Details for: LTK

Gene ID: 4058

Symbol: LTK

Ensembl ID: ENSG00000062524

Description: leukocyte receptor tyrosine kinase

Associated with

  • Atp binding
    (GO:0005524)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to retinoic acid
    (GO:0071300)
  • Membrane
    (GO:0016020)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Peptidyl-tyrosine autophosphorylation
    (GO:0038083)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cardiac muscle cell apoptotic process
    (GO:0010666)
  • Positive regulation of kinase activity
    (GO:0033674)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Protein binding
    (GO:0005515)
  • Protein kinase activity
    (GO:0004672)
  • Protein phosphorylation
    (GO:0006468)
  • Protein tyrosine kinase activity
    (GO:0004713)
  • Receptor complex
    (GO:0043235)
  • Receptor signaling protein tyrosine kinase activator activity
    (GO:0030298)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of neuron differentiation
    (GO:0045664)
  • Signal transduction
    (GO:0007165)
  • Transmembrane receptor protein tyrosine kinase activity
    (GO:0004714)
  • Transmembrane receptor protein tyrosine kinase signaling pathway
    (GO:0007169)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.08
    Marker Score: 735
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.96
    Marker Score: 324
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5327
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.87
    Marker Score: 2449
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 669
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.72
    Marker Score: 1044
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2807.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.61
    Marker Score: 6159
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.47
    Marker Score: 1206
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.47
    Marker Score: 817
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 428
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.44
    Marker Score: 467
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.42
    Marker Score: 1432
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5913
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.36
    Marker Score: 403
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.34
    Marker Score: 364
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.33
    Marker Score: 83
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.32
    Marker Score: 238
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.32
    Marker Score: 80
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.32
    Marker Score: 244
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 285
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.31
    Marker Score: 147
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.28
    Marker Score: 1759
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.27
    Marker Score: 512
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.27
    Marker Score: 236
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 82.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.25
    Marker Score: 88
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.25
    Marker Score: 420
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 159
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.25
    Marker Score: 505
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 149
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.22
    Marker Score: 1058
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.22
    Marker Score: 1904
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.21
    Marker Score: 658.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.21
    Marker Score: 134
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 117
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 377
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.17
    Marker Score: 207
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.17
    Marker Score: 214
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.16
    Marker Score: 313
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.16
    Marker Score: 156
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.16
    Marker Score: 244
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.16
    Marker Score: 96
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.15
    Marker Score: 82
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.15
    Marker Score: 81
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.15
    Marker Score: 212
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 342
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.14
    Marker Score: 72
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 72
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.13
    Marker Score: 207
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 91
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.13
    Marker Score: 156
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.13
    Marker Score: 127
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.12
    Marker Score: 106
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 78
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 66
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 127
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.11
    Marker Score: 162
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.11
    Marker Score: 92
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26

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Other Information

**Key characteristics:** - LTK is a transmembrane receptor protein that belongs to the protein tyrosine kinase (PTK) family of cell surface receptors. - It is expressed in a wide range of cell types, including immune cells, neurons, and epithelial cells. - LTK is a key regulator of cell cycle progression, proliferation, and survival. - It is involved in regulating the development and function of lymphoid organs, the nervous system, and the cardiovascular system. **Pathways and functions:** - LTK is a key regulator of cell population proliferation. - It is involved in the regulation of immune cell development and function, and it plays a role in the homeostasis of lymphoid organs. - LTK is also involved in the regulation of neuronal development and function. - It is involved in the regulation of cardiac muscle cell apoptosis. - It is involved in the regulation of neuron projection development. **Clinical significance:** - Mutations in the LTK gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - Targeting LTK has been shown to be a promising therapeutic strategy for a variety of diseases. **Additional information:** - The LTK gene is located on chromosome 19p13.2. - It is a well-documented gene, and there are a number of drugs that target it. - LTK is a highly conserved protein, and its sequence is similar in humans, mice, and other animals.

Genular Protein ID: 2973734619

Symbol: LTK_HUMAN

Name: Protein tyrosine kinase 1

UniProtKB Accession Codes:

P29376 A6NNJ8 B4DL89 E9PFX4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 3 Rhea 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7685902

Title: Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.

PubMed ID: 7685902

DOI: 10.1073/pnas.90.12.5404

PubMed ID: 1655406

Title: The ltk gene encodes a novel receptor-type protein tyrosine kinase.

PubMed ID: 1655406

DOI: 10.1002/j.1460-2075.1991.tb07841.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 2320375

Title: Human ltk: gene structure and preferential expression in human leukemic cells.

PubMed ID: 2320375

PubMed ID: 2156206

Title: Identification and chromosomal mapping of new human tyrosine kinase genes.

PubMed ID: 2156206

PubMed ID: 8084603

Title: Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.

PubMed ID: 8084603

PubMed ID: 9223670

Title: The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.

PubMed ID: 9223670

DOI: 10.1038/sj.onc.1201153

PubMed ID: 10445845

Title: Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.

PubMed ID: 10445845

DOI: 10.1038/sj.onc.1202736

PubMed ID: 14695357

Title: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.

PubMed ID: 14695357

DOI: 10.1093/hmg/ddh020

PubMed ID: 18849880

Title: Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.

PubMed ID: 18849880

DOI: 10.1097/wnr.0b013e3283186bf8

PubMed ID: 19815557

Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

PubMed ID: 19815557

DOI: 10.1074/jbc.m109.072660

PubMed ID: 20548102

Title: MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.

PubMed ID: 20548102

DOI: 10.1083/jcb.200912082

PubMed ID: 30061385

Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-alpha).

PubMed ID: 30061385

DOI: 10.1073/pnas.1807881115

PubMed ID: 34646012

Title: Structural basis of cytokine-mediated activation of ALK family receptors.

PubMed ID: 34646012

DOI: 10.1038/s41586-021-03959-5

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 864
  • Mass: 91681
  • Checksum: 0617F378AA04298E
  • Sequence:
    • MGCWGQLLVW FGAAGAILCS SPGSQETFLR SSPLPLASPS PRDPKVSAPP SILEPASPLN 
SPGTEGSWLF STCGASGRHG PTQTQCDGAY AGTSVVVTVG AAGQLRGVQL WRVPGPGQYL 
ISAYGAAGGK GAKNHLSRAH GVFVSAIFSL GLGESLYILV GQQGEDACPG GSPESQLVCL 
GESRAVEEHA AMDGSEGVPG SRRWAGGGGG GGGATYVFRV RAGELEPLLV AAGGGGRAYL 
RPRDRGRTQA SPEKLENRSE APGSGGRGGA AGGGGGWTSR APSPQAGRSL QEGAEGGQGC 
SEAWATLGWA AAGGFGGGGG ACTAGGGGGG YRGGDASETD NLWADGEDGV SFIHPSSELF 
LQPLAVTENH GEVEIRRHLN CSHCPLRDCQ WQAELQLAEC LCPEGMELAV DNVTCMDLHK 
PPGPLVLMVA VVATSTLSLL MVCGVLILVK QKKWQGLQEM RLPSPELELS KLRTSAIRTA 
PNPYYCQVGL GPAQSWPLPP GVTEVSPANV TLLRALGHGA FGEVYEGLVI GLPGDSSPLQ 
VAIKTLPELC SPQDELDFLM EALIISKFRH QNIVRCVGLS LRATPRLILL ELMSGGDMKS 
FLRHSRPHLG QPSPLVMRDL LQLAQDIAQG CHYLEENHFI HRDIAARNCL LSCAGPSRVA 
KIGDFGMARD IYRASYYRRG DRALLPVKWM PPEAFLEGIF TSKTDSWSFG VLLWEIFSLG 
YMPYPGRTNQ EVLDFVVGGG RMDPPRGCPG PVYRIMTQCW QHEPELRPSF ASILERLQYC 
TQDPDVLNSL LPMELGPTPE EEGTSGLGNR SLECLRPPQP QELSPEKLKS WGGSPLGPWL 
SSGLKPLKSR GLQPQNLWNP TYRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.