Details for: CL0000071

Cell ID: CL0000071

Cell Name: blood vessel endothelial cell

Marker Score Threshold: 1006
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell that lines the vasculature.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: AMELY (ENSG00000099721)
    Fold Change: 3.16
    Ensembl ID: ENSG00000099721
  • Gene Symbol: ALPP (ENSG00000163283)
    Fold Change: 3.16
    Ensembl ID: ENSG00000163283
  • Gene Symbol: AVP (ENSG00000101200)
    Fold Change: 3.16
    Ensembl ID: ENSG00000101200
  • Gene Symbol: ACRV1 (ENSG00000134940)
    Fold Change: 3.16
    Ensembl ID: ENSG00000134940
  • Gene Symbol: AMELX (ENSG00000125363)
    Fold Change: 3.16
    Ensembl ID: ENSG00000125363
  • Gene Symbol: AMY2A (ENSG00000243480)
    Fold Change: 3.16
    Ensembl ID: ENSG00000243480
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 3.16
    Ensembl ID: ENSG00000124812
  • Gene Symbol: ATP4A (ENSG00000105675)
    Fold Change: 3.16
    Ensembl ID: ENSG00000105675
  • Gene Symbol: BRS3 (ENSG00000102239)
    Fold Change: 3.16
    Ensembl ID: ENSG00000102239
  • Gene Symbol: ALPI (ENSG00000163295)
    Fold Change: 3.15
    Ensembl ID: ENSG00000163295
  • Gene Symbol: BPI (ENSG00000101425)
    Fold Change: 3.15
    Ensembl ID: ENSG00000101425
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 3.15
    Ensembl ID: ENSG00000161905
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 3.15
    Ensembl ID: ENSG00000002726
  • Gene Symbol: AMY1A (ENSG00000237763)
    Fold Change: 3.15
    Ensembl ID: ENSG00000237763
  • Gene Symbol: AMY1C (ENSG00000187733)
    Fold Change: 3.15
    Ensembl ID: ENSG00000187733
  • Gene Symbol: ATOH1 (ENSG00000172238)
    Fold Change: 3.14
    Ensembl ID: ENSG00000172238
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.75
    Ensembl ID: ENSG00000185883
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.6
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.5
    Ensembl ID: ENSG00000075624
  • Gene Symbol: C8B (ENSG00000021852)
    Fold Change: 2.44
    Ensembl ID: ENSG00000021852
  • Gene Symbol: NKX3 2 (ENSG00000109705)
    Fold Change: 2.39
    Ensembl ID: ENSG00000109705
  • Gene Symbol: APOC4 (ENSG00000267467)
    Fold Change: 2.39
    Ensembl ID: ENSG00000267467
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 2.37
    Ensembl ID: ENSG00000079557
  • Gene Symbol: OPN1SW (ENSG00000128617)
    Fold Change: 2.34
    Ensembl ID: ENSG00000128617
  • Gene Symbol: ARHGDIG (ENSG00000242173)
    Fold Change: 2.34
    Ensembl ID: ENSG00000242173
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 2.32
    Ensembl ID: ENSG00000248144
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 2.31
    Ensembl ID: ENSG00000187758
  • Gene Symbol: TNFRSF17 (ENSG00000048462)
    Fold Change: 2.28
    Ensembl ID: ENSG00000048462
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 2.28
    Ensembl ID: ENSG00000198049
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.26
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.24
    Ensembl ID: ENSG00000145741
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 2.23
    Ensembl ID: ENSG00000165462
  • Gene Symbol: ARR3 (ENSG00000120500)
    Fold Change: 2.22
    Ensembl ID: ENSG00000120500
  • Gene Symbol: AQP6 (ENSG00000086159)
    Fold Change: 2.22
    Ensembl ID: ENSG00000086159
  • Gene Symbol: BTN1A1 (ENSG00000124557)
    Fold Change: 2.21
    Ensembl ID: ENSG00000124557
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: 2.21
    Ensembl ID: ENSG00000129673
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135390
  • Gene Symbol: NAT2 (ENSG00000156006)
    Fold Change: 2.17
    Ensembl ID: ENSG00000156006
  • Gene Symbol: ALOX12B (ENSG00000179477)
    Fold Change: 2.16
    Ensembl ID: ENSG00000179477
  • Gene Symbol: AMPD1 (ENSG00000116748)
    Fold Change: 2.16
    Ensembl ID: ENSG00000116748
  • Gene Symbol: AIRE (ENSG00000160224)
    Fold Change: 2.14
    Ensembl ID: ENSG00000160224
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 2.14
    Ensembl ID: ENSG00000139352
  • Gene Symbol: C8A (ENSG00000157131)
    Fold Change: 2.14
    Ensembl ID: ENSG00000157131
  • Gene Symbol: ARSF (ENSG00000062096)
    Fold Change: 2.13
    Ensembl ID: ENSG00000062096
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.12
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ADH6 (ENSG00000172955)
    Fold Change: 2.11
    Ensembl ID: ENSG00000172955
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 2.09
    Ensembl ID: ENSG00000160683
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.07
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 2.07
    Ensembl ID: ENSG00000084674
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.94
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.9
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.89
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.89
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.89
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.88
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.85
    Ensembl ID: ENSG00000110955
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.85
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.85
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.85
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.84
    Ensembl ID: ENSG00000099624
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.81
    Ensembl ID: ENSG00000175899
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.76
    Ensembl ID: ENSG00000134825
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.75
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.71
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.65
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.65
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.64
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.63
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.59
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.59
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.56
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.56
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.54
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.51
    Ensembl ID: ENSG00000213465
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.5
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.46
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.46
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.45
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.43
    Ensembl ID: ENSG00000159199
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.4
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ADRA1D (ENSG00000171873)
    Fold Change: 1.39
    Ensembl ID: ENSG00000171873
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.37
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.32
    Ensembl ID: ENSG00000069849
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.3
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.29
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.28
    Ensembl ID: ENSG00000152518
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.27
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.26
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.23
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 1.22
    Ensembl ID: ENSG00000240583
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.2
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.19
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.18
    Ensembl ID: ENSG00000072110
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.18
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.16
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 1.11
    Ensembl ID: ENSG00000139567
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.01
    Ensembl ID: ENSG00000204217
Hovered Details

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Hovered Details

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**Key Characteristics** The blood vessel endothelial cell (ID CL0000071) is characterized by the following key features: 1. **Cell Adhesion and Migration**: The cell expresses genes involved in cell adhesion, such as CRISP1 and BRS3, which are involved in the regulation of cell-cell interactions and the migration of cells through the extracellular matrix. 2. **Signaling Pathways**: The cell expresses genes involved in signaling pathways, such as BRS3 and ATP4A, which are involved in the regulation of blood pressure and the maintenance of the extracellular matrix. 3. **Extracellular Matrix Regulation**: The cell expresses genes involved in the regulation of the extracellular matrix, such as AMELY and AMELX, which are involved in the synthesis and degradation of collagen and other matrix components. 4. **Blood Pressure Regulation**: The cell expresses genes involved in the regulation of blood pressure, such as BRS3 and ATP4A, which are involved in the regulation of vascular tone and blood flow. 5. **Vasculature-Specific Functions**: The cell expresses genes that are specific to the vasculature, such as AVP, which is involved in the regulation of water homeostasis and vasopressin-mediated signaling. **Clinical Significance** The blood vessel endothelial cell (ID CL0000071) plays a crucial role in maintaining the integrity of blood vessels and regulating blood flow. Dysfunction of this cell type has been implicated in various cardiovascular diseases, including hypertension, atherosclerosis, and thrombosis. Understanding the functions of this cell type and its interactions with other cells and molecules is essential for the development of novel therapeutic strategies for the treatment of these diseases. **Pathways and Signaling** The blood vessel endothelial cell (ID CL0000071) is involved in various signaling pathways, including: 1. **G-protein coupled receptor (GPCR) signaling**: The cell expresses genes involved in GPCR signaling, such as BRS3 and ATP4A, which are involved in the regulation of blood pressure and the maintenance of the extracellular matrix. 2. **Vasopressin-mediated signaling**: The cell expresses genes involved in vasopressin-mediated signaling, such as AVP, which is involved in the regulation of water homeostasis and vasopressin-mediated signaling. 3. **Nitric oxide-mediated signaling**: The cell expresses genes involved in nitric oxide-mediated signaling, which is involved in the regulation of vascular tone and blood flow. **Diseases and Disorders** The blood vessel endothelial cell (ID CL0000071) has been implicated in various diseases and disorders, including: 1. **Hypertension**: Dysfunction of this cell type has been implicated in the development of hypertension, a major risk factor for cardiovascular disease. 2. **Atherosclerosis**: The cell's dysfunction has been implicated in the development of atherosclerosis, a condition characterized by the buildup of plaque in the blood vessels. 3. **Thrombosis**: The cell's dysfunction has been implicated in the development of thrombosis, a condition characterized by the formation of blood clots in the blood vessels. **Future Directions** Future research should focus on understanding the complex interactions between the blood vessel endothelial cell (ID CL0000071) and other cells and molecules in the vasculature. This will involve the development of novel therapeutic strategies for the treatment of cardiovascular diseases, including hypertension, atherosclerosis, and thrombosis.