IGKV3 11 | ENSG00000241351 | NCBI 28914

Details for: IGKV3 11

Gene ID: 28914

Symbol: IGKV3 11

Ensembl ID: ENSG00000241351

Description: immunoglobulin kappa variable 3-11

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 10.3363
Cell Significance Index: -4.8800
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.5837
Cell Significance Index: 9.0300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0548
Cell Significance Index: 0.7900
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.0432
Cell Significance Index: 0.6300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0169
Cell Significance Index: 2.1700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0016
Cell Significance Index: -0.9200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0069
Cell Significance Index: -5.2000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0201
Cell Significance Index: -0.5000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0263
Cell Significance Index: -5.2200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0344
Cell Significance Index: -6.2000
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0362
Cell Significance Index: -0.5100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0475
Cell Significance Index: -4.8500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0737
Cell Significance Index: -4.5200
Cell Name: PP cell (CL0000696)
Fold Change: -0.0922
Cell Significance Index: -0.9400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1067
Cell Significance Index: -13.7800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1152
Cell Significance Index: -5.2200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1460
Cell Significance Index: -3.9100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1632
Cell Significance Index: -5.9900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1857
Cell Significance Index: -13.8400
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2338
Cell Significance Index: -3.4200
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2417
Cell Significance Index: -2.7000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2538
Cell Significance Index: -4.3100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2553
Cell Significance Index: -11.9100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2652
Cell Significance Index: -6.4300
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2686
Cell Significance Index: -3.1800
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2712
Cell Significance Index: -3.6900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2716
Cell Significance Index: -5.0200
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2761
Cell Significance Index: -7.0400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2808
Cell Significance Index: -4.8400
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.2827
Cell Significance Index: -3.1600
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.2847
Cell Significance Index: -3.2300
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2947
Cell Significance Index: -3.6500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3069
Cell Significance Index: -6.0000
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.3108
Cell Significance Index: -2.0700
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3153
Cell Significance Index: -4.0000
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3334
Cell Significance Index: -5.4000
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3406
Cell Significance Index: -5.8200
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3468
Cell Significance Index: -3.6900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3523
Cell Significance Index: -10.1500
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3538
Cell Significance Index: -3.7300
Cell Name: plasmablast (CL0000980)
Fold Change: -0.3620
Cell Significance Index: -3.3600
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.3680
Cell Significance Index: -4.3300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3691
Cell Significance Index: -5.5300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3740
Cell Significance Index: -6.3000
Cell Name: B cell (CL0000236)
Fold Change: -0.3800
Cell Significance Index: -4.4900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3841
Cell Significance Index: -5.6700
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.3900
Cell Significance Index: -5.1000
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3907
Cell Significance Index: -3.7500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3913
Cell Significance Index: -4.4500
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.3935
Cell Significance Index: -4.7500
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.3941
Cell Significance Index: -5.1000
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.3946
Cell Significance Index: -4.9800
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3974
Cell Significance Index: -4.0600
Cell Name: enterocyte (CL0000584)
Fold Change: -0.4078
Cell Significance Index: -2.5300
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.4134
Cell Significance Index: -3.7800
Cell Name: monocyte (CL0000576)
Fold Change: -0.4206
Cell Significance Index: -4.8400
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.4259
Cell Significance Index: -5.8400
Cell Name: thymocyte (CL0000893)
Fold Change: -0.4282
Cell Significance Index: -5.4100
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.4308
Cell Significance Index: -5.9800
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.4394
Cell Significance Index: -4.8500
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.4409
Cell Significance Index: -5.3600
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.4549
Cell Significance Index: -5.1500
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.4633
Cell Significance Index: -3.2600
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.4641
Cell Significance Index: -4.1400
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.4683
Cell Significance Index: -4.6200
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4717
Cell Significance Index: -6.0600
Cell Name: neutrophil (CL0000775)
Fold Change: -0.4723
Cell Significance Index: -5.9000
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.4789
Cell Significance Index: -4.9400
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4801
Cell Significance Index: -6.3000
Cell Name: promonocyte (CL0000559)
Fold Change: -0.4813
Cell Significance Index: -5.1400
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.4836
Cell Significance Index: -5.2900
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.4869
Cell Significance Index: -5.2400
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4895
Cell Significance Index: -6.3900
Cell Name: granulocyte (CL0000094)
Fold Change: -0.4941
Cell Significance Index: -5.9600
Cell Name: mast cell (CL0000097)
Fold Change: -0.4943
Cell Significance Index: -6.5100
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.5022
Cell Significance Index: -5.9400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5025
Cell Significance Index: -14.4100
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.5026
Cell Significance Index: -5.2300
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.5053
Cell Significance Index: -12.3300
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.5070
Cell Significance Index: -5.2200
Cell Name: pericyte (CL0000669)
Fold Change: -0.5075
Cell Significance Index: -6.0900
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.5081
Cell Significance Index: -5.6300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.5095
Cell Significance Index: -10.5700
Cell Name: immature B cell (CL0000816)
Fold Change: -0.5115
Cell Significance Index: -4.8400
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.5137
Cell Significance Index: -5.2400
Cell Name: osteoclast (CL0000092)
Fold Change: -0.5162
Cell Significance Index: -5.2700
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.5176
Cell Significance Index: -4.1600
Cell Name: glial cell (CL0000125)
Fold Change: -0.5184
Cell Significance Index: -5.6800
Cell Name: mature B cell (CL0000785)
Fold Change: -0.5193
Cell Significance Index: -3.3800
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.5194
Cell Significance Index: -5.2700
Cell Name: endocrine cell (CL0000163)
Fold Change: -0.5237
Cell Significance Index: -6.3300
Cell Name: chondrocyte (CL0000138)
Fold Change: -0.5240
Cell Significance Index: -6.0400
Cell Name: fibroblast (CL0000057)
Fold Change: -0.5251
Cell Significance Index: -4.9300
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.5267
Cell Significance Index: -4.8200
Cell Name: peg cell (CL4033014)
Fold Change: -0.5298
Cell Significance Index: -12.2400
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.5314
Cell Significance Index: -6.4700
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.5318
Cell Significance Index: -5.8900
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.5331
Cell Significance Index: -5.2600
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.5339
Cell Significance Index: -6.7600
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.5376
Cell Significance Index: -5.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV3-11 is a member of the immunoglobulin superfamily, which is involved in the recognition and binding of antigens. The gene encodes a kappa light chain variable region, which is important for the specificity and affinity of immunoglobulins. IGKV3-11 is characterized by its high expression in immune cells, such as CD16-positive natural killer cells and CD14-positive monocytes, which are key players in the innate and adaptive immune responses. The gene's expression is also observed in non-immune cells, including neurons and epithelial cells, suggesting a broader role in immune regulation. **Pathways and Functions** IGKV3-11 is involved in various signaling pathways, including: 1. **Adaptive Immune System**: IGKV3-11 plays a crucial role in the adaptive immune response, particularly in the recognition and elimination of pathogens. It is involved in the activation of B cells, which are essential for the production of immunoglobulins. 2. **Anti-inflammatory Response**: IGKV3-11 is involved in the regulation of the anti-inflammatory response, particularly in the context of Leishmania parasite infection. It is thought to modulate the activity of immune cells, such as natural killer cells and macrophages, to prevent excessive inflammation. 3. **Antigen Activation**: IGKV3-11 is involved in the activation of B cell receptors (BCRs), which leads to the generation of second messengers and the activation of downstream signaling pathways. 4. **Complement Cascade**: IGKV3-11 is involved in the regulation of the complement cascade, a series of proteins that help eliminate pathogens from the body. 5. **Cell Surface Interactions**: IGKV3-11 is involved in cell surface interactions, including binding and uptake of ligands by scavenger receptors. **Clinical Significance** IGKV3-11 has several clinical implications: 1. **Leishmania Infection**: IGKV3-11 is significantly upregulated in response to Leishmania parasite infection, suggesting a role in the immune response to this disease. 2. **Infectious Diseases**: IGKV3-11 is involved in the regulation of the immune response to various infectious diseases, including SARS-CoV and viral infections. 3. **Autoimmune Diseases**: IGKV3-11 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, due to its involvement in the regulation of the immune response. 4. **Cancer**: IGKV3-11 may be involved in the regulation of the immune response to cancer, particularly in the context of tumor-associated macrophages. In conclusion, IGKV3-11 is a gene that plays a crucial role in the adaptive and innate immune responses, particularly in the context of Leishmania parasite infection and other infectious diseases. Its expression is significantly upregulated in response to different types of infections, and it is involved in various signaling pathways, including the complement cascade and cell surface interactions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.