Details for: LTK

Gene ID: 4058

Symbol: LTK

Ensembl ID: ENSG00000062524

Description: leukocyte receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 16.9083
    Cell Significance Index: -2.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.3689
    Cell Significance Index: -2.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.1412
    Cell Significance Index: -2.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1119
    Cell Significance Index: 24.0900
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.0690
    Cell Significance Index: 5.9500
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.8962
    Cell Significance Index: 3.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7781
    Cell Significance Index: 22.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7210
    Cell Significance Index: 651.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7043
    Cell Significance Index: 42.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6922
    Cell Significance Index: 44.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6086
    Cell Significance Index: 66.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5555
    Cell Significance Index: 5.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5302
    Cell Significance Index: 52.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4587
    Cell Significance Index: 74.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4007
    Cell Significance Index: 14.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3954
    Cell Significance Index: 17.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3507
    Cell Significance Index: 24.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3233
    Cell Significance Index: 7.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2803
    Cell Significance Index: 53.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2535
    Cell Significance Index: 3.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2430
    Cell Significance Index: 5.0400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1892
    Cell Significance Index: 2.0500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.1740
    Cell Significance Index: 2.2800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1733
    Cell Significance Index: 1.1300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1582
    Cell Significance Index: 2.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1427
    Cell Significance Index: 2.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1154
    Cell Significance Index: 16.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1013
    Cell Significance Index: 20.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0850
    Cell Significance Index: 1.8100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0697
    Cell Significance Index: 0.5500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0631
    Cell Significance Index: 0.6000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.0511
    Cell Significance Index: 0.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0501
    Cell Significance Index: 1.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0396
    Cell Significance Index: 0.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0293
    Cell Significance Index: 3.4200
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.0179
    Cell Significance Index: 0.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0100
    Cell Significance Index: 0.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0073
    Cell Significance Index: 1.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0066
    Cell Significance Index: 0.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0050
    Cell Significance Index: 1.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0038
    Cell Significance Index: 0.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0031
    Cell Significance Index: 0.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0027
    Cell Significance Index: 1.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0020
    Cell Significance Index: -1.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0033
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0035
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -2.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0048
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0078
    Cell Significance Index: -0.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0079
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0087
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0098
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0102
    Cell Significance Index: -1.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0110
    Cell Significance Index: -1.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0124
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0143
    Cell Significance Index: -3.0100
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0166
    Cell Significance Index: -0.1200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0193
    Cell Significance Index: -0.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0202
    Cell Significance Index: -2.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0247
    Cell Significance Index: -2.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0252
    Cell Significance Index: -3.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0277
    Cell Significance Index: -3.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0298
    Cell Significance Index: -1.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0314
    Cell Significance Index: -3.2100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0323
    Cell Significance Index: -0.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0326
    Cell Significance Index: -2.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0350
    Cell Significance Index: -1.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0352
    Cell Significance Index: -2.3700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0372
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0383
    Cell Significance Index: -3.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0434
    Cell Significance Index: -1.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0438
    Cell Significance Index: -2.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0440
    Cell Significance Index: -1.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0463
    Cell Significance Index: -3.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0464
    Cell Significance Index: -2.1800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0467
    Cell Significance Index: -0.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0476
    Cell Significance Index: -2.6700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0478
    Cell Significance Index: -0.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0512
    Cell Significance Index: -2.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0538
    Cell Significance Index: -1.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0538
    Cell Significance Index: -1.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0550
    Cell Significance Index: -1.4800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0577
    Cell Significance Index: -0.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0603
    Cell Significance Index: -1.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0645
    Cell Significance Index: -3.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0718
    Cell Significance Index: -1.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0738
    Cell Significance Index: -1.9700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0744
    Cell Significance Index: -0.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0759
    Cell Significance Index: -3.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0764
    Cell Significance Index: -2.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0767
    Cell Significance Index: -2.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tyrosine Kinase Activity:** LTK is a non-receptor tyrosine kinase, which means it phosphorylates tyrosine residues on target proteins, leading to various downstream effects. 2. **Cellular Expression:** LTK is expressed in multiple cell types, including immune cells, neural cells, and epithelial cells, suggesting its broad functional roles. 3. **Signaling Pathways:** LTK is involved in various signaling pathways, including those related to cell proliferation, differentiation, and survival. 4. **Protein Binding:** LTK interacts with multiple proteins, including adapter proteins, transcription factors, and other kinases, to regulate cellular processes. **Pathways and Functions:** 1. **Cell Proliferation and Differentiation:** LTK regulates cell proliferation and differentiation in various cell types, including immune cells and neural cells. 2. **Apoptosis Regulation:** LTK negatively regulates apoptosis in some contexts, while positively regulating it in others, highlighting the complexity of its role in cell survival. 3. **Neurodevelopment:** LTK is involved in the development of neural cells, particularly in the formation of GABAergic interneurons and the regulation of neuron projection development. 4. **Cardiac Muscle Cell Apoptosis:** LTK positively regulates cardiac muscle cell apoptosis, which is essential for cardiac development and function. 5. **Immune Cell Development:** LTK plays a crucial role in the development and function of immune cells, including common lymphoid progenitors and early T lineage precursors. **Clinical Significance:** Dysregulation of LTK has been implicated in various diseases, including: 1. **Cancer:** Aberrant LTK expression has been linked to cancer development and progression, particularly in hematological malignancies. 2. **Neurological Disorders:** LTK dysregulation has been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Cardiovascular Disease:** Altered LTK expression has been linked to cardiovascular disease, including cardiac hypertrophy and apoptosis. In conclusion, the leukocyte receptor tyrosine kinase (LTK) is a multifaceted gene that plays a crucial role in immune cell development, signaling, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms and clinical significance of LTK.

Genular Protein ID: 2973734619

Symbol: LTK_HUMAN

Name: Protein tyrosine kinase 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7685902

Title: Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.

PubMed ID: 7685902

DOI: 10.1073/pnas.90.12.5404

PubMed ID: 1655406

Title: The ltk gene encodes a novel receptor-type protein tyrosine kinase.

PubMed ID: 1655406

DOI: 10.1002/j.1460-2075.1991.tb07841.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 2320375

Title: Human ltk: gene structure and preferential expression in human leukemic cells.

PubMed ID: 2320375

PubMed ID: 2156206

Title: Identification and chromosomal mapping of new human tyrosine kinase genes.

PubMed ID: 2156206

PubMed ID: 8084603

Title: Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.

PubMed ID: 8084603

PubMed ID: 9223670

Title: The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.

PubMed ID: 9223670

DOI: 10.1038/sj.onc.1201153

PubMed ID: 10445845

Title: Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.

PubMed ID: 10445845

DOI: 10.1038/sj.onc.1202736

PubMed ID: 14695357

Title: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.

PubMed ID: 14695357

DOI: 10.1093/hmg/ddh020

PubMed ID: 18849880

Title: Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.

PubMed ID: 18849880

DOI: 10.1097/wnr.0b013e3283186bf8

PubMed ID: 19815557

Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

PubMed ID: 19815557

DOI: 10.1074/jbc.m109.072660

PubMed ID: 20548102

Title: MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.

PubMed ID: 20548102

DOI: 10.1083/jcb.200912082

PubMed ID: 30061385

Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-alpha).

PubMed ID: 30061385

DOI: 10.1073/pnas.1807881115

PubMed ID: 34646012

Title: Structural basis of cytokine-mediated activation of ALK family receptors.

PubMed ID: 34646012

DOI: 10.1038/s41586-021-03959-5

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 864
  • Mass: 91681
  • Checksum: 0617F378AA04298E
  • Sequence:
  • MGCWGQLLVW FGAAGAILCS SPGSQETFLR SSPLPLASPS PRDPKVSAPP SILEPASPLN 
    SPGTEGSWLF STCGASGRHG PTQTQCDGAY AGTSVVVTVG AAGQLRGVQL WRVPGPGQYL 
    ISAYGAAGGK GAKNHLSRAH GVFVSAIFSL GLGESLYILV GQQGEDACPG GSPESQLVCL 
    GESRAVEEHA AMDGSEGVPG SRRWAGGGGG GGGATYVFRV RAGELEPLLV AAGGGGRAYL 
    RPRDRGRTQA SPEKLENRSE APGSGGRGGA AGGGGGWTSR APSPQAGRSL QEGAEGGQGC 
    SEAWATLGWA AAGGFGGGGG ACTAGGGGGG YRGGDASETD NLWADGEDGV SFIHPSSELF 
    LQPLAVTENH GEVEIRRHLN CSHCPLRDCQ WQAELQLAEC LCPEGMELAV DNVTCMDLHK 
    PPGPLVLMVA VVATSTLSLL MVCGVLILVK QKKWQGLQEM RLPSPELELS KLRTSAIRTA 
    PNPYYCQVGL GPAQSWPLPP GVTEVSPANV TLLRALGHGA FGEVYEGLVI GLPGDSSPLQ 
    VAIKTLPELC SPQDELDFLM EALIISKFRH QNIVRCVGLS LRATPRLILL ELMSGGDMKS 
    FLRHSRPHLG QPSPLVMRDL LQLAQDIAQG CHYLEENHFI HRDIAARNCL LSCAGPSRVA 
    KIGDFGMARD IYRASYYRRG DRALLPVKWM PPEAFLEGIF TSKTDSWSFG VLLWEIFSLG 
    YMPYPGRTNQ EVLDFVVGGG RMDPPRGCPG PVYRIMTQCW QHEPELRPSF ASILERLQYC 
    TQDPDVLNSL LPMELGPTPE EEGTSGLGNR SLECLRPPQP QELSPEKLKS WGGSPLGPWL 
    SSGLKPLKSR GLQPQNLWNP TYRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.