Details for: CXCR4

Gene ID: 7852

Symbol: CXCR4

Ensembl ID: ENSG00000121966

Description: C-X-C motif chemokine receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.9208
    Cell Significance Index: -32.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.0595
    Cell Significance Index: -47.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.2460
    Cell Significance Index: -47.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.1005
    Cell Significance Index: -40.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.7432
    Cell Significance Index: -40.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.4010
    Cell Significance Index: -48.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.5076
    Cell Significance Index: -12.0500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 33.6017
    Cell Significance Index: 90.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.2483
    Cell Significance Index: -31.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.0292
    Cell Significance Index: -43.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4880
    Cell Significance Index: -37.4400
  • Cell Name: centroblast (CL0009112)
    Fold Change: 9.4082
    Cell Significance Index: 21.9500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 8.3055
    Cell Significance Index: 55.1000
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 8.0389
    Cell Significance Index: 35.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.7767
    Cell Significance Index: -17.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.1488
    Cell Significance Index: 267.6600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.5551
    Cell Significance Index: 10.8400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.1659
    Cell Significance Index: 20.2100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 3.1656
    Cell Significance Index: 13.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2965
    Cell Significance Index: 270.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7111
    Cell Significance Index: 45.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3630
    Cell Significance Index: 31.4900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.3404
    Cell Significance Index: 13.4400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.2899
    Cell Significance Index: 22.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.9612
    Cell Significance Index: -2.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8968
    Cell Significance Index: 16.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8683
    Cell Significance Index: 165.2500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.8461
    Cell Significance Index: 8.9900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7883
    Cell Significance Index: 12.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6551
    Cell Significance Index: 64.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5931
    Cell Significance Index: 535.5500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.5717
    Cell Significance Index: 2.8600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.5337
    Cell Significance Index: 2.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4771
    Cell Significance Index: 12.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3536
    Cell Significance Index: 19.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2967
    Cell Significance Index: 48.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2475
    Cell Significance Index: 7.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1070
    Cell Significance Index: 13.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1021
    Cell Significance Index: 4.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0318
    Cell Significance Index: 3.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0298
    Cell Significance Index: 16.2600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0064
    Cell Significance Index: 0.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0032
    Cell Significance Index: 0.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0076
    Cell Significance Index: -0.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0176
    Cell Significance Index: -13.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0187
    Cell Significance Index: -35.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0254
    Cell Significance Index: -46.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0279
    Cell Significance Index: -0.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0293
    Cell Significance Index: -45.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0313
    Cell Significance Index: -19.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0465
    Cell Significance Index: -20.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0515
    Cell Significance Index: -37.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0517
    Cell Significance Index: -29.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0664
    Cell Significance Index: -13.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0707
    Cell Significance Index: -44.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0722
    Cell Significance Index: -2.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0957
    Cell Significance Index: -20.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0960
    Cell Significance Index: -27.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0985
    Cell Significance Index: -16.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0996
    Cell Significance Index: -45.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1057
    Cell Significance Index: -37.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1295
    Cell Significance Index: -7.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1415
    Cell Significance Index: -6.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1472
    Cell Significance Index: -26.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1498
    Cell Significance Index: -20.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1558
    Cell Significance Index: -3.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1886
    Cell Significance Index: -37.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1966
    Cell Significance Index: -22.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2023
    Cell Significance Index: -10.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2415
    Cell Significance Index: -30.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2433
    Cell Significance Index: -29.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2497
    Cell Significance Index: -5.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2627
    Cell Significance Index: -38.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2669
    Cell Significance Index: -8.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2728
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2801
    Cell Significance Index: -31.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2941
    Cell Significance Index: -4.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3058
    Cell Significance Index: -21.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3350
    Cell Significance Index: -38.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3575
    Cell Significance Index: -37.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3935
    Cell Significance Index: -29.3300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4697
    Cell Significance Index: -6.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5185
    Cell Significance Index: -31.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5270
    Cell Significance Index: -37.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5281
    Cell Significance Index: -40.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5461
    Cell Significance Index: -33.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5999
    Cell Significance Index: -40.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6026
    Cell Significance Index: -16.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6066
    Cell Significance Index: -48.0400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.6232
    Cell Significance Index: -5.8300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6621
    Cell Significance Index: -11.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6864
    Cell Significance Index: -43.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6922
    Cell Significance Index: -36.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7265
    Cell Significance Index: -37.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.7871
    Cell Significance Index: -6.6900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.8438
    Cell Significance Index: -7.3800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.8699
    Cell Significance Index: -9.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8733
    Cell Significance Index: -38.6300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8831
    Cell Significance Index: -38.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXCR4 is a non-selective GPCR that binds to the chemokine CXCL12, also known as stromal cell-derived factor 1 (SDF-1). It is a seven-transmembrane receptor with a characteristic structure and ligand-binding domain. CXCR4 is highly expressed in various cell types, including: * Immune cells (T cells, B cells, NK cells) * Stem cells (hematopoietic stem cells, mesenchymal stem cells) * Cancer cells (multiple types of cancer) * Brain cells (neurons, glial cells) CXCR4 is also expressed in the central nervous system, where it plays a role in neurogenesis, neuron migration, and axon guidance. **Pathways and Functions** CXCR4 is involved in various signaling pathways, including: 1. **Chemotaxis**: CXCR4 is a key receptor for CXCL12, which is involved in the migration of immune cells, stem cells, and cancer cells. 2. **Cell Signaling**: CXCR4 activates G-protein coupled signaling pathways, including the MAPK/ERK pathway, which regulates cell proliferation, differentiation, and survival. 3. **Apoptosis**: CXCR4 is involved in the regulation of programmed cell death, particularly in cancer cells. 4. **Neurogenesis**: CXCR4 plays a role in the development and maintenance of the central nervous system, including neurogenesis, neuron migration, and axon guidance. CXCR4 is also involved in various physiological processes, including: 1. **Immune Response**: CXCR4 is involved in the recruitment of immune cells to sites of inflammation. 2. **Stem Cell Migration**: CXCR4 is involved in the migration of stem cells to sites of tissue injury or inflammation. 3. **Cancer Progression**: CXCR4 is involved in the metastasis of cancer cells. **Clinical Significance** CXCR4 is implicated in various diseases, including: 1. **Multiple Myeloma**: CXCR4 is overexpressed in multiple myeloma cells and is involved in the regulation of cell migration and survival. 2. **Leukemia**: CXCR4 is overexpressed in leukemia cells and is involved in the regulation of cell migration and survival. 3. **Lymphoma**: CXCR4 is overexpressed in lymphoma cells and is involved in the regulation of cell migration and survival. 4. **Neurological Disorders**: CXCR4 is involved in the development and progression of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 5. **Cancer Metastasis**: CXCR4 is involved in the metastasis of cancer cells to sites of inflammation and immune cells. Targeting CXCR4 has been explored as a potential therapeutic strategy for various diseases, including cancer and neurological disorders.

Genular Protein ID: 1109432858

Symbol: CXCR4_HUMAN

Name: C-X-C chemokine receptor type 4

UniProtKB Accession Codes:

P61073 B2R5N0 O60835 P30991 P56438 Q53S69 Q9BXA0 Q9UKN2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 2 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 8 DrugCentral 1 EMBL 19 EMDB 9 Ensembl 2 EvolutionaryTrace 1 GO 67 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 19 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8329116

Title: Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation.

PubMed ID: 8329116

DOI: 10.1089/dna.1993.12.465

PubMed ID: 8234909

Title: A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells.

PubMed ID: 8234909

DOI: 10.1016/0167-0115(93)90392-l

PubMed ID: 8325644

Title: Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen.

PubMed ID: 8325644

DOI: 10.1006/geno.1993.1251

PubMed ID: 8276799

Title: Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.

PubMed ID: 8276799

DOI: 10.1016/s0021-9258(17)42339-8

PubMed ID: 7505609

Title: Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.

PubMed ID: 7505609

DOI: 10.1093/intimm/5.10.1239

PubMed ID: 8629022

Title: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.

PubMed ID: 8629022

DOI: 10.1126/science.272.5263.872

PubMed ID: 9468539

Title: Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1.

PubMed ID: 9468539

DOI: 10.1074/jbc.273.8.4754

PubMed ID: 9599023

Title: Genomic organization and promoter characterization of human CXCR4 gene.

PubMed ID: 9599023

DOI: 10.1016/s0014-5793(98)00359-7

PubMed ID: 10480633

Title: Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion.

PubMed ID: 10480633

DOI: 10.1089/088922299310296

PubMed ID: 9879064

Title: Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues.

PubMed ID: 9879064

DOI: 10.3109/10799899809047750

PubMed ID: 10452968

Title: CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant.

PubMed ID: 10452968

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8752280

Title: The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.

PubMed ID: 8752280

DOI: 10.1038/382829a0

PubMed ID: 8752281

Title: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1.

PubMed ID: 8752281

DOI: 10.1038/382833a0

PubMed ID: 8849450

Title: Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines.

PubMed ID: 8849450

DOI: 10.1126/science.274.5287.602

PubMed ID: 8929542

Title: CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.

PubMed ID: 8929542

DOI: 10.1016/s0092-8674(00)81393-8

PubMed ID: 9427609

Title: AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

PubMed ID: 9427609

DOI: 10.1038/nm0198-072

PubMed ID: 10089882

Title: Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.

PubMed ID: 10089882

DOI: 10.1016/s0092-8674(00)80577-2

PubMed ID: 10074102

Title: Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses.

PubMed ID: 10074102

DOI: 10.1128/jvi.73.4.2576-2586.1999

PubMed ID: 10074122

Title: Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.

PubMed ID: 10074122

DOI: 10.1128/jvi.73.4.2752-2761.1999

PubMed ID: 10644702

Title: beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.

PubMed ID: 10644702

DOI: 10.1074/jbc.275.4.2479

PubMed ID: 10825158

Title: Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities.

PubMed ID: 10825158

DOI: 10.1074/jbc.m000776200

PubMed ID: 10756055

Title: N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates.

PubMed ID: 10756055

DOI: 10.1128/jvi.74.9.4404-4413.2000

PubMed ID: 11027346

Title: Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1.

PubMed ID: 11027346

DOI: 10.1073/pnas.97.21.11466

PubMed ID: 11276205

Title: A CD14-independent LPS receptor cluster.

PubMed ID: 11276205

DOI: 10.1038/86342

PubMed ID: 12034737

Title: The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry.

PubMed ID: 12034737

DOI: 10.1074/jbc.m203361200

PubMed ID: 14602072

Title: The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.

PubMed ID: 14602072

DOI: 10.1016/s1534-5807(03)00321-6

PubMed ID: 12692554

Title: Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.

PubMed ID: 12692554

DOI: 10.1038/ng1149

PubMed ID: 15536153

Title: WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12.

PubMed ID: 15536153

DOI: 10.1182/blood-2004-06-2289

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17077324

Title: Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells.

PubMed ID: 17077324

DOI: 10.1182/blood-2006-05-023028

PubMed ID: 17197449

Title: Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.

PubMed ID: 17197449

DOI: 10.1074/jbc.c600270200

PubMed ID: 18834145

Title: Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases.

PubMed ID: 18834145

DOI: 10.1021/bi800965m

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19116316

Title: The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction.

PubMed ID: 19116316

DOI: 10.1091/mbc.e08-03-0308

PubMed ID: 19308288

Title: Staphylococcal superantigen-like 10 inhibits CXCL12-induced human tumor cell migration.

PubMed ID: 19308288

DOI: 10.1593/neo.81508

PubMed ID: 20048153

Title: Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.

PubMed ID: 20048153

DOI: 10.1074/jbc.m109.091173

PubMed ID: 20228059

Title: CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin.

PubMed ID: 20228059

DOI: 10.1074/jbc.m110.103408

PubMed ID: 20215400

Title: F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse.

PubMed ID: 20215400

DOI: 10.1242/jcs.064238

PubMed ID: 20505072

Title: Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.

PubMed ID: 20505072

DOI: 10.1091/mbc.e10-02-0169

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21540189

Title: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway.

PubMed ID: 21540189

DOI: 10.1074/jbc.m111.224071

PubMed ID: 22496149

Title: Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity.

PubMed ID: 22496149

DOI: 10.1182/blood-2011-08-372516

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24366360

Title: The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis.

PubMed ID: 24366360

DOI: 10.1182/blood-2013-09-525808

PubMed ID: 24553177

Title: Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia.

PubMed ID: 24553177

DOI: 10.1182/blood-2014-01-550905

PubMed ID: 24912431

Title: The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia.

PubMed ID: 24912431

DOI: 10.1038/leu.2014.187

PubMed ID: 28978524

Title: RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.

PubMed ID: 28978524

DOI: 10.1152/ajpcell.00193.2017

PubMed ID: 34927784

Title: ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.

PubMed ID: 34927784

DOI: 10.15252/embr.202051182

PubMed ID: 16725153

Title: Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12).

PubMed ID: 16725153

DOI: 10.1016/j.jmb.2006.04.052

PubMed ID: 18799424

Title: Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12.

PubMed ID: 18799424

DOI: 10.1126/scisignal.1160755

PubMed ID: 20929726

Title: Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.

PubMed ID: 20929726

DOI: 10.1126/science.1194396

PubMed ID: 25612609

Title: Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.

PubMed ID: 25612609

DOI: 10.1126/science.1261064

Sequence Information:

  • Length: 352
  • Mass: 39746
  • Checksum: 8C8476A186786B83
  • Sequence:
    • MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI 
LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL 
YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEKVVYVGV WIPALLLTIP DFIFANVSEA 
DDRYICDRFY PNDLWVVVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT 
TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI 
LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS

Genular Protein ID: 11814871

Symbol: A0A0U3FJG0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0U3FJG0

Database IDs:

ARBA 17 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 13 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 26321665

Title: Novel splice variants of CXCR4 identified by transcriptome sequencing.

PubMed ID: 26321665

DOI: 10.1016/j.bbrc.2015.08.113

Sequence Information:

  • Length: 385
  • Mass: 43403
  • Checksum: EBD3B9A635C96F00
  • Sequence:
    • MEGISENAPL PNVPNAPSDK HEDGKRPTHR RSARLGEEIY TSDNYTEEMG SGDYDSMKEP 
CFREENANFN KIFLPTIYSI IFLTGIVGNG LVILVMGYQK KLRSMTDKYR LHLSVADLLF 
VITLPFWAVD AVANWYFGNF LCKAVHVIYT VNLYSSVLIL AFISLDRYLA IVHATNSQRP 
RKLLAEKVVY VGVWIPALLL TIPDFIFANV SEADDRYICD RFYPNDLWVV VFQFQHIMVG 
LILPGIVILS CYCIIISKLS HSKGHQKRKA LKTTVILILA FFACWLPYYI GISIDSFILL 
EIIKQGCEFE NTVHKWISIT EALAFFHCCL NPILYAFLGA KFKTSAQHAL TSVSRGSSLK 
ILSKGKRGGH SSVSTESESS SFHSS

Genular Protein ID: 3078629319

Symbol: A0A0U3GXA9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0U3GXA9

Database IDs:

ARBA 17 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 26321665

Title: Novel splice variants of CXCR4 identified by transcriptome sequencing.

PubMed ID: 26321665

DOI: 10.1016/j.bbrc.2015.08.113

Sequence Information:

  • Length: 423
  • Mass: 47638
  • Checksum: 221C40E3744DC5A2
  • Sequence:
    • MEGISENAPL PNVPNAPSDK HEDGKRPTHR RSARLGEEVP FVHFLTLPPN IPQAPKGLRF 
KTAFSLPTTS CLKPRMIYTS DNYTEEMGSG DYDSMKEPCF REENANFNKI FLPTIYSIIF 
LTGIVGNGLV ILVMGYQKKL RSMTDKYRLH LSVADLLFVI TLPFWAVDAV ANWYFGNFLC 
KAVHVIYTVN LYSSVLILAF ISLDRYLAIV HATNSQRPRK LLAEKVVYVG VWIPALLLTI 
PDFIFANVSE ADDRYICDRF YPNDLWVVVF QFQHIMVGLI LPGIVILSCY CIIISKLSHS 
KGHQKRKALK TTVILILAFF ACWLPYYIGI SIDSFILLEI IKQGCEFENT VHKWISITEA 
LAFFHCCLNP ILYAFLGAKF KTSAQHALTS VSRGSSLKIL SKGKRGGHSS VSTESESSSF 
HSS

Genular Protein ID: 346435033

Symbol: A0A8Q3WLL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3WLL1

Database IDs:

ARBA 17 CDD 1 CTD 1 DisGeNET 1 EMBL 1 Ensembl 4 GO 8 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 337
  • Mass: 38012
  • Checksum: DEC9C09CD446CEEB
  • Sequence:
    • MGSGDYDSMK EPCFREENAN FNKIFLPTIY SIIFLTGIVG NGLVILVMGY QKKLRSMTDK 
YRLHLSVADL LFVITLPFWA VDAVANWYFG NFLCKAVHVI YTVNLYSSVL ILAFISLDRY 
LAIVHATNSQ RPRKLLAEKV VYVGVWIPAL LLTIPDFIFA NVSEADDRYI CDRFYPNDLW 
VVVFQFQHIM VGLILPGIVI LSCYCIIISK LSHSKGHQKR KALKTTVILI LAFFACWLPY 
YIGISIDSFI LLEIIKQGCE FENTVHKWIS ITEALAFFHC CLNPILYAFL GAKFKTSAQH 
ALTSVSRGSS LKILSKGKRG GHSSVSTESE SSSFHSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.