Details for: CL0000077

Cell ID: CL0000077

Cell Name: mesothelial cell

Marker Score Threshold: 401
(Derived using integrated single-cell and genomic data)

Description: A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement.

Synonyms: mesotheliocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.99
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.91
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.8
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.69
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.63
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.54
    Ensembl ID: ENSG00000143933
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.49
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.41
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.35
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.2
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.2
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.09
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.07
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.04
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.03
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.99
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.98
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.97
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.84
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.84
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.81
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.8
    Ensembl ID: ENSG00000122786
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.8
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.77
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.76
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.75
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.74
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.73
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.72
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.69
    Ensembl ID: ENSG00000077549
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.69
    Ensembl ID: ENSG00000172270
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.68
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.66
    Ensembl ID: ENSG00000116459
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.62
    Ensembl ID: ENSG00000149131
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.61
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.58
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.55
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.53
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.53
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.52
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.52
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.46
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.45
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.45
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.44
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.41
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.39
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.37
    Ensembl ID: ENSG00000069849
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.35
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.34
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.34
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.34
    Ensembl ID: ENSG00000010278
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.33
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 1.33
    Ensembl ID: ENSG00000105974
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.32
    Ensembl ID: ENSG00000159403
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.32
    Ensembl ID: ENSG00000151914
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.26
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.25
    Ensembl ID: ENSG00000072778
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 1.25
    Ensembl ID: ENSG00000125730
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.24
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.24
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.23
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.2
    Ensembl ID: ENSG00000122359
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.18
    Ensembl ID: ENSG00000004059
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.18
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.18
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.18
    Ensembl ID: ENSG00000146731
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.16
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CALB2 (ENSG00000172137)
    Fold Change: 1.16
    Ensembl ID: ENSG00000172137
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.14
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.11
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.11
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143153
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.07
    Ensembl ID: ENSG00000149257
  • Gene Symbol: BCHE (ENSG00000114200)
    Fold Change: 1.07
    Ensembl ID: ENSG00000114200
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.07
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.06
    Ensembl ID: ENSG00000118971
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 1.06
    Ensembl ID: ENSG00000105971
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164615
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.04
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.04
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.03
    Ensembl ID: ENSG00000196975
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.03
    Ensembl ID: ENSG00000145349
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.01
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.01
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.01
    Ensembl ID: ENSG00000165527
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.01
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1
    Ensembl ID: ENSG00000072110
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cellular Structure**: Mesothelial cells are flat, squamous-like epithelial cells with a characteristic morphology. 2. **Location**: These cells line the body's serous cavities, including the pleural, peritoneal, and pericardial spaces. 3. **Function**: Mesothelial cells synthesize and secrete lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement. 4. **Cell Signaling**: Mesothelial cells are involved in various cell signaling pathways, including those related to inflammation, immune response, and cancer. 5. **Genetic Characteristics**: Mesothelial cells express a range of genes involved in cell growth, differentiation, and survival. **Clinical Significance** 1. **Pleural Mesothelioma**: Mesothelial cells are implicated in the development of pleural mesothelioma, a rare and aggressive cancer of the pleura. 2. **Peritoneal Mesothelioma**: Mesothelial cells are also implicated in the development of peritoneal mesothelioma, a rare and aggressive cancer of the peritoneum. 3. **Pericardial Mesothelioma**: Mesothelial cells are implicated in the development of pericardial mesothelioma, a rare and aggressive cancer of the pericardium. 4. **Inflammatory Diseases**: Mesothelial cells are involved in various inflammatory diseases, including rheumatoid arthritis, lupus, and scleroderma. 5. **Tissue Repair**: Mesothelial cells play a crucial role in tissue repair and regeneration, particularly in the context of wound healing and fibrosis. **Molecular Mechanisms** 1. **Apoptotic Process**: Mesothelial cells are involved in the apoptotic process, which is a critical mechanism for cell death and tissue homeostasis. 2. **ATP:ADP Antiporter Activity**: Mesothelial cells express ATP:ADP antiporter activity, which is involved in energy metabolism and cell survival. 3. **Protein Binding**: Mesothelial cells express a range of proteins involved in cell signaling, including receptors, kinases, and phosphatases. 4. **Gene Expression**: Mesothelial cells express a range of genes involved in cell growth, differentiation, and survival, including those involved in inflammation and immune response. 5. **Mitochondrial Function**: Mesothelial cells have a high energy requirement and express a range of mitochondrial genes involved in energy metabolism and cell survival. In conclusion, mesothelial cells are a unique and fascinating cell type that plays a crucial role in various physiological and pathological processes. Further research is needed to fully understand the molecular mechanisms and clinical significance of mesothelial cells.