Details for: CCL14

Gene ID: 6358

Symbol: CCL14

Ensembl ID: ENSG00000276409

Description: C-C motif chemokine ligand 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 37.1122
    Cell Significance Index: 733.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 33.4060
    Cell Significance Index: 709.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 31.3816
    Cell Significance Index: 782.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 30.8676
    Cell Significance Index: 1081.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 28.7036
    Cell Significance Index: 620.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 28.6405
    Cell Significance Index: 937.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 26.5705
    Cell Significance Index: 846.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 26.4771
    Cell Significance Index: 552.6000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 25.5914
    Cell Significance Index: 503.6900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 23.2536
    Cell Significance Index: 402.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 22.6665
    Cell Significance Index: 455.0600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 13.1998
    Cell Significance Index: 94.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.9723
    Cell Significance Index: 124.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.4641
    Cell Significance Index: 61.2200
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.3724
    Cell Significance Index: 10.0600
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.1676
    Cell Significance Index: 9.8800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.1613
    Cell Significance Index: 4.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9807
    Cell Significance Index: 186.6400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.6859
    Cell Significance Index: 5.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5005
    Cell Significance Index: 30.0500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4869
    Cell Significance Index: 6.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3598
    Cell Significance Index: 58.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3331
    Cell Significance Index: 300.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3048
    Cell Significance Index: 33.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2721
    Cell Significance Index: 5.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2504
    Cell Significance Index: 24.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1976
    Cell Significance Index: 25.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1905
    Cell Significance Index: 13.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1817
    Cell Significance Index: 3.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1089
    Cell Significance Index: 13.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0261
    Cell Significance Index: 4.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0146
    Cell Significance Index: 0.4200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0125
    Cell Significance Index: 0.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0104
    Cell Significance Index: 0.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0038
    Cell Significance Index: 0.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0020
    Cell Significance Index: -0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0050
    Cell Significance Index: -1.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0154
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0166
    Cell Significance Index: -12.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0201
    Cell Significance Index: -14.7200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0256
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0260
    Cell Significance Index: -14.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0273
    Cell Significance Index: -14.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0369
    Cell Significance Index: -27.3100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0414
    Cell Significance Index: -0.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0694
    Cell Significance Index: -3.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0696
    Cell Significance Index: -13.8100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0766
    Cell Significance Index: -0.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0943
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1079
    Cell Significance Index: -18.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1081
    Cell Significance Index: -14.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1230
    Cell Significance Index: -15.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1236
    Cell Significance Index: -14.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1272
    Cell Significance Index: -14.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1403
    Cell Significance Index: -14.3300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2053
    Cell Significance Index: -2.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2077
    Cell Significance Index: -10.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2119
    Cell Significance Index: -15.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2512
    Cell Significance Index: -19.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2655
    Cell Significance Index: -13.7900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2791
    Cell Significance Index: -5.6800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2841
    Cell Significance Index: -4.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3106
    Cell Significance Index: -16.1800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3231
    Cell Significance Index: -3.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3243
    Cell Significance Index: -13.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3459
    Cell Significance Index: -16.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3879
    Cell Significance Index: -10.3800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3938
    Cell Significance Index: -4.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4253
    Cell Significance Index: -19.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4329
    Cell Significance Index: -12.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4386
    Cell Significance Index: -15.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4727
    Cell Significance Index: -12.4300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4827
    Cell Significance Index: -6.3000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4843
    Cell Significance Index: -6.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5050
    Cell Significance Index: -12.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5108
    Cell Significance Index: -18.7500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5123
    Cell Significance Index: -7.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5176
    Cell Significance Index: -7.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5283
    Cell Significance Index: -15.5600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.5412
    Cell Significance Index: -5.1500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5697
    Cell Significance Index: -7.4500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.6064
    Cell Significance Index: -7.1300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.6276
    Cell Significance Index: -6.8100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6421
    Cell Significance Index: -9.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6441
    Cell Significance Index: -16.4100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.6481
    Cell Significance Index: -8.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6790
    Cell Significance Index: -16.9600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.6898
    Cell Significance Index: -11.8500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7099
    Cell Significance Index: -11.9400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.7219
    Cell Significance Index: -12.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7619
    Cell Significance Index: -19.0000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.7693
    Cell Significance Index: -10.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7797
    Cell Significance Index: -16.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.7882
    Cell Significance Index: -11.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8124
    Cell Significance Index: -18.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8252
    Cell Significance Index: -13.8100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.8470
    Cell Significance Index: -10.0100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.8594
    Cell Significance Index: -10.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCL14 is a 8-kDa, four-cysteine-containing chemokine that belongs to the CC chemokine family. Its high affinity for CCR7, a G-protein coupled receptor, allows for efficient signaling and chemotaxis. CCL14 exhibits a unique ability to regulate the Erk1/2 cascade, a critical signaling pathway involved in cell proliferation, differentiation, and survival. Its expression is restricted to specific cell types, including endothelial cells, which are involved in the maintenance of tissue homeostasis and immune responses. **Pathways and Functions:** CCL14's primary function is to regulate immune responses by recruiting immune cells to sites of inflammation. Its interaction with CCR7 triggers a signaling cascade that leads to the activation of various cellular processes, including: 1. **Chemotaxis**: CCL14's ability to bind CCR7 enables the directed migration of immune cells towards the site of inflammation. 2. **Proliferation**: CCL14's interaction with CCR7 regulates the Erk1/2 cascade, promoting cell proliferation and survival. 3. **Signaling pathway**: CCL14's binding to CCR7 activates a G-protein coupled receptor signaling pathway, leading to the activation of various downstream targets. **Clinical Significance:** CCL14's role in immune responses and chemotaxis has significant implications for various diseases, including: 1. **Inflammatory disorders**: CCL14's involvement in the recruitment of immune cells to sites of inflammation makes it a potential therapeutic target for inflammatory diseases, such as rheumatoid arthritis and asthma. 2. **Cancer**: CCL14's expression in endothelial cells and its ability to regulate cell proliferation and survival make it a potential biomarker for cancer diagnosis and treatment. 3. **Autoimmune diseases**: CCL14's role in regulating immune responses and chemotaxis makes it a potential therapeutic target for autoimmune diseases, such as multiple sclerosis and type 1 diabetes. In conclusion, CCL14 is a key player in immune responses and chemotaxis, with significant implications for various diseases. Further research is needed to fully elucidate its function and potential therapeutic applications.

Genular Protein ID: 1545111099

Symbol: CCL14_HUMAN

Name: C-C motif chemokine 14

UniProtKB Accession Codes:

Q16627 E1P649 E1P650 Q13954

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8551235

Title: HCC-1, a novel chemokine from human plasma.

PubMed ID: 8551235

DOI: 10.1084/jem.183.1.295

PubMed ID: 9600961

Title: HCC-2, a human chemokine: gene structure, expression pattern, and biological activity.

PubMed ID: 9600961

DOI: 10.1073/pnas.95.11.6308

PubMed ID: 10213461

Title: Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES.

PubMed ID: 10213461

DOI: 10.1089/107999099314153

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10978165

Title: Posttranslationally processed forms of the human chemokine HCC-1.

PubMed ID: 10978165

DOI: 10.1021/bi992488q

PubMed ID: 11085751

Title: Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties.

PubMed ID: 11085751

DOI: 10.1084/jem.192.10.1501

PubMed ID: 17691823

Title: Structural and functional characterization of CC chemokine CCL14.

PubMed ID: 17691823

DOI: 10.1021/bi700936w

Sequence Information:

  • Length: 93
  • Mass: 10678
  • Checksum: DDDB899DC9148836
  • Sequence:
    • MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM DYYETNSQCS 
KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.