Details for: EZR
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 96.84rCSI 85.16%PRS 10.94
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CSI 92.88rCSI 72%PRS 14.38
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CSI 88.87rCSI 100%PRS 11.04
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CSI 84.42rCSI 63.02%PRS 25.35
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CSI 80.13rCSI 79.97%PRS 12.88
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CSI 76.95rCSI 51.84%PRS 18.17
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CSI 76.64rCSI 88.88%PRS 22.23
-
CSI 68.44rCSI 84.67%PRS 13.23
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CSI 65.6rCSI 64.78%PRS 53.75
-
CSI 61.6rCSI 46.6%PRS 20.73
-
CSI 61.52rCSI 99.67%PRS 15.31
-
CSI 59.55rCSI 51.77%PRS 18.67
-
CSI 59.48rCSI 90.85%PRS 15.12
-
CSI 57.91rCSI 74.27%PRS 17.42
-
CSI 56.55rCSI 70.34%PRS 15.93
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CSI 53.23rCSI 82.25%PRS 14.12
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CSI 53.2rCSI 55.73%PRS 14.04
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CSI 51.77rCSI 75.83%PRS 17.52
-
CSI 50.72rCSI 42.51%PRS 18.03
-
CSI 50.45rCSI 52.26%PRS 17.72
-
CSI 47.78rCSI 45.15%PRS 15.74
-
CSI 47.34rCSI 49.47%PRS 15.77
-
CSI 46.71rCSI 92.74%PRS 16.02
-
CSI 44.66rCSI 72.01%PRS 23.73
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CSI 44.34rCSI 34.88%PRS 18.02
-
CSI 43.03rCSI 44.89%PRS 15.46
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CSI 40.88rCSI 43.44%PRS 26.46
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CSI 39.36rCSI 89.73%PRS 15.62
-
CSI 39.14rCSI 57.27%PRS 15.93
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CSI 39.05rCSI 33.5%PRS 25.86
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CSI 36.22rCSI 38.82%PRS 13.87
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CSI 36.08rCSI 34.79%PRS 10.65
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CSI 35.85rCSI 51.39%PRS 20.67
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CSI 35.47rCSI 100%PRS 28.83
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CSI 34.92rCSI 99.88%PRS 26.58
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CSI 32.41rCSI 31.2%PRS 15.6
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CSI 31.72rCSI 57.63%PRS 23.04
-
CSI 31.53rCSI 24.29%PRS 13.78
-
CSI 31.13rCSI 68.18%PRS 20.11
-
CSI 29.85rCSI 46.31%PRS 22.78
-
CSI 29.28rCSI 58.37%PRS 25.25
-
CSI 28.89rCSI 61.5%PRS 24.18
-
CSI 28.57rCSI 62.37%PRS 30.07
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CSI 27.65rCSI 20.77%PRS 15.77
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CSI 26.24rCSI 40.32%PRS 21.18
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CSI 25.99rCSI 31.49%PRS 19.53
-
CSI 25.99rCSI 68.41%PRS 29.34
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CSI 25.96rCSI 50.49%PRS 15.43
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CSI 24.92rCSI 84.24%PRS 24.74
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CSI 24.91rCSI 59.13%PRS 18.88
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CSI 24.84rCSI 33.21%PRS 19.9
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CSI 23.56rCSI 31.52%PRS 56.07
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CSI 23.33rCSI 20.71%PRS 15.07
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CSI 22.71rCSI 23.79%PRS 16.11
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CSI 21.54rCSI 69.11%PRS 21.9
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CSI 21.25rCSI 14.92%PRS 37.55
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CSI 21.09rCSI 30.4%PRS 24.04
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CSI 20.92rCSI 60.52%PRS 33.04
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CSI 20.17rCSI 78.87%PRS 3.7
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CSI 20.13rCSI 57.46%PRS 25.78
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CSI 20.06rCSI 20.95%PRS 43.5
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CSI 19.36rCSI 16.28%PRS 24.17
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CSI 19.17rCSI 32.79%PRS 30.06
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CSI 18.94rCSI 16.59%PRS 19.98
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CSI 18.82rCSI 75.21%PRS 32.41
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CSI 18.62rCSI 60.95%PRS 40.67
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CSI 18.07rCSI 23.69%PRS 58.81
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CSI 17.83rCSI 42.79%PRS 27.08
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CSI 17.01rCSI 24.95%PRS 19.81
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CSI 16.91rCSI 50.43%PRS 36.33
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CSI 16.49rCSI 12.25%PRS 22.26
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CSI 16.29rCSI 18.33%PRS 24.21
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CSI 16.22rCSI 43.71%PRS 19.43
-
CSI 15.41rCSI 18.1%PRS 17.68
-
CSI 15.04rCSI 12.45%PRS 15.15
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CSI 14.94rCSI 38.61%PRS 14.03
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CSI 14.91rCSI 19.94%PRS 16.52
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CSI 14.68rCSI 20.8%PRS 14.03
-
CSI 14.59rCSI 35.64%PRS 14.9
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CSI 14.19rCSI 21.7%PRS 24.45
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CSI 13.46rCSI 70.69%PRS 26.32
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CSI 13.43rCSI 12.41%PRS 27.33
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CSI 13.37rCSI 13.14%PRS 42.03
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CSI 13.23rCSI 15.54%PRS 70.15
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CSI 13.22rCSI 9.23%PRS 15.9
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CSI 13.09rCSI 12.18%PRS 15.09
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CSI 13.05rCSI 10.89%PRS 41.9
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CSI 12.99rCSI 9.03%PRS 17.78
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CSI 12.72rCSI 17.99%PRS 20.89
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CSI 12.43rCSI 14.89%PRS 26.06
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CSI 12.29rCSI 70.87%PRS 19.55
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CSI 12.11rCSI 9.08%PRS 42
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CSI 11.98rCSI 13.88%PRS 43.49
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CSI 11.81rCSI 10.85%PRS 17.41
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CSI 11.7rCSI 17.66%PRS 15
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CSI 11.56rCSI 14.78%PRS 55.71
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CSI 11.4rCSI 9.21%PRS 24.04
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CSI 11.18rCSI 10.75%PRS 30.84
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CSI 11.12rCSI 8.65%PRS 21.83
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CSI 11.12rCSI 11.38%PRS 27.96
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CSI -8.3rCSI -32.1%PRS 20.9%
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CSI -4.8rCSI -3.8%PRS 10.4%
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CSI -4.3rCSI -5.7%PRS 28.7%
-
CSI -3.4rCSI -4.9%PRS 17.0%
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CSI -3.3rCSI -15.7%PRS 18.8%
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CSI -2.5rCSI -3.4%PRS 13.4%
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CSI -1.9rCSI -2.8%PRS 18.3%
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CSI -1.8rCSI -11.3%PRS 11.8%
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CSI -1.5rCSI -8.6%PRS 42.0%
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CSI -1.1rCSI -5.7%PRS 27.6%
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CSI -0.8rCSI -8.4%PRS 55.6%
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CSI -0.6rCSI -0.6%PRS 13.5%
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CSI -0.5rCSI -8.2%PRS 53.5%
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CSI -0.4rCSI -0.7%PRS 16.5%
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CSI -0.4rCSI -0.7%PRS 11.5%
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CSI -0.4rCSI -0.9%PRS 15.3%
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CSI 0.0rCSI 0.3%PRS 59.5%
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CSI 0.1rCSI 0.2%PRS 14.0%
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CSI 0.1rCSI 2.2%PRS 74.6%
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CSI 0.1rCSI 3.3%PRS 48.3%
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CSI 0.2rCSI 1.1%PRS 38.3%
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CSI 0.2rCSI 0.3%PRS 15.1%
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CSI 0.2rCSI 0.3%PRS 15.1%
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CSI 0.3rCSI 2.0%PRS 8.1%
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CSI 0.3rCSI 0.7%PRS 24.6%
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CSI 0.3rCSI 1.8%PRS 22.6%
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CSI 0.3rCSI 0.9%PRS 18.7%
-
CSI 0.3rCSI 2.4%PRS 29.3%
-
CSI 0.4rCSI 4.0%PRS 54.0%
-
CSI 0.4rCSI 1.6%PRS 29.8%
-
CSI 0.4rCSI 6.6%PRS 79.0%
-
CSI 0.4rCSI 2.4%PRS 23.1%
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CSI 0.4rCSI 10.0%PRS 77.0%
-
CSI 0.4rCSI 1.9%PRS 40.9%
-
CSI 0.5rCSI 6.6%PRS 86.5%
-
CSI 0.5rCSI 1.6%PRS 24.6%
-
CSI 0.5rCSI 1.6%PRS 54.3%
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CSI 0.5rCSI 14.4%PRS 80.2%
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CSI 0.5rCSI 3.6%PRS 40.1%
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CSI 0.5rCSI 1.3%PRS 39.1%
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CSI 0.5rCSI 2.4%PRS 38.9%
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CSI 0.5rCSI 0.9%PRS 19.9%
-
CSI 0.5rCSI 4.2%PRS 55.9%
-
CSI 0.5rCSI 16.1%PRS 33.9%
-
CSI 0.6rCSI 8.4%PRS 65.4%
-
CSI 0.6rCSI 3.7%PRS 22.0%
-
CSI 0.7rCSI 3.3%PRS 29.4%
-
CSI 0.7rCSI 4.5%PRS 46.1%
-
CSI 0.7rCSI 15.8%PRS 77.8%
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CSI 0.7rCSI 5.4%PRS 57.8%
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CSI 0.7rCSI 2.3%PRS 11.1%
-
CSI 0.7rCSI 1.1%PRS 21.0%
-
CSI 0.8rCSI 3.3%PRS 30.6%
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CSI 0.9rCSI 4.8%PRS 50.8%
-
CSI 0.9rCSI 1.1%PRS 17.5%
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CSI 1.0rCSI 1.0%PRS 16.4%
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CSI 1.0rCSI 4.5%PRS 26.7%
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CSI 1.1rCSI 11.2%PRS 42.0%
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CSI 1.3rCSI 11.5%PRS 40.8%
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CSI 1.3rCSI 2.3%PRS 11.2%
-
CSI 1.4rCSI 1.8%PRS 8.4%
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CSI 1.5rCSI 2.9%PRS 40.4%
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CSI 1.5rCSI 9.1%PRS 24.1%
-
CSI 1.5rCSI 39.6%PRS 62.4%
-
CSI 1.6rCSI 29.9%PRS 69.2%
-
CSI 1.6rCSI 3.9%PRS 22.5%
-
CSI 1.6rCSI 8.1%PRS 19.8%
-
CSI 1.6rCSI 1.3%PRS 15.0%
-
CSI 1.6rCSI 4.9%PRS 21.7%
-
CSI 1.7rCSI 35.1%PRS 66.6%
-
CSI 1.8rCSI 5.7%PRS 15.9%
-
CSI 1.8rCSI 3.4%PRS 18.8%
-
CSI 1.9rCSI 5.1%PRS 14.0%
-
CSI 1.9rCSI 2.7%PRS 11.7%
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CSI 1.9rCSI 33.3%PRS 55.6%
-
CSI 2.0rCSI 3.2%PRS 12.8%
-
CSI 2.0rCSI 13.2%PRS 68.8%
-
CSI 2.0rCSI 9.2%PRS 50.1%
-
CSI 2.1rCSI 16.1%PRS 31.4%
-
CSI 2.1rCSI 5.7%PRS 24.9%
-
CSI 2.2rCSI 4.1%PRS 29.5%
-
CSI 2.2rCSI 51.3%PRS 27.6%
-
CSI 2.2rCSI 6.4%PRS 17.1%
-
CSI 2.2rCSI 33.2%PRS 45.0%
-
CSI 2.3rCSI 3.1%PRS 30.7%
-
CSI 2.3rCSI 36.7%PRS 63.9%
-
CSI 2.3rCSI 3.8%PRS 17.7%
-
CSI 2.4rCSI 25.6%PRS 20.4%
-
CSI 2.4rCSI 2.3%PRS 15.4%
-
CSI 2.5rCSI 5.9%PRS 23.9%
-
CSI 2.5rCSI 4.4%PRS 13.9%
-
CSI 2.5rCSI 5.7%PRS 30.8%
-
CSI 2.5rCSI 4.0%PRS 19.4%
-
CSI 2.6rCSI 29.6%PRS 54.2%
-
CSI 2.6rCSI 5.5%PRS 25.1%
-
CSI 2.7rCSI 3.7%PRS 17.1%
-
CSI 2.7rCSI 12.0%PRS 14.8%
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CSI 2.7rCSI 10.2%PRS 12.8%
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CSI 2.7rCSI 5.6%PRS 34.1%
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CSI 2.8rCSI 9.0%PRS 18.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1250355649
Symbol: EZRI_HUMAN
Name: Ezrin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2591371
Title: cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1.
PubMed ID: 2591371
PubMed ID: 2674140
Title: Cytovillin, a microvillar Mr 75,000 protein. cDNA sequence, prokaryotic expression, and chromosomal localization.
PubMed ID: 2674140
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8713105
Title: Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.
PubMed ID: 8713105
PubMed ID: 1382070
Title: Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.
PubMed ID: 1382070
PubMed ID: 1381389
Title: Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells.
PubMed ID: 1381389
PubMed ID: 9314537
Title: Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.
PubMed ID: 9314537
PubMed ID: 12651155
Title: PACE-1, a novel protein that interacts with the C-terminal domain of ezrin.
PubMed ID: 12651155
PubMed ID: 12808036
Title: Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P.
PubMed ID: 12808036
PubMed ID: 15498789
Title: Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells.
PubMed ID: 15498789
PubMed ID: 15797715
Title: Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system.
PubMed ID: 15797715
PubMed ID: 17046996
Title: Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.
PubMed ID: 17046996
DOI: 10.1242/jcs.03218
PubMed ID: 17616675
Title: Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin.
PubMed ID: 17616675
PubMed ID: 17881735
Title: Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells.
PubMed ID: 17881735
PubMed ID: 18046454
Title: Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.
PubMed ID: 18046454
PubMed ID: 18270268
Title: Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells.
PubMed ID: 18270268
DOI: 10.1242/jcs.016246
PubMed ID: 19111582
Title: Generation and characterization of a novel, permanently active S100P mutant.
PubMed ID: 19111582
PubMed ID: 19555689
Title: MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.
PubMed ID: 19555689
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25417112
Title: Target-selective protein S-nitrosylation by sequence motif recognition.
PubMed ID: 25417112
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 12429733
Title: Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions.
PubMed ID: 12429733
PubMed ID: 27364155
Title: Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.
PubMed ID: 27364155
DOI: 10.1042/bcj20160541
Sequence Information:
- Length: 586
- Mass: 69413
- Checksum: F1B592CF49A7CC46
- Sequence:
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLHYV DNKGFPTWLK LDKKVSAQEV RKENPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKE VHKSGYLSSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR GMLKDNAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM MREKEELMLR LQDYEEKTKK AERELSEQIQ RALQLEEERK RAQEEAERLE ADRMAALRAK EELERQAVDQ IKSQEQLAAE LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP VSYHVQESLQ DEGAEPTGYS AELSSEGIRD DRNEEKRITE AEKNERVQRQ LLTLSSELSQ ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAL