Details for: TPO

Gene ID: 7173

Symbol: TPO

Ensembl ID: ENSG00000115705

Description: thyroid peroxidase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.86
    Marker Score: 4588
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.79
    Marker Score: 4596
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170085
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 864
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.14
    Marker Score: 2367
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.14
    Marker Score: 631
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 393
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.71
    Marker Score: 207.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.65
    Marker Score: 1048
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 374.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.57
    Marker Score: 298
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.56
    Marker Score: 806
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.51
    Marker Score: 126
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.47
    Marker Score: 3131
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 184.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.41
    Marker Score: 626
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 129
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 373
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.39
    Marker Score: 3660
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.35
    Marker Score: 196
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.34
    Marker Score: 107
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.33
    Marker Score: 80
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 565
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.32
    Marker Score: 760
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 287
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.32
    Marker Score: 902.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.31
    Marker Score: 112
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.29
    Marker Score: 490.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.28
    Marker Score: 148
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.27
    Marker Score: 58.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.26
    Marker Score: 117
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.24
    Marker Score: 90
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.23
    Marker Score: 1955
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.22
    Marker Score: 1323
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.21
    Marker Score: 125
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.19
    Marker Score: 204.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 108
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.17
    Marker Score: 84
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 161
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.16
    Marker Score: 53
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.15
    Marker Score: 186
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.15
    Marker Score: 212
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 162
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.15
    Marker Score: 131
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.13
    Marker Score: 443
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 140
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.12
    Marker Score: 7496
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 96
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.1
    Marker Score: 154

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Other Information

**Key Characteristics:** TPO is a heterodimeric enzyme consisting of two subunits, alpha and beta. The alpha subunit contains a catalytic domain, while the beta subunit has a thyroid hormone-binding domain. TPO is highly specific for iodide oxidation, with a high affinity for iodide and a low affinity for other substrates. The enzyme is also capable of generating hydrogen peroxide, which can have both antioxidant and pro-oxidant effects. **Pathways and Functions:** TPO's primary function is in the thyroid gland, where it plays a crucial role in thyroid hormone synthesis. However, its expression in other cell types has revealed a broader range of functions. TPO is involved in: 1. **Cellular oxidant detoxification:** TPO can convert hydrogen peroxide into water and oxygen, thereby regulating oxidative stress levels. 2. **Hormone biosynthesis:** TPO is essential for the synthesis of thyroid hormones, including thyroxine (T4) and triiodothyronine (T3). 3. **Immune cell regulation:** TPO has been found in various immune cells, including granulocytes, monocytes, and dendritic cells, where it may play a role in regulating oxidative stress and inflammation. 4. **Antioxidant activity:** TPO can scavenge reactive oxygen species (ROS) and reduce oxidative damage to cells. **Clinical Significance:** TPO's involvement in immune-related disorders has been implicated in several diseases, including: 1. **Autoimmune thyroid disease:** TPO antibodies are a hallmark of autoimmune thyroid disease, such as Hashimoto's thyroiditis and Graves' disease. 2. **Atherosclerosis:** Elevated TPO levels have been linked to atherosclerosis, a condition characterized by the buildup of plaque in arterial walls. 3. **Cancer:** TPO has been found to be overexpressed in certain types of cancer, including breast and ovarian cancer. 4. **Neurodegenerative diseases:** TPO may play a role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, TPO is a multifaceted enzyme with a complex role in thyroid hormone production and immune function. Its widespread expression in various cell types has revealed a broader range of functions, including cellular oxidant detoxification, hormone biosynthesis, and immune cell regulation. Further research is needed to fully elucidate the clinical significance of TPO in immune-related disorders and to explore its potential as a therapeutic target.

Genular Protein ID: 3958855602

Symbol: PERT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P07202 P09934 P09935 Q8IUL0 Q8NF94 Q8NF95 Q8NF96 Q8NF97 Q8TCI9

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChEBI 39 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 5 EMBL 27 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 7 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 1 RefSeq 7 Rhea 16 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3475693

Title: Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs.

PubMed ID: 3475693

DOI: 10.1073/pnas.84.16.5555

PubMed ID: 3453124

Title: Complete nucleotide sequence of the human thyroperoxidase-microsomal antigen cDNA.

PubMed ID: 3453124

DOI: 10.1093/nar/15.16.6735

PubMed ID: 2548579

Title: Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene.

PubMed ID: 2548579

DOI: 10.1021/bi00436a054

PubMed ID: 2308857

Title: Nucleotide sequence of the alternatively spliced human thyroid peroxidase cDNA, TPO-2.

PubMed ID: 2308857

DOI: 10.1093/nar/18.3.670

PubMed ID: 12454013

Title: Increasing diversity of human thyroperoxidase generated by alternative splicing. Characterization by molecular cloning of new transcripts with single- and multispliced mRNAs.

PubMed ID: 12454013

DOI: 10.1074/jbc.m209513200

PubMed ID: 3654979

Title: Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase.

PubMed ID: 3654979

DOI: 10.1172/jci113181

PubMed ID: 2383265

Title: Evidence for an alternate splicing in the thyroperoxidase messenger from patients with Graves' disease.

PubMed ID: 2383265

DOI: 10.1016/0006-291x(90)92152-p

PubMed ID: 15561711

Title: Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.

PubMed ID: 15561711

DOI: 10.1074/jbc.m407709200

PubMed ID: 7550241

Title: Identification of five novel inactivating mutations in the human thyroid peroxidase gene by denaturing gradient gel electrophoresis.

PubMed ID: 7550241

DOI: 10.1002/humu.1380060104

PubMed ID: 9024270

Title: Molecular analysis of mutated thyroid peroxidase detected in patients with total iodide organification defects.

PubMed ID: 9024270

DOI: 10.1210/jcem.82.2.3729

PubMed ID: 10468986

Title: A novel mutation in the TPO gene in goitrous hypothyroid patients with iodide organification defect.

PubMed ID: 10468986

DOI: 10.1046/j.1365-2265.1999.00746.x

PubMed ID: 10084596

Title: Two different mutations in the thyroid peroxidase gene of a large inbred Amish kindred: power and limits of homozygosity mapping.

PubMed ID: 10084596

DOI: 10.1210/jcem.84.3.5541

PubMed ID: 9924196

Title: A novel mutation in the human thyroid peroxidase gene resulting in a total iodide organification defect.

PubMed ID: 9924196

DOI: 10.1677/joe.0.1600267

PubMed ID: 11061528

Title: Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update).

PubMed ID: 11061528

DOI: 10.1210/jcem.85.10.6878

PubMed ID: 11415848

Title: Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism.

PubMed ID: 11415848

DOI: 10.1530/eje.0.1450019

PubMed ID: 11916616

Title: Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism.

PubMed ID: 11916616

DOI: 10.1530/eje.0.1460491

PubMed ID: 12213873

Title: High prevalence of a novel mutation (2268 insT) of the thyroid peroxidase gene in Taiwanese patients with total iodide organification defect, and evidence for a founder effect.

PubMed ID: 12213873

DOI: 10.1210/jc.2002-020153

PubMed ID: 11874711

Title: Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations.

PubMed ID: 11874711

DOI: 10.1677/joe.0.1720627

PubMed ID: 12490071

Title: Genetics of specific phenotypes of congenital hypothyroidism: a population-based approach.

PubMed ID: 12490071

DOI: 10.1089/105072502320908277

PubMed ID: 12864797

Title: Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings.

PubMed ID: 12864797

DOI: 10.1046/j.1365-2265.2003.01823.x

PubMed ID: 12938097

Title: Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect.

PubMed ID: 12938097

DOI: 10.1002/humu.9175

PubMed ID: 12843174

Title: Monoallelic expression of mutant thyroid peroxidase allele causing total iodide organification defect.

PubMed ID: 12843174

DOI: 10.1210/jc.2002-021377

PubMed ID: 16284446

Title: Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidism.

PubMed ID: 16284446

DOI: 10.1507/endocrj.52.643

PubMed ID: 16684826

Title: Goitrous congenital hypothyroidism and hearing impairment associated with mutations in the TPO and SLC26A4/PDS genes.

PubMed ID: 16684826

DOI: 10.1210/jc.2006-0142

PubMed ID: 27305979

Title: Mutations in the genes for thyroglobulin and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability.

PubMed ID: 27305979

DOI: 10.1038/jhg.2016.62

Sequence Information:

  • Length: 933
  • Mass: 102963
  • Checksum: F67C5F1A4AEE0B29
  • Sequence:
    • MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV DTAMYATMQR 
NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA MKRKVNLKTQ QSQHPTDALS 
EDLLSIIANM SGCLPYMLPP KCPNTCLANK YRPITGACNN RDHPRWGASN TALARWLPPV 
YEDGFSQPRG WNPGFLYNGF PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD 
IAFTPQSTSK AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD 
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL RVHARLRDSG 
RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV PSLTALHTLW LREHNRLAAA 
LKALNAHWSA DAVYQEARKV VGALHQIITL RDYIPRILGP EAFQQYVGPY EGYDSTANPT 
VSNVFSTAAF RFGHATIHPL VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR 
GLLARPAKLQ VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL 
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG PLFACLIGKQ 
MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG LTRVPMDAFQ VGKFPEDFES 
CDSITGMNLE AWRETFPQDD KCGFPESVEN GDFVHCEESG RRVLVYSCRH GYELQGREQL 
TCTQEGWDFQ PPLCKDVNEC ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD 
SGRLPRVTWI SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ 
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL

Genular Protein ID: 546288911

Symbol: Q6P534_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P534

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PROSITE 1 PeptideAtlas 1 PharmGKB 1 RefSeq 4 SAM 1 SMR 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 174
  • Mass: 19308
  • Checksum: 7DB070D17232882E
  • Sequence:
    • MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV DTAMYATMQR 
NLKKRGILSA AQLLSFSKLP EPTSGVIARA AEIMETSIQA MKRKVNLKTQ QSQHPTDALS 
EDLLSIIANM SGCLPYMLPP KCPNTCLANK YRPITGACNN RKMKYKPDHS ETAN

Genular Protein ID: 3336246376

Symbol: Q502Y3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q502Y3

Database IDs:

ARBA 23 Allergome 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 31 ChiTaRS 1 DNASU 1 EC 5 EMBL 2 GO 8 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 10 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 PeroxiBase 1 Pfam 3 PharmGKB 1 RefSeq 4 Rhea 16 SAM 3 SMART 3 SMR 1 SUPFAM 3 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 933
  • Mass: 102937
  • Checksum: C0148BC7787238E7
  • Sequence:
    • MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV DTAMYATMQR 
NLKKRGILSA AQLLSFSKLP EPTSGVIARA AEIMETSIQA MKRKVNLKTQ QSQHPTDALS 
EDLLSIIANM SGCLPYMLPP KCPNTCLANK YRPITGACNN RDHPRWGASN TALARWLPPV 
YEDGFSQPRG WNPGFLYNGF PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD 
IAFTPQSTSK AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD 
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL RVHARLRDSG 
RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV PSLTALHTLW LREHNRLAAA 
LKALNAHWSA DAVYQEARKV VGALHQIITL RDYIPRILGP EAFQQYVGPY EGYDSTANPT 
VSNVFSTAAF RFGHATIHPL VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR 
GLLARPAKLQ VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL 
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG PLFACLIGKQ 
MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG LTRVPMDAFQ VGKFPEDFES 
CDSITGMNLE AWRETFPQDD KCGFPESVEN GDFVHCEESG RRVLVYSCRH GYELQGREQL 
TCTQEGWDFQ PPLCKDVNEC ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD 
SGRLPRVTWI SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ 
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.