Details for: CYYR1 AS1

Gene ID: 100996571

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: CYYR1 AS1

Ensembl ID: ENSG00000197934

Description: CYYR1 antisense RNA 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • VIP GABAergic cortical interneuron CL4023016
    CSI 6.88
    rCSI 8.22%
    PRS 99.82
  • cerebral cortex endothelial cell CL1001602
    CSI 6.28
    rCSI 10.85%
    PRS 99.92
  • sncg GABAergic cortical interneuron CL4023015
    CSI 5.3
    rCSI 8.52%
    PRS 99.76
  • cardiac endothelial cell CL0010008
    CSI 4.94
    rCSI 19.94%
    PRS 99.94
  • blood vessel endothelial cell CL0000071
    CSI 4.3
    rCSI 8.93%
    PRS 99.92
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 3.78
    rCSI 6.35%
    PRS 99.84
  • retinal pigment epithelial cell CL0002586
    CSI 3.17
    rCSI 6.29%
    PRS 99.75
  • endothelial cell of vascular tree CL0002139
    CSI 2.83
    rCSI 15.47%
    PRS 99.4
  • L6b glutamatergic cortical neuron CL4023038
    CSI 2.23
    rCSI 6.98%
    PRS 99.77
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.85
    rCSI 7%
    PRS 99.65
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.64
    rCSI 3.99%
    PRS 99.54
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.39
    rCSI 4.34%
    PRS 99.85
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.38
    rCSI 4.95%
    PRS 99.67
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.31
    rCSI 7.74%
    PRS 99.74

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CYYR1 AS1](/details-gene/100996571) is a long non-coding antisense RNA located on chromosome 21. Expression data indicates that this gene is a significant marker for distinct cell populations within the nervous and vascular systems. **Overall**, it shows high significance in various subtypes of cortical neurons, particularly `[VIP GABAergic cortical interneuron](/details-cell/CL4023016)`, and in multiple types of endothelial cells, including `[cerebral cortex endothelial cell](/details-cell/CL1001602)` and `[cardiac endothelial cell](/details-cell/CL0010008)`. As an antisense transcript, its primary function is likely the regulation of its sense-strand counterpart, the protein-coding gene `CYYR1`, which is implicated in cell adhesion and migration processes. ## Cellular Roles and Expression Landscape The expression profile of `[CYYR1 AS1](/details-gene/100996571)` points to specialized roles in both the central nervous system and the vasculature. Within the brain, `[CYYR1 AS1](/details-gene/100996571)` is a prominent marker for specific neuronal subtypes. It exhibits its highest significance in inhibitory interneurons, such as `[VIP GABAergic cortical interneuron](/details-cell/CL4023016)` (CSI: 6.88), `[sncg GABAergic cortical interneuron](/details-cell/CL4023015)` (CSI: 5.30), and `[lamp5 GABAergic cortical interneuron](/details-cell/CL4023011)` (CSI: 3.78). Its significance in several glutamatergic neuron populations, though lower, further suggests a broad role in regulating cortical circuitry. Concurrently, the gene demonstrates a strong endothelial signature. It is highly significant in `[cerebral cortex endothelial cell](/details-cell/CL1001602)` (CSI: 6.28), `[cardiac endothelial cell](/details-cell/CL0010008)` (CSI: 4.94), and `[blood vessel endothelial cell](/details-cell/CL0000071)` (CSI: 4.30). This pattern suggests a conserved function in maintaining endothelial cell identity or function, such as vascular integrity or angiogenesis, across different tissues. The additional high significance in `[retinal pigment epithelial cell](/details-cell/CL0002586)` further highlights its role in specialized barrier-forming cell types. This dual-expression landscape suggests that `[CYYR1 AS1](/details-gene/100996571)` may be involved in shared molecular programs between these distinct cell lineages, potentially related to cell-cell communication, adhesion, or barrier function. ## Pathways and Molecular Function Direct functional annotations for `[CYYR1 AS1](/details-gene/100996571)` are not available in major pathway databases like Reactome or Gene Ontology. However, as an antisense long non-coding RNA, its function is strongly presumed to involve the regulation of the `CYYR1` gene, which is transcribed from the opposite strand at the same genomic locus. The `CYYR1` protein is known to be involved in cell adhesion and migration. The high significance of `[CYYR1 AS1](/details-gene/100996571)` in endothelial cells is consistent with a role in modulating vascular biology through the regulation of `CYYR1`. Similarly, its expression in neurons could relate to `CYYR1`-mediated processes such as axon guidance or synaptic stability. Potential mechanisms of regulation by `[CYYR1 AS1](/details-gene/100996571)` include altering the stability of `CYYR1` mRNA, interfering with its transcription, or guiding epigenetic modifications to the `CYYR1` gene locus. ## Research Directions The specific co-expression of `[CYYR1 AS1](/details-gene/100996571)` in distinct neuronal and endothelial cell types provides a foundation for several testable hypotheses regarding its function in health and disease. 1. **Hypothesis 1:** In `[cerebral cortex endothelial cell](/details-cell/CL1001602)`, `[CYYR1 AS1](/details-gene/100996571)` acts as a negative regulator of `CYYR1` expression to control the permeability of the blood-brain barrier. Overexpression or knockdown of the lncRNA would therefore alter barrier integrity. 2. **Hypothesis 2:** `[CYYR1 AS1](/details-gene/100996571)` expression in `[VIP GABAergic cortical interneuron](/details-cell/CL4023016)` is dynamically regulated by neuronal activity, where it functions to fine-tune `CYYR1` levels to modulate synaptic structure or function. To test the first hypothesis, a targeted knockdown of `[CYYR1 AS1](/details-gene/100996571)` could be performed in an *in vitro* model of the human blood-brain barrier, such as induced pluripotent stem cell (iPSC)-derived brain microvascular endothelial cells. The effects on `CYYR1` mRNA and protein levels could be quantified using qRT-PCR and western blotting. Subsequently, barrier function could be assessed by measuring transendothelial electrical resistance (TEER) and the passage of fluorescently-labeled dextrans. Given its specific expression pattern and its nature as a non-coding RNA, `[CYYR1 AS1](/details-gene/100996571)` presents a potential therapeutic target. Its regulation could be particularly relevant for diseases involving endothelial dysfunction, such as stroke or diabetic retinopathy, or neurodevelopmental disorders where cortical interneuron function is impaired. As an RNA molecule, it is amenable to therapeutic modulation using nucleic acid-based drugs like antisense oligonucleotides (ASOs), which could be designed to either inhibit its function or degrade the transcript, thereby altering the expression of the pathogenic `CYYR1` target.