Details for: LINC01982

Gene ID: 105371830

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC01982

Ensembl ID: ENSG00000263317

Description: long intergenic non-protein coding RNA 1982

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • mesothelial cell CL0000077
    CSI 6.19
    rCSI 24.19%
    PRS 99.36
  • endocardial cell CL0002350
    CSI 4.38
    rCSI 20.96%
    PRS 99.88
  • lung ciliated cell CL1000271
    CSI 3.72
    rCSI 4.3%
    PRS 99.94

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
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  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC01982](/details-gene/105371830) is a long intergenic non-protein coding RNA (lncRNA) located on chromosome 17q22. Expression data indicate a specialized role for this gene, with its significance being highest in distinct cell populations that form biological linings and surfaces. **Overall**, it is most prominently expressed in [mesothelial cell](/details-cell/CL0000077), which lines the body's serous cavities, [endocardial cell](/details-cell/CL0002350), which forms the inner lining of the heart chambers, and [lung ciliated cell](/details-cell/CL1000271), critical for mucociliary clearance in the airways. This pattern suggests a potential function related to the maintenance of barrier integrity, cellular adhesion, or specialized surface functions in these tissues. ## Cellular Roles and Expression Landscape The expression profile of [LINC01982](/details-gene/105371830) points towards a specialized function within specific epithelial and endothelial-like lineages. The highest cell significance index (CSI) is observed in [mesothelial cell](/details-cell/CL0000077) (CSI: 6.19), followed by [endocardial cell](/details-cell/CL0002350) (CSI: 4.38) and [lung ciliated cell](/details-cell/CL1000271) (CSI: 3.72). These cell types share a common characteristic as components of vital biological interfaces, responsible for secretion, protection, and transport. The significant expression in these functionally related but anatomically distinct cell types suggests that [LINC01982](/details-gene/105371830) may regulate a core molecular program associated with lining cells. Its role could be tied to maintaining the unique structural or functional properties of these cellular layers, such as the regulation of cell junction proteins, cytoskeletal organization, or pathways governing cellular responses to mechanical stress and environmental cues. The absence of comprehensive expression data across a wider array of cell types, particularly non-expressing cells, currently limits a full assessment of its cellular specificity. ## Pathways and Molecular Function The specific molecular pathways and functions involving [LINC01982](/details-gene/105371830) are not yet well-characterized, as detailed functional annotations are currently unavailable. As a long non-coding RNA, it is hypothesized to function as a regulatory molecule, potentially by influencing gene expression at the transcriptional or post-transcriptional level. Its enrichment in mesothelial, endocardial, and ciliated cells suggests it may modulate pathways critical to the biology of these cells, such as those involved in cell adhesion, planar cell polarity, or response to fluid shear stress, but direct evidence is lacking. ## Research Directions The specific and high expression of [LINC01982](/details-gene/105371830) in lining cells provides a strong foundation for targeted functional investigation. ### Proposed Testable Hypotheses 1. **[LINC01982](/details-gene/105371830) is essential for maintaining the barrier integrity of mesothelial cell layers.** Given its top expression in [mesothelial cell](/details-cell/CL0000077), this lncRNA could regulate the expression of genes involved in forming tight junctions or adherens junctions, which are critical for controlling fluid and cell transit across mesothelial surfaces. 2. **[LINC01982](/details-gene/105371830) is involved in the development or function of cilia in respiratory epithelial cells.** Its significant expression in [lung ciliated cell](/details-cell/CL1000271) suggests a potential role in ciliogenesis or the regulation of ciliary beat frequency, processes fundamental to mucociliary clearance. ### Suggested Key Experiment To test the hypothesis that [LINC01982](/details-gene/105371830) is critical for barrier function in mesothelial cells, one could perform a loss-of-function study. Primary human mesothelial cells could be cultured on transwell inserts and transfected with antisense oligonucleotides (ASOs) or a CRISPRi system targeting [LINC01982](/details-gene/105371830). The impact on barrier function could be quantified by measuring Transepithelial Electrical Resistance (TEER). Concurrently, RNA-sequencing could be performed on knockdown and control cells to identify downstream gene expression changes, particularly focusing on cell adhesion molecules, while immunofluorescence microscopy could be used to visualize the localization and integrity of key junctional proteins like ZO-1 and E-cadherin. ### Therapeutic Potential As a lncRNA, [LINC01982](/details-gene/105371830) presents a potential therapeutic target for nucleic acid-based therapies, such as ASOs. If its dysregulation is linked to diseases involving the breakdown of mesothelial barriers (e.g., peritoneal adhesions, malignant mesothelioma) or ciliopathies, targeting it could offer a novel therapeutic strategy. For example, if its overexpression contributes to pathological fibrosis, ASO-mediated inhibition could be beneficial. Conversely, if its loss compromises barrier integrity, developing strategies to restore its expression could be explored. Its specific expression profile suggests that systemic delivery of a therapeutic might have a favorable side-effect profile, primarily affecting the target cell populations.