Details for: HOXD8

Gene ID: 3234

Symbol: HOXD8

Ensembl ID: ENSG00000175879

Description: homeobox D8

Associated with

  • Anterior/posterior axis specification, embryo
    (GO:0008595)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal system morphogenesis
    (GO:0048705)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.9377
    Cell Significance Index: -13.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.3255
    Cell Significance Index: 108.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.3898
    Cell Significance Index: 73.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.6333
    Cell Significance Index: 501.1300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.0188
    Cell Significance Index: 7.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.6032
    Cell Significance Index: 12.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5396
    Cell Significance Index: 17.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3896
    Cell Significance Index: 37.2400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1438
    Cell Significance Index: 18.3500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8667
    Cell Significance Index: 10.0800
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.7368
    Cell Significance Index: 2.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6977
    Cell Significance Index: 14.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6342
    Cell Significance Index: 62.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6130
    Cell Significance Index: 21.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5403
    Cell Significance Index: 6.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4929
    Cell Significance Index: 445.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4360
    Cell Significance Index: 7.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4108
    Cell Significance Index: 24.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3755
    Cell Significance Index: 40.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3393
    Cell Significance Index: 55.1800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2848
    Cell Significance Index: 3.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2155
    Cell Significance Index: 29.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2054
    Cell Significance Index: 9.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2043
    Cell Significance Index: 14.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1838
    Cell Significance Index: 9.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1505
    Cell Significance Index: 3.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1427
    Cell Significance Index: 11.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1182
    Cell Significance Index: 86.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0866
    Cell Significance Index: 2.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0758
    Cell Significance Index: 1.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0569
    Cell Significance Index: 0.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0371
    Cell Significance Index: 1.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0220
    Cell Significance Index: 3.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0062
    Cell Significance Index: 0.1800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0111
    Cell Significance Index: -0.6800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0144
    Cell Significance Index: -0.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0151
    Cell Significance Index: -1.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0203
    Cell Significance Index: -15.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0245
    Cell Significance Index: -13.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0259
    Cell Significance Index: -14.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0277
    Cell Significance Index: -3.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0369
    Cell Significance Index: -3.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0397
    Cell Significance Index: -18.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0444
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0506
    Cell Significance Index: -0.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0543
    Cell Significance Index: -0.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0674
    Cell Significance Index: -13.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0732
    Cell Significance Index: -14.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0740
    Cell Significance Index: -12.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0983
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1167
    Cell Significance Index: -13.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1171
    Cell Significance Index: -2.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1176
    Cell Significance Index: -2.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1211
    Cell Significance Index: -15.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1220
    Cell Significance Index: -2.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1248
    Cell Significance Index: -14.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1264
    Cell Significance Index: -4.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1424
    Cell Significance Index: -3.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1571
    Cell Significance Index: -4.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1767
    Cell Significance Index: -5.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1796
    Cell Significance Index: -5.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2054
    Cell Significance Index: -15.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2228
    Cell Significance Index: -17.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2456
    Cell Significance Index: -11.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2544
    Cell Significance Index: -13.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2632
    Cell Significance Index: -12.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2657
    Cell Significance Index: -1.8000
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2843
    Cell Significance Index: -1.6700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2884
    Cell Significance Index: -4.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3013
    Cell Significance Index: -4.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3087
    Cell Significance Index: -17.3200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3187
    Cell Significance Index: -4.4700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3286
    Cell Significance Index: -2.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3460
    Cell Significance Index: -5.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3484
    Cell Significance Index: -6.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3650
    Cell Significance Index: -15.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3723
    Cell Significance Index: -5.2900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.3972
    Cell Significance Index: -3.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4037
    Cell Significance Index: -14.8200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4113
    Cell Significance Index: -5.8500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4422
    Cell Significance Index: -3.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4798
    Cell Significance Index: -12.8400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4809
    Cell Significance Index: -6.6000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.4927
    Cell Significance Index: -4.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4936
    Cell Significance Index: -15.7200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4969
    Cell Significance Index: -12.6600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.5112
    Cell Significance Index: -5.1900
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.5202
    Cell Significance Index: -2.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5209
    Cell Significance Index: -13.9100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.5273
    Cell Significance Index: -3.2300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.5605
    Cell Significance Index: -3.2900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5620
    Cell Significance Index: -8.1600
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.5665
    Cell Significance Index: -4.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5814
    Cell Significance Index: -14.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6149
    Cell Significance Index: -13.4700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.6258
    Cell Significance Index: -6.5800
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.6515
    Cell Significance Index: -6.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** HOXD8 is widely expressed in various tissues, including the kidney, hematopoietic stem cells, microglial cells, and ciliated epithelial cells. Its expression is particularly notable in the development of the kidney and the immune system. 2. **Transcriptional Regulation:** HOXD8 acts as a transcriptional activator or repressor, regulating the expression of target genes involved in developmental processes, such as skeletal morphogenesis and immune cell development. 3. **Cell-Specific Expression:** HOXD8 exhibits cell-specific expression patterns, suggesting its involvement in specialized functions within different cell types. 4. **Evolutionary Conservation:** HOXD8 is highly conserved across species, indicating its importance in fundamental biological processes. **Pathways and Functions:** 1. **Anterior-Posterior Axis Specification:** HOXD8 plays a crucial role in the establishment of the anterior-posterior body axis during embryogenesis, influencing the development of various tissues and organs. 2. **Skeletal Morphogenesis:** HOXD8 regulates the expression of genes involved in skeletal morphogenesis, contributing to the development of the vertebral column and other skeletal structures. 3. **Immune System Development:** HOXD8 is involved in the development of immune cells, including hematopoietic stem cells and granulocyte-monocyte progenitor cells, highlighting its importance in immune system function. 4. **Chromatin Structure and Gene Expression:** HOXD8 influences chromatin structure and gene expression by regulating the activity of RNA polymerase II and other transcriptional regulators. **Clinical Significance:** 1. **Immune-Related Disorders:** Aberrant expression or function of HOXD8 has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** HOXD8 has been identified as a potential oncogene in certain types of cancer, including leukemia and lymphoma, where it may contribute to tumorigenesis and cancer progression. 3. **Neurological Disorders:** HOXD8 has been linked to neurological disorders, such as Parkinson's disease and schizophrenia, where it may play a role in the development of these conditions. 4. **Gene Therapy:** HOXD8 has been identified as a potential target for gene therapy in the treatment of immune-related disorders and cancer. In conclusion, HOXD8 is a multifunctional transcription factor that plays a critical role in developmental processes, immune system development, and disease pathogenesis. Further research on HOXD8 is necessary to fully elucidate its immunological significance and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 2495310360

Symbol: HXD8_HUMAN

Name: Homeobox protein Hox-D8

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2568311

Title: Complementary homeo protein gradients in developing limb buds.

PubMed ID: 2568311

DOI: 10.1101/gad.3.5.641

Sequence Information:

  • Length: 290
  • Mass: 31911
  • Checksum: 75FF95A73E2AA85F
  • Sequence:
  • MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFAPEV GGRHAAAAAA LQLYGNSAAG 
    FPHAPPQAHA HPHPSPPPSG TGCGGREGRG QEYFHPGGGS PAAAYQAAPP PPPHPPPPPP 
    PPPCGGIACH GEPAKFYGYD NLQRQPIFTT QQEAELVQYP DCKSSSGNIG EDPDHLNQSS 
    SPSQMFPWMR PQAAPGRRRG RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ 
    VKIWFQNRRM KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN

Genular Protein ID: 3441254384

Symbol: A0A0A0MSX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 106
  • Mass: 12941
  • Checksum: FCEE1BC0DF94BC80
  • Sequence:
  • MFPWMRPQAA PGRRRGRQTY SRFQTLELEK EFLFNPYLTR KRRIEVSHAL ALTERQVKIW 
    FQNRRMKWKK ENNKDKFPVS RQEVKDGETK KEAQELEEDR AEGLTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.