Details for: TSPAN7

Gene ID: 7102

Symbol: TSPAN7

Ensembl ID: ENSG00000156298

Description: tetraspanin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 355.2664
    Cell Significance Index: -55.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 216.9187
    Cell Significance Index: -55.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 150.3104
    Cell Significance Index: -61.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.0626
    Cell Significance Index: -45.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.0390
    Cell Significance Index: -55.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.1439
    Cell Significance Index: -45.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.2879
    Cell Significance Index: -54.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.3109
    Cell Significance Index: -54.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1167
    Cell Significance Index: -55.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.5854
    Cell Significance Index: 398.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.1626
    Cell Significance Index: 51.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.6381
    Cell Significance Index: 64.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9509
    Cell Significance Index: 130.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8476
    Cell Significance Index: 107.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6548
    Cell Significance Index: 532.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.6098
    Cell Significance Index: 31.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.4547
    Cell Significance Index: 58.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.3433
    Cell Significance Index: 144.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3048
    Cell Significance Index: 826.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1654
    Cell Significance Index: 24.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5558
    Cell Significance Index: 98.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1034
    Cell Significance Index: 74.1900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1028
    Cell Significance Index: 8.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0778
    Cell Significance Index: 745.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.0433
    Cell Significance Index: 17.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8828
    Cell Significance Index: 797.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8821
    Cell Significance Index: 23.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6027
    Cell Significance Index: 17.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5969
    Cell Significance Index: 64.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5748
    Cell Significance Index: 93.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4003
    Cell Significance Index: 10.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3839
    Cell Significance Index: 20.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2050
    Cell Significance Index: 9.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2022
    Cell Significance Index: 13.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1592
    Cell Significance Index: 3.4500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.1344
    Cell Significance Index: 1.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0959
    Cell Significance Index: 9.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0751
    Cell Significance Index: 2.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0458
    Cell Significance Index: 20.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0131
    Cell Significance Index: 0.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0096
    Cell Significance Index: -1.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0172
    Cell Significance Index: -32.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0186
    Cell Significance Index: -13.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0258
    Cell Significance Index: -16.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0287
    Cell Significance Index: -21.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0382
    Cell Significance Index: -70.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0456
    Cell Significance Index: -70.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0457
    Cell Significance Index: -8.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0518
    Cell Significance Index: -70.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0539
    Cell Significance Index: -9.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0582
    Cell Significance Index: -32.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0724
    Cell Significance Index: -54.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0762
    Cell Significance Index: -48.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0865
    Cell Significance Index: -47.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1102
    Cell Significance Index: -23.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1186
    Cell Significance Index: -53.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1351
    Cell Significance Index: -26.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1486
    Cell Significance Index: -4.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1612
    Cell Significance Index: -9.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1651
    Cell Significance Index: -28.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1708
    Cell Significance Index: -49.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2158
    Cell Significance Index: -26.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2782
    Cell Significance Index: -5.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2888
    Cell Significance Index: -39.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3058
    Cell Significance Index: -18.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3145
    Cell Significance Index: -32.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3441
    Cell Significance Index: -50.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3534
    Cell Significance Index: -7.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3641
    Cell Significance Index: -7.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3878
    Cell Significance Index: -45.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4020
    Cell Significance Index: -51.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4248
    Cell Significance Index: -48.4900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4282
    Cell Significance Index: -5.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4459
    Cell Significance Index: -51.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4720
    Cell Significance Index: -55.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5525
    Cell Significance Index: -57.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5620
    Cell Significance Index: -11.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6327
    Cell Significance Index: -20.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6345
    Cell Significance Index: -50.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6554
    Cell Significance Index: -10.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6726
    Cell Significance Index: -22.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6974
    Cell Significance Index: -53.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6976
    Cell Significance Index: -51.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7491
    Cell Significance Index: -15.5400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7685
    Cell Significance Index: -9.7000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7784
    Cell Significance Index: -8.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7808
    Cell Significance Index: -13.5000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7814
    Cell Significance Index: -6.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8262
    Cell Significance Index: -53.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8484
    Cell Significance Index: -23.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8597
    Cell Significance Index: -21.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8665
    Cell Significance Index: -61.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8860
    Cell Significance Index: -19.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8876
    Cell Significance Index: -46.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0375
    Cell Significance Index: -25.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0619
    Cell Significance Index: -37.2000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -1.0947
    Cell Significance Index: -4.0800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -1.1034
    Cell Significance Index: -9.7200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1210
    Cell Significance Index: -24.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.1272
    Cell Significance Index: -52.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSPAN7 is a type II transmembrane protein, consisting of four tandem repeats of a 40-amino acid motif. Its unique structure allows it to interact with various partners, including receptors, ligands, and other proteins, thereby modulating signaling pathways and cell behavior. Notably, TSPAN7 has been implicated in the trafficking of AMPA receptors, a type of glutamate receptor essential for synaptic plasticity and neuronal function. Additionally, its interactions with other proteins, such as GABA receptors and neurotransmitter receptors, suggest a role in regulating neurotransmission and neuronal excitability. **Pathways and Functions:** TSPAN7's involvement in various cellular processes can be attributed to its ability to interact with multiple partners, including: 1. **Cell surface interactions**: TSPAN7's binding to other proteins, such as integrins and selectins, facilitates cell-cell interactions and adhesion, which are critical for maintaining tissue structure and function. 2. **Glutamate binding**: TSPAN7's interaction with AMPA receptors and glutamate ligands regulates synaptic plasticity and neuronal excitability, highlighting its role in learning and memory. 3. **Neurotransmitter receptors and postsynaptic signal transmission**: TSPAN7's binding to GABA receptors and other neurotransmitter receptors modulates neurotransmission and neuronal excitability, influencing neural circuit function. 4. **Hemostasis**: TSPAN7's expression in endothelial cells and its involvement in cell-cell interactions suggest a role in maintaining vascular integrity and preventing thrombosis. 5. **Protein binding**: TSPAN7's ability to interact with a wide range of proteins, including receptors and other proteins, underscores its potential as a modulator of various signaling pathways. **Clinical Significance:** TSPAN7's involvement in immune and neurological responses has significant clinical implications. Dysregulation of TSPAN7 has been implicated in various diseases, including: 1. **Neurological disorders**: TSPAN7's role in regulating neurotransmission and synaptic plasticity makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and epilepsy. 2. **Immune system dysregulation**: TSPAN7's involvement in cell-cell interactions and immune responses suggests its potential as a therapeutic target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: TSPAN7's expression in various cancer types, including lung and breast cancer, highlights its potential as a biomarker or therapeutic target. In conclusion, TSPAN7 is a multifunctional protein with far-reaching implications in immune and neurological function. Further research is needed to fully elucidate the mechanisms by which TSPAN7 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 4183244972

Symbol: TSN7_HUMAN

Name: Tetraspanin-7

UniProtKB Accession Codes:

P41732 B2R5W7 D3DWB1 Q8WVG5 Q9UEY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 1 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8420826

Title: Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily.

PubMed ID: 8420826

DOI: 10.1007/bf00191884

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 7768645

Title: Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily.

PubMed ID: 7768645

DOI: 10.1002/ijc.2910610519

PubMed ID: 10655063

Title: A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation.

PubMed ID: 10655063

DOI: 10.1038/72829

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20630051

Title: Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein.

PubMed ID: 20630051

DOI: 10.1186/1743-422x-7-156

Sequence Information:

  • Length: 249
  • Mass: 27574
  • Checksum: F2CF4517DB388173
  • Sequence:
    • MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL IAENSTNAPY 
VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL AELVAGISGF VFRHEIKDTF 
LRTYTDAMQT YNGNDERSRA VDHVQRSLSC CGVQNYTNWS TSPYFLEHGI PPSCCMNETD 
CNPQDLHNLT VAATKVNQKG CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF 
ITANQYEMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.