Details for: TSPAN7

Gene ID: 7102

Symbol: TSPAN7

Ensembl ID: ENSG00000156298

Description: tetraspanin 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.7
    Marker Score: 4463
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.59
    Marker Score: 8249
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.31
    Marker Score: 24994
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.21
    Marker Score: 3024
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.09
    Marker Score: 6284.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.98
    Marker Score: 7577
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.97
    Marker Score: 15965
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.91
    Marker Score: 15268
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.81
    Marker Score: 2415
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.52
    Marker Score: 50204
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.43
    Marker Score: 92361
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.41
    Marker Score: 51348
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.37
    Marker Score: 10966
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.36
    Marker Score: 3259
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.29
    Marker Score: 9510
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.25
    Marker Score: 17283
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.25
    Marker Score: 4498
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.15
    Marker Score: 79334
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.08
    Marker Score: 1111
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.08
    Marker Score: 8025
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.06
    Marker Score: 19331
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.05
    Marker Score: 30696
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.04
    Marker Score: 2959
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.01
    Marker Score: 123866
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.01
    Marker Score: 637
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.99
    Marker Score: 3294
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.98
    Marker Score: 799
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.98
    Marker Score: 1032
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.93
    Marker Score: 411
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.89
    Marker Score: 3195
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17878
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.88
    Marker Score: 7651.5
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.83
    Marker Score: 2573
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.83
    Marker Score: 5212
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.83
    Marker Score: 443
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.82
    Marker Score: 612
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15610
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.79
    Marker Score: 3631
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.71
    Marker Score: 716
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7
    Marker Score: 30090
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.68
    Marker Score: 426
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.66
    Marker Score: 2051.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2492
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.55
    Marker Score: 372
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.54
    Marker Score: 2135
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.54
    Marker Score: 457.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.47
    Marker Score: 321
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.46
    Marker Score: 1473
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.41
    Marker Score: 849
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.4
    Marker Score: 544
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.37
    Marker Score: 512
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.34
    Marker Score: 4506
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.34
    Marker Score: 756
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.34
    Marker Score: 365
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.33
    Marker Score: 702
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20790
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.3
    Marker Score: 1174
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.28
    Marker Score: 288
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.23
    Marker Score: 4780
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.2
    Marker Score: 1276
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.2
    Marker Score: 1290
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.18
    Marker Score: 1061
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.18
    Marker Score: 776
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.17
    Marker Score: 696
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.15
    Marker Score: 570
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.13
    Marker Score: 980
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.13
    Marker Score: 38194
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.1
    Marker Score: 1269
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.1
    Marker Score: 606
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.09
    Marker Score: 1025
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.05
    Marker Score: 243
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.01
    Marker Score: 3158
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48007
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.99
    Marker Score: 402
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.98
    Marker Score: 1218
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.98
    Marker Score: 2615
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.97
    Marker Score: 403
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.95
    Marker Score: 412
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.93
    Marker Score: 1006
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.93
    Marker Score: 9619
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.92
    Marker Score: 3856
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5228
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.92
    Marker Score: 437
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.91
    Marker Score: 8027
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.9
    Marker Score: 2157
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.89
    Marker Score: 8992
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.89
    Marker Score: 420
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.88
    Marker Score: 470
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.85
    Marker Score: 645.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.83
    Marker Score: 829.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 635.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.82
    Marker Score: 425

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Other Information

**Key Characteristics:** TSPAN7 is a type II transmembrane protein, consisting of four tandem repeats of a 40-amino acid motif. Its unique structure allows it to interact with various partners, including receptors, ligands, and other proteins, thereby modulating signaling pathways and cell behavior. Notably, TSPAN7 has been implicated in the trafficking of AMPA receptors, a type of glutamate receptor essential for synaptic plasticity and neuronal function. Additionally, its interactions with other proteins, such as GABA receptors and neurotransmitter receptors, suggest a role in regulating neurotransmission and neuronal excitability. **Pathways and Functions:** TSPAN7's involvement in various cellular processes can be attributed to its ability to interact with multiple partners, including: 1. **Cell surface interactions**: TSPAN7's binding to other proteins, such as integrins and selectins, facilitates cell-cell interactions and adhesion, which are critical for maintaining tissue structure and function. 2. **Glutamate binding**: TSPAN7's interaction with AMPA receptors and glutamate ligands regulates synaptic plasticity and neuronal excitability, highlighting its role in learning and memory. 3. **Neurotransmitter receptors and postsynaptic signal transmission**: TSPAN7's binding to GABA receptors and other neurotransmitter receptors modulates neurotransmission and neuronal excitability, influencing neural circuit function. 4. **Hemostasis**: TSPAN7's expression in endothelial cells and its involvement in cell-cell interactions suggest a role in maintaining vascular integrity and preventing thrombosis. 5. **Protein binding**: TSPAN7's ability to interact with a wide range of proteins, including receptors and other proteins, underscores its potential as a modulator of various signaling pathways. **Clinical Significance:** TSPAN7's involvement in immune and neurological responses has significant clinical implications. Dysregulation of TSPAN7 has been implicated in various diseases, including: 1. **Neurological disorders**: TSPAN7's role in regulating neurotransmission and synaptic plasticity makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and epilepsy. 2. **Immune system dysregulation**: TSPAN7's involvement in cell-cell interactions and immune responses suggests its potential as a therapeutic target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: TSPAN7's expression in various cancer types, including lung and breast cancer, highlights its potential as a biomarker or therapeutic target. In conclusion, TSPAN7 is a multifunctional protein with far-reaching implications in immune and neurological function. Further research is needed to fully elucidate the mechanisms by which TSPAN7 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 4183244972

Symbol: TSN7_HUMAN

Name: Tetraspanin-7

UniProtKB Accession Codes:

P41732 B2R5W7 D3DWB1 Q8WVG5 Q9UEY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 1 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8420826

Title: Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily.

PubMed ID: 8420826

DOI: 10.1007/bf00191884

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 7768645

Title: Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily.

PubMed ID: 7768645

DOI: 10.1002/ijc.2910610519

PubMed ID: 10655063

Title: A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation.

PubMed ID: 10655063

DOI: 10.1038/72829

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20630051

Title: Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein.

PubMed ID: 20630051

DOI: 10.1186/1743-422x-7-156

Sequence Information:

  • Length: 249
  • Mass: 27574
  • Checksum: F2CF4517DB388173
  • Sequence:
    • MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL IAENSTNAPY 
VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL AELVAGISGF VFRHEIKDTF 
LRTYTDAMQT YNGNDERSRA VDHVQRSLSC CGVQNYTNWS TSPYFLEHGI PPSCCMNETD 
CNPQDLHNLT VAATKVNQKG CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF 
ITANQYEMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.