EZR | ENSG00000092820 | NCBI 7430

Details for: EZR

Gene ID: 7430

Symbol: EZR

Ensembl ID: ENSG00000092820

Description: ezrin

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
L1cam interactions
(R-HSA-373760)
Nervous system development
(R-HSA-9675108)
Netrin-1 signaling
(R-HSA-373752)
Recycling pathway of l1
(R-HSA-437239)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Sensory processing of sound by outer hair cells of the cochlea
(R-HSA-9662361)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament
(GO:0005884)
Actin filament binding
(GO:0051015)
Actin filament bundle assembly
(GO:0051017)
Adherens junction
(GO:0005912)
Apical plasma membrane
(GO:0016324)
Astral microtubule organization
(GO:0030953)
Atpase binding
(GO:0051117)
Basolateral plasma membrane
(GO:0016323)
Brush border
(GO:0005903)
Cadherin binding
(GO:0045296)
Cell adhesion molecule binding
(GO:0050839)
Cellular response to camp
(GO:0071320)
Cortical cytoskeleton
(GO:0030863)
Cortical microtubule organization
(GO:0043622)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Endosome
(GO:0005768)
Establishment of centrosome localization
(GO:0051660)
Establishment of endothelial barrier
(GO:0061028)
Establishment of epithelial cell apical/basal polarity
(GO:0045198)
Extracellular space
(GO:0005615)
Fibrillar center
(GO:0001650)
Filopodium
(GO:0030175)
Filopodium assembly
(GO:0046847)
Focal adhesion
(GO:0005925)
Gland morphogenesis
(GO:0022612)
Identical protein binding
(GO:0042802)
Immunological synapse
(GO:0001772)
Intestinal d-glucose absorption
(GO:0001951)
Leukocyte cell-cell adhesion
(GO:0007159)
Membrane
(GO:0016020)
Membrane to membrane docking
(GO:0022614)
Microtubule binding
(GO:0008017)
Microvillus
(GO:0005902)
Microvillus assembly
(GO:0030033)
Microvillus membrane
(GO:0031528)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of p38mapk cascade
(GO:1903753)
Negative regulation of t cell receptor signaling pathway
(GO:0050860)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Plasma membrane
(GO:0005886)
Positive regulation of early endosome to late endosome transport
(GO:2000643)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of protein localization to early endosome
(GO:1902966)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Postsynaptic actin cytoskeleton organization
(GO:0098974)
Protein-containing complex
(GO:0032991)
Protein-containing complex localization
(GO:0031503)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase a binding
(GO:0051018)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein kinase a regulatory subunit binding
(GO:0034237)
Protein kinase a signaling
(GO:0010737)
Protein localization to cell cortex
(GO:0072697)
Protein localization to plasma membrane
(GO:0072659)
Receptor internalization
(GO:0031623)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of cell shape
(GO:0008360)
Regulation of cell size
(GO:0008361)
Regulation of microvillus length
(GO:0032532)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Regulation of organelle assembly
(GO:1902115)
Rna binding
(GO:0003723)
Ruffle
(GO:0001726)
Ruffle membrane
(GO:0032587)
S100 protein binding
(GO:0044548)
Sphingosine-1-phosphate receptor signaling pathway
(GO:0003376)
Terminal web assembly
(GO:1902896)
Uropod
(GO:0001931)
Vesicle
(GO:0031982)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 493.1685
Cell Significance Index: -76.7100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 303.5561
Cell Significance Index: -77.0000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 196.5056
Cell Significance Index: -80.9500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 190.3474
Cell Significance Index: -77.3300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 166.9955
Cell Significance Index: -85.9000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 128.4011
Cell Significance Index: -86.1600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 81.6136
Cell Significance Index: -77.9200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 65.6552
Cell Significance Index: -80.9500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 27.0339
Cell Significance Index: -72.4200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 22.7514
Cell Significance Index: -69.8800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.9273
Cell Significance Index: -82.5800
Cell Name: centroblast (CL0009112)
Fold Change: 12.5929
Cell Significance Index: 29.3800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.9790
Cell Significance Index: -21.8400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 7.0453
Cell Significance Index: 188.1200
Cell Name: epidermal cell (CL0000362)
Fold Change: 5.1098
Cell Significance Index: 11.5200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 4.6967
Cell Significance Index: 43.2500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.6229
Cell Significance Index: 298.2500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.3390
Cell Significance Index: 511.7000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 3.8620
Cell Significance Index: 200.6200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.7942
Cell Significance Index: 171.9800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.4384
Cell Significance Index: 161.6000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.3935
Cell Significance Index: 611.7400
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.3902
Cell Significance Index: 1851.4500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.2777
Cell Significance Index: 89.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.9360
Cell Significance Index: 361.0100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.7683
Cell Significance Index: 206.3200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.7067
Cell Significance Index: 58.6400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.5916
Cell Significance Index: 74.6700
Cell Name: lactocyte (CL0002325)
Fold Change: 2.5260
Cell Significance Index: 326.3400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 2.5007
Cell Significance Index: 15.3900
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.4962
Cell Significance Index: 15.5100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.3091
Cell Significance Index: 251.1700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.0001
Cell Significance Index: 29.9700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.7194
Cell Significance Index: 48.0500
Cell Name: peg cell (CL4033014)
Fold Change: 1.7188
Cell Significance Index: 39.7100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.5561
Cell Significance Index: 687.9700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4578
Cell Significance Index: 237.1000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.1941
Cell Significance Index: 35.0700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7639
Cell Significance Index: 689.7300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6831
Cell Significance Index: 130.0000
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.6709
Cell Significance Index: 9.5500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5617
Cell Significance Index: 72.0100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5461
Cell Significance Index: 41.9100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5366
Cell Significance Index: 25.0200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4219
Cell Significance Index: 29.8400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2987
Cell Significance Index: 7.8600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2950
Cell Significance Index: 29.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2731
Cell Significance Index: 37.5100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2282
Cell Significance Index: 45.2800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2046
Cell Significance Index: 385.1700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1812
Cell Significance Index: 115.0600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1415
Cell Significance Index: 7.3700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1114
Cell Significance Index: 84.3300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1112
Cell Significance Index: 18.9900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0894
Cell Significance Index: 0.9300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0835
Cell Significance Index: 2.9400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0467
Cell Significance Index: 34.2200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0355
Cell Significance Index: -26.2600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0472
Cell Significance Index: -6.8700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0475
Cell Significance Index: -87.5400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0523
Cell Significance Index: -80.4900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0569
Cell Significance Index: -35.5400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0607
Cell Significance Index: -82.5000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0613
Cell Significance Index: -6.2600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0759
Cell Significance Index: -42.8100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0838
Cell Significance Index: -57.9600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1457
Cell Significance Index: -66.1100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1601
Cell Significance Index: -18.2700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.2235
Cell Significance Index: -80.1600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2412
Cell Significance Index: -50.8000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2532
Cell Significance Index: -1.5300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2589
Cell Significance Index: -74.5000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2639
Cell Significance Index: -3.6000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3438
Cell Significance Index: -39.3900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3620
Cell Significance Index: -6.6900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3628
Cell Significance Index: -9.0700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.3919
Cell Significance Index: -78.6200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5237
Cell Significance Index: -61.0400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6311
Cell Significance Index: -16.9100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6797
Cell Significance Index: -70.7700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7537
Cell Significance Index: -59.6900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.7553
Cell Significance Index: -46.4300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8616
Cell Significance Index: -48.3500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.0577
Cell Significance Index: -22.5300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.0629
Cell Significance Index: -36.9400
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.0878
Cell Significance Index: -27.7900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.1593
Cell Significance Index: -13.1700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2096
Cell Significance Index: -74.1600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.2337
Cell Significance Index: -33.0000
Cell Name: kidney cell (CL1000497)
Fold Change: -1.2888
Cell Significance Index: -10.2900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.2895
Cell Significance Index: -41.3000
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.2907
Cell Significance Index: -22.2500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.2970
Cell Significance Index: -87.2100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.3381
Cell Significance Index: -67.6200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -1.3755
Cell Significance Index: -11.8200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.3764
Cell Significance Index: -86.7500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.4001
Cell Significance Index: -20.6700
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -1.4498
Cell Significance Index: -13.7700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.4746
Cell Significance Index: -77.4200
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -1.4979
Cell Significance Index: -9.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Structural organization**: Ezrin consists of three main domains: the N-terminal actin-binding domain, the central ERM domain, and the C-terminal protein-protein interaction domain. 2. **Actin-binding properties**: Ezrin binds to actin filaments, promoting their organization and dynamics, and regulating cell shape and adhesion. 3. **Cell adhesion and polarity**: Ezrin interacts with various adhesion molecules, such as cadherins and L1CAM, to maintain cell-cell and cell-extracellular matrix interactions, and regulates epithelial and endothelial cell polarity. 4. **Signaling pathways**: Ezrin modulates various signaling pathways, including those involving ERK, p38MAPK, and NF-κB, influencing cell growth, differentiation, and survival. **Pathways and Functions** Ezrin's functions can be broadly categorized into the following pathways and processes: 1. **Actin cytoskeleton organization**: Ezrin regulates actin filament organization, dynamics, and interaction with other cytoskeletal proteins. 2. **Cell adhesion and polarity**: Ezrin maintains cell-cell and cell-extracellular matrix interactions, regulating cell shape, morphology, and polarity. 3. **Signaling pathways**: Ezrin modulates various signaling pathways, influencing cell growth, differentiation, and survival. 4. **Cell migration and motility**: Ezrin regulates cell migration and motility, particularly in epithelial and endothelial cells. 5. **Cancer and metastasis**: Ezrin's dysregulation has been implicated in cancer progression, metastasis, and resistance to therapy. 6. **Neurological disorders**: Ezrin has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. **Clinical Significance** Ezrin's dysregulation has been implicated in various diseases, including: 1. **Cancer**: Ezrin's overexpression or mutation has been associated with breast, lung, colon, and other cancers, promoting metastasis and resistance to therapy. 2. **Cardiovascular disease**: Ezrin's dysregulation has been linked to cardiovascular disease, including atherosclerosis, hypertension, and cardiac arrhythmias. 3. **Neurological disorders**: Ezrin's involvement in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, highlights its potential as a therapeutic target. 4. **Inflammatory diseases**: Ezrin's dysregulation has been implicated in inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. In conclusion, Ezrin is a multifunctional protein that plays a critical role in maintaining cell shape, adhesion, and polarity, and regulating various signaling pathways. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of cancer, cardiovascular disease, neurological disorders, and inflammatory diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ezrin

Genular Protein ID: 1250355649

Symbol: EZRI_HUMAN

Name: Ezrin

UniProtKB Accession Codes:

P15311 E1P5A8 P23714 Q4VX75 Q96CU8 Q9NSJ4

Database IDs:

Citations:

PubMed ID: 2591371

Title: cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1.

PubMed ID: 2591371

DOI: 10.1002/j.1460-2075.1989.tb08598.x

PubMed ID: 2674140

Title: Cytovillin, a microvillar Mr 75,000 protein. cDNA sequence, prokaryotic expression, and chromosomal localization.

PubMed ID: 2674140

DOI: 10.1016/s0021-9258(19)84765-8

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8713105

Title: Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.

PubMed ID: 8713105

DOI: 10.1006/bbrc.1996.1082

PubMed ID: 1382070

Title: Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.

PubMed ID: 1382070

DOI: 10.1016/s0021-9258(18)41769-3

PubMed ID: 1381389

Title: Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells.

PubMed ID: 1381389

PubMed ID: 9314537

Title: Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.

PubMed ID: 9314537

DOI: 10.1083/jcb.139.1.169

PubMed ID: 12651155

Title: PACE-1, a novel protein that interacts with the C-terminal domain of ezrin.

PubMed ID: 12651155

DOI: 10.1016/s0014-4827(02)00054-x

PubMed ID: 12808036

Title: Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P.

PubMed ID: 12808036

DOI: 10.1091/mbc.e02-09-0553

PubMed ID: 15498789

Title: Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells.

PubMed ID: 15498789

DOI: 10.1093/carcin/bgh312

PubMed ID: 15797715

Title: Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system.

PubMed ID: 15797715

DOI: 10.1016/j.mcn.2004.11.014

PubMed ID: 17046996

Title: Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

PubMed ID: 17046996

DOI: 10.1242/jcs.03218

PubMed ID: 17616675

Title: Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin.

PubMed ID: 17616675

DOI: 10.1158/0008-5472.can-06-3575

PubMed ID: 17881735

Title: Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells.

PubMed ID: 17881735

DOI: 10.1091/mbc.e06-12-1144

PubMed ID: 18046454

Title: Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.

PubMed ID: 18046454

DOI: 10.1038/sj.emboj.7601943

PubMed ID: 18270268

Title: Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells.

PubMed ID: 18270268

DOI: 10.1242/jcs.016246

PubMed ID: 19111582

Title: Generation and characterization of a novel, permanently active S100P mutant.

PubMed ID: 19111582

DOI: 10.1016/j.bbamcr.2008.11.012

PubMed ID: 19555689

Title: MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.

PubMed ID: 19555689

DOI: 10.1016/j.febslet.2009.06.034

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25417112

Title: Target-selective protein S-nitrosylation by sequence motif recognition.

PubMed ID: 25417112

DOI: 10.1016/j.cell.2014.09.032

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12429733

Title: Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions.

PubMed ID: 12429733

DOI: 10.1074/jbc.m210601200

PubMed ID: 27364155

Title: Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.

PubMed ID: 27364155

DOI: 10.1042/bcj20160541

Sequence Information:

Length: 586
Mass: 69413
Checksum: F1B592CF49A7CC46
Sequence:

MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLHYV DNKGFPTWLK 
LDKKVSAQEV RKENPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE 
TAVLLGSYAV QAKFGDYNKE VHKSGYLSSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR 
GMLKDNAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF 
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI 
EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM MREKEELMLR LQDYEEKTKK 
AERELSEQIQ RALQLEEERK RAQEEAERLE ADRMAALRAK EELERQAVDQ IKSQEQLAAE 
LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP 
VSYHVQESLQ DEGAEPTGYS AELSSEGIRD DRNEEKRITE AEKNERVQRQ LLTLSSELSQ 
ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAL

Database document:

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Details for: EZR

Associated with

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Other Information

cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. PubMed ID: 2591371

Cytovillin, a microvillar Mr 75,000 protein. cDNA sequence, prokaryotic expression, and chromosomal localization. PubMed ID: 2674140

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes. PubMed ID: 8713105

Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin. PubMed ID: 1382070

Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells. PubMed ID: 1381389

Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. PubMed ID: 9314537

PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. PubMed ID: 12651155

Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P. PubMed ID: 12808036

Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. PubMed ID: 15498789

Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system. PubMed ID: 15797715

Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. PubMed ID: 17046996

Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin. PubMed ID: 17616675

Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. PubMed ID: 17881735

Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering. PubMed ID: 18046454

Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells. PubMed ID: 18270268

Generation and characterization of a novel, permanently active S100P mutant. PubMed ID: 19111582

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. PubMed ID: 19555689

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Target-selective protein S-nitrosylation by sequence motif recognition. PubMed ID: 25417112

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. PubMed ID: 12429733

Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin. PubMed ID: 27364155