Details for: PKN3

Gene ID: 29941

Symbol: PKN3

Ensembl ID: ENSG00000160447

Description: protein kinase N3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.9387
    Cell Significance Index: -6.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.7448
    Cell Significance Index: -6.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.8558
    Cell Significance Index: -7.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6410
    Cell Significance Index: -5.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5678
    Cell Significance Index: 298.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2606
    Cell Significance Index: 18.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0316
    Cell Significance Index: 102.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6883
    Cell Significance Index: 621.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6378
    Cell Significance Index: 44.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5916
    Cell Significance Index: 64.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5864
    Cell Significance Index: 95.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5503
    Cell Significance Index: 109.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4536
    Cell Significance Index: 27.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3656
    Cell Significance Index: 7.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2530
    Cell Significance Index: 4.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2130
    Cell Significance Index: 2.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2087
    Cell Significance Index: 9.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1666
    Cell Significance Index: 7.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1518
    Cell Significance Index: 4.3800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1423
    Cell Significance Index: 0.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1143
    Cell Significance Index: 6.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1016
    Cell Significance Index: 2.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0848
    Cell Significance Index: 9.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0822
    Cell Significance Index: 1.7500
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.0815
    Cell Significance Index: 0.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0579
    Cell Significance Index: 3.0100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0570
    Cell Significance Index: 0.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0524
    Cell Significance Index: 1.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0488
    Cell Significance Index: 6.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0360
    Cell Significance Index: 5.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0284
    Cell Significance Index: 5.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0228
    Cell Significance Index: 0.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0203
    Cell Significance Index: 0.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0170
    Cell Significance Index: 4.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0164
    Cell Significance Index: 2.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0118
    Cell Significance Index: 8.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0102
    Cell Significance Index: 5.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0068
    Cell Significance Index: 3.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0013
    Cell Significance Index: -0.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0017
    Cell Significance Index: -0.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0074
    Cell Significance Index: -2.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0111
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0120
    Cell Significance Index: -7.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0153
    Cell Significance Index: -2.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0219
    Cell Significance Index: -0.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0255
    Cell Significance Index: -3.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0257
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0285
    Cell Significance Index: -3.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0287
    Cell Significance Index: -1.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0298
    Cell Significance Index: -4.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0303
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0353
    Cell Significance Index: -7.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0420
    Cell Significance Index: -4.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0467
    Cell Significance Index: -0.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0518
    Cell Significance Index: -3.6600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0536
    Cell Significance Index: -0.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0597
    Cell Significance Index: -0.8600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0640
    Cell Significance Index: -0.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0654
    Cell Significance Index: -6.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0656
    Cell Significance Index: -4.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0664
    Cell Significance Index: -5.1000
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0715
    Cell Significance Index: -0.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0780
    Cell Significance Index: -4.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0850
    Cell Significance Index: -6.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0940
    Cell Significance Index: -2.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1017
    Cell Significance Index: -6.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1103
    Cell Significance Index: -6.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1139
    Cell Significance Index: -2.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1165
    Cell Significance Index: -1.7600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1165
    Cell Significance Index: -1.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1168
    Cell Significance Index: -3.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1381
    Cell Significance Index: -2.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1389
    Cell Significance Index: -2.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1394
    Cell Significance Index: -7.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1465
    Cell Significance Index: -3.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1560
    Cell Significance Index: -3.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1580
    Cell Significance Index: -6.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1587
    Cell Significance Index: -4.3200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.1597
    Cell Significance Index: -1.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1738
    Cell Significance Index: -6.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1852
    Cell Significance Index: -1.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1861
    Cell Significance Index: -4.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1867
    Cell Significance Index: -2.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1885
    Cell Significance Index: -3.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1888
    Cell Significance Index: -7.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1899
    Cell Significance Index: -6.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1922
    Cell Significance Index: -1.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1922
    Cell Significance Index: -4.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1934
    Cell Significance Index: -5.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PKN3 is a serine/threonine kinase that belongs to the Protein Kinase N family. It has a molecular weight of approximately 40 kDa and is highly conserved across species. PKN3 is a monomeric protein that is activated by diacylglycerol (DAG) and phospholipase C (PLC) signaling pathways. It phosphorylates and activates downstream targets, including Rho GTPases, which are essential for regulating cell migration, cytoskeleton dynamics, and cell growth. PKN3 is also known to interact with various proteins, including Rho GTPases, actin-binding proteins, and transcription factors, which further highlights its complex role in cellular signaling. **Pathways and Functions** PKN3 is involved in various signaling pathways, including: 1. **Rho GTPase signaling**: PKN3 phosphorylates and activates Rho GTPases, which are essential for regulating cell migration, cytoskeleton dynamics, and cell growth. 2. **Intracellular signaling**: PKN3 is activated by DAG and PLC signaling pathways, which triggers a cascade of downstream events, including the activation of Rho GTPases and the regulation of cell growth and proliferation. 3. **Cytoskeleton dynamics**: PKN3 regulates cytoskeleton dynamics by phosphorylating and activating actin-binding proteins, which are essential for cell migration and shape changes. 4. **Cell migration**: PKN3 is involved in regulating cell migration by phosphorylating and activating Rho GTPases, which are essential for regulating cytoskeleton dynamics and cell growth. **Clinical Significance** PKN3 has been implicated in various diseases, including: 1. **Neurological disorders**: PKN3 has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is thought to play a role in regulating cell migration and cytoskeleton dynamics. 2. **Cancer**: PKN3 has been implicated in various types of cancer, including colon cancer and breast cancer, where it is thought to play a role in regulating cell growth and proliferation. 3. **Gastrointestinal disorders**: PKN3 has been associated with gastrointestinal disorders, such as inflammatory bowel disease, where it is thought to play a role in regulating cell migration and inflammation. In conclusion, PKN3 is a serine/threonine kinase that plays a crucial role in various cellular processes, including signal transduction, cell migration, and proliferation. Its expression is widespread in the human body, and it has been implicated in various diseases, including neurological disorders, cancer, and gastrointestinal disorders. Further studies are needed to fully elucidate the role of PKN3 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 260453556

Symbol: PKN3_HUMAN

Name: Serine/threonine-protein kinase N3

UniProtKB Accession Codes:

Q6P5Z2 Q9UM03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10441506

Title: Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.

PubMed ID: 10441506

DOI: 10.1006/bbrc.1999.1116

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15282551

Title: PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.

PubMed ID: 15282551

DOI: 10.1038/sj.emboj.7600345

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 889
  • Mass: 99421
  • Checksum: F3891DA1420DF54E
  • Sequence:
    • MEEGAPRQPG PSQWPPEDEK EVIRRAIQKE LKIKEGVENL RRVATDRRHL GHVQQLLRSS 
NRRLEQLHGE LRELHARILL PGPGPGPAEP VASGPRPWAE QLRARHLEAL RRQLHVELKV 
KQGAENMTHT CASGTPKERK LLAAAQQMLR DSQLKVALLR MKISSLEASG SPEPGPELLA 
EELQHRLHVE AAVAEGAKNV VKLLSSRRTQ DRKALAEAQA QLQESSQKLD LLRLALEQLL 
EQLPPAHPLR SRVTRELRAA VPGYPQPSGT PVKPTALTGT LQVRLLGCEQ LLTAVPGRSP 
AAALASSPSE GWLRTKAKHQ RGRGELASEV LAVLKVDNRV VGQTGWGQVA EQSWDQTFVI 
PLERARELEI GVHWRDWRQL CGVAFLRLED FLDNACHQLS LSLVPQGLLF AQVTFCDPVI 
ERRPRLQRQE RIFSKRRGQD FLRASQMNLG MAAWGRLVMN LLPPCSSPST ISPPKGCPRT 
PTTLREASDP ATPSNFLPKK TPLGEEMTPP PKPPRLYLPQ EPTSEETPRT KRPHMEPRTR 
RGPSPPASPT RKPPRLQDFR CLAVLGRGHF GKVLLVQFKG TGKYYAIKAL KKQEVLSRDE 
IESLYCEKRI LEAVGCTGHP FLLSLLACFQ TSSHACFVTE FVPGGDLMMQ IHEDVFPEPQ 
ARFYVACVVL GLQFLHEKKI IYRDLKLDNL LLDAQGFLKI ADFGLCKEGI GFGDRTSTFC 
GTPEFLAPEV LTQEAYTRAV DWWGLGVLLY EMLVGECPFP GDTEEEVFDC IVNMDAPYPG 
FLSVQGLEFI QKLLQKCPEK RLGAGEQDAE EIKVQPFFRT TNWQALLART IQPPFVPTLC 
GPADLRYFEG EFTGLPPALT PPAPHSLLTA RQQAAFRDFD FVSERFLEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.