Details for: FGF23

Gene ID: 8074

Symbol: FGF23

Ensembl ID: ENSG00000118972

Description: fibroblast growth factor 23

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.14
    Marker Score: 2922
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.58
    Marker Score: 6979
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.58
    Marker Score: 200074
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.51
    Marker Score: 11083
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.27
    Marker Score: 172885
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.59
    Marker Score: 2455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2581
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1328
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.81
    Marker Score: 5355
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.65
    Marker Score: 170
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1211
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.48
    Marker Score: 7500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.47
    Marker Score: 219
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.37
    Marker Score: 153
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.35
    Marker Score: 204
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.32
    Marker Score: 359
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 185
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.31
    Marker Score: 90
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.3
    Marker Score: 84
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.21
    Marker Score: 51
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2
    Marker Score: 137
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 92
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 88
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.19
    Marker Score: 86
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.18
    Marker Score: 170
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.17
    Marker Score: 266
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.17
    Marker Score: 117
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.16
    Marker Score: 412
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 242
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.14
    Marker Score: 1225
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.13
    Marker Score: 71
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 134
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.11
    Marker Score: 83
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.11
    Marker Score: 58
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 224
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.1
    Marker Score: 281
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1
    Marker Score: 629
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 153
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.09
    Marker Score: 790
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.08
    Marker Score: 206
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.08
    Marker Score: 101
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.07
    Marker Score: 705
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.07
    Marker Score: 437
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.06
    Marker Score: 3955
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 83
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 238
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 103
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.05
    Marker Score: 40

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Other Information

**Key Characteristics** FGF23 is a member of the fibroblast growth factor family, which consists of 22 members involved in various biological processes, including development, growth, and differentiation. FGF23 is a secreted protein with a molecular weight of approximately 25 kDa. It is characterized by the presence of a conserved amino-terminal domain and a carboxy-terminal domain with a unique structure. FGF23 is highly conserved across species, with high sequence homology to its mammalian counterparts. **Pathways and Functions** FGF23 exerts its effects through binding to its specific receptor, FGF23R, which is expressed on the surface of various cells, including osteocytes, renal tubular cells, and neurons. The FGF23-FGF23R interaction triggers a signaling cascade that leads to the activation of several downstream pathways, including: 1. **Phosphate ion homeostasis**: FGF23 stimulates the reabsorption of phosphate in the kidneys, leading to increased phosphate excretion in the urine. 2. **Calcium ion homeostasis**: FGF23 regulates calcium levels by inhibiting the expression of calcium-sensing receptors on osteocytes, leading to increased bone resorption and release of calcium into the bloodstream. 3. **Cell differentiation and proliferation**: FGF23 regulates the differentiation and proliferation of various cell types, including osteoblasts, chondrocytes, and neurons. 4. **Inflammation and immune response**: FGF23 modulates the expression of inflammatory cytokines and chemokines, influencing the immune response and tissue damage. **Clinical Significance** Dysregulation of FGF23 has been implicated in various diseases, including: 1. **Kidney disease**: Elevated FGF23 levels have been observed in patients with chronic kidney disease, where it contributes to the development of secondary hyperparathyroidism and osteodystrophy. 2. **Osteoporosis**: Abnormal FGF23 levels have been linked to osteoporosis, particularly in patients with vitamin D deficiency. 3. **Metabolic disorders**: FGF23 dysregulation has been implicated in metabolic disorders, such as type 2 diabetes and cardiovascular disease. 4. **Neurological disorders**: FGF23 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FGF23 is a critical regulator of phosphate homeostasis and mineral ion metabolism, with significant implications for various diseases. Further research is needed to fully understand the mechanisms of FGF23 action and its role in disease pathology.

Genular Protein ID: 2226208968

Symbol: FGF23_HUMAN

Name: Fibroblast growth factor 23

UniProtKB Accession Codes:

Q9GZV9 Q4V758

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 9 EMDB 2 Ensembl 1 EvolutionaryTrace 1 GO 33 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 40 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11032749

Title: Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain.

PubMed ID: 11032749

DOI: 10.1006/bbrc.2000.3696

PubMed ID: 11062477

Title: Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.

PubMed ID: 11062477

DOI: 10.1038/81664

PubMed ID: 11344269

Title: Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia.

PubMed ID: 11344269

DOI: 10.1073/pnas.101545198

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11409890

Title: FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate.

PubMed ID: 11409890

DOI: 10.1006/bbrc.2001.5084

PubMed ID: 11157998

Title: The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting.

PubMed ID: 11157998

DOI: 10.1210/jcem.86.2.7408

PubMed ID: 12130585

Title: Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo.

PubMed ID: 12130585

DOI: 10.1210/endo.143.8.8795

PubMed ID: 12952917

Title: FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting.

PubMed ID: 12952917

DOI: 10.1172/jci18399

PubMed ID: 15268897

Title: FGF23 is processed by proprotein convertases but not by PHEX.

PubMed ID: 15268897

DOI: 10.1016/j.bone.2004.04.002

PubMed ID: 15040831

Title: FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis.

PubMed ID: 15040831

DOI: 10.1359/jbmr.0301264

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 16638743

Title: Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation.

PubMed ID: 16638743

DOI: 10.1074/jbc.m602469200

PubMed ID: 18282132

Title: Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro.

PubMed ID: 18282132

DOI: 10.1359/jbmr.080220

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 31932717

Title: Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.

PubMed ID: 31932717

DOI: 10.1038/s41589-019-0444-x

PubMed ID: 17339340

Title: Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.

PubMed ID: 17339340

DOI: 10.1128/mcb.02249-06

PubMed ID: 16151858

Title: A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification.

PubMed ID: 16151858

DOI: 10.1007/s00439-005-0026-8

PubMed ID: 15590700

Title: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

PubMed ID: 15590700

DOI: 10.1093/hmg/ddi034

PubMed ID: 16030159

Title: A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis.

PubMed ID: 16030159

DOI: 10.1210/jc.2005-0301

PubMed ID: 24680727

Title: A new missense mutation in FGF23 gene in a male with hyperostosis-hyperphosphatemia syndrome (HHS).

PubMed ID: 24680727

DOI: 10.1016/j.gene.2014.03.052

Sequence Information:

  • Length: 251
  • Mass: 27954
  • Checksum: 6093BD0CC50C2489
  • Sequence:
    • MLGARLRLWV CALCSVCSMS VLRAYPNASP LLGSSWGGLI HLYTATARNS YHLQIHKNGH 
VDGAPHQTIY SALMIRSEDA GFVVITGVMS RRYLCMDFRG NIFGSHYFDP ENCRFQHQTL 
ENGYDVYHSP QYHFLVSLGR AKRAFLPGMN PPPYSQFLSR RNEIPLIHFN TPIPRRHTRS 
AEDDSERDPL NVLKPRARMT PAPASCSQEL PSAEDNSPMA SDPLGVVRGG RVNTHAGGTG 
PEGCRPFAKF I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.