Details for: PGF

Gene ID: 5228

Symbol: PGF

Ensembl ID: ENSG00000119630

Description: placental growth factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.3485
    Cell Significance Index: -13.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.2387
    Cell Significance Index: -13.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 36.3153
    Cell Significance Index: -14.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.3067
    Cell Significance Index: -12.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.6816
    Cell Significance Index: -13.1700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 7.6914
    Cell Significance Index: 47.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 6.5094
    Cell Significance Index: 173.8100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 6.4454
    Cell Significance Index: 54.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2285
    Cell Significance Index: -12.7400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.8367
    Cell Significance Index: 19.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.0356
    Cell Significance Index: 22.1300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.9951
    Cell Significance Index: 16.5000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.7619
    Cell Significance Index: 18.7200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.0093
    Cell Significance Index: 4.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8183
    Cell Significance Index: 155.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7959
    Cell Significance Index: 14.0700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.5443
    Cell Significance Index: 4.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4474
    Cell Significance Index: 403.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4350
    Cell Significance Index: 15.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4046
    Cell Significance Index: 5.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3482
    Cell Significance Index: 18.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3276
    Cell Significance Index: 9.3900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2735
    Cell Significance Index: 3.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2713
    Cell Significance Index: 44.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2648
    Cell Significance Index: 1.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2362
    Cell Significance Index: 25.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2325
    Cell Significance Index: 29.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2267
    Cell Significance Index: 22.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1445
    Cell Significance Index: 9.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1286
    Cell Significance Index: 14.9900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1197
    Cell Significance Index: 0.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1109
    Cell Significance Index: 6.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1109
    Cell Significance Index: 7.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0573
    Cell Significance Index: 1.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0484
    Cell Significance Index: 0.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0373
    Cell Significance Index: 1.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0252
    Cell Significance Index: 3.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0230
    Cell Significance Index: 0.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0203
    Cell Significance Index: 8.9600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0147
    Cell Significance Index: 0.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0100
    Cell Significance Index: 0.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0078
    Cell Significance Index: 0.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0076
    Cell Significance Index: 0.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0069
    Cell Significance Index: 1.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0004
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0057
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0083
    Cell Significance Index: -15.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0099
    Cell Significance Index: -15.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0108
    Cell Significance Index: -1.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0108
    Cell Significance Index: -5.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -14.9300
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0139
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0191
    Cell Significance Index: -12.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0201
    Cell Significance Index: -11.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0213
    Cell Significance Index: -0.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0234
    Cell Significance Index: -3.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0241
    Cell Significance Index: -1.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0281
    Cell Significance Index: -10.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0297
    Cell Significance Index: -8.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0299
    Cell Significance Index: -13.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0319
    Cell Significance Index: -0.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0403
    Cell Significance Index: -4.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0412
    Cell Significance Index: -8.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0432
    Cell Significance Index: -2.0300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0452
    Cell Significance Index: -0.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0517
    Cell Significance Index: -2.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0551
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0686
    Cell Significance Index: -14.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0695
    Cell Significance Index: -11.8600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0747
    Cell Significance Index: -1.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0764
    Cell Significance Index: -11.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0812
    Cell Significance Index: -3.3300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0851
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0898
    Cell Significance Index: -10.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0913
    Cell Significance Index: -10.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1015
    Cell Significance Index: -3.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1040
    Cell Significance Index: -2.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1045
    Cell Significance Index: -7.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1129
    Cell Significance Index: -5.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1133
    Cell Significance Index: -2.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1170
    Cell Significance Index: -3.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1236
    Cell Significance Index: -6.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1274
    Cell Significance Index: -13.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1485
    Cell Significance Index: -11.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1585
    Cell Significance Index: -12.5500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1618
    Cell Significance Index: -1.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1686
    Cell Significance Index: -12.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1850
    Cell Significance Index: -12.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1863
    Cell Significance Index: -12.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1964
    Cell Significance Index: -10.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1975
    Cell Significance Index: -2.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2014
    Cell Significance Index: -11.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2177
    Cell Significance Index: -5.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2635
    Cell Significance Index: -7.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2912
    Cell Significance Index: -10.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3127
    Cell Significance Index: -13.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLGF is a member of the VEGF family, which consists of six related proteins (VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PLGF). PLGF is a disulfide-linked homodimer, consisting of two identical subunits. It is highly homologous to VEGF-A, with a high degree of sequence similarity. PLGF is also known as VEGF-C, although it does not bind to the VEGF receptor (VEGFR). Instead, it binds to VEGFR-3, a receptor that is specific to VEGF-C and VEGF-D. **Pathways and Functions:** PLGF is involved in several cellular processes, including: 1. **Angiogenesis:** PLGF is a potent angiogenic factor, promoting the formation of new blood vessels through the induction of endothelial cell proliferation, migration, and differentiation. 2. **Cell Proliferation:** PLGF stimulates cell proliferation in various cell types, including endothelial cells, smooth muscle cells, and cancer cells. 3. **Chemotaxis:** PLGF promotes the migration of cells towards the site of angiogenesis, through the induction of chemotactic responses in endothelial cells and other cell types. 4. **Signaling:** PLGF binds to VEGFR-3, triggering a signaling cascade that regulates various cellular processes, including cell proliferation, migration, and differentiation. **Clinical Significance:** PLGF has been implicated in several diseases, including: 1. **Cancer:** PLGF expression is often upregulated in cancer cells, promoting tumor angiogenesis and metastasis. 2. **Cardiovascular Diseases:** PLGF is involved in the development of atherosclerosis, hypertension, and cardiac hypertrophy, through the promotion of endothelial cell proliferation and migration. 3. **Inflammatory Disorders:** PLGF is involved in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis, through the promotion of endothelial cell activation and migration. 4. **Pregnancy:** PLGF is essential for placental development and function, and its dysregulation can lead to pregnancy complications, such as preeclampsia. In conclusion, PLGF is a key player in angiogenesis and cell proliferation, with significant implications for various diseases. Further research is needed to fully understand the mechanisms by which PLGF regulates cellular processes and to develop therapeutic strategies targeting this growth factor.

Genular Protein ID: 2239046545

Symbol: PLGF_HUMAN

Name: Placenta growth factor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1924389

Title: Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

PubMed ID: 1924389

DOI: 10.1073/pnas.88.20.9267

PubMed ID: 8148155

Title: A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta.

PubMed ID: 8148155

DOI: 10.3109/08977199308991586

PubMed ID: 9207183

Title: Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing.

PubMed ID: 9207183

DOI: 10.1006/bbrc.1997.6813

PubMed ID: 14568677

Title: Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human trophoblast and endothelial cells.

PubMed ID: 14568677

DOI: 10.1016/s0165-0378(03)00082-2

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7929268

Title: Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

PubMed ID: 7929268

DOI: 10.1016/s0021-9258(18)47298-5

PubMed ID: 7681160

Title: Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.

PubMed ID: 7681160

PubMed ID: 21215706

Title: HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

PubMed ID: 21215706

DOI: 10.1016/j.ccr.2010.11.009

PubMed ID: 11069911

Title: The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.

PubMed ID: 11069911

DOI: 10.1074/jbc.m008055200

Sequence Information:

  • Length: 221
  • Mass: 24789
  • Checksum: D364C6A73C1C6987
  • Sequence:
  • MPVMRLFPCF LQLLAGLALP AVPPQQWALS AGNGSSEVEV VPFQEVWGRS YCRALERLVD 
    VVSEYPSEVE HMFSPSCVSL LRCTGCCGDE NLHCVPVETA NVTMQLLKIR SGDRPSYVEL 
    TFSQHVRCEC RHSPGRQSPD MPGDFRADAP SFLPPRRSLP MLFRMEWGCA LTGSQSAVWP 
    SSPVPEEIPR MHPGRNGKKQ QRKPLREKMK PERCGDAVPR R

Genular Protein ID: 600099152

Symbol: G3XA84_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 169
  • Mass: 19210
  • Checksum: 3A4E39334A9FE0B4
  • Sequence:
  • MPVMRLFPCF LQLLAGLALP AVPPQWALSA GNGSSEVEVV PFQEVWGRSY CRALERLVDV 
    VSEYPSEVEH MFSPSCVSLL RCTGCCGDEN LHCVPVETAN VTMQLLKIRS GDRPSYVELT 
    FSQHVRCECR PLREKMKPER RRPKGRGKRR REKQRPTDCH LCGDAVPRR

Genular Protein ID: 1882043196

Symbol: Q53XY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 170
  • Mass: 19338
  • Checksum: 02CDE4CC54A09637
  • Sequence:
  • MPVMRLFPCF LQLLAGLALP AVPPQQWALS AGNGSSEVEV VPFQEVWGRS YCRALERLVD 
    VVSEYPSEVE HMFSPSCVSL LRCTGCCGDE NLHCVPVETA NVTMQLLKIR SGDRPSYVEL 
    TFSQHVRCEC RPLREKMKPE RRRPKGRGKR RREKQRPTDC HLCGDAVPRR

Genular Protein ID: 3860821955

Symbol: Q86TW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 171
  • Mass: 17522
  • Checksum: 7279DB7D7CC9BC76
  • Sequence:
  • SHALRAPALR AGRALRADRA LRELGSGTSS AVGGAGPEPR PGSVPETQAR TGCSLRRELL 
    SAEETASTDG RPATGGPGVA LGARRTIPGT RLPLGAPPRR AAPRRVPQPQ PYLRAPDSAR 
    LPEDARTTGR GLGAAVREAS SPPLSSSPPV PGAPRGMSMV VFPRSPLARD V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.