Details for: MAP4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 651.5147
Cell Significance Index: -101.3400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 391.3368
Cell Significance Index: -99.2600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 198.9102
Cell Significance Index: -93.9100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 188.5013
Cell Significance Index: -76.5800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 172.3805
Cell Significance Index: -88.6700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 140.3381
Cell Significance Index: -94.1700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 82.6064
Cell Significance Index: -101.8500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 80.5452
Cell Significance Index: -76.9000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 32.2301
Cell Significance Index: -86.3400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 26.6153
Cell Significance Index: -58.2500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 25.8715
Cell Significance Index: -102.0900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 25.6784
Cell Significance Index: -78.8700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 12.2215
Cell Significance Index: 314.1500 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 9.9366
Cell Significance Index: 76.5900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 9.5104
Cell Significance Index: 2736.4300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 8.1535
Cell Significance Index: 198.9400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 6.1274
Cell Significance Index: 470.2100 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 5.0982
Cell Significance Index: 82.2600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.8707
Cell Significance Index: 55.6700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 3.4196
Cell Significance Index: 66.7400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 3.0880
Cell Significance Index: 45.5900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.4451
Cell Significance Index: 127.3600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.1221
Cell Significance Index: 421.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.1065
Cell Significance Index: 58.8700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9842
Cell Significance Index: 398.0300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.6952
Cell Significance Index: 232.8000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.6092
Cell Significance Index: 290.0900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.5654
Cell Significance Index: 87.8400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4722
Cell Significance Index: 528.0400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4671
Cell Significance Index: 180.3900 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.3969
Cell Significance Index: 179.0800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.1138
Cell Significance Index: 68.4600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.0378
Cell Significance Index: 69.7800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.9664
Cell Significance Index: 50.7400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8112
Cell Significance Index: 88.2400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7361
Cell Significance Index: 664.6500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.7316
Cell Significance Index: 994.7900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7033
Cell Significance Index: 384.0900 - Cell Name: peg cell (CL4033014)
Fold Change: 0.6880
Cell Significance Index: 15.9000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6758
Cell Significance Index: 109.9100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5921
Cell Significance Index: 261.7600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5535
Cell Significance Index: 35.7100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.5507
Cell Significance Index: 1036.9400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5345
Cell Significance Index: 25.1200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4804
Cell Significance Index: 13.8400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4560
Cell Significance Index: 9.8800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.4162
Cell Significance Index: 640.7500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.3964
Cell Significance Index: 731.1200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.3078
Cell Significance Index: 4.4200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2966
Cell Significance Index: 134.6100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2544
Cell Significance Index: 161.6000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1602
Cell Significance Index: 1.4800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.1560
Cell Significance Index: 3.3400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1080
Cell Significance Index: 2.9400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0823
Cell Significance Index: 14.0600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0019
Cell Significance Index: 0.0500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0105
Cell Significance Index: -0.1800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0289
Cell Significance Index: -21.2000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0293
Cell Significance Index: -5.5800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0376
Cell Significance Index: -5.4700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0515
Cell Significance Index: -32.1300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0545
Cell Significance Index: -2.4700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0613
Cell Significance Index: -45.3900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0659
Cell Significance Index: -8.5200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0924
Cell Significance Index: -69.9100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1183
Cell Significance Index: -1.4100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1221
Cell Significance Index: -68.8300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1386
Cell Significance Index: -2.3400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1456
Cell Significance Index: -7.5600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1493
Cell Significance Index: -9.4100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1704
Cell Significance Index: -17.4100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1718
Cell Significance Index: -4.1200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1905
Cell Significance Index: -8.8800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1976
Cell Significance Index: -5.6400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2532
Cell Significance Index: -18.8700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.2549
Cell Significance Index: -25.2200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2814
Cell Significance Index: -1.7000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2838
Cell Significance Index: -59.7700 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.2946
Cell Significance Index: -3.7100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3108
Cell Significance Index: -7.7700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3227
Cell Significance Index: -9.2500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3400
Cell Significance Index: -40.1000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4480
Cell Significance Index: -52.2100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4604
Cell Significance Index: -47.9400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4679
Cell Significance Index: -32.3600 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.4700
Cell Significance Index: -4.1400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4836
Cell Significance Index: -55.4100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4911
Cell Significance Index: -56.0600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5077
Cell Significance Index: -35.9100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.5427
Cell Significance Index: -19.0700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6872
Cell Significance Index: -18.0700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7224
Cell Significance Index: -31.9600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7541
Cell Significance Index: -12.6200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9145
Cell Significance Index: -29.2900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9277
Cell Significance Index: -73.4700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.9405
Cell Significance Index: -19.5100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9866
Cell Significance Index: -37.3600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.1321
Cell Significance Index: -16.7100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1356
Cell Significance Index: -69.6200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.2020
Cell Significance Index: -25.6000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3841448485
Symbol: MAP4_HUMAN
Name: Microtubule-associated protein 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1718985
Title: A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences.
PubMed ID: 1718985
PubMed ID: 7857940
Title: Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains.
PubMed ID: 7857940
DOI: 10.1021/bi00007a025
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1905296
Title: Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau.
PubMed ID: 1905296
DOI: 10.1242/jcs.98.1.27
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 10791892
Title: Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization.
PubMed ID: 10791892
DOI: 10.1247/csf.25.33
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 14759258
PubMed ID: 16093351
Title: Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4.
PubMed ID: 16093351
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17487921
Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
PubMed ID: 17487921
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 17693683
Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
PubMed ID: 17693683
PubMed ID: 18088087
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29180244
Title: Dual loss of p110delta PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features.
PubMed ID: 29180244
PubMed ID: 34782749
Title: Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.
PubMed ID: 34782749
Sequence Information:
- Length: 1152
- Mass: 121005
- Checksum: 061A69AC18593339
- Sequence:
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP TEFLEEKMAY QEYPNSQNWP EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA DLVFPSSATA DTSIFAGQND PLKDSYGMSP CNTAVVPQGW SVEALNSPHS ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE IMMGLKTTDM APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM ALVKDMELPT EKEVALVKDV RWPTETDVSS AKNVVLPTET EVAPAKDVTL LKETERASPI KMDLAPSKDM GPPKENKKET ERASPIKMDL APSKDMGPPK ENKIVPAKDL VLLSEIEVAQ ANDIISSTEI SSAEKVALSS ETEVALARDM TLPPETNVIL TKDKALPLEA EVAPVKDMAQ LPETEIAPAK DVAPSTVKEV GLLKDMSPLS ETEMALGKDV TPPPETEVVL IKNVCLPPEM EVALTEDQVP ALKTEAPLAK DGVLTLANNV TPAKDVPPLS ETEATPVPIK DMEIAQTQKG ISEDSHLESL QDVGQSAAPT FMISPETVTG TGKKCSLPAE EDSVLEKLGE RKPCNSQPSE LSSETSGIAR PEEGRPVVSG TGNDITTPPN KELPPSPEKK TKPLATTQPA KTSTSKAKTQ PTSLPKQPAP TTIGGLNKKP MSLASGLVPA APPKRPAVAS ARPSILPSKD VKPKPIADAK APEKRASPSK PASAPASRSG SKSTQTVAKT TTAAAVASTG PSSRSPSTLL PKKPTAIKTE GKPAEVKKMT AKSVPADLSR PKSTSTSSMK KTTTLSGTAP AAGVVPSRVK ATPMPSRPST TPFIDKKPTS AKPSSTTPRL SRLATNTSAP DLKNVRSKVG STENIKHQPG GGRAKVEKKT EAAATTRKPE SNAVTKTAGP IASAQKQPAG KVQIVSKKVS YSHIQSKCGS KDNIKHVPGG GNVQIQNKKV DISKVSSKCG SKANIKHKPG GGDVKIESQK LNFKEKAQAK VGSLDNVGHL PAGGAVKTEG GGSEAPLCPG PPAGEEPAIS EAAPEAGAPT SASGLNGHPT LSGGGDQREA QTLDSQIQET SI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.