Details for: TPO

Gene ID: 7173

Symbol: TPO

Ensembl ID: ENSG00000115705

Description: thyroid peroxidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.3071
    Cell Significance Index: 47.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.4463
    Cell Significance Index: 21.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4311
    Cell Significance Index: 31.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.8267
    Cell Significance Index: 50.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3967
    Cell Significance Index: 75.4900
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.3533
    Cell Significance Index: 2.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3238
    Cell Significance Index: 19.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1975
    Cell Significance Index: 3.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1937
    Cell Significance Index: 5.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1673
    Cell Significance Index: 18.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1447
    Cell Significance Index: 2.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0865
    Cell Significance Index: 5.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0854
    Cell Significance Index: 77.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0815
    Cell Significance Index: 1.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0801
    Cell Significance Index: 50.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0761
    Cell Significance Index: 7.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0532
    Cell Significance Index: 8.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0390
    Cell Significance Index: 7.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0170
    Cell Significance Index: 0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0066
    Cell Significance Index: 9.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0028
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0027
    Cell Significance Index: 5.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0017
    Cell Significance Index: 0.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0012
    Cell Significance Index: 0.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0003
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0012
    Cell Significance Index: -0.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0035
    Cell Significance Index: -1.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0041
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0069
    Cell Significance Index: -1.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0071
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0083
    Cell Significance Index: -1.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0109
    Cell Significance Index: -1.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0140
    Cell Significance Index: -1.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0152
    Cell Significance Index: -2.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0159
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0173
    Cell Significance Index: -3.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0216
    Cell Significance Index: -1.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0217
    Cell Significance Index: -2.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0260
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0273
    Cell Significance Index: -3.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0275
    Cell Significance Index: -3.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0312
    Cell Significance Index: -4.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0315
    Cell Significance Index: -3.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0326
    Cell Significance Index: -0.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0349
    Cell Significance Index: -2.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0440
    Cell Significance Index: -1.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0453
    Cell Significance Index: -0.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0489
    Cell Significance Index: -1.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0523
    Cell Significance Index: -3.9000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0528
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0599
    Cell Significance Index: -1.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0601
    Cell Significance Index: -3.8800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0635
    Cell Significance Index: -0.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0651
    Cell Significance Index: -1.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0657
    Cell Significance Index: -3.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0675
    Cell Significance Index: -2.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0693
    Cell Significance Index: -3.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0778
    Cell Significance Index: -2.4600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0779
    Cell Significance Index: -1.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0796
    Cell Significance Index: -3.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0817
    Cell Significance Index: -2.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0845
    Cell Significance Index: -2.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0855
    Cell Significance Index: -3.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0887
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0890
    Cell Significance Index: -2.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0898
    Cell Significance Index: -2.9400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0898
    Cell Significance Index: -2.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0915
    Cell Significance Index: -2.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0931
    Cell Significance Index: -1.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1025
    Cell Significance Index: -3.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1133
    Cell Significance Index: -2.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1161
    Cell Significance Index: -3.1000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1167
    Cell Significance Index: -1.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1173
    Cell Significance Index: -3.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1173
    Cell Significance Index: -2.9300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1211
    Cell Significance Index: -1.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1215
    Cell Significance Index: -3.4000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1272
    Cell Significance Index: -2.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1291
    Cell Significance Index: -3.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1299
    Cell Significance Index: -4.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1306
    Cell Significance Index: -1.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1310
    Cell Significance Index: -3.5100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1327
    Cell Significance Index: -1.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1350
    Cell Significance Index: -3.8700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1366
    Cell Significance Index: -1.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1397
    Cell Significance Index: -3.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1425
    Cell Significance Index: -1.8000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1483
    Cell Significance Index: -2.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1489
    Cell Significance Index: -1.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1502
    Cell Significance Index: -7.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1517
    Cell Significance Index: -1.5700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1521
    Cell Significance Index: -2.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1550
    Cell Significance Index: -2.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TPO is a heterodimeric enzyme consisting of two subunits, alpha and beta. The alpha subunit contains a catalytic domain, while the beta subunit has a thyroid hormone-binding domain. TPO is highly specific for iodide oxidation, with a high affinity for iodide and a low affinity for other substrates. The enzyme is also capable of generating hydrogen peroxide, which can have both antioxidant and pro-oxidant effects. **Pathways and Functions:** TPO's primary function is in the thyroid gland, where it plays a crucial role in thyroid hormone synthesis. However, its expression in other cell types has revealed a broader range of functions. TPO is involved in: 1. **Cellular oxidant detoxification:** TPO can convert hydrogen peroxide into water and oxygen, thereby regulating oxidative stress levels. 2. **Hormone biosynthesis:** TPO is essential for the synthesis of thyroid hormones, including thyroxine (T4) and triiodothyronine (T3). 3. **Immune cell regulation:** TPO has been found in various immune cells, including granulocytes, monocytes, and dendritic cells, where it may play a role in regulating oxidative stress and inflammation. 4. **Antioxidant activity:** TPO can scavenge reactive oxygen species (ROS) and reduce oxidative damage to cells. **Clinical Significance:** TPO's involvement in immune-related disorders has been implicated in several diseases, including: 1. **Autoimmune thyroid disease:** TPO antibodies are a hallmark of autoimmune thyroid disease, such as Hashimoto's thyroiditis and Graves' disease. 2. **Atherosclerosis:** Elevated TPO levels have been linked to atherosclerosis, a condition characterized by the buildup of plaque in arterial walls. 3. **Cancer:** TPO has been found to be overexpressed in certain types of cancer, including breast and ovarian cancer. 4. **Neurodegenerative diseases:** TPO may play a role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, TPO is a multifaceted enzyme with a complex role in thyroid hormone production and immune function. Its widespread expression in various cell types has revealed a broader range of functions, including cellular oxidant detoxification, hormone biosynthesis, and immune cell regulation. Further research is needed to fully elucidate the clinical significance of TPO in immune-related disorders and to explore its potential as a therapeutic target.

Genular Protein ID: 3958855602

Symbol: PERT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P07202 P09934 P09935 Q8IUL0 Q8NF94 Q8NF95 Q8NF96 Q8NF97 Q8TCI9

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChEBI 39 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 5 EMBL 27 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 1 RefSeq 7 Rhea 16 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3475693

Title: Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs.

PubMed ID: 3475693

DOI: 10.1073/pnas.84.16.5555

PubMed ID: 3453124

Title: Complete nucleotide sequence of the human thyroperoxidase-microsomal antigen cDNA.

PubMed ID: 3453124

DOI: 10.1093/nar/15.16.6735

PubMed ID: 2548579

Title: Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene.

PubMed ID: 2548579

DOI: 10.1021/bi00436a054

PubMed ID: 2308857

Title: Nucleotide sequence of the alternatively spliced human thyroid peroxidase cDNA, TPO-2.

PubMed ID: 2308857

DOI: 10.1093/nar/18.3.670

PubMed ID: 12454013

Title: Increasing diversity of human thyroperoxidase generated by alternative splicing. Characterization by molecular cloning of new transcripts with single- and multispliced mRNAs.

PubMed ID: 12454013

DOI: 10.1074/jbc.m209513200

PubMed ID: 3654979

Title: Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase.

PubMed ID: 3654979

DOI: 10.1172/jci113181

PubMed ID: 2383265

Title: Evidence for an alternate splicing in the thyroperoxidase messenger from patients with Graves' disease.

PubMed ID: 2383265

DOI: 10.1016/0006-291x(90)92152-p

PubMed ID: 15561711

Title: Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.

PubMed ID: 15561711

DOI: 10.1074/jbc.m407709200

PubMed ID: 7550241

Title: Identification of five novel inactivating mutations in the human thyroid peroxidase gene by denaturing gradient gel electrophoresis.

PubMed ID: 7550241

DOI: 10.1002/humu.1380060104

PubMed ID: 9024270

Title: Molecular analysis of mutated thyroid peroxidase detected in patients with total iodide organification defects.

PubMed ID: 9024270

DOI: 10.1210/jcem.82.2.3729

PubMed ID: 10468986

Title: A novel mutation in the TPO gene in goitrous hypothyroid patients with iodide organification defect.

PubMed ID: 10468986

DOI: 10.1046/j.1365-2265.1999.00746.x

PubMed ID: 10084596

Title: Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping.

PubMed ID: 10084596

DOI: 10.1210/jcem.84.3.5541

PubMed ID: 9924196

Title: A novel mutation in the human thyroid peroxidase gene resulting in a total iodide organification defect.

PubMed ID: 9924196

DOI: 10.1677/joe.0.1600267

PubMed ID: 11061528

Title: Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update).

PubMed ID: 11061528

DOI: 10.1210/jcem.85.10.6878

PubMed ID: 11415848

Title: Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism.

PubMed ID: 11415848

DOI: 10.1530/eje.0.1450019

PubMed ID: 11916616

Title: Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism.

PubMed ID: 11916616

DOI: 10.1530/eje.0.1460491

PubMed ID: 12213873

Title: High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect.

PubMed ID: 12213873

DOI: 10.1210/jc.2002-020153

PubMed ID: 11874711

Title: Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations.

PubMed ID: 11874711

DOI: 10.1677/joe.0.1720627

PubMed ID: 12490071

Title: Genetics of specific phenotypes of congenital hypothyroidism: a population-based approach.

PubMed ID: 12490071

DOI: 10.1089/105072502320908277

PubMed ID: 12864797

Title: Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings.

PubMed ID: 12864797

DOI: 10.1046/j.1365-2265.2003.01823.x

PubMed ID: 12938097

Title: Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect.

PubMed ID: 12938097

DOI: 10.1002/humu.9175

PubMed ID: 12843174

Title: Monoallelic expression of mutant thyroid peroxidase allele causing total iodide organification defect.

PubMed ID: 12843174

DOI: 10.1210/jc.2002-021377

PubMed ID: 16284446

Title: Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism.

PubMed ID: 16284446

DOI: 10.1507/endocrj.52.643

PubMed ID: 16684826

Title: Goitrous congenital hypothyroidism and hearing impairment associated with mutations in the TPO and SLC26A4/PDS genes.

PubMed ID: 16684826

DOI: 10.1210/jc.2006-0142

PubMed ID: 27305979

Title: Mutations in the genes for thyroglobulin and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability.

PubMed ID: 27305979

DOI: 10.1038/jhg.2016.62

Sequence Information:

  • Length: 933
  • Mass: 102963
  • Checksum: F67C5F1A4AEE0B29
  • Sequence:
    • MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV DTAMYATMQR 
NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA MKRKVNLKTQ QSQHPTDALS 
EDLLSIIANM SGCLPYMLPP KCPNTCLANK YRPITGACNN RDHPRWGASN TALARWLPPV 
YEDGFSQPRG WNPGFLYNGF PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD 
IAFTPQSTSK AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD 
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL RVHARLRDSG 
RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV PSLTALHTLW LREHNRLAAA 
LKALNAHWSA DAVYQEARKV VGALHQIITL RDYIPRILGP EAFQQYVGPY EGYDSTANPT 
VSNVFSTAAF RFGHATIHPL VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR 
GLLARPAKLQ VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL 
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG PLFACLIGKQ 
MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG LTRVPMDAFQ VGKFPEDFES 
CDSITGMNLE AWRETFPQDD KCGFPESVEN GDFVHCEESG RRVLVYSCRH GYELQGREQL 
TCTQEGWDFQ PPLCKDVNEC ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD 
SGRLPRVTWI SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ 
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL

Genular Protein ID: 3336246376

Symbol: Q502Y3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q502Y3

Database IDs:

ARBA 23 Allergome 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 31 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 5 EMBL 2 GO 8 Gene3D 3 InterPro 12 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 PeroxiBase 1 Pfam 3 PharmGKB 1 RefSeq 4 Rhea 16 SAM 3 SMART 3 SMR 1 SUPFAM 3 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 933
  • Mass: 102937
  • Checksum: C0148BC7787238E7
  • Sequence:
    • MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV DTAMYATMQR 
NLKKRGILSA AQLLSFSKLP EPTSGVIARA AEIMETSIQA MKRKVNLKTQ QSQHPTDALS 
EDLLSIIANM SGCLPYMLPP KCPNTCLANK YRPITGACNN RDHPRWGASN TALARWLPPV 
YEDGFSQPRG WNPGFLYNGF PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD 
IAFTPQSTSK AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD 
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL RVHARLRDSG 
RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV PSLTALHTLW LREHNRLAAA 
LKALNAHWSA DAVYQEARKV VGALHQIITL RDYIPRILGP EAFQQYVGPY EGYDSTANPT 
VSNVFSTAAF RFGHATIHPL VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR 
GLLARPAKLQ VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL 
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG PLFACLIGKQ 
MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG LTRVPMDAFQ VGKFPEDFES 
CDSITGMNLE AWRETFPQDD KCGFPESVEN GDFVHCEESG RRVLVYSCRH GYELQGREQL 
TCTQEGWDFQ PPLCKDVNEC ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD 
SGRLPRVTWI SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ 
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL

Genular Protein ID: 546288911

Symbol: Q6P534_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P534

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PROSITE 1 PeptideAtlas 1 PharmGKB 1 RefSeq 4 SAM 1 SMR 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 174
  • Mass: 19308
  • Checksum: 7DB070D17232882E
  • Sequence:
    • MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV DTAMYATMQR 
NLKKRGILSA AQLLSFSKLP EPTSGVIARA AEIMETSIQA MKRKVNLKTQ QSQHPTDALS 
EDLLSIIANM SGCLPYMLPP KCPNTCLANK YRPITGACNN RKMKYKPDHS ETAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.