Details for: ABLIM2

Gene ID: 84448

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ABLIM2

Ensembl ID: ENSG00000163995

Description: actin binding LIM protein family member 2

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • sncg GABAergic cortical interneuron CL4023015
    CSI 19
    rCSI 30.56%
    PRS 96.79
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 16.13
    rCSI 39.21%
    PRS 96.02
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 15.15
    rCSI 26.75%
    PRS 97.03
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 15.04
    rCSI 18.72%
    PRS 96.61
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 13.53
    rCSI 22.71%
    PRS 97.33
  • sst GABAergic cortical interneuron CL4023017
    CSI 12.89
    rCSI 16.61%
    PRS 97.38
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 12.67
    rCSI 39.62%
    PRS 97.34
  • VIP GABAergic cortical interneuron CL4023016
    CSI 11.08
    rCSI 13.23%
    PRS 96.95
  • L6b glutamatergic cortical neuron CL4023038
    CSI 10.56
    rCSI 33%
    PRS 96.94
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 10.06
    rCSI 36.18%
    PRS 96.43
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 10
    rCSI 21.69%
    PRS 95.16
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 8.39
    rCSI 31.71%
    PRS 96.44
  • inhibitory interneuron CL0000498
    CSI 7.74
    rCSI 17.87%
    PRS 97.1
  • podocyte CL0000653
    CSI 7.14
    rCSI 31.74%
    PRS 98.9
  • blood vessel endothelial cell CL0000071
    CSI 7.06
    rCSI 14.65%
    PRS 99.01
  • vascular leptomeningeal cell CL4023051
    CSI 6.58
    rCSI 11.54%
    PRS 98.15
  • neuron CL0000540
    CSI 6.55
    rCSI 17.44%
    PRS 94.92
  • retinal bipolar neuron CL0000748
    CSI 6.51
    rCSI 12.2%
    PRS 97.23
  • rod bipolar cell CL0000751
    CSI 6.46
    rCSI 11.61%
    PRS 97.76
  • hepatic stellate cell CL0000632
    CSI 6.3
    rCSI 23.59%
    PRS 98.77
  • astrocyte of the cerebral cortex CL0002605
    CSI 6.22
    rCSI 13.95%
    PRS 97.13
  • lung neuroendocrine cell CL1000223
    CSI 6.03
    rCSI 8.92%
    PRS 98.63
  • retinal ganglion cell CL0000740
    CSI 5.87
    rCSI 12.97%
    PRS 96.95
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 5.83
    rCSI 34.34%
    PRS 96.52
  • cardiac muscle cell CL0000746
    CSI 5.61
    rCSI 8.05%
    PRS 97.26
  • retina horizontal cell CL0000745
    CSI 5.3
    rCSI 8.08%
    PRS 98.37
  • interneuron CL0000099
    CSI 5.24
    rCSI 10.51%
    PRS 98.1
  • central nervous system neuron CL2000029
    CSI 4.9
    rCSI 36.02%
    PRS 97.36
  • mesothelial cell CL0000077
    CSI 4.75
    rCSI 18.58%
    PRS 96.3
  • parietal epithelial cell CL1000452
    CSI 4.16
    rCSI 11.11%
    PRS 98.33
  • cerebral cortex neuron CL0010012
    CSI 3.93
    rCSI 16.02%
    PRS 96.65
  • fast muscle cell CL0000190
    CSI 3.88
    rCSI 15.17%
    PRS 95.06
  • pancreatic A cell CL0000171
    CSI 3.78
    rCSI 3.96%
    PRS 99
  • glutamatergic neuron CL0000679
    CSI 3.75
    rCSI 7.7%
    PRS 95.07
  • lung pericyte CL0009089
    CSI 3.74
    rCSI 9.86%
    PRS 99.56
  • medium spiny neuron CL1001474
    CSI 3.58
    rCSI 30.82%
    PRS 96.82
  • cerebral cortex endothelial cell CL1001602
    CSI 3.36
    rCSI 5.81%
    PRS 98.04
  • neural cell CL0002319
    CSI 3.29
    rCSI 12.41%
    PRS 94.96
  • GABAergic neuron CL0000617
    CSI 3.08
    rCSI 10.31%
    PRS 94.87
  • serotonergic neuron CL0000850
    CSI 2.99
    rCSI 13.35%
    PRS 94.13
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.98
    rCSI 18.62%
    PRS 97.43
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 2.85
    rCSI 6.82%
    PRS 95.93
  • dopaminergic neuron CL0000700
    CSI 2.77
    rCSI 15.65%
    PRS 96.15
  • renal interstitial pericyte CL1001318
    CSI 2.61
    rCSI 7.2%
    PRS 98.88
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 2.6
    rCSI 8.55%
    PRS 95.5
  • H1 horizontal cell CL0004217
    CSI 2.54
    rCSI 10.05%
    PRS 96.73
  • ON parasol ganglion cell CL4033052
    CSI 2.51
    rCSI 35.6%
    PRS 96.49
  • type B pancreatic cell CL0000169
    CSI 1.79
    rCSI 3.97%
    PRS 98.8
  • direct pathway medium spiny neuron CL4023026
    CSI 1.71
    rCSI 40.94%
    PRS 95.43
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.69
    rCSI 40.81%
    PRS 95.25
  • regular atrial cardiac myocyte CL0002129
    CSI 1.58
    rCSI 5.08%
    PRS 97.94
  • basket cell CL0000118
    CSI 1.57
    rCSI 9.82%
    PRS 91.95
  • ON midget ganglion cell CL4033046
    CSI 1.53
    rCSI 31.26%
    PRS 96.61
  • OFF midget ganglion cell CL4033047
    CSI 1.51
    rCSI 30.72%
    PRS 96.58
  • blood vessel smooth muscle cell CL0019018
    CSI 1.33
    rCSI 10.8%
    PRS 99.02
  • H2 horizontal cell CL0004218
    CSI 0.9
    rCSI 4.5%
    PRS 97.01

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ABLIM2](/details-gene/84448) (Actin Binding LIM Protein Family Member 2) is a protein-coding gene located on chromosome 4p16.1. As its name suggests, it functions primarily as an actin-binding protein, playing a crucial role in the organization and dynamics of the actin cytoskeleton. **Overall**, expression data reveals that [ABLIM2](/details-gene/84448) is a highly significant gene within the central nervous system, showing prominent expression in a diverse array of both inhibitory (GABAergic) and excitatory (glutamatergic) cortical neurons. Its function is closely tied to pathways governing nervous system development, particularly [axon guidance](/details-link/R-HSA-422475) and [Netrin-1 signaling](/details-link/R-HSA-373752), consistent with its role in modulating the cellular architecture essential for neuronal connectivity. ## Cellular Roles and Expression Landscape The expression profile of [ABLIM2](/details-gene/84448) firmly establishes its importance in neuronal cell populations. The gene demonstrates its highest significance in various subtypes of cortical interneurons, including [sncg GABAergic cortical interneurons](/details-cell/CL4023015) (CSI: 19.00), [caudal ganglionic eminence derived cortical interneurons](/details-cell/CL4023064) (CSI: 15.15), and multiple other GABAergic subtypes ([pvalb](/details-cell/CL4023018), [lamp5](/details-cell/CL4023011), [sst](/details-cell/CL4023017), and [VIP](/details-cell/CL4023016)). Concurrently, [ABLIM2](/details-gene/84448) is also a key marker in excitatory glutamatergic neurons of the cortex, such as [L2/3-6 intratelencephalic projecting glutamatergic neurons](/details-cell/CL4023040) (CSI: 16.13) and [L5 extratelencephalic projecting glutamatergic cortical neurons](/details-cell/CL4023041) (CSI: 10.06). This broad but potent expression across functionally distinct neuronal classes suggests a fundamental role in maintaining the structural integrity and dynamic processes common to cortical neurons. While its primary role is neuronal, [ABLIM2](/details-gene/84448) also shows moderate significance in specialized non-neuronal cells like [podocytes](/details-cell/CL0000653) and [blood vessel endothelial cells](/details-cell/CL0000071), indicating a more widespread, albeit less prominent, function in regulating the actin cytoskeleton in other tissues. ## Pathways and Molecular Function Functionally, [ABLIM2](/details-gene/84448) is annotated with key molecular functions including [actin filament binding](/details-link/GO:0051015) and [protein binding](/details-link/GO:0005515), which directly supports its biological role in [cytoskeleton organization](/details-link/GO:0007010) and [lamellipodium assembly](/details-link/GO:0030032). Research has confirmed its ability to directly associate with F-actin ([Link](https://doi.org/10.1074/jbc.m607549200)). The gene's involvement in higher-order biological processes is strongly oriented towards the nervous system. Reactome pathway analysis places [ABLIM2](/details-gene/84448) in the context of [Nervous system development](/details-link/R-HSA-9675108), and more specifically, within the [Axon guidance](/details-link/R-HSA-422475) pathway. This is consistent with its high expression in developing and mature neurons, where precise control of the actin cytoskeleton is essential for growth cone motility, synapse formation, and the establishment of correct neural circuits. Its participation in [Netrin-1 signaling](/details-link/R-HSA-373752) further suggests it acts as a downstream effector that translates extracellular guidance cues into cytoskeletal changes. ## Research Directions The robust and specific expression of [ABLIM2](/details-gene/84448) in a wide range of cortical neurons, coupled with its role in actin dynamics, points toward critical functions in both the development and maintenance of the central nervous system. This provides a foundation for several testable hypotheses. 1. **Hypothesis 1:** Given its role in the [Axon guidance](/details-link/R-HSA-422475) pathway, [ABLIM2](/details-gene/84448) may function as a critical modulator of growth cone steering during corticogenesis. Its dysregulation could lead to defects in neuronal migration and the establishment of proper laminar and columnar structures in the cortex. 2. **Hypothesis 2:** In the mature brain, the high expression of [ABLIM2](/details-gene/84448) across diverse neuronal types suggests a role in synaptic plasticity. It may be essential for the structural remodeling of dendritic spines—highly actin-rich structures—that underlies learning and memory. **Experimental Approach:** To test the second hypothesis regarding synaptic plasticity, a conditional knockout (cKO) mouse model could be generated, allowing for the deletion of [ABLIM2](/details-gene/84448) specifically in adult forebrain excitatory neurons (e.g., using a Camk2a-Cre driver). High-resolution two-photon in vivo imaging could then be used to monitor dendritic spine density and dynamics in the cortex of these cKO mice compared to wild-type controls. Furthermore, electrophysiological recordings from cortical slices could assess for deficits in long-term potentiation (LTP), a cellular correlate of memory, providing a direct functional readout of synaptic integrity. **Therapeutic Potential:** As an intracellular structural protein primarily expressed in the CNS, [ABLIM2](/details-gene/84448) presents a challenging therapeutic target for systemic drug delivery due to the blood-brain barrier. However, if mutations or expression changes in [ABLIM2](/details-gene/84448) are linked to neurodevelopmental or neurodegenerative disorders characterized by cytoskeletal or synaptic pathology (e.g., certain forms of autism spectrum disorder or Alzheimer's disease), it could become a focal point for understanding disease mechanisms. Therapeutic strategies would likely be indirect, aiming to modulate upstream regulators or downstream effectors of [ABLIM2](/details-gene/84448) function rather than targeting the protein itself, potentially through gene therapy or CNS-delivered oligonucleotides.

Genular Protein ID: 3794540634

Symbol: ABLM2_HUMAN

Name: Actin-binding LIM protein 2

UniProtKB Accession Codes:

Q6H8Q1 E9PF39 Q08E71 Q19VH0 Q6H8Q0 Q6NX73 Q8N3C5 Q8N9E9 Q8N9G2 Q96JL7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 4 CTD 1 ChEBI 16 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 Reactome 1 RefSeq 8 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17194709

Title: Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin.

PubMed ID: 17194709

DOI: 10.1074/jbc.m607549200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18772397

Title: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.

PubMed ID: 18772397

DOI: 10.1126/science.1164368

Sequence Information:

  • Length: 611
  • Mass: 67812
  • Checksum: 225A4E25646B370B
  • Sequence:
    • MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 
GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 
RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 
KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 
CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 
AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG DQDDRSYKQC 
RTSSPSSTGS VSLGRYTPTS RSPQHYSRPG SESGRSTPSL SVLSDSKPPP STYQQAPRHF 
HVPDTGVKDN IYRKPPIYRQ HAARRSDGED GSLDQDNRKK SSWLMLKGDA DTRTNSPDLD 
TQSLSHSSGT DRDPLQRMAG DSFHSRFPYS KSDPLPGHGK NGLDQRNANL APCGADPDAS 
WGMREYKIYP YDSLIVTNRI RVKLPKDVDR TRLERHLSPE EFQEVFGMSI EEFDRLALWK 
RNDLKKKALL F

Genular Protein ID: 1893524230

Symbol: A0A140VK02_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VK02

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 4 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 Pfam 3 PhylomeDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 645
  • Mass: 71542
  • Checksum: 50C4FDC1B30AD41E
  • Sequence:
    • MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 
GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 
RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 
KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 
CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 
AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG DQDDRSYKQC 
RTSSPSSTGS VSLGRYTPTS RSPQHYSRPA GTVSVGTSSC LSLSQHPSPT SVFRHHYIPY 
FRGSESGRST PSLSVLSDSK PPPSTYQQAP RHFHVPDTGV KDNIYRKPPI YRQHAARRSD 
GEDGSLDQDN RKQKSSWLML KGDADTRTNS PDLDTQSLSH SSGTDRDPLQ RMAGDSFHSR 
FPYSKSDPLP GHGKNGLDQR NANLAPCGAD PDASWGMREY KIYPYDSLIV TNRIRVKLPK 
DVDRTRLERH LSPEEFQEVF GMSIEEFDRL ALWKRNDLKK KALLF

Genular Protein ID: 508282942

Symbol: F5GYR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GYR0

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 4 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 650
  • Mass: 71968
  • Checksum: B990ADB222263E8F
  • Sequence:
    • MGVPGGDTVS QPQAAPSPLE KSPSTAILCN TCGNVCKGEV LRVQDKYFHI KCFVCKACGC 
DLAEGGFFVR QGEYICTLDY QRLYGTRCFS CDQFIEGEVV SALGKTYHPD CFVCAVCRLP 
FPPGDRVTFN GKECMCQKCS LPVSVGSSAH LSQGLRSCGG CGTEIKNGQA LVALDKHWHL 
GCFKCKSCGK LLNAEYISKD GLPYCEADYH AKFGIRCDSC EKYITGRVLE AGEKHYHPSC 
ALCVRCGQMF AEGEEMYLQG SSIWHPACRQ AARTEDRNKE TRTSSESIIS VPASSTSGSP 
SRVIYAKLGG EILDYRDLAA LPKSKAIYDI DRPDMISYSP YISHSAGDRQ SYGEGDQDDR 
SYKQCRTSSP SSTGSVSLGR YTPTSRSPQH YSRPAGTVSV GTSSCLSLSQ HPSPTSVFRH 
HYIPYFRGSE SGRSTPSLSV LSDSKPPPST YQQAPRHFHV PDTGVKDNIY RKPPIYRQHA 
ARRSDGEDGS LDQDNRKQKS SWLMLKGDAD TRTNSPDLDT QSLSHSSGTD RDPLQRMAGD 
SFHSRFPYSK SDPLPGHGKN GLDQRNANLA PCGADPDASW GMREYKIYPY DSLIVTNRIR 
VKLPKDVDRT RLERHLSPEE FQEVFGMSIE EFDRLALWKR NDLKKKALLF