Details for: PLGLB1

Gene ID: 5343

Symbol: PLGLB1

Ensembl ID: ENSG00000183281

Description: plasminogen like B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.5454
    Cell Significance Index: -5.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.7090
    Cell Significance Index: -5.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.7690
    Cell Significance Index: -5.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.4179
    Cell Significance Index: 74.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.0867
    Cell Significance Index: -5.5900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.7896
    Cell Significance Index: 6.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3616
    Cell Significance Index: -2.9800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9507
    Cell Significance Index: 5.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8807
    Cell Significance Index: 59.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.8794
    Cell Significance Index: 15.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7611
    Cell Significance Index: 33.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7385
    Cell Significance Index: 27.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6850
    Cell Significance Index: 67.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6275
    Cell Significance Index: 566.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6180
    Cell Significance Index: 17.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4641
    Cell Significance Index: 9.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4324
    Cell Significance Index: 10.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3954
    Cell Significance Index: 64.3200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.3894
    Cell Significance Index: 5.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3569
    Cell Significance Index: 38.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3482
    Cell Significance Index: 5.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3436
    Cell Significance Index: 21.1200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3392
    Cell Significance Index: 5.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2956
    Cell Significance Index: 58.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2762
    Cell Significance Index: 5.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2551
    Cell Significance Index: 7.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2253
    Cell Significance Index: 2.8000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.2160
    Cell Significance Index: 2.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1971
    Cell Significance Index: 70.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1904
    Cell Significance Index: 11.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1895
    Cell Significance Index: 13.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1590
    Cell Significance Index: 3.8800
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.1585
    Cell Significance Index: 1.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1221
    Cell Significance Index: 23.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1066
    Cell Significance Index: 8.1800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0980
    Cell Significance Index: 1.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0922
    Cell Significance Index: 5.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0909
    Cell Significance Index: 2.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0657
    Cell Significance Index: 18.9000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0645
    Cell Significance Index: 1.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0579
    Cell Significance Index: 0.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0573
    Cell Significance Index: 11.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0421
    Cell Significance Index: 2.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0390
    Cell Significance Index: 21.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0267
    Cell Significance Index: 1.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0169
    Cell Significance Index: 1.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0100
    Cell Significance Index: 1.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0075
    Cell Significance Index: 0.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -2.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0047
    Cell Significance Index: -2.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0055
    Cell Significance Index: -3.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0056
    Cell Significance Index: -0.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0067
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0096
    Cell Significance Index: -5.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0099
    Cell Significance Index: -0.4500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0168
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0179
    Cell Significance Index: -3.0600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0188
    Cell Significance Index: -0.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0188
    Cell Significance Index: -0.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0192
    Cell Significance Index: -0.2900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0221
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0226
    Cell Significance Index: -2.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0236
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0272
    Cell Significance Index: -5.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0288
    Cell Significance Index: -3.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0321
    Cell Significance Index: -0.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0323
    Cell Significance Index: -0.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0326
    Cell Significance Index: -2.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0332
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0359
    Cell Significance Index: -4.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0393
    Cell Significance Index: -5.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0431
    Cell Significance Index: -1.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0462
    Cell Significance Index: -0.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0468
    Cell Significance Index: -4.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0481
    Cell Significance Index: -0.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0539
    Cell Significance Index: -2.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0546
    Cell Significance Index: -5.6900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0557
    Cell Significance Index: -0.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0577
    Cell Significance Index: -2.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0642
    Cell Significance Index: -2.0600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0642
    Cell Significance Index: -0.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0678
    Cell Significance Index: -5.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0687
    Cell Significance Index: -5.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0702
    Cell Significance Index: -3.3000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0736
    Cell Significance Index: -0.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0756
    Cell Significance Index: -5.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0787
    Cell Significance Index: -1.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0829
    Cell Significance Index: -2.6400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0889
    Cell Significance Index: -1.1400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0901
    Cell Significance Index: -0.8000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0905
    Cell Significance Index: -1.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0910
    Cell Significance Index: -1.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLGLB1 is a gene with a broad expression profile, with significantly high levels observed in periportal region hepatocytes, centrilobular region hepatocytes, and midzonal region hepatocytes, all of which are involved in liver function and metabolism. Its expression is also detected in early T lineage precursors, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, tuft cells of the colon, BEST4+ intestinal epithelial cells, and human intestinal crypt stem cells of the colon. These findings suggest that PLGLB1 plays a crucial role in the development and maintenance of various tissues, including the liver, brain, and gut. **Pathways and Functions:** PLGLB1 has been implicated in several signaling pathways, including those involved in cell growth, differentiation, and survival. Its expression is associated with the regulation of hepatocyte function, particularly in the context of liver regeneration and fibrosis. PLGLB1 has been shown to interact with other genes involved in the TGF-β (transforming growth factor-beta) signaling pathway, which is crucial for maintaining tissue homeostasis and preventing fibrosis. Additionally, PLGLB1 has been found to be involved in the regulation of intestinal stem cell function and the maintenance of the intestinal epithelial barrier. **Clinical Significance:** The discovery of PLGLB1's role in maintaining tissue homeostasis and its implications for human disease have significant clinical implications. For instance, PLGLB1's expression in hepatocytes suggests that alterations in PLGLB1 expression may contribute to liver diseases, such as hepatitis and cirrhosis. Furthermore, PLGLB1's involvement in the TGF-β signaling pathway implies that dysregulation of this pathway may contribute to fibrotic diseases, including liver and kidney fibrosis. Additionally, PLGLB1's role in maintaining intestinal stem cell function and the intestinal epithelial barrier suggests that alterations in PLGLB1 expression may contribute to gastrointestinal disorders, such as inflammatory bowel disease. In conclusion, PLGLB1 is a novel gene with a broad expression profile and multiple functions in maintaining tissue homeostasis. Its implications for human disease are significant, and further research is needed to fully elucidate the role of PLGLB1 in various diseases. As an expert immunologist, it is essential to continue investigating the mechanisms by which PLGLB1 regulates cell growth, differentiation, and survival, with the ultimate goal of developing new therapeutic strategies for the treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.