Details for: SELE

Gene ID: 6401

Symbol: SELE

Ensembl ID: ENSG00000007908

Description: selectin E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 10.0572
    Cell Significance Index: 72.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.8764
    Cell Significance Index: 121.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.9928
    Cell Significance Index: 45.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 3.1272
    Cell Significance Index: 109.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2898
    Cell Significance Index: 79.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9186
    Cell Significance Index: 22.2500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.9056
    Cell Significance Index: 10.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8153
    Cell Significance Index: 17.6600
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.7428
    Cell Significance Index: 5.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6386
    Cell Significance Index: 9.8800
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: 0.4177
    Cell Significance Index: 2.6900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3934
    Cell Significance Index: 4.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3836
    Cell Significance Index: 5.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3738
    Cell Significance Index: 71.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3609
    Cell Significance Index: 203.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2818
    Cell Significance Index: 27.8800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.2683
    Cell Significance Index: 1.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.2548
    Cell Significance Index: 188.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2379
    Cell Significance Index: 12.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2133
    Cell Significance Index: 192.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.1820
    Cell Significance Index: 38.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1788
    Cell Significance Index: 1.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1406
    Cell Significance Index: 22.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1202
    Cell Significance Index: 3.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0981
    Cell Significance Index: 10.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0849
    Cell Significance Index: 15.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0787
    Cell Significance Index: 2.2600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0649
    Cell Significance Index: 1.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0647
    Cell Significance Index: 8.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0629
    Cell Significance Index: 39.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0481
    Cell Significance Index: 1.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0325
    Cell Significance Index: 4.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0307
    Cell Significance Index: 2.1200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0132
    Cell Significance Index: 0.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0072
    Cell Significance Index: 0.4300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0028
    Cell Significance Index: 0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0007
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0036
    Cell Significance Index: -0.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0056
    Cell Significance Index: -8.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0061
    Cell Significance Index: -8.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0065
    Cell Significance Index: -2.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0101
    Cell Significance Index: -0.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0115
    Cell Significance Index: -0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0133
    Cell Significance Index: -4.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0144
    Cell Significance Index: -1.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0151
    Cell Significance Index: -8.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0163
    Cell Significance Index: -7.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0188
    Cell Significance Index: -3.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0202
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0269
    Cell Significance Index: -3.0700
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.0306
    Cell Significance Index: -0.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0343
    Cell Significance Index: -1.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0400
    Cell Significance Index: -0.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0432
    Cell Significance Index: -6.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0455
    Cell Significance Index: -2.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0464
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0472
    Cell Significance Index: -5.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0501
    Cell Significance Index: -5.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0602
    Cell Significance Index: -8.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0647
    Cell Significance Index: -6.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0672
    Cell Significance Index: -3.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0691
    Cell Significance Index: -2.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0698
    Cell Significance Index: -7.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0869
    Cell Significance Index: -1.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0955
    Cell Significance Index: -7.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0956
    Cell Significance Index: -4.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0960
    Cell Significance Index: -6.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1009
    Cell Significance Index: -2.8200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1015
    Cell Significance Index: -1.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1052
    Cell Significance Index: -4.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1194
    Cell Significance Index: -4.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1255
    Cell Significance Index: -5.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1352
    Cell Significance Index: -8.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1385
    Cell Significance Index: -2.9000
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.1481
    Cell Significance Index: -1.1800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1562
    Cell Significance Index: -2.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1587
    Cell Significance Index: -5.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1709
    Cell Significance Index: -9.5900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1741
    Cell Significance Index: -2.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1752
    Cell Significance Index: -6.4300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1758
    Cell Significance Index: -1.9100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1794
    Cell Significance Index: -3.6500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1826
    Cell Significance Index: -4.5600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1886
    Cell Significance Index: -3.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1964
    Cell Significance Index: -6.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1987
    Cell Significance Index: -10.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2041
    Cell Significance Index: -6.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2114
    Cell Significance Index: -5.6700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2159
    Cell Significance Index: -3.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2168
    Cell Significance Index: -5.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2206
    Cell Significance Index: -5.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2267
    Cell Significance Index: -7.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2274
    Cell Significance Index: -6.0700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2285
    Cell Significance Index: -2.7800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2299
    Cell Significance Index: -3.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Expression:** SELE is primarily expressed on the surface of endothelial cells, particularly on the external side of the plasma membrane. 2. **Molecular Structure:** SELE is a transmembrane glycoprotein with a carbohydrate-binding domain, which allows it to interact with sialic acid-containing ligands on the surface of leukocytes. 3. **Function:** SELE mediates the initial adhesion of leukocytes to the endothelial surface, facilitating their rolling and subsequent migration into tissues. **Pathways and Functions:** 1. **Leukocyte Migration:** SELE is involved in the positive regulation of leukocyte migration, which is essential for the immune response to inflammation. 2. **Inflammatory Response:** SELE plays a critical role in the inflammatory response, particularly in the recruitment of leukocytes to sites of inflammation. 3. **Cell-Cell Adhesion:** SELE mediates heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, facilitating the interaction between leukocytes and endothelial cells. 4. **Cytoskeletal Rearrangement:** SELE is involved in the regulation of cytoskeletal rearrangement, which is necessary for leukocyte migration and adhesion. **Clinical Significance:** 1. **Inflammatory Diseases:** Altered expression of SELE has been implicated in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and multiple sclerosis. 2. **Cancer:** SELE has been identified as a potential target for cancer immunotherapy, as it can modulate the immune response and inhibit tumor growth. 3. **Cardiovascular Diseases:** SELE has been linked to cardiovascular diseases, including atherosclerosis and myocardial infarction, due to its role in leukocyte adhesion and inflammation. **Significantly Expressed Cells:** 1. **Conventional Dendritic Cell:** SELE is expressed on the surface of conventional dendritic cells, which play a critical role in the initiation of the immune response. 2. **Hematopoietic Cell:** SELE is expressed on hematopoietic cells, including granulocyte-monocyte progenitor cells, which are involved in the production of immune cells. 3. **Granulocyte Monocyte Progenitor Cell:** SELE is expressed on granulocyte-monocyte progenitor cells, which are precursors to neutrophils and monocytes. In conclusion, SELE (selectin E) is a complex molecule that plays a critical role in the immune system, particularly in the regulation of leukocyte migration and cell-cell adhesion. Its dysregulation has been implicated in various inflammatory diseases and cancer. Further research is necessary to fully understand the intricacies of SELE and its potential therapeutic applications.

Genular Protein ID: 2712225366

Symbol: LYAM2_HUMAN

Name: E-selectin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1689848

Title: Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions.

PubMed ID: 1689848

DOI: 10.1073/pnas.87.5.1673

PubMed ID: 2466335

Title: Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.

PubMed ID: 2466335

DOI: 10.1126/science.2466335

PubMed ID: 1703529

Title: Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1.

PubMed ID: 1703529

DOI: 10.1016/s0021-9258(18)52267-5

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1701274

Title: ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.

PubMed ID: 1701274

DOI: 10.1126/science.1701274

PubMed ID: 18606703

Title: Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.

PubMed ID: 18606703

DOI: 10.4049/jimmunol.181.2.1480

PubMed ID: 28011641

Title: Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

PubMed ID: 28011641

DOI: 10.1074/jbc.m116.767186

PubMed ID: 7681016

Title: Modelling the carbohydrate recognition domain of human E-selectin.

PubMed ID: 7681016

DOI: 10.1016/0014-5793(93)80026-q

PubMed ID: 7509040

Title: Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.

PubMed ID: 7509040

DOI: 10.1038/367532a0

PubMed ID: 11081633

Title: Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.

PubMed ID: 11081633

DOI: 10.1016/s0092-8674(00)00138-0

PubMed ID: 26117840

Title: E-selectin ligand complexes adopt an extended high-affinity conformation.

PubMed ID: 26117840

DOI: 10.1093/jmcb/mjv046

PubMed ID: 7533025

Title: E-selectin polymorphism and atherosclerosis: an association study.

PubMed ID: 7533025

DOI: 10.1093/hmg/3.11.1935

PubMed ID: 8557254

Title: DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis.

PubMed ID: 8557254

DOI: 10.1007/bf00218826

PubMed ID: 9933738

Title: A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease.

PubMed ID: 9933738

DOI: 10.1007/bf02256419

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 10982036

Title: Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort.

PubMed ID: 10982036

DOI: 10.1007/s004390000325

PubMed ID: 12649084

Title: E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions.

PubMed ID: 12649084

DOI: 10.1161/01.atv.0000067427.40133.59

PubMed ID: 24688092

Title: Implications of the E-selectin S128R mutation for drug discovery.

PubMed ID: 24688092

DOI: 10.1093/glycob/cwu026

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 610
  • Mass: 66655
  • Checksum: 7D43E3C0D1229229
  • Sequence:
  • MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN 
    SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK 
    DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC 
    TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV 
    ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK 
    AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP 
    VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN 
    EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELHGS TQLECTSQGQ 
    WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW 
    SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD 
    GSYQKPSYIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.