response to infections, influencing the production of cytokines and chemokines, and the activation of immune cells. In conclusion, TYROBP is a multifunctional protein that plays a critical role in regulating immune responses, cellular defense, and nervous system development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and therapeutic potential.

Genular Protein ID: 3786314690

Symbol: TYOBP_HUMAN

Name: Killer-activating receptor-associated protein

UniProtKB Accession Codes:

O43914 A8K2X0 F5H389 Q6FGA5 Q9UMT3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 6 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9490415

Title: Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.

PubMed ID: 9490415

DOI: 10.1038/35642

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9655483

Title: Association of DAP12 with activating CD94/NKG2C NK cell receptors.

PubMed ID: 9655483

DOI: 10.1016/s1074-7613(00)80574-9

PubMed ID: 10449773

Title: Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.

PubMed ID: 10449773

DOI: 10.1073/pnas.96.17.9792

PubMed ID: 10604985

Title: Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.

PubMed ID: 10604985

DOI: 10.4049/jimmunol.164.1.9

PubMed ID: 10888890

Title: Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

PubMed ID: 10888890

DOI: 10.1038/77153

PubMed ID: 10799849

Title: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.

PubMed ID: 10799849

DOI: 10.4049/jimmunol.164.10.4991

PubMed ID: 11602640

Title: A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.

PubMed ID: 11602640

DOI: 10.1084/jem.194.8.1111

PubMed ID: 12370476

Title: Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms.

PubMed ID: 12370476

DOI: 10.1212/wnl.59.7.1105

PubMed ID: 11922939

Title: TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.

PubMed ID: 11922939

DOI: 10.1016/s0161-5890(02)00004-4

PubMed ID: 15557162

Title: Molecular characterization of a novel immune receptor restricted to the monocytic lineage.

PubMed ID: 15557162

DOI: 10.4049/jimmunol.173.11.6703

PubMed ID: 15940674

Title: The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.

PubMed ID: 15940674

DOI: 10.1002/eji.200425843

PubMed ID: 17012248

Title: Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

PubMed ID: 17012248

DOI: 10.1096/fj.06-5800com

PubMed ID: 16920917

Title: Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways.

PubMed ID: 16920917

DOI: 10.4049/jimmunol.177.5.2819

PubMed ID: 17928527

Title: Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

PubMed ID: 17928527

DOI: 10.1182/blood-2007-04-085787

PubMed ID: 18624290

Title: Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.

PubMed ID: 18624290

DOI: 10.1002/eji.200838434

PubMed ID: 18957693

Title: Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.

PubMed ID: 18957693

DOI: 10.1126/scisignal.1159665

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21727189

Title: The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.

PubMed ID: 21727189

DOI: 10.1084/jem.20101623

PubMed ID: 23715743

Title: DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells.

PubMed ID: 23715743

DOI: 10.1189/jlb.0213093

PubMed ID: 25957402

Title: DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response.

PubMed ID: 25957402

DOI: 10.1074/jbc.m115.645986

PubMed ID: 26221034

Title: Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.

PubMed ID: 26221034

DOI: 10.1074/jbc.m115.643361

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26358190

Title: Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.

PubMed ID: 26358190

DOI: 10.1038/cr.2015.108

PubMed ID: 20890284

Title: The structural basis for intramembrane assembly of an activating immunoreceptor complex.

PubMed ID: 20890284

DOI: 10.1038/ni.1943

PubMed ID: 25981043

Title: Transmembrane complexes of DAP12 crystallized in lipid membranes provide insights into control of oligomerization in immunoreceptor assembly.

PubMed ID: 25981043

DOI: 10.1016/j.celrep.2015.04.045

PubMed ID: 27658901

Title: TYROBP genetic variants in early-onset Alzheimer's disease.

PubMed ID: 27658901

DOI: 10.1016/j.neurobiolaging.2016.07.028

PubMed ID: 28716534

Title: Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.

PubMed ID: 28716534

DOI: 10.1016/j.neurobiolaging.2017.06.019

Sequence Information:

  • Length: 113
  • Mass: 12179
  • Checksum: 267CB1C1756F89F0
  • Sequence:
    • MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD LVLTVLIALA 
VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD VYSDLNTQRP YYK

Genular Protein ID: 177418576

Symbol: X6RGC9_HUMAN

Name: N/A

UniProtKB Accession Codes:

X6RGC9

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 101
  • Mass: 10972
  • Checksum: 63633932D40DCC95
  • Sequence:
    • MGGLEPCSRL LLLPLLLAVS DCSCSTVSPG VLAGIVMGDL VLTVLIALAV YFLGRLVPRG 
RGAAEATRKQ RITETESPYQ ELQGQRSDVY SDLNTQRPYY K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.