Details for: IL16

Gene ID: 3603

Symbol: IL16

Ensembl ID: ENSG00000172349

Description: interleukin 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.2205
    Cell Significance Index: -14.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.2915
    Cell Significance Index: -18.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.5437
    Cell Significance Index: -10.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.4148
    Cell Significance Index: -19.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7847
    Cell Significance Index: -14.5300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 8.6417
    Cell Significance Index: 23.1500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 6.5129
    Cell Significance Index: 15.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6721
    Cell Significance Index: -14.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8063
    Cell Significance Index: -15.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.8584
    Cell Significance Index: 36.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.6992
    Cell Significance Index: 29.1200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.5323
    Cell Significance Index: 19.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4444
    Cell Significance Index: 42.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4201
    Cell Significance Index: 167.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.0789
    Cell Significance Index: 7.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6649
    Cell Significance Index: 33.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6238
    Cell Significance Index: 61.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5565
    Cell Significance Index: 502.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3951
    Cell Significance Index: 10.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3074
    Cell Significance Index: 50.0000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2962
    Cell Significance Index: 2.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2790
    Cell Significance Index: 18.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2665
    Cell Significance Index: 95.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2580
    Cell Significance Index: 5.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2146
    Cell Significance Index: 40.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2046
    Cell Significance Index: 22.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1493
    Cell Significance Index: 29.9500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0926
    Cell Significance Index: 1.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0653
    Cell Significance Index: 4.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0569
    Cell Significance Index: 1.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0134
    Cell Significance Index: 0.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0070
    Cell Significance Index: 4.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0049
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0005
    Cell Significance Index: 0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0123
    Cell Significance Index: -1.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0190
    Cell Significance Index: -14.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0223
    Cell Significance Index: -12.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0225
    Cell Significance Index: -16.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0251
    Cell Significance Index: -4.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0254
    Cell Significance Index: -18.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0262
    Cell Significance Index: -16.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0270
    Cell Significance Index: -11.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0286
    Cell Significance Index: -0.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0294
    Cell Significance Index: -16.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0341
    Cell Significance Index: -15.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0366
    Cell Significance Index: -10.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0374
    Cell Significance Index: -0.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0424
    Cell Significance Index: -1.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0452
    Cell Significance Index: -2.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0465
    Cell Significance Index: -9.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0771
    Cell Significance Index: -4.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0782
    Cell Significance Index: -13.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0793
    Cell Significance Index: -16.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0837
    Cell Significance Index: -8.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0948
    Cell Significance Index: -13.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0980
    Cell Significance Index: -1.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1015
    Cell Significance Index: -12.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1133
    Cell Significance Index: -14.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1296
    Cell Significance Index: -4.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1298
    Cell Significance Index: -2.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1315
    Cell Significance Index: -15.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1349
    Cell Significance Index: -14.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1370
    Cell Significance Index: -17.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1462
    Cell Significance Index: -16.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1603
    Cell Significance Index: -6.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1639
    Cell Significance Index: -3.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1681
    Cell Significance Index: -7.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1728
    Cell Significance Index: -13.2600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1852
    Cell Significance Index: -1.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1881
    Cell Significance Index: -11.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1892
    Cell Significance Index: -8.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2088
    Cell Significance Index: -14.0400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2093
    Cell Significance Index: -3.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2110
    Cell Significance Index: -14.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2142
    Cell Significance Index: -3.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2198
    Cell Significance Index: -8.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2356
    Cell Significance Index: -18.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2357
    Cell Significance Index: -17.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2405
    Cell Significance Index: -13.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2462
    Cell Significance Index: -3.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2599
    Cell Significance Index: -16.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2674
    Cell Significance Index: -13.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2941
    Cell Significance Index: -15.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2993
    Cell Significance Index: -8.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3215
    Cell Significance Index: -14.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3368
    Cell Significance Index: -11.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3479
    Cell Significance Index: -18.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3614
    Cell Significance Index: -7.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3752
    Cell Significance Index: -11.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3832
    Cell Significance Index: -9.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3888
    Cell Significance Index: -12.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4459
    Cell Significance Index: -16.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4502
    Cell Significance Index: -11.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4628
    Cell Significance Index: -10.0000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4638
    Cell Significance Index: -9.6800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.4674
    Cell Significance Index: -2.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL-16 is a 10-kDa protein, consisting of two subunits: a pro-domain and a mature domain. The pro-domain is responsible for binding to the CD4 receptor, facilitating the interaction with T cells. The mature domain, in turn, exhibits chemotactic activity, promoting the migration of leukocytes towards sites of inflammation. IL-16 is primarily produced by epithelial cells, fibroblasts, and immune cells, including T cells and B cells. **Pathways and Functions:** IL-16 is involved in several key signaling pathways, including: 1. **CD4 receptor binding:** IL-16 binds to the CD4 receptor on T cells, facilitating their activation and proliferation. 2. **Cytokine signaling:** IL-16 interacts with various cytokines, including IL-1α, IL-6, and IL-12, to modulate immune responses. 3. **Chemotaxis:** IL-16 exhibits chemotactic activity, attracting leukocytes to sites of inflammation. 4. **Calcium ion transport:** IL-16 regulates calcium ion transport, which is essential for various cellular processes, including cell signaling and differentiation. IL-16 plays a crucial role in regulating immune responses, including: 1. **T cell activation:** IL-16 promotes T cell activation, proliferation, and differentiation. 2. **B cell activation:** IL-16 also activates B cells, leading to their activation and antibody production. 3. **Inflammation:** IL-16 contributes to the development of inflammatory responses by promoting the recruitment of leukocytes. **Clinical Significance:** IL-16 has been implicated in various disease states, including: 1. **Asthma:** IL-16 is involved in the pathogenesis of asthma, where it promotes airway inflammation and hyperresponsiveness. 2. **Rheumatoid arthritis:** IL-16 is elevated in the synovial fluid of patients with rheumatoid arthritis, contributing to joint inflammation and destruction. 3. **Cancer:** IL-16 has been shown to promote tumor growth and metastasis in various cancer types, including breast and lung cancer. 4. **Neurological disorders:** IL-16 has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, IL-16 is a multifaceted cytokine that plays a crucial role in regulating immune responses, inflammation, and various disease states. Its dysregulation has significant implications for the development of therapeutic strategies for these conditions. Further research is needed to fully elucidate the mechanisms by which IL-16 regulates immune responses and to explore its potential as a therapeutic target.

Genular Protein ID: 1360267611

Symbol: IL16_HUMAN

Name: Pro-interleukin-16

UniProtKB Accession Codes:

Q14005 A6NM20 A8MU65 B5TY35 B9EGR6 H3BVH5 Q16435 Q6VVE6 Q6ZMQ7 Q9UP18

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 1 CPTC 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12923170

Title: PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits.

PubMed ID: 12923170

DOI: 10.1074/jbc.m306669200

PubMed ID: 19906316

Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.

PubMed ID: 19906316

DOI: 10.1186/1471-2164-10-518

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9990060

Title: GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes.

PubMed ID: 9990060

DOI: 10.1073/pnas.96.4.1541

PubMed ID: 8609984

Title: Interleukin-16 or not?

PubMed ID: 8609984

DOI: 10.1038/381030a0

PubMed ID: 7910967

Title: Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.

PubMed ID: 7910967

DOI: 10.1073/pnas.91.11.5109

PubMed ID: 9422780

Title: Processing and activation of pro-interleukin-16 by caspase-3.

PubMed ID: 9422780

DOI: 10.1074/jbc.273.2.1144

PubMed ID: 11032842

Title: Nuclear translocation of the N-terminal prodomain of interleukin-16.

PubMed ID: 11032842

DOI: 10.1074/jbc.m008513200

PubMed ID: 11276202

Title: Gene regulation mediated by calcium signals in T lymphocytes.

PubMed ID: 11276202

DOI: 10.1038/86318

PubMed ID: 12450396

Title: Prointerleukin-16 contains a functional CcN motif that regulates nuclear localization.

PubMed ID: 12450396

DOI: 10.1021/bi020163v

PubMed ID: 12620798

Title: Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein.

PubMed ID: 12620798

DOI: 10.1016/s0042-6822(02)00056-9

PubMed ID: 14734747

Title: Nuclear pro-IL-16 regulation of T cell proliferation: p27(KIP1)-dependent G0/G1 arrest mediated by inhibition of Skp2 transcription.

PubMed ID: 14734747

DOI: 10.4049/jimmunol.172.3.1654

PubMed ID: 18097041

Title: Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP.

PubMed ID: 18097041

DOI: 10.4049/jimmunol.180.1.402

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9699630

Title: Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site.

PubMed ID: 9699630

DOI: 10.1038/1376

Sequence Information:

  • Length: 1332
  • Mass: 141752
  • Checksum: EDF68567B2AF120C
  • Sequence:
    • MESHSRAGKS RKSAKFRSIS RSLMLCNAKT SDDGSSPDEK YPDPFEISLA QGKEGIFHSS 
VQLADTSEAG PSSVPDLALA SEAAQLQAAG NDRGKTCRRI FFMKESSTAS SREKPGKLEA 
QSSNFLFPKA CHQRARSNST SVNPYCTREI DFPMTKKSAA PTDRQPYSLC SNRKSLSQQL 
DCPAGKAAGT SRPTRSLSTA QLVQPSGGLQ ASVISNIVLM KGQAKGLGFS IVGGKDSIYG 
PIGIYVKTIF AGGAAAADGR LQEGDEILEL NGESMAGLTH QDALQKFKQA KKGLLTLTVR 
TRLTAPPSLC SHLSPPLCRS LSSSTCITKD SSSFALESPS APISTAKPNY RIMVEVSLQK 
EAGVGLGIGL CSVPYFQCIS GIFVHTLSPG SVAHLDGRLR CGDEIVEISD SPVHCLTLNE 
VYTILSHCDP GPVPIIVSRH PDPQVSEQQL KEAVAQAVEN TKFGKERHQW SLEGVKRLES 
SWHGRPTLEK EREKNSAPPH RRAQKVMIRS SSDSSYMSGS PGGSPGSGSA EKPSSDVDIS 
THSPSLPLAR EPVVLSIASS RLPQESPPLP ESRDSHPPLR LKKSFEILVR KPMSSKPKPP 
PRKYFKSDSD PQKSLEEREN SSCSSGHTPP TCGQEARELL PLLLPQEDTA GRSPSASAGC 
PGPGIGPQTK SSTEGEPGWR RASPVTQTSP IKHPLLKRQA RMDYSFDTTA EDPWVRISDC 
IKNLFSPIMS ENHGHMPLQP NASLNEEEGT QGHPDGTPPK LDTANGTPKV YKSADSSTVK 
KGPPVAPKPA WFRQSLKGLR NRASDPRGLP DPALSTQPAP ASREHLGSHI RASSSSSSIR 
QRISSFETFG SSQLPDKGAQ RLSLQPSSGE AAKPLGKHEE GRFSGLLGRG AAPTLVPQQP 
EQVLSSGSPA ASEARDPGVS ESPPPGRQPN QKTLPPGPDP LLRLLSTQAE ESQGPVLKMP 
SQRARSFPLT RSQSCETKLL DEKTSKLYSI SSQVSSAVMK SLLCLPSSIS CAQTPCIPKE 
GASPTSSSNE DSAANGSAET SALDTGFSLN LSELREYTEG LTEAKEDDDG DHSSLQSGQS 
VISLLSSEEL KKLIEEVKVL DEATLKQLDG IHVTILHKEE GAGLGFSLAG GADLENKVIT 
VHRVFPNGLA SQEGTIQKGN EVLSINGKSL KGTTHHDALA ILRQAREPRQ AVIVTRKLTP 
EAMPDLNSST DSAASASAAS DVSVESTAEA TVCTVTLEKM SAGLGFSLEG GKGSLHGDKP 
LTINRIFKGA ASEQSETVQP GDEILQLGGT AMQGLTRFEA WNIIKALPDG PVTIVIRRKS 
LQSKETTAAG DS

Genular Protein ID: 117545354

Symbol: Q9UME6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UME6

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 9144227

Title: Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor.

PubMed ID: 9144227

DOI: 10.1073/pnas.94.10.5273

Sequence Information:

  • Length: 631
  • Mass: 66746
  • Checksum: 7E5055E5C12147AA
  • Sequence:
    • MDYSFDTTAE DPWVRISDCI KNLFSPIMSE NHGHMPLQPN ASLNEEEGTQ GHPDGTPPKL 
DTANGTPKVY KSADSSTVKK GPPVAPKPAW FRQSLKGLRN RASDPRGLPD PALSTQPAPA 
SREHLGSHIR ASSSSSSIRQ RISSFETFGS SQLPDKGAQR LSLQPSSGEA AKPLGKHEEG 
RFSGLLGRGA APTLVPQQPE QVLSSGSPAA SEARDPGVSE SPPPRRQPNQ KTLPPGPDPL 
LRLLSTQAEE SQGPVLKMPS QRARSFPLTR SQSCETKLLD EKTSKLYSIS SQVSSAVMKS 
LLCLPSSISC AQTPCIPKEG ASPTSSSNED SAANGSAETS ALDTGFSLNL SELREYTEGL 
TEAKEDDDGD HSSLQSGQSV ISLLSSEELK KLIEEVKVLD EATLKQLDGI HVTILHKEEG 
AGLGFSLAGG ADLENKVITV HRVFPNGLAS QEGTIQKGNE VLSINGKSLK GTTHHDALAI 
LRQAREPRQA VIVTRKLTPE AMPDLNSSTD SAASASAASD VSVESTAEAT VCTVTLEKMS 
AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW 
NIIKALPDGP VTIVIRRKSL QSKETTAAGD S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.