Details for: CLDN5

Gene ID: 7122

Symbol: CLDN5

Ensembl ID: ENSG00000184113

Description: claudin 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.1784
    Cell Significance Index: -16.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.8441
    Cell Significance Index: -15.9400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 51.0259
    Cell Significance Index: -21.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.0553
    Cell Significance Index: -15.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.6755
    Cell Significance Index: -29.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2689
    Cell Significance Index: -16.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.5594
    Cell Significance Index: 204.2700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 7.7848
    Cell Significance Index: 55.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.4360
    Cell Significance Index: 61.7600
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 5.2939
    Cell Significance Index: 19.7300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 4.1843
    Cell Significance Index: 26.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1561
    Cell Significance Index: -16.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.5157
    Cell Significance Index: 28.0700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 2.8189
    Cell Significance Index: 38.6000
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: 2.3322
    Cell Significance Index: 15.0200
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.5062
    Cell Significance Index: 5.2400
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.3768
    Cell Significance Index: 11.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.1360
    Cell Significance Index: 29.0200
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.0604
    Cell Significance Index: 4.5600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0558
    Cell Significance Index: 15.1900
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.8683
    Cell Significance Index: 5.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.8342
    Cell Significance Index: 5.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.6468
    Cell Significance Index: 19.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4177
    Cell Significance Index: 14.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3883
    Cell Significance Index: 38.4100
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.2606
    Cell Significance Index: 1.7900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1841
    Cell Significance Index: 1.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0080
    Cell Significance Index: 1.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0071
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0086
    Cell Significance Index: -16.2800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0122
    Cell Significance Index: -0.1500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0138
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0144
    Cell Significance Index: -26.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0200
    Cell Significance Index: -3.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0226
    Cell Significance Index: -14.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0246
    Cell Significance Index: -13.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0246
    Cell Significance Index: -18.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0283
    Cell Significance Index: -15.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0324
    Cell Significance Index: -9.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0351
    Cell Significance Index: -15.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0364
    Cell Significance Index: -16.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0389
    Cell Significance Index: -13.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0403
    Cell Significance Index: -4.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0417
    Cell Significance Index: -2.5700
  • Cell Name: endothelial cell of respiratory system lymphatic vessel (CL0009086)
    Fold Change: -0.0446
    Cell Significance Index: -0.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0625
    Cell Significance Index: -8.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0807
    Cell Significance Index: -16.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0893
    Cell Significance Index: -18.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0969
    Cell Significance Index: -7.2300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0998
    Cell Significance Index: -1.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1001
    Cell Significance Index: -13.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1042
    Cell Significance Index: -17.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1055
    Cell Significance Index: -15.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1238
    Cell Significance Index: -12.6500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1319
    Cell Significance Index: -1.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1329
    Cell Significance Index: -15.6700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1390
    Cell Significance Index: -1.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1481
    Cell Significance Index: -18.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1582
    Cell Significance Index: -16.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1613
    Cell Significance Index: -18.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1716
    Cell Significance Index: -13.1700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1818
    Cell Significance Index: -2.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1839
    Cell Significance Index: -10.3200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2179
    Cell Significance Index: -1.7200
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: -0.2206
    Cell Significance Index: -1.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2228
    Cell Significance Index: -14.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2351
    Cell Significance Index: -11.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2401
    Cell Significance Index: -15.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2429
    Cell Significance Index: -14.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2441
    Cell Significance Index: -15.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2669
    Cell Significance Index: -11.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3356
    Cell Significance Index: -15.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3482
    Cell Significance Index: -9.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3588
    Cell Significance Index: -18.8400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4016
    Cell Significance Index: -8.5900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4040
    Cell Significance Index: -8.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4255
    Cell Significance Index: -19.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4293
    Cell Significance Index: -22.3000
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.4345
    Cell Significance Index: -3.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4694
    Cell Significance Index: -11.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4695
    Cell Significance Index: -12.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4699
    Cell Significance Index: -7.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4719
    Cell Significance Index: -15.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4762
    Cell Significance Index: -17.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4778
    Cell Significance Index: -16.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5019
    Cell Significance Index: -14.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5103
    Cell Significance Index: -13.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5284
    Cell Significance Index: -15.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5438
    Cell Significance Index: -17.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5507
    Cell Significance Index: -14.7100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5635
    Cell Significance Index: -6.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5646
    Cell Significance Index: -28.5300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.5803
    Cell Significance Index: -6.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5886
    Cell Significance Index: -14.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5929
    Cell Significance Index: -14.7900
  • Cell Name: endothelial cell of arteriole (CL1000412)
    Fold Change: -0.5981
    Cell Significance Index: -5.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6222
    Cell Significance Index: -16.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CLDN5 is a transmembrane protein with 18 transmembrane domains, consisting of four extracellular loops and four intracellular domains. It is expressed in various cell types, including endothelial cells, epithelial cells, and enteroendocrine cells. The protein is highly specific to the blood-retinal barrier and blood-brain barrier, where it plays a crucial role in maintaining the selective permeability of these barriers. **Pathways and Functions** CLDN5 is involved in various cellular processes, including: 1. **Cell-cell adhesion**: CLDN5 forms tight junctions with other claudin family members, ensuring the integrity of epithelial and endothelial barriers. 2. **Blood-retinal barrier formation**: CLDN5 is essential for the maintenance of the blood-retinal barrier, regulating the passage of ions and molecules between the bloodstream and the retina. 3. **Blood-brain barrier formation**: CLDN5 also plays a crucial role in maintaining the blood-brain barrier, regulating the passage of ions and molecules between the bloodstream and the brain. 4. **Endothelial barrier maintenance**: CLDN5 is involved in maintaining the integrity of the endothelial barrier of blood vessels, regulating the passage of ions and molecules between the bloodstream and the underlying tissues. 5. **Cell migration and angiogenesis**: CLDN5 has been shown to regulate cell migration and angiogenesis, influencing the formation of new blood vessels. **Clinical Significance** Dysregulation of CLDN5 has been implicated in various diseases, including: 1. **Retinal diseases**: Mutations in CLDN5 have been associated with retinal diseases, such as retinitis pigmentosa and macular degeneration. 2. **Neurological disorders**: CLDN5 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer**: CLDN5 has been shown to be involved in cancer progression, particularly in the formation of blood vessels and metastasis. 4. **Cardiovascular disease**: CLDN5 has been implicated in cardiovascular disease, particularly in the formation of atherosclerotic plaques and vascular permeability. In conclusion, CLDN5 is an essential protein involved in maintaining the integrity of epithelial and endothelial barriers, regulating cell-cell adhesion, and influencing various cellular processes. Dysregulation of CLDN5 has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 1774401821

Symbol: CLD5_HUMAN

Name: Claudin-5

UniProtKB Accession Codes:

O00501 B3KS11 Q53XW2 Q8WUW3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192844

Title: Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome.

PubMed ID: 9192844

DOI: 10.1006/geno.1997.4734

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 218
  • Mass: 23147
  • Checksum: 9F7F9E194D25425F
  • Sequence:
    • MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCVVQSTG 
HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA GAQCTTCVAP GPAKARVALT 
GGVLYLFCGL LALVPLCWFA NIVVREFYDP SVPVSQKYEL GAALYIGWAA TALLMVGGCL 
LCCGAWVCTG RPDLSFPVKY SAPRRPTATG DYDKKNYV

Genular Protein ID: 2871604910

Symbol: D3DX19_HUMAN

Name: N/A

UniProtKB Accession Codes:

D3DX19

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 4 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 4 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18477386

Title: Finishing the finished human chromosome 22 sequence.

PubMed ID: 18477386

DOI: 10.1186/gb-2008-9-5-r78

Sequence Information:

  • Length: 303
  • Mass: 31626
  • Checksum: 373519327EFBECDF
  • Sequence:
    • MTRARIGCFG PGGRARGTES APEPSKRVPP GRSWQTQEVR QTRGANGLGP RAGSAGAKAP 
GPAQGAAQHG LGGSAGLRVR VSPLAMGSAA LEILGLVLCL VGWGGLILAC GLPMWQVTAF 
LDHNIVTAQT TWKGLWMSCV VQSTGHMQCK VYDSVLALST EVQAARALTV SAVLLAFVAL 
FVTLAGAQCT TCVAPGPAKA RVALTGGVLY LFCGLLALVP LCWFANIVVR EFYDPSVPVS 
QKYELGAALY IGWAATALLM VGGCLLCCGA WVCTGRPDLS FPVKYSAPRR PTATGDYDKK 
NYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.