Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 10.0572
Cell Significance Index: 72.2300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.8764
Cell Significance Index: 121.5200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.9928
Cell Significance Index: 45.3600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 3.1272
Cell Significance Index: 109.8900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.2898
Cell Significance Index: 79.0800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.9186
Cell Significance Index: 22.2500 - Cell Name: myometrial cell (CL0002366)
Fold Change: 0.9056
Cell Significance Index: 10.4300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8153
Cell Significance Index: 17.6600 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.7428
Cell Significance Index: 5.4500 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.6386
Cell Significance Index: 9.8800 - Cell Name: vein endothelial cell of respiratory system (CL4033008)
Fold Change: 0.4177
Cell Significance Index: 2.6900 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.3934
Cell Significance Index: 4.1800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.3836
Cell Significance Index: 5.7800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3738
Cell Significance Index: 71.1400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.3609
Cell Significance Index: 203.5600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2818
Cell Significance Index: 27.8800 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 0.2683
Cell Significance Index: 1.0000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.2548
Cell Significance Index: 188.7300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2379
Cell Significance Index: 12.3900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2133
Cell Significance Index: 192.5700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.1820
Cell Significance Index: 38.3300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1788
Cell Significance Index: 1.0800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1406
Cell Significance Index: 22.8800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1202
Cell Significance Index: 3.0900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0981
Cell Significance Index: 10.6700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0849
Cell Significance Index: 15.3100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0787
Cell Significance Index: 2.2600 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.0649
Cell Significance Index: 1.0300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0647
Cell Significance Index: 8.2900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0629
Cell Significance Index: 39.2700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0481
Cell Significance Index: 1.0300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0325
Cell Significance Index: 4.0000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0307
Cell Significance Index: 2.1200 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.0132
Cell Significance Index: 0.1700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0072
Cell Significance Index: 0.4300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0028
Cell Significance Index: 0.0400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0007
Cell Significance Index: 0.1400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0019
Cell Significance Index: -3.6100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0023
Cell Significance Index: -1.4300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0036
Cell Significance Index: -0.6200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0053
Cell Significance Index: -9.7500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0056
Cell Significance Index: -8.6800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0061
Cell Significance Index: -8.3200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0065
Cell Significance Index: -2.8600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0090
Cell Significance Index: -6.8500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0101
Cell Significance Index: -0.2900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0115
Cell Significance Index: -0.5200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0133
Cell Significance Index: -4.7600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0140
Cell Significance Index: -0.3500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0144
Cell Significance Index: -1.8600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0151
Cell Significance Index: -8.2600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0163
Cell Significance Index: -7.4200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0188
Cell Significance Index: -3.7800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0202
Cell Significance Index: -5.8200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0269
Cell Significance Index: -3.0700 - Cell Name: gut endothelial cell (CL0000131)
Fold Change: -0.0306
Cell Significance Index: -0.2100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0343
Cell Significance Index: -1.1000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0400
Cell Significance Index: -0.8300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0432
Cell Significance Index: -6.2800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0455
Cell Significance Index: -2.1200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0464
Cell Significance Index: -3.4600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0472
Cell Significance Index: -5.4100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0501
Cell Significance Index: -5.8400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0602
Cell Significance Index: -8.2700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0647
Cell Significance Index: -6.7400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0672
Cell Significance Index: -3.3900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0691
Cell Significance Index: -2.8300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0698
Cell Significance Index: -7.1300 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0869
Cell Significance Index: -1.3200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0955
Cell Significance Index: -7.3300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0956
Cell Significance Index: -4.2300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0960
Cell Significance Index: -6.4600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1009
Cell Significance Index: -2.8200 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1015
Cell Significance Index: -1.4800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1052
Cell Significance Index: -4.9500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1194
Cell Significance Index: -4.5200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1255
Cell Significance Index: -5.4600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1352
Cell Significance Index: -8.3100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1385
Cell Significance Index: -2.9000 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: -0.1481
Cell Significance Index: -1.1800 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.1562
Cell Significance Index: -2.1500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1587
Cell Significance Index: -5.5600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1709
Cell Significance Index: -9.5900 - Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1741
Cell Significance Index: -2.1400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1752
Cell Significance Index: -6.4300 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.1758
Cell Significance Index: -1.9100 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1794
Cell Significance Index: -3.6500 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1826
Cell Significance Index: -4.5600 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.1886
Cell Significance Index: -3.2400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1964
Cell Significance Index: -6.4300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1987
Cell Significance Index: -10.3200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2041
Cell Significance Index: -6.5000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2114
Cell Significance Index: -5.6700 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.2159
Cell Significance Index: -3.2300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2168
Cell Significance Index: -5.9000 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2206
Cell Significance Index: -5.5000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.2267
Cell Significance Index: -7.1700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2274
Cell Significance Index: -6.0700 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.2285
Cell Significance Index: -2.7800 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.2299
Cell Significance Index: -3.2700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2712225366
Symbol: LYAM2_HUMAN
Name: E-selectin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1689848
Title: Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions.
PubMed ID: 1689848
PubMed ID: 2466335
Title: Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.
PubMed ID: 2466335
PubMed ID: 1703529
Title: Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1.
PubMed ID: 1703529
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1701274
Title: ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.
PubMed ID: 1701274
PubMed ID: 18606703
Title: Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.
PubMed ID: 18606703
PubMed ID: 28011641
Title: Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.
PubMed ID: 28011641
PubMed ID: 7681016
Title: Modelling the carbohydrate recognition domain of human E-selectin.
PubMed ID: 7681016
PubMed ID: 7509040
Title: Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.
PubMed ID: 7509040
DOI: 10.1038/367532a0
PubMed ID: 11081633
Title: Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
PubMed ID: 11081633
PubMed ID: 26117840
Title: E-selectin ligand complexes adopt an extended high-affinity conformation.
PubMed ID: 26117840
DOI: 10.1093/jmcb/mjv046
PubMed ID: 7533025
Title: E-selectin polymorphism and atherosclerosis: an association study.
PubMed ID: 7533025
PubMed ID: 8557254
Title: DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis.
PubMed ID: 8557254
DOI: 10.1007/bf00218826
PubMed ID: 9933738
Title: A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease.
PubMed ID: 9933738
DOI: 10.1007/bf02256419
PubMed ID: 10391210
Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
PubMed ID: 10391210
DOI: 10.1038/10297
PubMed ID: 10982036
Title: Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort.
PubMed ID: 10982036
PubMed ID: 12649084
Title: E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions.
PubMed ID: 12649084
PubMed ID: 24688092
Title: Implications of the E-selectin S128R mutation for drug discovery.
PubMed ID: 24688092
PubMed ID: 25787250
Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.
PubMed ID: 25787250
Sequence Information:
- Length: 610
- Mass: 66655
- Checksum: 7D43E3C0D1229229
- Sequence:
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD GSYQKPSYIL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.