IGKV3 11 | ENSG00000241351 | NCBI 28914

Details for: IGKV3 11

Gene ID: 28914

Symbol: IGKV3 11

Ensembl ID: ENSG00000241351

Description: immunoglobulin kappa variable 3-11

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.99
Marker Score: 162,062
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 6.68
Marker Score: 8,260
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 3.25
Marker Score: 2,513
Cell Name: microglial cell (CL0000129)
Fold Change: 2.42
Marker Score: 4,400
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.66
Marker Score: 1,400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.62
Marker Score: 4,029
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.46
Marker Score: 1,573
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 863
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7,634
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,793
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 789
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,812
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,037
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.98
Marker Score: 2,478
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,310
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,288
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.81
Marker Score: 1,309
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 389
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.71
Marker Score: 406
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: blood cell (CL0000081)
Fold Change: 0.59
Marker Score: 6,811
Cell Name: plasmablast (CL0000980)
Fold Change: 0.58
Marker Score: 768
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 145
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.45
Marker Score: 271
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.44
Marker Score: 424
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.43
Marker Score: 151
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.43
Marker Score: 893
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.42
Marker Score: 177
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.37
Marker Score: 314
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.37
Marker Score: 194
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.35
Marker Score: 683
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.35
Marker Score: 193
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.34
Marker Score: 303
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.32
Marker Score: 268
Cell Name: memory B cell (CL0000787)
Fold Change: 0.32
Marker Score: 243
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.31
Marker Score: 184
Cell Name: immature B cell (CL0000816)
Fold Change: 0.31
Marker Score: 205
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.3
Marker Score: 304
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.28
Marker Score: 221
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.28
Marker Score: 73
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.28
Marker Score: 76
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.28
Marker Score: 259
Cell Name: B cell (CL0000236)
Fold Change: 0.27
Marker Score: 254
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.25
Marker Score: 255
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.25
Marker Score: 223
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.25
Marker Score: 108
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.22
Marker Score: 76
Cell Name: plasma cell (CL0000786)
Fold Change: 0.2
Marker Score: 224
Cell Name: naive B cell (CL0000788)
Fold Change: 0.19
Marker Score: 172
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.19
Marker Score: 131
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.18
Marker Score: 290
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.18
Marker Score: 172
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.17
Marker Score: 394
Cell Name: T cell (CL0000084)
Fold Change: 0.17
Marker Score: 293
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.17
Marker Score: 38
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.16
Marker Score: 36
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.16
Marker Score: 178
Cell Name: mast cell (CL0000097)
Fold Change: 0.16
Marker Score: 95
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.16
Marker Score: 134
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.16
Marker Score: 95
Cell Name: platelet (CL0000233)
Fold Change: 0.15
Marker Score: 69
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.15
Marker Score: 39
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.15
Marker Score: 263
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.15
Marker Score: 38
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.14
Marker Score: 8,077
Cell Name: fibroblast (CL0000057)
Fold Change: 0.14
Marker Score: 139
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.14
Marker Score: 99
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.14
Marker Score: 117
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.14
Marker Score: 92
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.14
Marker Score: 40
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.14
Marker Score: 33
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.13
Marker Score: 76
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.13
Marker Score: 40
Cell Name: ionocyte (CL0005006)
Fold Change: 0.13
Marker Score: 38
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.12
Marker Score: 47
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.12
Marker Score: 151
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.12
Marker Score: 31
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.12
Marker Score: 56
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.12
Marker Score: 39
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.12
Marker Score: 34
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.12
Marker Score: 46
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.12
Marker Score: 140
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.12
Marker Score: 34
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.11
Marker Score: 184
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.11
Marker Score: 70
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.11
Marker Score: 78
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.11
Marker Score: 30
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.11
Marker Score: 39
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.11
Marker Score: 79
Cell Name: reticular cell (CL0000432)
Fold Change: 0.1
Marker Score: 38
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.1
Marker Score: 70
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.1
Marker Score: 133
Cell Name: enucleated reticulocyte (CL0002422)
Fold Change: 0.1
Marker Score: 38
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.1
Marker Score: 38
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.1
Marker Score: 5,220
Cell Name: T-helper 2 cell (CL0000546)
Fold Change: 0.1
Marker Score: 40

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** IGKV3-11 is a member of the immunoglobulin superfamily, which is involved in the recognition and binding of antigens. The gene encodes a kappa light chain variable region, which is important for the specificity and affinity of immunoglobulins. IGKV3-11 is characterized by its high expression in immune cells, such as CD16-positive natural killer cells and CD14-positive monocytes, which are key players in the innate and adaptive immune responses. The gene's expression is also observed in non-immune cells, including neurons and epithelial cells, suggesting a broader role in immune regulation. **Pathways and Functions** IGKV3-11 is involved in various signaling pathways, including: 1. **Adaptive Immune System**: IGKV3-11 plays a crucial role in the adaptive immune response, particularly in the recognition and elimination of pathogens. It is involved in the activation of B cells, which are essential for the production of immunoglobulins. 2. **Anti-inflammatory Response**: IGKV3-11 is involved in the regulation of the anti-inflammatory response, particularly in the context of Leishmania parasite infection. It is thought to modulate the activity of immune cells, such as natural killer cells and macrophages, to prevent excessive inflammation. 3. **Antigen Activation**: IGKV3-11 is involved in the activation of B cell receptors (BCRs), which leads to the generation of second messengers and the activation of downstream signaling pathways. 4. **Complement Cascade**: IGKV3-11 is involved in the regulation of the complement cascade, a series of proteins that help eliminate pathogens from the body. 5. **Cell Surface Interactions**: IGKV3-11 is involved in cell surface interactions, including binding and uptake of ligands by scavenger receptors. **Clinical Significance** IGKV3-11 has several clinical implications: 1. **Leishmania Infection**: IGKV3-11 is significantly upregulated in response to Leishmania parasite infection, suggesting a role in the immune response to this disease. 2. **Infectious Diseases**: IGKV3-11 is involved in the regulation of the immune response to various infectious diseases, including SARS-CoV and viral infections. 3. **Autoimmune Diseases**: IGKV3-11 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, due to its involvement in the regulation of the immune response. 4. **Cancer**: IGKV3-11 may be involved in the regulation of the immune response to cancer, particularly in the context of tumor-associated macrophages. In conclusion, IGKV3-11 is a gene that plays a crucial role in the adaptive and innate immune responses, particularly in the context of Leishmania parasite infection and other infectious diseases. Its expression is significantly upregulated in response to different types of infections, and it is involved in various signaling pathways, including the complement cascade and cell surface interactions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.