Details for: LTK
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 16.9083
Cell Significance Index: -2.6300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 10.3689
Cell Significance Index: -2.6300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 2.1412
Cell Significance Index: -2.6400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.1119
Cell Significance Index: 24.0900 - Cell Name: salivary gland glandular cell (CL1001596)
Fold Change: 1.0690
Cell Significance Index: 5.9500 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 0.8962
Cell Significance Index: 3.3400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7781
Cell Significance Index: 22.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7210
Cell Significance Index: 651.0300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7043
Cell Significance Index: 42.2800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6922
Cell Significance Index: 44.6600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6086
Cell Significance Index: 66.2000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.5555
Cell Significance Index: 5.7500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5302
Cell Significance Index: 52.4500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4587
Cell Significance Index: 74.6100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.4007
Cell Significance Index: 14.0800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3954
Cell Significance Index: 17.9200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3507
Cell Significance Index: 24.2600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.3233
Cell Significance Index: 7.0800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2803
Cell Significance Index: 53.3500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2535
Cell Significance Index: 3.6300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2430
Cell Significance Index: 5.0400 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.1892
Cell Significance Index: 2.0500 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.1740
Cell Significance Index: 2.2800 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.1733
Cell Significance Index: 1.1300 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1582
Cell Significance Index: 2.2200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1427
Cell Significance Index: 2.1500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.1154
Cell Significance Index: 16.7800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1013
Cell Significance Index: 20.3300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0850
Cell Significance Index: 1.8100 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.0697
Cell Significance Index: 0.5500 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.0631
Cell Significance Index: 0.6000 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.0511
Cell Significance Index: 0.7000 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0501
Cell Significance Index: 1.2500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0396
Cell Significance Index: 0.9900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0293
Cell Significance Index: 3.4200 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.0179
Cell Significance Index: 0.1300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0100
Cell Significance Index: 0.3800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0073
Cell Significance Index: 1.4500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0066
Cell Significance Index: 0.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0050
Cell Significance Index: 1.7900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0038
Cell Significance Index: 0.1700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0031
Cell Significance Index: 0.0900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0027
Cell Significance Index: 1.9000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0004
Cell Significance Index: 0.6700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0006
Cell Significance Index: -1.0400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0007
Cell Significance Index: -1.1100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0009
Cell Significance Index: -0.0300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0013
Cell Significance Index: -1.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0020
Cell Significance Index: -1.0800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0031
Cell Significance Index: -1.9900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0033
Cell Significance Index: -0.0200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0035
Cell Significance Index: -2.6700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0038
Cell Significance Index: -2.7900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0041
Cell Significance Index: -2.9900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0041
Cell Significance Index: -0.1800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0048
Cell Significance Index: -2.1700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0049
Cell Significance Index: -2.7600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0078
Cell Significance Index: -0.4800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0079
Cell Significance Index: -0.2100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0087
Cell Significance Index: -1.0000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0098
Cell Significance Index: -2.8200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0102
Cell Significance Index: -1.7500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0110
Cell Significance Index: -1.9800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0124
Cell Significance Index: -1.7000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0143
Cell Significance Index: -3.0100 - Cell Name: enteric neuron (CL0007011)
Fold Change: -0.0166
Cell Significance Index: -0.1200 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.0193
Cell Significance Index: -0.2700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0202
Cell Significance Index: -2.4800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0247
Cell Significance Index: -2.5700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0252
Cell Significance Index: -3.2500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0277
Cell Significance Index: -3.2700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0298
Cell Significance Index: -1.3900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0314
Cell Significance Index: -3.2100 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0323
Cell Significance Index: -0.4300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0326
Cell Significance Index: -2.5100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0350
Cell Significance Index: -1.8200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0352
Cell Significance Index: -2.3700 - Cell Name: pro-B cell (CL0000826)
Fold Change: -0.0372
Cell Significance Index: -0.4000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0383
Cell Significance Index: -3.0300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0434
Cell Significance Index: -1.5200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0438
Cell Significance Index: -2.2800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0440
Cell Significance Index: -1.2300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0463
Cell Significance Index: -3.4500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0464
Cell Significance Index: -2.1800 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.0467
Cell Significance Index: -0.2900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0476
Cell Significance Index: -2.6700 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: -0.0478
Cell Significance Index: -0.5000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0512
Cell Significance Index: -2.6900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0538
Cell Significance Index: -1.7200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0538
Cell Significance Index: -1.7600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0550
Cell Significance Index: -1.4800 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0577
Cell Significance Index: -0.7700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0603
Cell Significance Index: -1.5500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0645
Cell Significance Index: -3.2600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0718
Cell Significance Index: -1.5400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0738
Cell Significance Index: -1.9700 - Cell Name: colonocyte (CL1000347)
Fold Change: -0.0744
Cell Significance Index: -0.4600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0759
Cell Significance Index: -3.1100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0764
Cell Significance Index: -2.0800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0767
Cell Significance Index: -2.8200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2973734619
Symbol: LTK_HUMAN
Name: Protein tyrosine kinase 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7685902
Title: Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.
PubMed ID: 7685902
PubMed ID: 1655406
Title: The ltk gene encodes a novel receptor-type protein tyrosine kinase.
PubMed ID: 1655406
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 2320375
Title: Human ltk: gene structure and preferential expression in human leukemic cells.
PubMed ID: 2320375
PubMed ID: 2156206
Title: Identification and chromosomal mapping of new human tyrosine kinase genes.
PubMed ID: 2156206
PubMed ID: 8084603
Title: Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.
PubMed ID: 8084603
PubMed ID: 9223670
Title: The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
PubMed ID: 9223670
PubMed ID: 10445845
Title: Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.
PubMed ID: 10445845
PubMed ID: 14695357
Title: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.
PubMed ID: 14695357
DOI: 10.1093/hmg/ddh020
PubMed ID: 18849880
Title: Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.
PubMed ID: 18849880
PubMed ID: 19815557
Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
PubMed ID: 19815557
PubMed ID: 20548102
Title: MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.
PubMed ID: 20548102
PubMed ID: 30061385
Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-alpha).
PubMed ID: 30061385
PubMed ID: 34646012
Title: Structural basis of cytokine-mediated activation of ALK family receptors.
PubMed ID: 34646012
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 864
- Mass: 91681
- Checksum: 0617F378AA04298E
- Sequence:
MGCWGQLLVW FGAAGAILCS SPGSQETFLR SSPLPLASPS PRDPKVSAPP SILEPASPLN SPGTEGSWLF STCGASGRHG PTQTQCDGAY AGTSVVVTVG AAGQLRGVQL WRVPGPGQYL ISAYGAAGGK GAKNHLSRAH GVFVSAIFSL GLGESLYILV GQQGEDACPG GSPESQLVCL GESRAVEEHA AMDGSEGVPG SRRWAGGGGG GGGATYVFRV RAGELEPLLV AAGGGGRAYL RPRDRGRTQA SPEKLENRSE APGSGGRGGA AGGGGGWTSR APSPQAGRSL QEGAEGGQGC SEAWATLGWA AAGGFGGGGG ACTAGGGGGG YRGGDASETD NLWADGEDGV SFIHPSSELF LQPLAVTENH GEVEIRRHLN CSHCPLRDCQ WQAELQLAEC LCPEGMELAV DNVTCMDLHK PPGPLVLMVA VVATSTLSLL MVCGVLILVK QKKWQGLQEM RLPSPELELS KLRTSAIRTA PNPYYCQVGL GPAQSWPLPP GVTEVSPANV TLLRALGHGA FGEVYEGLVI GLPGDSSPLQ VAIKTLPELC SPQDELDFLM EALIISKFRH QNIVRCVGLS LRATPRLILL ELMSGGDMKS FLRHSRPHLG QPSPLVMRDL LQLAQDIAQG CHYLEENHFI HRDIAARNCL LSCAGPSRVA KIGDFGMARD IYRASYYRRG DRALLPVKWM PPEAFLEGIF TSKTDSWSFG VLLWEIFSLG YMPYPGRTNQ EVLDFVVGGG RMDPPRGCPG PVYRIMTQCW QHEPELRPSF ASILERLQYC TQDPDVLNSL LPMELGPTPE EEGTSGLGNR SLECLRPPQP QELSPEKLKS WGGSPLGPWL SSGLKPLKSR GLQPQNLWNP TYRS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.