Details for: GABRR2

Gene ID: 2570

Symbol: GABRR2

Ensembl ID: ENSG00000111886

Description: gamma-aminobutyric acid type A receptor subunit rho2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0081
    Cell Significance Index: 7.7700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.6145
    Cell Significance Index: 8.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3902
    Cell Significance Index: 10.4600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.3696
    Cell Significance Index: 4.4800
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: 0.3696
    Cell Significance Index: 4.5400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.3558
    Cell Significance Index: 4.0200
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: 0.1888
    Cell Significance Index: 2.3300
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.1649
    Cell Significance Index: 1.8900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.1389
    Cell Significance Index: 1.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0989
    Cell Significance Index: 14.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0770
    Cell Significance Index: 1.9800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0700
    Cell Significance Index: 1.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0557
    Cell Significance Index: 4.2800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0550
    Cell Significance Index: 0.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0406
    Cell Significance Index: 0.9900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0389
    Cell Significance Index: 1.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0336
    Cell Significance Index: 6.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0293
    Cell Significance Index: 10.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0205
    Cell Significance Index: 0.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0199
    Cell Significance Index: 3.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0194
    Cell Significance Index: 1.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0154
    Cell Significance Index: 3.0900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0113
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0100
    Cell Significance Index: 18.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0089
    Cell Significance Index: 6.1600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0074
    Cell Significance Index: 0.1000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0063
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0034
    Cell Significance Index: 5.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0033
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0026
    Cell Significance Index: 3.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0005
    Cell Significance Index: -0.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0041
    Cell Significance Index: -0.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0050
    Cell Significance Index: -0.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0054
    Cell Significance Index: -2.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0058
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0092
    Cell Significance Index: -1.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0105
    Cell Significance Index: -0.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0108
    Cell Significance Index: -0.2100
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.0115
    Cell Significance Index: -0.1400
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0139
    Cell Significance Index: -0.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0140
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0167
    Cell Significance Index: -3.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0182
    Cell Significance Index: -2.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0204
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0211
    Cell Significance Index: -2.4600
  • Cell Name: giant bipolar cell (CL4033035)
    Fold Change: -0.0222
    Cell Significance Index: -0.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0233
    Cell Significance Index: -2.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0234
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0236
    Cell Significance Index: -2.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0252
    Cell Significance Index: -2.6200
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0265
    Cell Significance Index: -0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0268
    Cell Significance Index: -1.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0288
    Cell Significance Index: -1.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0299
    Cell Significance Index: -2.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0342
    Cell Significance Index: -3.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0342
    Cell Significance Index: -0.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0374
    Cell Significance Index: -0.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0376
    Cell Significance Index: -1.0500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0432
    Cell Significance Index: -0.6200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0454
    Cell Significance Index: -0.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0486
    Cell Significance Index: -2.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0493
    Cell Significance Index: -0.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0524
    Cell Significance Index: -2.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0554
    Cell Significance Index: -2.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0591
    Cell Significance Index: -3.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0596
    Cell Significance Index: -2.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0602
    Cell Significance Index: -1.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0607
    Cell Significance Index: -2.3000
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0648
    Cell Significance Index: -0.7800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0650
    Cell Significance Index: -0.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0697
    Cell Significance Index: -1.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0698
    Cell Significance Index: -1.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0716
    Cell Significance Index: -2.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0735
    Cell Significance Index: -2.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0751
    Cell Significance Index: -2.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0792
    Cell Significance Index: -1.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0816
    Cell Significance Index: -2.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0836
    Cell Significance Index: -1.1900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0848
    Cell Significance Index: -1.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0852
    Cell Significance Index: -2.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0883
    Cell Significance Index: -2.6000
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: -0.0927
    Cell Significance Index: -0.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0936
    Cell Significance Index: -2.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0964
    Cell Significance Index: -2.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0970
    Cell Significance Index: -2.0300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0975
    Cell Significance Index: -0.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0985
    Cell Significance Index: -2.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0995
    Cell Significance Index: -2.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0997
    Cell Significance Index: -2.5400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0999
    Cell Significance Index: -1.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit composition:** GABRR2 is a subunit of the GABA_A receptor complex, which consists of multiple subunits that assemble to form functional receptors. 2. **Chloride channel activity:** GABRR2 is involved in chloride channel activity, which is critical for regulating the excitability of neurons. 3. **Regulation of membrane potential:** GABRR2 plays a role in regulating membrane potential, particularly in the context of GABAergic signaling. 4. **Signal transduction:** GABRR2 is involved in signal transduction pathways, including those involved in visual perception and neuronal excitability. 5. **Expression in various tissues:** GABRR2 is expressed in multiple cell types, including kidney proximal convoluted tubule epithelial cells, enterocytes, colon goblet cells, cardiac endothelial cells, erythrocytes, granulocyte monocyte progenitor cells, intestinal crypt stem cells, transit amplifying cells, and enterocytes. **Pathways and Functions:** 1. **GABAergic signaling:** GABRR2 is essential for the proper functioning of GABA_A receptors, which are involved in regulating neuronal excitability and synaptic transmission. 2. **Chloride channel activity:** GABRR2 is involved in chloride channel activity, which is critical for regulating the excitability of neurons. 3. **Regulation of membrane potential:** GABRR2 plays a role in regulating membrane potential, particularly in the context of GABAergic signaling. 4. **Signal transduction:** GABRR2 is involved in signal transduction pathways, including those involved in visual perception and neuronal excitability. 5. **Visual perception:** GABRR2 has been implicated in visual perception, particularly in the context of GABAergic signaling in the retina. **Clinical Significance:** Dysregulation of GABRR2 has been implicated in various neurological and psychiatric disorders, including epilepsy, anxiety disorders, and schizophrenia. Mutations in the GABRR2 gene have been associated with an increased risk of developing these conditions. Furthermore, GABRR2 has been implicated in other diseases, including kidney disease, where it plays a role in regulating chloride channel activity and membrane potential. In conclusion, GABRR2 is a critical component of the GABA_A receptor complex, which plays a vital role in regulating neuronal excitability and synaptic transmission. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into the mechanisms of GABRR2 and its role in disease.

Genular Protein ID: 1026174237

Symbol: GBRR2_HUMAN

Name: GABA(A) receptor subunit rho-2

UniProtKB Accession Codes:

P28476 A2BDE4 Q9H153

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 4 Ensembl 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1315307

Title: Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.

PubMed ID: 1315307

DOI: 10.1016/0888-7543(92)90312-g

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 465
  • Mass: 54151
  • Checksum: 209700077636A395
  • Sequence:
    • MPYFTRLILF LFCLMVLVES RKPKRKRWTG QVEMPKPSHL YKKNLDVTKI RKGKPQQLLR 
VDEHDFSMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM TLYLRHYWKD ERLAFSSASN 
KSMTFDGRLV KKIWVPDVFF VHSKRSFTHD TTTDNIMLRV FPDGHVLYSM RITVTAMCNM 
DFSHFPLDSQ TCSLELESYA YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA 
FYSSTGWYNR LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDRRAV PARVSLGITT 
VLTMTTIITG VNASMPRVSY VKAVDIYLWV SFVFVFLSVL EYAAVNYLTT VQERKERKLR 
EKFPCMCGML HSKTMMLDGS YSESEANSLA GYPRSHILTE EERQDKIVVH LGLSGEANAA 
RKKGLLKGQT GFRIFQNTHA IDKYSRLIFP ASYIFFNLIY WSVFS

Genular Protein ID: 1151405162

Symbol: B4DER2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DER2

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 13 Gene3D 2 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 1 Pfam 4 RefSeq 4 Rhea 1 RuleBase 1 SUPFAM 2

Sequence Information:

  • Length: 366
  • Mass: 42690
  • Checksum: 48BEC0340ABCF92F
  • Sequence:
    • MTLYLRHYWK DERLAFSSAS NKSMTFDGRL VKKIWVPDVF FVHSKRSFTH DTTTDNIMLR 
VFPDGHVLYS MRITVTAMCN MDFSHFPLDS QTCSLELESY AYTDEDLMLY WKNGDESLKT 
DEKISLSQFL IQKFHTTSRL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS 
WVSFWIDRRA VPARVSLGIT TVLTMTTIIT GVNASMPRVS YVKAVDIYLW VSFVFVFLSV 
LEYAAVNYLT TVQERKERKL REKFPCMCGM LHSKTMMLDG SYSESEANSL AGYPRSHILT 
EEERQDKIVV HLGLSGEANA ARKKGLLKGQ TGFRIFQNTH AIDKYSRLIF PASYIFFNLI 
YWSVFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.