Details for: MPP1

Gene ID: 4354

Symbol: MPP1

Ensembl ID: ENSG00000130830

Description: MAGUK p55 scaffold protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.4546
    Cell Significance Index: -18.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 42.6753
    Cell Significance Index: -17.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.4537
    Cell Significance Index: -19.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.8344
    Cell Significance Index: -7.0600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 20.0920
    Cell Significance Index: 9.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7678
    Cell Significance Index: -18.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5451
    Cell Significance Index: -17.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.1794
    Cell Significance Index: 49.1900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.2821
    Cell Significance Index: 6.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9177
    Cell Significance Index: 35.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1380
    Cell Significance Index: 68.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1213
    Cell Significance Index: 30.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0329
    Cell Significance Index: 66.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6055
    Cell Significance Index: 98.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5913
    Cell Significance Index: 533.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5305
    Cell Significance Index: 106.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5072
    Cell Significance Index: 50.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4732
    Cell Significance Index: 32.7300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4511
    Cell Significance Index: 5.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4243
    Cell Significance Index: 22.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3431
    Cell Significance Index: 17.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2686
    Cell Significance Index: 7.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2197
    Cell Significance Index: 43.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2027
    Cell Significance Index: 72.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1204
    Cell Significance Index: 15.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1167
    Cell Significance Index: 80.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1107
    Cell Significance Index: 15.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1056
    Cell Significance Index: 2.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1036
    Cell Significance Index: 19.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0876
    Cell Significance Index: 38.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0777
    Cell Significance Index: 8.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0586
    Cell Significance Index: 1.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0355
    Cell Significance Index: 19.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0228
    Cell Significance Index: 3.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0183
    Cell Significance Index: 0.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0117
    Cell Significance Index: 0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0079
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0017
    Cell Significance Index: -0.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0026
    Cell Significance Index: -0.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0049
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -9.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0061
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0122
    Cell Significance Index: -8.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0123
    Cell Significance Index: -6.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0148
    Cell Significance Index: -1.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0184
    Cell Significance Index: -2.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0199
    Cell Significance Index: -15.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0294
    Cell Significance Index: -13.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0452
    Cell Significance Index: -9.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0596
    Cell Significance Index: -6.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0627
    Cell Significance Index: -11.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0649
    Cell Significance Index: -18.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0692
    Cell Significance Index: -10.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0733
    Cell Significance Index: -4.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0776
    Cell Significance Index: -4.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0896
    Cell Significance Index: -11.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0980
    Cell Significance Index: -6.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1031
    Cell Significance Index: -4.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1053
    Cell Significance Index: -2.6900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.1055
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1118
    Cell Significance Index: -13.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1130
    Cell Significance Index: -13.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1212
    Cell Significance Index: -4.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1374
    Cell Significance Index: -4.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1405
    Cell Significance Index: -2.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1517
    Cell Significance Index: -1.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1615
    Cell Significance Index: -10.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1647
    Cell Significance Index: -17.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1722
    Cell Significance Index: -8.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1866
    Cell Significance Index: -14.7800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1895
    Cell Significance Index: -1.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2082
    Cell Significance Index: -15.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2137
    Cell Significance Index: -13.1000
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.2156
    Cell Significance Index: -1.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2240
    Cell Significance Index: -6.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2258
    Cell Significance Index: -3.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2259
    Cell Significance Index: -5.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2332
    Cell Significance Index: -6.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2368
    Cell Significance Index: -13.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2422
    Cell Significance Index: -3.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2583
    Cell Significance Index: -4.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2606
    Cell Significance Index: -12.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3143
    Cell Significance Index: -8.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3167
    Cell Significance Index: -16.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3171
    Cell Significance Index: -6.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3863
    Cell Significance Index: -9.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3933
    Cell Significance Index: -10.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4044
    Cell Significance Index: -12.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4051
    Cell Significance Index: -6.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4161
    Cell Significance Index: -21.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4191
    Cell Significance Index: -10.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4252
    Cell Significance Index: -13.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4253
    Cell Significance Index: -14.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4296
    Cell Significance Index: -15.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4350
    Cell Significance Index: -15.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MPP1 gene is primarily expressed in cells of the immune system, such as monocytes, macrophages, and lymphocytes, as well as in cells of the hematopoietic lineage, including erythrocytes and megakaryocytes. The protein product of this gene, MPP1, is a 55-kDa scaffold protein that interacts with multiple signaling molecules, influencing various cellular processes. **Pathways and Functions:** MPP1 is integral to several signaling pathways that regulate immune responses, including: 1. **Cell-cell junction**: MPP1 contributes to the formation and maintenance of cell-cell junctions, which are essential for the proper functioning of the immune system. 2. **Regulation of neutrophil chemotaxis**: MPP1 modulates the migration of neutrophils, a crucial step in the innate immune response. 3. **Sensory perception**: MPP1 is involved in the sensory processing of sound, particularly in the outer hair cells of the cochlea, highlighting its role in auditory function. 4. **Guanylate kinase activity**: MPP1 possesses guanylate kinase activity, which is essential for the regulation of various signaling pathways. **Clinical Significance:** Dysregulation of the MPP1 gene has been implicated in several diseases, including: 1. **Immunodeficiency disorders**: Mutations in the MPP1 gene can lead to impaired immune function, increasing susceptibility to infections. 2. **Cancer**: Altered expression of MPP1 has been observed in various types of cancer, suggesting its potential as a biomarker or therapeutic target. 3. **Neurological disorders**: The involvement of MPP1 in sensory perception and auditory function highlights its potential role in neurological disorders, such as hearing loss and tinnitus. In conclusion, the MPP1 gene is a multifaceted protein that plays a critical role in regulating various cellular processes, including immune responses and sensory perception. Further research is necessary to fully elucidate the functions of MPP1 and its implications for human health and disease.

Genular Protein ID: 1488428059

Symbol: EM55_HUMAN

Name: 55 kDa erythrocyte membrane protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1713685

Title: Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.

PubMed ID: 1713685

DOI: 10.1073/pnas.88.15.6595

PubMed ID: 1301163

Title: The gene encoding the palmitoylated erythrocyte membrane protein, p55, originates at the CpG island 3' to the factor VIII gene.

PubMed ID: 1301163

DOI: 10.1093/hmg/1.2.97

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17584769

Title: MPP1 links the Usher protein network and the Crumbs protein complex in the retina.

PubMed ID: 17584769

DOI: 10.1093/hmg/ddm147

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19144871

Title: Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin.

PubMed ID: 19144871

DOI: 10.3181/0809-rm-275

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22496366

Title: Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.

PubMed ID: 22496366

DOI: 10.1074/jbc.m111.332981

PubMed ID: 29475958

Title: Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.

PubMed ID: 29475958

DOI: 10.1074/jbc.w118.002209

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16741958

Title: Solution structure of human erythroid p55 PDZ domain.

PubMed ID: 16741958

DOI: 10.1002/prot.21028

Sequence Information:

  • Length: 466
  • Mass: 52296
  • Checksum: DC68AA68EF48A26E
  • Sequence:
  • MTLKASEGES GGSMHTALSD LYLEHLLQKR SRPEAVSHPL NTVTEDMYTN GSPAPGSPAQ 
    VKGQEVRKVR LIQFEKVTEE PMGITLKLNE KQSCTVARIL HGGMIHRQGS LHVGDEILEI 
    NGTNVTNHSV DQLQKAMKET KGMISLKVIP NQQSRLPALQ MFMRAQFDYD PKKDNLIPCK 
    EAGLKFATGD IIQIINKDDS NWWQGRVEGS SKESAGLIPS PELQEWRVAS MAQSAPSEAP 
    SCSPFGKKKK YKDKYLAKHS SIFDQLDVVS YEEVVRLPAF KRKTLVLIGA SGVGRSHIKN 
    ALLSQNPEKF VYPVPYTTRP PRKSEEDGKE YHFISTEEMT RNISANEFLE FGSYQGNMFG 
    TKFETVHQIH KQNKIAILDI EPQTLKIVRT AELSPFIVFI APTDQGTQTE ALQQLQKDSE 
    AIRSQYAHYF DLSLVNNGVD ETLKKLQEAF DQACSSPQWV PVSWVY

Genular Protein ID: 3265659268

Symbol: B4E325_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 449
  • Mass: 50154
  • Checksum: B3089699935612ED
  • Sequence:
  • MTLKASEGES GGSMHTALSD LYLEHLLQKR SRPEAVSHPL NTVTEDMYTN GSPAPGSPAQ 
    VKGQEGITLK LNEKQSCTVA RILHGGMIHR QGSLHVGDEI LEINGTNVTN HSVDQLQKAM 
    KETKGMISLK VIPNQQSRLP ALQMFMRAQF DYDPKKDNLI PCKEAGLKFA TGDIIQIINK 
    DDSNWWQGRV EGSSKESAGL IPSPELQEWR VASMAQSAPS EAPSCSPFGK KKKYKDKYLA 
    KHSSIFDQLD VVSYEEVVRL PAFKRKTLVL IGASGVGRSH IKNALLSQNP EKFVYPVPYT 
    TRPPRKSEED GKEYHFISTE EMTRNISANE FLEFGSYQGN MFGTKFETVH QIHKQNKIAI 
    LDIEPQTLKI VRTAELSPFI VFIAPTDQGT QTEALQQLQK DSEAIRSQYA HYFDLSLVNN 
    GVDETLKKLQ EAFGQACSSP QWVPVSWVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.