Details for: CL0000115

Cell ID: CL0000115

Cell Name: endothelial cell

Marker Score Threshold: 896
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.

Synonyms: endotheliocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.54
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.32
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.49
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.21
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.02
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.99
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.71
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.67
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.66
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.59
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.52
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.51
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.47
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.46
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.41
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.4
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.36
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.33
    Ensembl ID: ENSG00000130303
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.3
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.25
    Ensembl ID: ENSG00000152518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.2
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.13
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.1
    Ensembl ID: ENSG00000122786
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.08
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.08
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.06
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.03
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.99
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.98
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143933
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.96
    Ensembl ID: ENSG00000100300
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.94
    Ensembl ID: ENSG00000155366
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.93
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.92
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.9
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.84
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.84
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.83
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.81
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.8
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.8
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.79
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.74
    Ensembl ID: ENSG00000168374
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.74
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.73
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.69
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.63
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.59
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.58
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.57
    Ensembl ID: ENSG00000160014
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.56
    Ensembl ID: ENSG00000104964
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.55
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.54
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.54
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.53
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.51
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.49
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.48
    Ensembl ID: ENSG00000140299
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.45
    Ensembl ID: ENSG00000149131
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.43
    Ensembl ID: ENSG00000138279
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.41
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.39
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.38
    Ensembl ID: ENSG00000072110
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.36
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.36
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.35
    Ensembl ID: ENSG00000087088
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.31
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.3
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.29
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.28
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.28
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.28
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.26
    Ensembl ID: ENSG00000128595
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.26
    Ensembl ID: ENSG00000107262
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.25
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.22
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.21
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.21
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.19
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.17
    Ensembl ID: ENSG00000198363
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.16
    Ensembl ID: ENSG00000163697
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.13
    Ensembl ID: ENSG00000147872
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.12
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 1.1
    Ensembl ID: ENSG00000139567
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.09
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.09
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.08
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.08
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.07
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.07
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.06
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.03
    Ensembl ID: ENSG00000058668
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143322
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.02
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.01
    Ensembl ID: ENSG00000106546
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Morphology**: Endothelial cells are typically squamous or cuboidal in shape, with a thin, flat shape that allows for efficient gas exchange and nutrient transport. 2. **Vimentin Filaments**: Endothelial cells are characterized by the presence of vimentin filaments, which provide structural support and maintain cell shape. 3. **Mesodermal Origin**: Endothelial cells are derived from the mesoderm, a layer of cells that gives rise to connective tissue, blood vessels, and other structures. 4. **Adaptive Immune System**: Endothelial cells play a critical role in the adaptive immune system, interacting with APCs to present antigens to T-cells. 5. **Iron Ion Homeostasis**: Endothelial cells regulate iron ion homeostasis, which is essential for maintaining proper immune function. **Clinical Significance** 1. **Vascular Health**: Endothelial cells play a critical role in maintaining vascular health, regulating blood flow, and preventing vascular disease. 2. **Immune Response**: Endothelial cells interact with APCs to present antigens to T-cells, facilitating immune responses and preventing infection. 3. **Iron Deficiency**: Endothelial cell dysfunction can lead to iron deficiency, which can impair immune function and increase the risk of infections. 4. **Inflammatory Disorders**: Endothelial cells are involved in the development of inflammatory disorders, such as atherosclerosis and rheumatoid arthritis. 5. **Cancer Metastasis**: Endothelial cells can facilitate cancer metastasis by providing a route for tumor cells to invade and colonize new tissues. In conclusion, endothelial cells are a critical component of the immune system, playing a key role in regulating immune responses and maintaining vascular health. Understanding the biology and function of endothelial cells is essential for developing effective treatments for various diseases, including vascular disorders and inflammatory conditions.