Details for: IL16

Gene ID: 3603

Symbol: IL16

Ensembl ID: ENSG00000172349

Description: interleukin 16

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.71
    Marker Score: 4517
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.56
    Marker Score: 13522
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.27
    Marker Score: 27653.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.06
    Marker Score: 1143
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.93
    Marker Score: 1866
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.81
    Marker Score: 17914
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.8
    Marker Score: 1611
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.75
    Marker Score: 3059
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.75
    Marker Score: 1321
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.74
    Marker Score: 2985.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.74
    Marker Score: 1632
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.7
    Marker Score: 840
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.69
    Marker Score: 19646.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.68
    Marker Score: 3288
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.66
    Marker Score: 87734
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.62
    Marker Score: 2897
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.61
    Marker Score: 4525
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.61
    Marker Score: 2277
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1132
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.55
    Marker Score: 4603
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.54
    Marker Score: 3766
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.52
    Marker Score: 916
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.51
    Marker Score: 1489
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.5
    Marker Score: 6444
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.48
    Marker Score: 4680
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.48
    Marker Score: 3096.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.43
    Marker Score: 4176.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.4
    Marker Score: 1556
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.39
    Marker Score: 449
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.39
    Marker Score: 320
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.38
    Marker Score: 841
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.37
    Marker Score: 486.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.36
    Marker Score: 1207
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.35
    Marker Score: 603.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.29
    Marker Score: 1547.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.28
    Marker Score: 752
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.28
    Marker Score: 332
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.26
    Marker Score: 1048
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.25
    Marker Score: 803
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.24
    Marker Score: 694
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.24
    Marker Score: 1156
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.23
    Marker Score: 812
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.22
    Marker Score: 827
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.22
    Marker Score: 7803.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.22
    Marker Score: 370
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.21
    Marker Score: 522
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.18
    Marker Score: 588
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.17
    Marker Score: 1193
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.16
    Marker Score: 1279
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.15
    Marker Score: 1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4742
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.13
    Marker Score: 268
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.1
    Marker Score: 358
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.1
    Marker Score: 1190
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.09
    Marker Score: 801
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.08
    Marker Score: 275
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.08
    Marker Score: 787.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.08
    Marker Score: 908
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.08
    Marker Score: 2980
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.06
    Marker Score: 234
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.04
    Marker Score: 2591.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.02
    Marker Score: 900
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.02
    Marker Score: 357
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.02
    Marker Score: 422
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.02
    Marker Score: 2762.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.02
    Marker Score: 610
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.01
    Marker Score: 824
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.01
    Marker Score: 6044
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71718
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1
    Marker Score: 846
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47943
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.98
    Marker Score: 1061
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.95
    Marker Score: 587
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.95
    Marker Score: 253
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.95
    Marker Score: 688
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.94
    Marker Score: 553
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.94
    Marker Score: 309
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 431
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.93
    Marker Score: 515
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.92
    Marker Score: 220
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.91
    Marker Score: 630
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2715
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.89
    Marker Score: 1736
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.88
    Marker Score: 274
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.88
    Marker Score: 1034
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.88
    Marker Score: 198
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.87
    Marker Score: 588
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5252
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.86
    Marker Score: 1192
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4843
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.84
    Marker Score: 3454
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.84
    Marker Score: 635
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.84
    Marker Score: 843
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.84
    Marker Score: 607

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Other Information

**Key characteristics:** * IL16 is a pro-inflammatory cytokine that promotes the recruitment of immune cells to sites of inflammation. * It is produced by activated macrophages, dendritic cells, and mast cells in response to various stimuli, including infection, injury, and tissue damage. * IL16 binds to the CD28 receptor on the surface of immune cells, which triggers intracellular signaling pathways that promote the recruitment of these cells to the site of inflammation. **Pathways and functions:** * IL16 signaling pathways are activated by various receptors, including the CD28 receptor and the IL16 receptor (IL16R). * Upon binding of IL16 to its receptor, it triggers the phosphorylation of the IL16 receptor and the subsequent activation of downstream signaling pathways. * These pathways include the JAK/STAT, MAPK, and PI3K/AKT signaling pathways. * IL16 signaling promotes the migration of immune cells, such as neutrophils, macrophages, and dendritic cells, to sites of inflammation. * It also promotes the activation of inflammatory effector cells, such as macrophages and dendritic cells, which can produce cytokines and chemokines that further recruit immune cells to the site of inflammation. **Clinical significance:** * IL16 is a key cytokine in the pathogenesis of various inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and asthma. * It is produced by activated macrophages and dendritic cells in response to infection or injury. * Blockade of IL16 signaling has been shown to inhibit inflammation and reduce disease activity in animal models of inflammatory diseases. * Therefore, IL16 is a potential target for the treatment of inflammatory diseases.

Genular Protein ID: 1360267611

Symbol: IL16_HUMAN

Name: Pro-interleukin-16

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12923170

Title: PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits.

PubMed ID: 12923170

DOI: 10.1074/jbc.m306669200

PubMed ID: 19906316

Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.

PubMed ID: 19906316

DOI: 10.1186/1471-2164-10-518

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9990060

Title: GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes.

PubMed ID: 9990060

DOI: 10.1073/pnas.96.4.1541

PubMed ID: 8609984

Title: Interleukin-16 or not?

PubMed ID: 8609984

DOI: 10.1038/381030a0

PubMed ID: 7910967

Title: Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.

PubMed ID: 7910967

DOI: 10.1073/pnas.91.11.5109

PubMed ID: 9422780

Title: Processing and activation of pro-interleukin-16 by caspase-3.

PubMed ID: 9422780

DOI: 10.1074/jbc.273.2.1144

PubMed ID: 11032842

Title: Nuclear translocation of the N-terminal prodomain of interleukin-16.

PubMed ID: 11032842

DOI: 10.1074/jbc.m008513200

PubMed ID: 11276202

Title: Gene regulation mediated by calcium signals in T lymphocytes.

PubMed ID: 11276202

DOI: 10.1038/86318

PubMed ID: 12450396

Title: Prointerleukin-16 contains a functional CcN motif that regulates nuclear localization.

PubMed ID: 12450396

DOI: 10.1021/bi020163v

PubMed ID: 12620798

Title: Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein.

PubMed ID: 12620798

DOI: 10.1016/s0042-6822(02)00056-9

PubMed ID: 14734747

Title: Nuclear pro-IL-16 regulation of T cell proliferation: p27(KIP1)-dependent G0/G1 arrest mediated by inhibition of Skp2 transcription.

PubMed ID: 14734747

DOI: 10.4049/jimmunol.172.3.1654

PubMed ID: 18097041

Title: Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP.

PubMed ID: 18097041

DOI: 10.4049/jimmunol.180.1.402

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9699630

Title: Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site.

PubMed ID: 9699630

DOI: 10.1038/1376

Sequence Information:

  • Length: 1332
  • Mass: 141752
  • Checksum: EDF68567B2AF120C
  • Sequence:
  • MESHSRAGKS RKSAKFRSIS RSLMLCNAKT SDDGSSPDEK YPDPFEISLA QGKEGIFHSS 
    VQLADTSEAG PSSVPDLALA SEAAQLQAAG NDRGKTCRRI FFMKESSTAS SREKPGKLEA 
    QSSNFLFPKA CHQRARSNST SVNPYCTREI DFPMTKKSAA PTDRQPYSLC SNRKSLSQQL 
    DCPAGKAAGT SRPTRSLSTA QLVQPSGGLQ ASVISNIVLM KGQAKGLGFS IVGGKDSIYG 
    PIGIYVKTIF AGGAAAADGR LQEGDEILEL NGESMAGLTH QDALQKFKQA KKGLLTLTVR 
    TRLTAPPSLC SHLSPPLCRS LSSSTCITKD SSSFALESPS APISTAKPNY RIMVEVSLQK 
    EAGVGLGIGL CSVPYFQCIS GIFVHTLSPG SVAHLDGRLR CGDEIVEISD SPVHCLTLNE 
    VYTILSHCDP GPVPIIVSRH PDPQVSEQQL KEAVAQAVEN TKFGKERHQW SLEGVKRLES 
    SWHGRPTLEK EREKNSAPPH RRAQKVMIRS SSDSSYMSGS PGGSPGSGSA EKPSSDVDIS 
    THSPSLPLAR EPVVLSIASS RLPQESPPLP ESRDSHPPLR LKKSFEILVR KPMSSKPKPP 
    PRKYFKSDSD PQKSLEEREN SSCSSGHTPP TCGQEARELL PLLLPQEDTA GRSPSASAGC 
    PGPGIGPQTK SSTEGEPGWR RASPVTQTSP IKHPLLKRQA RMDYSFDTTA EDPWVRISDC 
    IKNLFSPIMS ENHGHMPLQP NASLNEEEGT QGHPDGTPPK LDTANGTPKV YKSADSSTVK 
    KGPPVAPKPA WFRQSLKGLR NRASDPRGLP DPALSTQPAP ASREHLGSHI RASSSSSSIR 
    QRISSFETFG SSQLPDKGAQ RLSLQPSSGE AAKPLGKHEE GRFSGLLGRG AAPTLVPQQP 
    EQVLSSGSPA ASEARDPGVS ESPPPGRQPN QKTLPPGPDP LLRLLSTQAE ESQGPVLKMP 
    SQRARSFPLT RSQSCETKLL DEKTSKLYSI SSQVSSAVMK SLLCLPSSIS CAQTPCIPKE 
    GASPTSSSNE DSAANGSAET SALDTGFSLN LSELREYTEG LTEAKEDDDG DHSSLQSGQS 
    VISLLSSEEL KKLIEEVKVL DEATLKQLDG IHVTILHKEE GAGLGFSLAG GADLENKVIT 
    VHRVFPNGLA SQEGTIQKGN EVLSINGKSL KGTTHHDALA ILRQAREPRQ AVIVTRKLTP 
    EAMPDLNSST DSAASASAAS DVSVESTAEA TVCTVTLEKM SAGLGFSLEG GKGSLHGDKP 
    LTINRIFKGA ASEQSETVQP GDEILQLGGT AMQGLTRFEA WNIIKALPDG PVTIVIRRKS 
    LQSKETTAAG DS

Genular Protein ID: 117545354

Symbol: Q9UME6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9144227

Title: Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor.

PubMed ID: 9144227

DOI: 10.1073/pnas.94.10.5273

Sequence Information:

  • Length: 631
  • Mass: 66746
  • Checksum: 7E5055E5C12147AA
  • Sequence:
  • MDYSFDTTAE DPWVRISDCI KNLFSPIMSE NHGHMPLQPN ASLNEEEGTQ GHPDGTPPKL 
    DTANGTPKVY KSADSSTVKK GPPVAPKPAW FRQSLKGLRN RASDPRGLPD PALSTQPAPA 
    SREHLGSHIR ASSSSSSIRQ RISSFETFGS SQLPDKGAQR LSLQPSSGEA AKPLGKHEEG 
    RFSGLLGRGA APTLVPQQPE QVLSSGSPAA SEARDPGVSE SPPPRRQPNQ KTLPPGPDPL 
    LRLLSTQAEE SQGPVLKMPS QRARSFPLTR SQSCETKLLD EKTSKLYSIS SQVSSAVMKS 
    LLCLPSSISC AQTPCIPKEG ASPTSSSNED SAANGSAETS ALDTGFSLNL SELREYTEGL 
    TEAKEDDDGD HSSLQSGQSV ISLLSSEELK KLIEEVKVLD EATLKQLDGI HVTILHKEEG 
    AGLGFSLAGG ADLENKVITV HRVFPNGLAS QEGTIQKGNE VLSINGKSLK GTTHHDALAI 
    LRQAREPRQA VIVTRKLTPE AMPDLNSSTD SAASASAASD VSVESTAEAT VCTVTLEKMS 
    AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW 
    NIIKALPDGP VTIVIRRKSL QSKETTAAGD S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.