Details for: MAGI1 AS1

Gene ID: 100873983

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: MAGI1 AS1

Ensembl ID: ENSG00000240175

Description: MAGI1 antisense RNA 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cardiac muscle cell CL0000746
    CSI 5.84
    rCSI 8.38%
    PRS 96.76
  • adipocyte CL0000136
    CSI 4.05
    rCSI 5.2%
    PRS 97.24
  • blood vessel endothelial cell CL0000071
    CSI 3.12
    rCSI 6.48%
    PRS 98.73
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.38
    rCSI 7.94%
    PRS 98.19
  • H1 horizontal cell CL0004217
    CSI 1.33
    rCSI 5.26%
    PRS 96.2
  • retinal ganglion cell CL0000740
    CSI 1.28
    rCSI 2.84%
    PRS 96.47
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.23
    rCSI 4.42%
    PRS 95.9
  • regular ventricular cardiac myocyte CL0002131
    CSI 1.18
    rCSI 7.4%
    PRS 97.07
  • H2 horizontal cell CL0004218
    CSI 0.96
    rCSI 4.78%
    PRS 96.65
  • ON midget ganglion cell CL4033046
    CSI 0.79
    rCSI 16%
    PRS 96.02
  • ON parasol ganglion cell CL4033052
    CSI 0.57
    rCSI 8.08%
    PRS 95.84
  • OFF midget ganglion cell CL4033047
    CSI 0.56
    rCSI 11.45%
    PRS 95.99

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MAGI1 AS1](/details-gene/100873983) is a long non-coding RNA (lncRNA) located on chromosome 3. As an antisense transcript, it is presumed to regulate the expression of the MAGI1 gene. **Overall** expression data indicates that [MAGI1 AS1](/details-gene/100873983) is most significantly expressed in structurally critical cell types, including [cardiac muscle cell](/details-cell/CL0000746), [adipocyte](/details-cell/CL0000136), and [blood vessel endothelial cell](/details-cell/CL0000071). This expression pattern suggests a potential role in maintaining the integrity and function of cardiovascular and metabolic tissues. ## Cellular Roles and Expression Landscape The expression profile of [MAGI1 AS1](/details-gene/100873983) points towards a specialized role in non-hematopoietic tissues. Its highest significance scores are observed in cells fundamental to organ structure and function. The most prominent expression is in [cardiac muscle cell](/details-cell/CL0000746) (CSI: 5.84), followed by [adipocyte](/details-cell/CL0000136) (CSI: 4.05) and [blood vessel endothelial cell](/details-cell/CL0000071) (CSI: 3.12), indicating a potentially crucial role within the cardiovascular and metabolic systems. In addition to these major sites of expression, [MAGI1 AS1](/details-gene/100873983) is also significantly expressed in several other specialized cell types. These include [pulmonary alveolar type 1 cell](/details-cell/CL0002062) (CSI: 1.38), which is critical for gas exchange in the lungs, as well as various neuronal subtypes in the retina, such as [H1 horizontal cell](/details-cell/CL0004217) (CSI: 1.33) and [retinal ganglion cell](/details-cell/CL0000740) (CSI: 1.28). This diverse expression pattern suggests that [MAGI1 AS1](/details-gene/100873983) may be involved in shared molecular processes related to cell structure or signaling in multiple distinct tissues. ## Pathways and Molecular Function Detailed functional annotations for [MAGI1 AS1](/details-gene/100873983) are not currently available in pathway databases such as Reactome or Gene Ontology (GO). As an antisense transcript, its primary mechanism is likely the post-transcriptional regulation of its sense-strand counterpart, MAGI1. The MAGI1 protein is a scaffold protein known to be involved in the assembly of protein complexes at cell-cell junctions, including tight junctions and adherens junctions. Therefore, it is plausible that [MAGI1 AS1](/details-gene/100873983) influences processes related to cell adhesion, junctional integrity, and intracellular signaling by modulating the availability of MAGI1. ## Research Directions The specific role of [MAGI1 AS1](/details-gene/100873983) remains largely unexplored, but its distinct expression pattern provides a foundation for several testable hypotheses. 1. Given its high expression in [cardiac muscle cell](/details-cell/CL0000746) and [blood vessel endothelial cell](/details-cell/CL0000071), [MAGI1 AS1](/details-gene/100873983) likely contributes to cardiovascular homeostasis by regulating the expression of MAGI1, thereby maintaining the structural integrity of cardiac tissue and the vascular endothelium. 2. The significant expression in [adipocyte](/details-cell/CL0000136) suggests a potential involvement in metabolic regulation, where it might influence adipogenesis, lipid storage, or insulin signaling pathways. 3. Its consistent, albeit lower, expression in various retinal neurons, including ganglion and horizontal cells, indicates a possible role in maintaining synaptic structure or neuronal function within the visual system. To test the primary hypothesis regarding its cardiovascular function, a targeted knockdown experiment could be performed. Using antisense oligonucleotides (ASOs) or siRNA to deplete [MAGI1 AS1](/details-gene/100873983) in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and endothelial cells would be a suitable model. The impact on cell function could be assessed by measuring changes in MAGI1 protein levels via Western blot, evaluating cell junction integrity through immunofluorescence microscopy of junctional proteins (e.g., VE-cadherin, N-cadherin), and analyzing cellular electrical properties or barrier function. As a lncRNA, [MAGI1 AS1](/details-gene/100873983) is a druggable target for RNA-based therapeutics. If dysregulation of this transcript is linked to pathologies such as cardiomyopathy, atherosclerosis, or metabolic syndrome, it could emerge as a novel therapeutic target. However, its high expression in multiple critical tissues suggests that systemic administration of an inhibitor could lead to significant off-target effects, necessitating the development of tissue-specific delivery systems.