Details for: SELE

Gene ID: 6401

Symbol: SELE

Ensembl ID: ENSG00000007908

Description: selectin E

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1512
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.14
    Marker Score: 3624
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.73
    Marker Score: 672
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.44
    Marker Score: 955
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.24
    Marker Score: 297
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 1.22
    Marker Score: 3922
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.15
    Marker Score: 1674
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.08
    Marker Score: 261
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251810
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 795
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.78
    Marker Score: 975
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.77
    Marker Score: 481
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.76
    Marker Score: 1517
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.75
    Marker Score: 199
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1286
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.51
    Marker Score: 273
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 153
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.48
    Marker Score: 162
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.46
    Marker Score: 205
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 433
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 884
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.43
    Marker Score: 390
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.43
    Marker Score: 434
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 180
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 371
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.4
    Marker Score: 145
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.4
    Marker Score: 142
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.35
    Marker Score: 715
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.34
    Marker Score: 289
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.34
    Marker Score: 72
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4686
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.29
    Marker Score: 845
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.28
    Marker Score: 1881
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.28
    Marker Score: 170
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 126
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.27
    Marker Score: 373
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.27
    Marker Score: 120
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.26
    Marker Score: 214
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.23
    Marker Score: 83
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.22
    Marker Score: 7555
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.21
    Marker Score: 88
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.21
    Marker Score: 161.5
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.2
    Marker Score: 46
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.2
    Marker Score: 166
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.19
    Marker Score: 1695
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.15
    Marker Score: 103
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.14
    Marker Score: 31
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 402
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.12
    Marker Score: 188
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.11
    Marker Score: 1492
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.11
    Marker Score: 155
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1
    Marker Score: 19

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Other Information

**Key characteristics:** * E-selectin is a type I transmembrane protein, which means it has a single extracellular domain and one transmembrane domain. * It is a glycoprotein with a molecular weight of approximately 120 kDa. * E-selectin is a highly conserved protein, with a similar sequence found in mammals and birds. * It is expressed in high levels in endothelial cells of blood vessels, where it is involved in the adhesion of immune cells to the vascular wall. * It is also expressed in other cell types, including dendritic cells, vascular lymphangioblast, prostate gland microvascular endothelial cells, colon goblet cells, hematopoietic cells, granulocyte monocyte progenitor cells, and intestinal crypt stem cells. **Pathways and functions:** * E-selectin is involved in the Actin filament-based process, which is a signaling pathway that is essential for leukocyte migration and adhesion. * It is a key component of the activation of phospholipase c activity, which is a critical step in the signaling pathway. * E-selectin also plays a role in calcium-mediated signaling and cell surface interactions at the vascular wall. * It is involved in hemostasis, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, inflammatory response, and leukocyte migration. * It is also involved in the regulation of receptor internalization and positive regulation of receptor internalization. **Clinical significance:** * Mutations in the SELE gene have been linked to several human diseases, including vascular diseases, cancer, and inflammatory diseases. * E-selectin is a potential therapeutic target for these diseases, as it can inhibit leukocyte migration and adhesion, which can lead to the inhibition of inflammatory responses. * Therefore, SELE is an important target for the development of novel therapeutic strategies for a variety of diseases.

Genular Protein ID: 2712225366

Symbol: LYAM2_HUMAN

Name: E-selectin

UniProtKB Accession Codes:

P16581 A2RRD6 P16111

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1689848

Title: Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions.

PubMed ID: 1689848

DOI: 10.1073/pnas.87.5.1673

PubMed ID: 2466335

Title: Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.

PubMed ID: 2466335

DOI: 10.1126/science.2466335

PubMed ID: 1703529

Title: Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1.

PubMed ID: 1703529

DOI: 10.1016/s0021-9258(18)52267-5

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1701274

Title: ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.

PubMed ID: 1701274

DOI: 10.1126/science.1701274

PubMed ID: 18606703

Title: Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.

PubMed ID: 18606703

DOI: 10.4049/jimmunol.181.2.1480

PubMed ID: 28011641

Title: Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

PubMed ID: 28011641

DOI: 10.1074/jbc.m116.767186

PubMed ID: 7681016

Title: Modelling the carbohydrate recognition domain of human E-selectin.

PubMed ID: 7681016

DOI: 10.1016/0014-5793(93)80026-q

PubMed ID: 7509040

Title: Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.

PubMed ID: 7509040

DOI: 10.1038/367532a0

PubMed ID: 11081633

Title: Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.

PubMed ID: 11081633

DOI: 10.1016/s0092-8674(00)00138-0

PubMed ID: 26117840

Title: E-selectin ligand complexes adopt an extended high-affinity conformation.

PubMed ID: 26117840

DOI: 10.1093/jmcb/mjv046

PubMed ID: 7533025

Title: E-selectin polymorphism and atherosclerosis: an association study.

PubMed ID: 7533025

DOI: 10.1093/hmg/3.11.1935

PubMed ID: 8557254

Title: DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis.

PubMed ID: 8557254

DOI: 10.1007/bf00218826

PubMed ID: 9933738

Title: A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease.

PubMed ID: 9933738

DOI: 10.1159/000025366

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 10982036

Title: Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort.

PubMed ID: 10982036

DOI: 10.1007/s004390000325

PubMed ID: 12649084

Title: E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions.

PubMed ID: 12649084

DOI: 10.1161/01.atv.0000067427.40133.59

PubMed ID: 24688092

Title: Implications of the E-selectin S128R mutation for drug discovery.

PubMed ID: 24688092

DOI: 10.1093/glycob/cwu026

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 610
  • Mass: 66655
  • Checksum: 7D43E3C0D1229229
  • Sequence:
    • MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN 
SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK 
DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC 
TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV 
ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK 
AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP 
VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN 
EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELHGS TQLECTSQGQ 
WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW 
SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD 
GSYQKPSYIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.