FGF23 | ENSG00000118972 | NCBI 8074

Details for: FGF23

Gene ID: 8074

Symbol: FGF23

Ensembl ID: ENSG00000118972

Description: fibroblast growth factor 23

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1c and klotho ligand binding and activation
(R-HSA-190374)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism of proteins
(R-HSA-392499)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Calcium ion homeostasis
(GO:0055074)
Cellular response to interleukin-6
(GO:0071354)
Cellular response to leptin stimulus
(GO:0044320)
Cellular response to parathyroid hormone stimulus
(GO:0071374)
Cellular response to vitamin d
(GO:0071305)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular region
(GO:0005576)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Intracellular phosphate ion homeostasis
(GO:0030643)
Negative regulation of bone mineralization
(GO:0030502)
Negative regulation of hormone secretion
(GO:0046888)
Negative regulation of osteoblast differentiation
(GO:0045668)
Neurogenesis
(GO:0022008)
Phosphate ion homeostasis
(GO:0055062)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mapkkk cascade by fibroblast growth factor receptor signaling pathway
(GO:0090080)
Positive regulation of vitamin d 24-hydroxylase activity
(GO:0010980)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Regulation of phosphate transport
(GO:0010966)
Response to magnesium ion
(GO:0032026)
Response to sodium phosphate
(GO:1904383)
Type 1 fibroblast growth factor receptor binding
(GO:0005105)
Vitamin d catabolic process
(GO:0042369)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 33.0965
Cell Significance Index: 180.4700
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 10.4793
Cell Significance Index: -1.6300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 5.5984
Cell Significance Index: -1.4200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 1.3382
Cell Significance Index: -1.6500
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.7825
Cell Significance Index: 8.1000
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.7733
Cell Significance Index: 6.1100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 0.4181
Cell Significance Index: -1.6500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3075
Cell Significance Index: 7.9000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3042
Cell Significance Index: 19.1700
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.2083
Cell Significance Index: 1.2300
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.1861
Cell Significance Index: 8.0900
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.1115
Cell Significance Index: 1.4400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0983
Cell Significance Index: 4.4600
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.0948
Cell Significance Index: 0.7000
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.0547
Cell Significance Index: 0.4400
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.0520
Cell Significance Index: 0.3500
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.0493
Cell Significance Index: 0.5800
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0411
Cell Significance Index: 0.5700
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0392
Cell Significance Index: 0.5500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0376
Cell Significance Index: 7.5500
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.0366
Cell Significance Index: 0.3000
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.0275
Cell Significance Index: 0.3800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0241
Cell Significance Index: 0.6000
Cell Name: keratocyte (CL0002363)
Fold Change: 0.0221
Cell Significance Index: 0.3500
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.0204
Cell Significance Index: 0.1300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0156
Cell Significance Index: 0.8100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0136
Cell Significance Index: 3.9100
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.0099
Cell Significance Index: 0.1200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0094
Cell Significance Index: 0.1400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0041
Cell Significance Index: 1.4600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0029
Cell Significance Index: 0.5800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0001
Cell Significance Index: -0.1200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0002
Cell Significance Index: -0.4100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0007
Cell Significance Index: -1.1200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0013
Cell Significance Index: -1.7100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0022
Cell Significance Index: -1.6000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0024
Cell Significance Index: -1.5500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0027
Cell Significance Index: -1.4700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0028
Cell Significance Index: -0.4000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0028
Cell Significance Index: -1.5900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0029
Cell Significance Index: -0.2200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0033
Cell Significance Index: -1.5200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0042
Cell Significance Index: -0.4900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0061
Cell Significance Index: -1.1000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0078
Cell Significance Index: -1.6400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0086
Cell Significance Index: -1.4600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0097
Cell Significance Index: -0.1800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0098
Cell Significance Index: -1.3400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0103
Cell Significance Index: -0.6900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0115
Cell Significance Index: -0.3300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0131
Cell Significance Index: -1.6100
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.0137
Cell Significance Index: -0.1300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0152
Cell Significance Index: -1.5800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0154
Cell Significance Index: -0.4900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0165
Cell Significance Index: -0.5800
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0167
Cell Significance Index: -0.2400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0168
Cell Significance Index: -0.5500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0181
Cell Significance Index: -1.8500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0191
Cell Significance Index: -1.1700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0193
Cell Significance Index: -0.5500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0194
Cell Significance Index: -1.1900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0210
Cell Significance Index: -1.1000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0234
Cell Significance Index: -0.3500
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0234
Cell Significance Index: -0.5700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0243
Cell Significance Index: -1.5700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0248
Cell Significance Index: -0.8700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0258
Cell Significance Index: -1.4500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0265
Cell Significance Index: -1.1700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0285
Cell Significance Index: -1.0800
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0292
Cell Significance Index: -0.4000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0301
Cell Significance Index: -1.4200
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0315
Cell Significance Index: -0.5300
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.0328
Cell Significance Index: -0.5300
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0341
Cell Significance Index: -0.4900
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.0379
Cell Significance Index: -0.3800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0380
Cell Significance Index: -0.9500
Cell Name: osteoclast (CL0000092)
Fold Change: -0.0392
Cell Significance Index: -0.4000
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.0392
Cell Significance Index: -0.3500
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0396
Cell Significance Index: -0.8400
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0413
Cell Significance Index: -1.0300
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0415
Cell Significance Index: -0.8100
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0428
Cell Significance Index: -0.8600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0440
Cell Significance Index: -1.1800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0454
Cell Significance Index: -0.9500
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0467
Cell Significance Index: -0.9500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0481
Cell Significance Index: -1.0400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0500
Cell Significance Index: -1.6000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0512
Cell Significance Index: -1.7800
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0515
Cell Significance Index: -0.7600
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0522
Cell Significance Index: -1.3300
Cell Name: salivary gland cell (CL0009005)
Fold Change: -0.0532
Cell Significance Index: -0.6600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0539
Cell Significance Index: -1.9800
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0541
Cell Significance Index: -0.7700
Cell Name: platelet (CL0000233)
Fold Change: -0.0544
Cell Significance Index: -0.5600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0547
Cell Significance Index: -1.4600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0551
Cell Significance Index: -1.5000
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0552
Cell Significance Index: -1.0800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0553
Cell Significance Index: -1.6300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0554
Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FGF23 is a secreted protein that belongs to the fibroblast growth factor family. It is characterized by its ability to bind to specific receptors, including FGFR2, FGFR3, and FGFR4, which activate downstream signaling pathways. FGF23 has several key characteristics that distinguish it from other growth factors: 1. **Phosphate-regulating activity**: FGF23 acts as a regulator of phosphate homeostasis by inhibiting renal phosphate reabsorption and promoting phosphate excretion. 2. **Vitamin D metabolism**: FGF23 regulates vitamin D metabolism by inhibiting the expression of 1-alpha-hydroxylase, an enzyme essential for converting 25-hydroxyvitamin D to its active form, 1,25-dihydroxyvitamin D. 3. **Bone mineralization**: FGF23 regulates osteoclast activity and bone mineralization by modulating the expression of genes involved in bone formation and resorption. 4. **Cellular localization**: FGF23 is primarily produced in osteocytes and bone cells, where it regulates bone metabolism. **Pathways and Functions** FGF23 is involved in several signaling pathways that regulate various physiological processes, including: 1. **Calcium and phosphate homeostasis**: FGF23 regulates phosphate reabsorption and excretion in the kidneys, maintaining calcium and phosphate balance in the body. 2. **Vitamin D metabolism**: FGF23 inhibits the expression of 1-alpha-hydroxylase, regulating vitamin D metabolism and bone mineralization. 3. **Bone metabolism**: FGF23 regulates osteoclast activity and bone mineralization by modulating the expression of genes involved in bone formation and resorption. 4. **Cell proliferation and differentiation**: FGF23 regulates cell proliferation and differentiation by activating downstream signaling pathways, including the ERK1/2 and PI3K/AKT cascades. **Clinical Significance** Dysregulation of FGF23 has been implicated in various diseases, including: 1. **Renal failure**: Elevated FGF23 levels are associated with progressive kidney disease and cardiovascular mortality. 2. **Osteodystrophy**: Abnormal FGF23 expression is linked to osteomalacia, osteoporosis, and other bone disorders. 3. **Vascular calcification**: Elevated FGF23 levels are associated with vascular calcification and cardiovascular disease. 4. **Neurological disorders**: FGF23 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FGF23 is a critical regulator of phosphate homeostasis and vitamin D metabolism. Its dysregulation has significant clinical implications, and further research is needed to fully understand the mechanisms underlying its role in various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 23

Genular Protein ID: 2226208968

Symbol: FGF23_HUMAN

Name: Fibroblast growth factor 23

UniProtKB Accession Codes:

Q9GZV9 Q4V758

Database IDs:

Citations:

PubMed ID: 11032749

Title: Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain.

PubMed ID: 11032749

DOI: 10.1006/bbrc.2000.3696

PubMed ID: 11062477

Title: Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.

PubMed ID: 11062477

DOI: 10.1038/81664

PubMed ID: 11344269

Title: Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia.

PubMed ID: 11344269

DOI: 10.1073/pnas.101545198

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11409890

Title: FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate.

PubMed ID: 11409890

DOI: 10.1006/bbrc.2001.5084

PubMed ID: 11157998

Title: The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting.

PubMed ID: 11157998

DOI: 10.1210/jcem.86.2.7408

PubMed ID: 12130585

Title: Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo.

PubMed ID: 12130585

DOI: 10.1210/endo.143.8.8795

PubMed ID: 12952917

Title: FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting.

PubMed ID: 12952917

DOI: 10.1172/jci18399

PubMed ID: 15268897

Title: FGF23 is processed by proprotein convertases but not by PHEX.

PubMed ID: 15268897

DOI: 10.1016/j.bone.2004.04.002

PubMed ID: 15040831

Title: FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis.

PubMed ID: 15040831

DOI: 10.1359/jbmr.0301264

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 16638743

Title: Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation.

PubMed ID: 16638743

DOI: 10.1074/jbc.m602469200

PubMed ID: 18282132

Title: Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro.

PubMed ID: 18282132

DOI: 10.1359/jbmr.080220

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 31932717

Title: Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.

PubMed ID: 31932717

DOI: 10.1038/s41589-019-0444-x

PubMed ID: 17339340

Title: Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.

PubMed ID: 17339340

DOI: 10.1128/mcb.02249-06

PubMed ID: 16151858

Title: A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification.

PubMed ID: 16151858

DOI: 10.1007/s00439-005-0026-8

PubMed ID: 15590700

Title: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

PubMed ID: 15590700

DOI: 10.1093/hmg/ddi034

PubMed ID: 16030159

Title: A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis.

PubMed ID: 16030159

DOI: 10.1210/jc.2005-0301

PubMed ID: 24680727

Title: A new missense mutation in FGF23 gene in a male with hyperostosis-hyperphosphatemia syndrome (HHS).

PubMed ID: 24680727

DOI: 10.1016/j.gene.2014.03.052

Sequence Information:

Length: 251
Mass: 27954
Checksum: 6093BD0CC50C2489
Sequence:

MLGARLRLWV CALCSVCSMS VLRAYPNASP LLGSSWGGLI HLYTATARNS YHLQIHKNGH 
VDGAPHQTIY SALMIRSEDA GFVVITGVMS RRYLCMDFRG NIFGSHYFDP ENCRFQHQTL 
ENGYDVYHSP QYHFLVSLGR AKRAFLPGMN PPPYSQFLSR RNEIPLIHFN TPIPRRHTRS 
AEDDSERDPL NVLKPRARMT PAPASCSQEL PSAEDNSPMA SDPLGVVRGG RVNTHAGGTG 
PEGCRPFAKF I

Database document:

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Details for: FGF23

Associated with

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Other Information

Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. PubMed ID: 11032749

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. PubMed ID: 11062477

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. PubMed ID: 11344269

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. PubMed ID: 11409890

The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting. PubMed ID: 11157998

Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo. PubMed ID: 12130585

FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. PubMed ID: 12952917

FGF23 is processed by proprotein convertases but not by PHEX. PubMed ID: 15268897

FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. PubMed ID: 15040831

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. PubMed ID: 16638743

Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro. PubMed ID: 18282132

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3. PubMed ID: 31932717

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. PubMed ID: 17339340

A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification. PubMed ID: 16151858

An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. PubMed ID: 15590700

A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis. PubMed ID: 16030159

A new missense mutation in FGF23 gene in a male with hyperostosis-hyperphosphatemia syndrome (HHS). PubMed ID: 24680727