Details for: CLEC1B

Gene ID: 51266

Symbol: CLEC1B

Ensembl ID: ENSG00000165682

Description: C-type lectin domain family 1 member B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 10.7938
    Cell Significance Index: 219.6300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 8.5506
    Cell Significance Index: -1.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.4013
    Cell Significance Index: -1.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 3.7521
    Cell Significance Index: -1.9300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.9875
    Cell Significance Index: 28.4000
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.4102
    Cell Significance Index: 3.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.0706
    Cell Significance Index: -1.3200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.0140
    Cell Significance Index: 8.0100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8179
    Cell Significance Index: 11.7200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3820
    Cell Significance Index: 6.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2927
    Cell Significance Index: 4.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2786
    Cell Significance Index: 3.9900
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.2177
    Cell Significance Index: 1.5700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1288
    Cell Significance Index: 1.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0425
    Cell Significance Index: 1.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0205
    Cell Significance Index: 0.3000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0187
    Cell Significance Index: 0.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0170
    Cell Significance Index: 0.3200
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.0151
    Cell Significance Index: 0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0028
    Cell Significance Index: 0.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0030
    Cell Significance Index: -0.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0031
    Cell Significance Index: -1.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0042
    Cell Significance Index: -1.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0055
    Cell Significance Index: -1.1000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0062
    Cell Significance Index: -0.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0066
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0074
    Cell Significance Index: -0.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0075
    Cell Significance Index: -0.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0086
    Cell Significance Index: -1.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0089
    Cell Significance Index: -1.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0097
    Cell Significance Index: -0.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0105
    Cell Significance Index: -0.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0129
    Cell Significance Index: -1.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0130
    Cell Significance Index: -1.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0145
    Cell Significance Index: -1.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0157
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0169
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0177
    Cell Significance Index: -2.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0184
    Cell Significance Index: -1.2400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0191
    Cell Significance Index: -0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0205
    Cell Significance Index: -0.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0215
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0229
    Cell Significance Index: -0.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0233
    Cell Significance Index: -1.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0235
    Cell Significance Index: -1.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0238
    Cell Significance Index: -1.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0239
    Cell Significance Index: -0.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0242
    Cell Significance Index: -1.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0294
    Cell Significance Index: -1.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0305
    Cell Significance Index: -0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0334
    Cell Significance Index: -1.5700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0344
    Cell Significance Index: -0.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0356
    Cell Significance Index: -1.0500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0361
    Cell Significance Index: -0.5000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0365
    Cell Significance Index: -0.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0368
    Cell Significance Index: -1.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0369
    Cell Significance Index: -2.0700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0396
    Cell Significance Index: -0.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0400
    Cell Significance Index: -0.9700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0403
    Cell Significance Index: -0.6000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0406
    Cell Significance Index: -0.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0407
    Cell Significance Index: -0.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0409
    Cell Significance Index: -1.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0412
    Cell Significance Index: -1.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0413
    Cell Significance Index: -0.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0425
    Cell Significance Index: -1.3600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0432
    Cell Significance Index: -0.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0442
    Cell Significance Index: -0.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0447
    Cell Significance Index: -1.1400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0448
    Cell Significance Index: -0.5800
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0452
    Cell Significance Index: -0.4000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0460
    Cell Significance Index: -0.6600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0461
    Cell Significance Index: -0.5900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0466
    Cell Significance Index: -0.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0472
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0484
    Cell Significance Index: -1.3800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0485
    Cell Significance Index: -0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0489
    Cell Significance Index: -1.8500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0492
    Cell Significance Index: -0.5700
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0495
    Cell Significance Index: -0.3800
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0499
    Cell Significance Index: -0.6200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0515
    Cell Significance Index: -0.3700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0521
    Cell Significance Index: -0.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0528
    Cell Significance Index: -1.3500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0533
    Cell Significance Index: -0.5100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0558
    Cell Significance Index: -0.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0565
    Cell Significance Index: -1.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0571
    Cell Significance Index: -1.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLEC1B is a transmembrane receptor that belongs to the C-type lectin domain family, characterized by the presence of a C-type lectin domain, a transmembrane domain, and an intracellular domain. This structure enables CLEC1B to bind to specific carbohydrate ligands, interact with other receptors, and modulate downstream signaling pathways. Notably, CLEC1B is expressed in various cell types, including endothelial cells, hematopoietic cells, and immune cells, highlighting its broad tissue distribution and functional diversity. **Pathways and Functions:** CLEC1B is involved in multiple signaling pathways that regulate various cellular responses, including: 1. **Carbohydrate binding**: CLEC1B recognizes and binds to specific carbohydrate ligands, triggering a signaling cascade that modulates immune responses, inflammation, and cell adhesion. 2. **Cell surface receptor signaling pathway**: CLEC1B interacts with other receptors, such as the G protein-coupled receptor (GPCR) family, to regulate signaling pathways involved in cell proliferation, differentiation, and survival. 3. **Hemostasis**: CLEC1B plays a critical role in regulating platelet activation, aggregation, and formation, ensuring proper blood clotting and preventing excessive bleeding. 4. **Immune response**: CLEC1B modulates immune responses by regulating the activation and function of immune cells, such as dendritic cells, T cells, and B cells. 5. **Stress response**: CLEC1B is involved in the cellular response to stress, including heat shock, oxidative stress, and inflammation. **Clinical Significance:** The dysregulation of CLEC1B has been implicated in various diseases, including: 1. **Inflammatory disorders**: CLEC1B is overexpressed in inflammatory conditions, such as arthritis, atherosclerosis, and sepsis, suggesting its role in the regulation of immune responses and inflammation. 2. **Cancer**: CLEC1B has been shown to be overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer, indicating its potential as a biomarker and therapeutic target. 3. **Cardiovascular diseases**: CLEC1B plays a critical role in regulating platelet activation and aggregation, making it a potential target for the prevention and treatment of cardiovascular diseases. In conclusion, CLEC1B is a multifunctional protein that plays a critical role in various cellular processes, including immune response, hemostasis, and cellular signaling. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying CLEC1B function and its potential as a therapeutic target.

Genular Protein ID: 2563367542

Symbol: CLC1B_HUMAN

Name: C-type lectin domain family 1 member B

UniProtKB Accession Codes:

Q9P126 Q6UWX7 Q8NHR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10671229

Title: Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells.

PubMed ID: 10671229

DOI: 10.1002/1521-4141(200002)30:2<697::aid-immu697>3.0.co;2-m

PubMed ID: 16940507

Title: DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets.

PubMed ID: 16940507

DOI: 10.1128/jvi.00136-06

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16174766

Title: A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

PubMed ID: 16174766

DOI: 10.1182/blood-2005-05-1994

PubMed ID: 18215137

Title: Renal cells activate the platelet receptor CLEC-2 through podoplanin.

PubMed ID: 18215137

DOI: 10.1042/bj20071216

PubMed ID: 18955485

Title: G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.

PubMed ID: 18955485

DOI: 10.1074/jbc.m806895200

PubMed ID: 19785988

Title: RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation.

PubMed ID: 19785988

DOI: 10.1016/j.bbrc.2009.09.087

PubMed ID: 19824697

Title: The platelet receptor CLEC-2 is active as a dimer.

PubMed ID: 19824697

DOI: 10.1021/bi901427d

PubMed ID: 20154219

Title: CLEC-2 activates Syk through dimerization.

PubMed ID: 20154219

DOI: 10.1182/blood-2009-08-237834

PubMed ID: 17132623

Title: The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.

PubMed ID: 17132623

DOI: 10.1074/jbc.m610383200

Sequence Information:

  • Length: 229
  • Mass: 26596
  • Checksum: B39BF202AAE6DDD9
  • Sequence:
    • MQDEDGYITL NIKTRKPALI SVGSASSSWW RVMALILLIL CVGMVVGLVA LGIWSVMQRN 
YLQGENENRT GTLQQLAKRF CQYVVKQSEL KGTFKGHKCS PCDTNWRYYG DSCYGFFRHN 
LTWEESKQYC TDMNATLLKI DNRNIVEYIK ARTHLIRWVG LSRQKSNEVW KWEDGSVISE 
NMFEFLEDGK GNMNCAYFHN GKMHPTFCEN KHYLMCERKA GMTKVDQLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.