Details for: MB

Gene ID: 4151

Symbol: MB

Ensembl ID: ENSG00000198125

Description: myoglobin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 17.4882
    Cell Significance Index: -11.7400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 11.3216
    Cell Significance Index: 276.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 9.1150
    Cell Significance Index: 134.5700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 7.9274
    Cell Significance Index: 127.9100
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 6.1484
    Cell Significance Index: 17.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4016
    Cell Significance Index: -14.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.6633
    Cell Significance Index: 204.3800
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 1.5053
    Cell Significance Index: 11.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4461
    Cell Significance Index: 1305.7400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.3998
    Cell Significance Index: 17.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0800
    Cell Significance Index: 117.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0182
    Cell Significance Index: 61.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9287
    Cell Significance Index: 43.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9126
    Cell Significance Index: 148.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5793
    Cell Significance Index: 40.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5204
    Cell Significance Index: 7.1000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4971
    Cell Significance Index: 7.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4543
    Cell Significance Index: 15.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4477
    Cell Significance Index: 33.3700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4362
    Cell Significance Index: 4.5000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.3216
    Cell Significance Index: 1.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3141
    Cell Significance Index: 4.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2526
    Cell Significance Index: 48.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1538
    Cell Significance Index: 19.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1528
    Cell Significance Index: 15.1200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1517
    Cell Significance Index: 2.2700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1485
    Cell Significance Index: 1.9500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1210
    Cell Significance Index: 1.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0844
    Cell Significance Index: 2.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0651
    Cell Significance Index: 2.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0367
    Cell Significance Index: 20.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0274
    Cell Significance Index: 0.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0212
    Cell Significance Index: 3.8200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0175
    Cell Significance Index: 0.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0079
    Cell Significance Index: 5.4900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0067
    Cell Significance Index: 0.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0045
    Cell Significance Index: 0.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0015
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0085
    Cell Significance Index: -11.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0087
    Cell Significance Index: -16.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0123
    Cell Significance Index: -5.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0145
    Cell Significance Index: -10.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0162
    Cell Significance Index: -10.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0166
    Cell Significance Index: -1.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0171
    Cell Significance Index: -0.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0187
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0191
    Cell Significance Index: -10.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0202
    Cell Significance Index: -15.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0232
    Cell Significance Index: -10.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0255
    Cell Significance Index: -3.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0310
    Cell Significance Index: -3.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0324
    Cell Significance Index: -0.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0368
    Cell Significance Index: -1.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0378
    Cell Significance Index: -13.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0403
    Cell Significance Index: -11.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0458
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0537
    Cell Significance Index: -11.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0599
    Cell Significance Index: -11.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0661
    Cell Significance Index: -11.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0688
    Cell Significance Index: -10.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0695
    Cell Significance Index: -13.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0704
    Cell Significance Index: -8.0700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0887
    Cell Significance Index: -1.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0898
    Cell Significance Index: -6.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0986
    Cell Significance Index: -13.5400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1006
    Cell Significance Index: -1.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1079
    Cell Significance Index: -5.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1088
    Cell Significance Index: -1.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1181
    Cell Significance Index: -2.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1203
    Cell Significance Index: -14.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1419
    Cell Significance Index: -7.3700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1495
    Cell Significance Index: -1.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1611
    Cell Significance Index: -16.7700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1619
    Cell Significance Index: -1.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1768
    Cell Significance Index: -4.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1779
    Cell Significance Index: -3.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1856
    Cell Significance Index: -11.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1996
    Cell Significance Index: -12.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2068
    Cell Significance Index: -10.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2078
    Cell Significance Index: -13.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2163
    Cell Significance Index: -11.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2417
    Cell Significance Index: -5.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2439
    Cell Significance Index: -5.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2505
    Cell Significance Index: -2.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2593
    Cell Significance Index: -9.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2703
    Cell Significance Index: -3.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2737
    Cell Significance Index: -15.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2960
    Cell Significance Index: -4.4600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3002
    Cell Significance Index: -3.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3004
    Cell Significance Index: -6.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3045
    Cell Significance Index: -10.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3239
    Cell Significance Index: -8.5200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3264
    Cell Significance Index: -5.0500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3467
    Cell Significance Index: -8.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3495
    Cell Significance Index: -15.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3619
    Cell Significance Index: -9.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3707
    Cell Significance Index: -11.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Oxygen-binding capacity:** Myoglobin's high affinity for oxygen allows it to store and release oxygen in a controlled manner, making it an essential component in tissues with high energy demands, such as the heart and brain. 2. **Heme-binding properties:** Myoglobin's heme group is responsible for its oxygen-binding capacity, and its ability to bind metal ions, such as iron and copper, is essential for its function. 3. **Cell-type specificity:** Myoglobin is expressed in various cell types, including erythrocytes, cardiac muscle cells, and neurons, highlighting its adaptability and versatility in different tissues. 4. **Response to hypoxia:** Myoglobin's expression is upregulated in response to hypoxia, indicating its role in maintaining cellular homeostasis under conditions of low oxygen availability. **Pathways and Functions:** 1. **Oxygen transport and storage:** Myoglobin's ability to bind and release oxygen makes it essential for maintaining cellular oxygen levels, particularly in tissues with high energy demands. 2. **Heme binding and metabolism:** Myoglobin's heme group is involved in the regulation of heme metabolism, including the breakdown and recycling of heme. 3. **Nitrite reductase activity:** Myoglobin's ability to reduce nitrite to nitric oxide is essential for maintaining cellular homeostasis and preventing oxidative stress. 4. **Superoxide radical removal:** Myoglobin's peroxidase activity allows it to remove superoxide radicals, which are essential for maintaining cellular redox balance. **Clinical Significance:** 1. **Cardiovascular diseases:** Myoglobin's expression in cardiac muscle cells makes it an essential biomarker for cardiac stress and injury, such as myocardial infarction. 2. **Neurological disorders:** Myoglobin's expression in neurons suggests its potential role in maintaining cognitive function and neuroprotection. 3. **Hypoxia-related disorders:** Myoglobin's expression in response to hypoxia highlights its potential role in maintaining cellular homeostasis in conditions of low oxygen availability, such as anemia and chronic obstructive pulmonary disease (COPD). 4. **Cancer research:** Myoglobin's expression in various cell types, including cancer cells, suggests its potential role in cancer progression and metastasis. In conclusion, myoglobin is a multifaceted protein that plays a crucial role in maintaining cellular homeostasis, particularly in response to hypoxia. Its expression in various cell types and its involvement in multiple signaling pathways underscore its importance in maintaining tissue function and preventing disease. Further research is needed to fully elucidate the role of myoglobin in immunology and cellular function.

Genular Protein ID: 3183087238

Symbol: MYG_HUMAN

Name: N/A

UniProtKB Accession Codes:

P02144 Q52H51 Q5THY7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6571704

Title: Organization of the human myoglobin gene.

PubMed ID: 6571704

DOI: 10.1002/j.1460-2075.1984.tb01825.x

PubMed ID: 2989088

Title: Cloning of the human myoglobin gene.

PubMed ID: 2989088

DOI: 10.1016/0378-1119(85)90231-8

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 5285572

Title: Primary structure of human myoglobin.

PubMed ID: 5285572

DOI: 10.1038/newbio232149a0

PubMed ID: 11452891

Title: The myoglobin of primates. I. Hylobates agilis (gibbon).

PubMed ID: 11452891

DOI: 10.1016/0005-2795(71)90140-1

PubMed ID: 4627044

Title: The myoglobin of primates. II. Pan troglodytes (chimpanzee).

PubMed ID: 4627044

DOI: 10.1016/0005-2795(72)90107-9

PubMed ID: 7895732

Title: The human myocardial two-dimensional gel protein database: update 1994.

PubMed ID: 7895732

DOI: 10.1002/elps.11501501209

PubMed ID: 32891753

Title: Myoglobin promotes nitrite-dependent mitochondrial S-nitrosation to mediate cytoprotection after hypoxia/reoxygenation.

PubMed ID: 32891753

DOI: 10.1016/j.niox.2020.08.005

PubMed ID: 2342104

Title: X-ray crystal structure of a recombinant human myoglobin mutant at 2.8-A resolution.

PubMed ID: 2342104

DOI: 10.1016/s0022-2836(05)80181-0

PubMed ID: 5805522

Title: Abnormal human myoglobin: 53 (D4) glutamic acid-->lysine.

PubMed ID: 5805522

DOI: 10.1038/223832a0

PubMed ID: 5555219

Title: The third variant of human myoglobin showing an unusual amino acid substitution: 138(H16)arginine-->tryptophan.

PubMed ID: 5555219

DOI: 10.1016/0005-2795(71)90288-1

PubMed ID: 5555226

Title: A human myoglobin variant 133 (H-10)lysine-->asparagine.

PubMed ID: 5555226

DOI: 10.1016/0005-2795(71)90309-6

PubMed ID: 5540041

Title: The second variant of human myoglobin; 138(H16) arginine leads to glutamine.

PubMed ID: 5540041

DOI: 10.1111/j.1365-2141.1971.tb00787.x

PubMed ID: 30918256

Title: Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions.

PubMed ID: 30918256

DOI: 10.1038/s41467-019-09111-2

PubMed ID: 34679218

Title: Pseudoperoxidase activity, conformational stability, and aggregation propensity of the His98Tyr myoglobin variant: implications for the onset of myoglobinopathy.

PubMed ID: 34679218

DOI: 10.1111/febs.16235

PubMed ID: 35527200

Title: Myoglobinopathy affecting facial and oropharyngeal muscles.

PubMed ID: 35527200

DOI: 10.1016/j.nmd.2022.02.010

Sequence Information:

  • Length: 154
  • Mass: 17184
  • Checksum: F6A41F19A525F09C
  • Sequence:
    • MGLSDGEWQL VLNVWGKVEA DIPGHGQEVL IRLFKGHPET LEKFDKFKHL KSEDEMKASE 
DLKKHGATVL TALGGILKKK GHHEAEIKPL AQSHATKHKI PVKYLEFISE CIIQVLQSKH 
PGDFGADAQG AMNKALELFR KDMASNYKEL GFQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.