Details for: CLDN5

Gene ID: 7122

Symbol: CLDN5

Ensembl ID: ENSG00000184113

Description: claudin 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.82
    Marker Score: 14804
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.82
    Marker Score: 6984
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.94
    Marker Score: 3391
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.92
    Marker Score: 5693
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 3.14
    Marker Score: 1876
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.11
    Marker Score: 6220
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.65
    Marker Score: 2494
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.21
    Marker Score: 2223
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.11
    Marker Score: 818
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.11
    Marker Score: 3563
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.07
    Marker Score: 440
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.93
    Marker Score: 799
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.83
    Marker Score: 1652
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.62
    Marker Score: 394
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.55
    Marker Score: 339
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169185
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.38
    Marker Score: 1482
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.38
    Marker Score: 1234
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.34
    Marker Score: 313
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.3
    Marker Score: 331
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.26
    Marker Score: 304
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.13
    Marker Score: 708
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.07
    Marker Score: 249
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.05
    Marker Score: 1991
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.03
    Marker Score: 1108
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48031
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2446
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5301
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.85
    Marker Score: 215
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.85
    Marker Score: 564
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.84
    Marker Score: 215
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.81
    Marker Score: 222
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.74
    Marker Score: 3013
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.69
    Marker Score: 1445
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.68
    Marker Score: 451
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.65
    Marker Score: 230
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.61
    Marker Score: 257
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.6
    Marker Score: 989
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 393.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.55
    Marker Score: 152
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.54
    Marker Score: 8697
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.51
    Marker Score: 136
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.47
    Marker Score: 131
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.47
    Marker Score: 173
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.46
    Marker Score: 484
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.43
    Marker Score: 162
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.43
    Marker Score: 731.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.43
    Marker Score: 478
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.41
    Marker Score: 206
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.4
    Marker Score: 135
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.39
    Marker Score: 408
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.39
    Marker Score: 6089
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.34
    Marker Score: 110.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.33
    Marker Score: 148
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.31
    Marker Score: 156
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.31
    Marker Score: 89
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.3
    Marker Score: 77
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.28
    Marker Score: 98
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.28
    Marker Score: 523
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.27
    Marker Score: 258
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.26
    Marker Score: 240
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.26
    Marker Score: 525
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.25
    Marker Score: 126
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.25
    Marker Score: 121
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.24
    Marker Score: 314
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.24
    Marker Score: 143
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.24
    Marker Score: 417
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.23
    Marker Score: 134
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.23
    Marker Score: 83
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.22
    Marker Score: 193
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.22
    Marker Score: 153
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 121
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 193
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.19
    Marker Score: 39
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.19
    Marker Score: 43
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.19
    Marker Score: 218
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.19
    Marker Score: 327
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 183
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.19
    Marker Score: 120
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.18
    Marker Score: 47

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Other Information

**Key Characteristics** CLDN5 is a transmembrane protein with 18 transmembrane domains, consisting of four extracellular loops and four intracellular domains. It is expressed in various cell types, including endothelial cells, epithelial cells, and enteroendocrine cells. The protein is highly specific to the blood-retinal barrier and blood-brain barrier, where it plays a crucial role in maintaining the selective permeability of these barriers. **Pathways and Functions** CLDN5 is involved in various cellular processes, including: 1. **Cell-cell adhesion**: CLDN5 forms tight junctions with other claudin family members, ensuring the integrity of epithelial and endothelial barriers. 2. **Blood-retinal barrier formation**: CLDN5 is essential for the maintenance of the blood-retinal barrier, regulating the passage of ions and molecules between the bloodstream and the retina. 3. **Blood-brain barrier formation**: CLDN5 also plays a crucial role in maintaining the blood-brain barrier, regulating the passage of ions and molecules between the bloodstream and the brain. 4. **Endothelial barrier maintenance**: CLDN5 is involved in maintaining the integrity of the endothelial barrier of blood vessels, regulating the passage of ions and molecules between the bloodstream and the underlying tissues. 5. **Cell migration and angiogenesis**: CLDN5 has been shown to regulate cell migration and angiogenesis, influencing the formation of new blood vessels. **Clinical Significance** Dysregulation of CLDN5 has been implicated in various diseases, including: 1. **Retinal diseases**: Mutations in CLDN5 have been associated with retinal diseases, such as retinitis pigmentosa and macular degeneration. 2. **Neurological disorders**: CLDN5 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer**: CLDN5 has been shown to be involved in cancer progression, particularly in the formation of blood vessels and metastasis. 4. **Cardiovascular disease**: CLDN5 has been implicated in cardiovascular disease, particularly in the formation of atherosclerotic plaques and vascular permeability. In conclusion, CLDN5 is an essential protein involved in maintaining the integrity of epithelial and endothelial barriers, regulating cell-cell adhesion, and influencing various cellular processes. Dysregulation of CLDN5 has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 1774401821

Symbol: CLD5_HUMAN

Name: Claudin-5

UniProtKB Accession Codes:

O00501 B3KS11 Q53XW2 Q8WUW3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192844

Title: Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome.

PubMed ID: 9192844

DOI: 10.1006/geno.1997.4734

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 218
  • Mass: 23147
  • Checksum: 9F7F9E194D25425F
  • Sequence:
    • MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCVVQSTG 
HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA GAQCTTCVAP GPAKARVALT 
GGVLYLFCGL LALVPLCWFA NIVVREFYDP SVPVSQKYEL GAALYIGWAA TALLMVGGCL 
LCCGAWVCTG RPDLSFPVKY SAPRRPTATG DYDKKNYV

Genular Protein ID: 2871604910

Symbol: D3DX19_HUMAN

Name: N/A

UniProtKB Accession Codes:

D3DX19

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 4 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 4 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 303
  • Mass: 31626
  • Checksum: 373519327EFBECDF
  • Sequence:
    • MTRARIGCFG PGGRARGTES APEPSKRVPP GRSWQTQEVR QTRGANGLGP RAGSAGAKAP 
GPAQGAAQHG LGGSAGLRVR VSPLAMGSAA LEILGLVLCL VGWGGLILAC GLPMWQVTAF 
LDHNIVTAQT TWKGLWMSCV VQSTGHMQCK VYDSVLALST EVQAARALTV SAVLLAFVAL 
FVTLAGAQCT TCVAPGPAKA RVALTGGVLY LFCGLLALVP LCWFANIVVR EFYDPSVPVS 
QKYELGAALY IGWAATALLM VGGCLLCCGA WVCTGRPDLS FPVKYSAPRR PTATGDYDKK 
NYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.