Details for: S100A3

Gene ID: 6274

Symbol: S100A3

Ensembl ID: ENSG00000188015

Description: S100 calcium binding protein A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.6319
    Cell Significance Index: -7.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.9659
    Cell Significance Index: -6.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.0643
    Cell Significance Index: -8.7100
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 5.8114
    Cell Significance Index: 6.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.9358
    Cell Significance Index: 27.7400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.6341
    Cell Significance Index: 23.7300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7679
    Cell Significance Index: 6.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1626
    Cell Significance Index: 2.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1243
    Cell Significance Index: 54.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1011
    Cell Significance Index: 5.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0540
    Cell Significance Index: 3.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0474
    Cell Significance Index: 5.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0236
    Cell Significance Index: 21.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0211
    Cell Significance Index: 0.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0086
    Cell Significance Index: 1.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0040
    Cell Significance Index: 0.2000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0018
    Cell Significance Index: -0.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0046
    Cell Significance Index: -0.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0064
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0083
    Cell Significance Index: -6.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0084
    Cell Significance Index: -1.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0091
    Cell Significance Index: -4.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0114
    Cell Significance Index: -8.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0123
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0155
    Cell Significance Index: -8.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0155
    Cell Significance Index: -11.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0176
    Cell Significance Index: -2.1600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0226
    Cell Significance Index: -0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0243
    Cell Significance Index: -4.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0255
    Cell Significance Index: -2.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0339
    Cell Significance Index: -5.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0376
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0429
    Cell Significance Index: -4.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0436
    Cell Significance Index: -4.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0442
    Cell Significance Index: -8.8700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0452
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0544
    Cell Significance Index: -11.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0599
    Cell Significance Index: -10.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0638
    Cell Significance Index: -0.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0712
    Cell Significance Index: -5.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0727
    Cell Significance Index: -8.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0864
    Cell Significance Index: -2.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0921
    Cell Significance Index: -7.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1100
    Cell Significance Index: -4.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1158
    Cell Significance Index: -8.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1167
    Cell Significance Index: -6.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1199
    Cell Significance Index: -2.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1291
    Cell Significance Index: -8.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1376
    Cell Significance Index: -6.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1514
    Cell Significance Index: -5.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1572
    Cell Significance Index: -3.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1623
    Cell Significance Index: -9.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1711
    Cell Significance Index: -4.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1724
    Cell Significance Index: -8.0400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1828
    Cell Significance Index: -3.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1832
    Cell Significance Index: -7.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1986
    Cell Significance Index: -2.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2076
    Cell Significance Index: -7.6200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2123
    Cell Significance Index: -3.0200
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.2312
    Cell Significance Index: -2.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2468
    Cell Significance Index: -8.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2567
    Cell Significance Index: -7.5600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2577
    Cell Significance Index: -2.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2643
    Cell Significance Index: -7.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2675
    Cell Significance Index: -7.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2785
    Cell Significance Index: -7.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2788
    Cell Significance Index: -8.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2877
    Cell Significance Index: -8.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2901
    Cell Significance Index: -4.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2999
    Cell Significance Index: -3.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3007
    Cell Significance Index: -8.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3202
    Cell Significance Index: -8.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3385
    Cell Significance Index: -8.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3396
    Cell Significance Index: -8.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3397
    Cell Significance Index: -8.4900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3545
    Cell Significance Index: -4.5800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3571
    Cell Significance Index: -4.8900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3578
    Cell Significance Index: -4.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3642
    Cell Significance Index: -6.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3760
    Cell Significance Index: -9.4000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3819
    Cell Significance Index: -4.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3821
    Cell Significance Index: -6.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3890
    Cell Significance Index: -6.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3939
    Cell Significance Index: -8.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3982
    Cell Significance Index: -8.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4005
    Cell Significance Index: -8.5000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4007
    Cell Significance Index: -4.7200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4035
    Cell Significance Index: -8.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4045
    Cell Significance Index: -8.7400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4054
    Cell Significance Index: -5.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4073
    Cell Significance Index: -5.2700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4119
    Cell Significance Index: -5.0100
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.4154
    Cell Significance Index: -3.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4177
    Cell Significance Index: -7.7200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.4198
    Cell Significance Index: -4.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4227
    Cell Significance Index: -9.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4250
    Cell Significance Index: -10.3700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4255
    Cell Significance Index: -8.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4314
    Cell Significance Index: -8.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding properties:** S100A3 is a calcium-binding protein, which allows it to interact with calcium ions and regulate various cellular processes. 2. **Cellular localization:** S100A3 is expressed in multiple cell types, including glutamatergic neurons, alveolar capillary type 2 endothelial cells, microglial cells, and osteoclasts. 3. **Protein-protein interactions:** S100A3 interacts with other proteins, including actin, myosin, and calmodulin, to regulate cellular processes. 4. **Cellular signaling:** S100A3 is involved in various cell signaling pathways, including the MAPK and PI3K/AKT pathways. **Pathways and Functions:** 1. **Calcium homeostasis:** S100A3 regulates calcium homeostasis by binding to calcium ions and modulating calcium-dependent enzymes and channels. 2. **Cell adhesion and migration:** S100A3 interacts with actin and myosin to regulate cell adhesion and migration. 3. **Inflammation and immune response:** S100A3 is involved in the regulation of inflammatory responses and immune cell function, including the activation of microglial cells. 4. **Cell proliferation and differentiation:** S100A3 regulates cell proliferation and differentiation in various cell types, including epithelial cells and osteoclasts. **Clinical Significance:** Dysregulation of S100A3 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of S100A3 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Inflammatory disorders:** S100A3 has been implicated in the regulation of inflammatory responses and immune cell function, making it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Cardiovascular diseases:** S100A3 has been shown to regulate vascular smooth muscle cell proliferation and migration, making it a potential target for the treatment of cardiovascular diseases, such as atherosclerosis and restenosis. 4. **Neurological disorders:** S100A3 has been implicated in the regulation of neuronal function and survival, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, S100A3 is a calcium-regulated protein with diverse roles in immune cells and tissue homeostasis. Its dysregulation has been implicated in various diseases, making it a potential target for the treatment of these conditions. Further research is needed to fully understand the mechanisms of S100A3 and its role in human disease.

Genular Protein ID: 2600905183

Symbol: S10A3_HUMAN

Name: Protein S100-A3

UniProtKB Accession Codes:

P33764 D3DV51 Q6FGE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8341667

Title: Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.

PubMed ID: 8341667

DOI: 10.1073/pnas.90.14.6547

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9920417

Title: Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model.

PubMed ID: 9920417

DOI: 10.1016/s0167-4889(98)00138-4

PubMed ID: 12470658

Title: Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles.

PubMed ID: 12470658

DOI: 10.1016/s0006-291x(02)02744-4

PubMed ID: 18083705

Title: Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle.

PubMed ID: 18083705

DOI: 10.1074/jbc.m709357200

PubMed ID: 12136135

Title: Metal-free MIRAS phasing: structure of apo-S100A3.

PubMed ID: 12136135

DOI: 10.1107/s0907444902008430

PubMed ID: 21377473

Title: Refined crystal structures of human Ca(2+)/Zn(2+)-binding S100A3 protein characterized by two disulfide bridges.

PubMed ID: 21377473

DOI: 10.1016/j.jmb.2011.02.055

Sequence Information:

  • Length: 101
  • Mass: 11713
  • Checksum: ABCAF4B7E5F2E0A1
  • Sequence:
    • MARPLEQAVA AIVCTFQEYA GRCGDKYKLC QAELKELLQK ELATWTPTEF RECDYNKFMS 
VLDTNKDCEV DFVEYVRSLA CLCLYCHEYF KDCPSEPPCS Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.