Details for: CCL14

Gene ID: 6358

Symbol: CCL14

Ensembl ID: ENSG00000276409

Description: C-C motif chemokine ligand 14

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.09
    Marker Score: 508
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2
    Marker Score: 3381
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.89
    Marker Score: 413
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.86
    Marker Score: 3711
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.54
    Marker Score: 327
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.33
    Marker Score: 516
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.33
    Marker Score: 319
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.2
    Marker Score: 1031
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7688
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 689
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.08
    Marker Score: 1084
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.99
    Marker Score: 891
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 407
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.98
    Marker Score: 227
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.82
    Marker Score: 918
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.76
    Marker Score: 178
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2905
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 416
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.63
    Marker Score: 390
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 389
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.53
    Marker Score: 140
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.51
    Marker Score: 140
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.44
    Marker Score: 201
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 372
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.4
    Marker Score: 432
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 217
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.38
    Marker Score: 173
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 207
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.32
    Marker Score: 81
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.31
    Marker Score: 174
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.31
    Marker Score: 129
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.3
    Marker Score: 434
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.29
    Marker Score: 214
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.29
    Marker Score: 140
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.28
    Marker Score: 532
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.27
    Marker Score: 178.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.27
    Marker Score: 252
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.26
    Marker Score: 657
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.24
    Marker Score: 233
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.22
    Marker Score: 233
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.21
    Marker Score: 214
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2
    Marker Score: 171
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.19
    Marker Score: 342
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 370
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.17
    Marker Score: 162
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.15
    Marker Score: 234.5
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.14
    Marker Score: 118
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.14
    Marker Score: 260.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.12
    Marker Score: 195
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.11
    Marker Score: 66
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.11
    Marker Score: 245
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.11
    Marker Score: 3677
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1
    Marker Score: 102
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 176
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.1
    Marker Score: 156
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.09
    Marker Score: 29.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.09
    Marker Score: 22.5
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.09
    Marker Score: 29.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.09
    Marker Score: 29.5
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.08
    Marker Score: 28.5

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Other Information

**Key Characteristics:** CCL14 is a 8-kDa, four-cysteine-containing chemokine that belongs to the CC chemokine family. Its high affinity for CCR7, a G-protein coupled receptor, allows for efficient signaling and chemotaxis. CCL14 exhibits a unique ability to regulate the Erk1/2 cascade, a critical signaling pathway involved in cell proliferation, differentiation, and survival. Its expression is restricted to specific cell types, including endothelial cells, which are involved in the maintenance of tissue homeostasis and immune responses. **Pathways and Functions:** CCL14's primary function is to regulate immune responses by recruiting immune cells to sites of inflammation. Its interaction with CCR7 triggers a signaling cascade that leads to the activation of various cellular processes, including: 1. **Chemotaxis**: CCL14's ability to bind CCR7 enables the directed migration of immune cells towards the site of inflammation. 2. **Proliferation**: CCL14's interaction with CCR7 regulates the Erk1/2 cascade, promoting cell proliferation and survival. 3. **Signaling pathway**: CCL14's binding to CCR7 activates a G-protein coupled receptor signaling pathway, leading to the activation of various downstream targets. **Clinical Significance:** CCL14's role in immune responses and chemotaxis has significant implications for various diseases, including: 1. **Inflammatory disorders**: CCL14's involvement in the recruitment of immune cells to sites of inflammation makes it a potential therapeutic target for inflammatory diseases, such as rheumatoid arthritis and asthma. 2. **Cancer**: CCL14's expression in endothelial cells and its ability to regulate cell proliferation and survival make it a potential biomarker for cancer diagnosis and treatment. 3. **Autoimmune diseases**: CCL14's role in regulating immune responses and chemotaxis makes it a potential therapeutic target for autoimmune diseases, such as multiple sclerosis and type 1 diabetes. In conclusion, CCL14 is a key player in immune responses and chemotaxis, with significant implications for various diseases. Further research is needed to fully elucidate its function and potential therapeutic applications.

Genular Protein ID: 1545111099

Symbol: CCL14_HUMAN

Name: C-C motif chemokine 14

UniProtKB Accession Codes:

Q16627 E1P649 E1P650 Q13954

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8551235

Title: HCC-1, a novel chemokine from human plasma.

PubMed ID: 8551235

DOI: 10.1084/jem.183.1.295

PubMed ID: 9600961

Title: HCC-2, a human chemokine: gene structure, expression pattern, and biological activity.

PubMed ID: 9600961

DOI: 10.1073/pnas.95.11.6308

PubMed ID: 10213461

Title: Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES.

PubMed ID: 10213461

DOI: 10.1089/107999099314153

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10978165

Title: Posttranslationally processed forms of the human chemokine HCC-1.

PubMed ID: 10978165

DOI: 10.1021/bi992488q

PubMed ID: 11085751

Title: Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties.

PubMed ID: 11085751

DOI: 10.1084/jem.192.10.1501

PubMed ID: 17691823

Title: Structural and functional characterization of CC chemokine CCL14.

PubMed ID: 17691823

DOI: 10.1021/bi700936w

Sequence Information:

  • Length: 93
  • Mass: 10678
  • Checksum: DDDB899DC9148836
  • Sequence:
    • MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM DYYETNSQCS 
KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.