FOS | ENSG00000170345 | NCBI 2353

Details for: FOS

Gene ID: 2353

Symbol: FOS

Ensembl ID: ENSG00000170345

Description: Fos proto-oncogene, AP-1 transcription factor subunit

Associated with

Activation of the ap-1 family of transcription factors
(R-HSA-450341)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cytokine signaling in immune system
(R-HSA-1280215)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-17 signaling
(R-HSA-448424)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Ngf-stimulated transcription
(R-HSA-9031628)
Npas4 regulates expression of target genes
(R-HSA-9768919)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Oxidative stress induced senescence
(R-HSA-2559580)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional regulation by npas4
(R-HSA-9634815)
Transcriptional regulation by tp53
(R-HSA-3700989)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to zinc ion starvation
(GO:0034224)
Chromatin binding
(GO:0003682)
Conditioned taste aversion
(GO:0001661)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna methylation
(GO:0006306)
Female pregnancy
(GO:0007565)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Myoblast proliferation
(GO:0051450)
Nervous system development
(GO:0007399)
Osteoclast differentiation
(GO:0030316)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
R-smad binding
(GO:0070412)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to activity
(GO:0014823)
Response to corticosterone
(GO:0051412)
Response to ethanol
(GO:0045471)
Response to gravity
(GO:0009629)
Response to immobilization stress
(GO:0035902)
Response to insulin
(GO:0032868)
Response to light stimulus
(GO:0009416)
Response to lipopolysaccharide
(GO:0032496)
Response to muscle stretch
(GO:0035994)
Response to progesterone
(GO:0032570)
Response to toxic substance
(GO:0009636)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle cell differentiation
(GO:0035914)
Skeletal muscle cell proliferation
(GO:0014856)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.41
Marker Score: 7,041
Cell Name: acinar cell (CL0000622)
Fold Change: 4.68
Marker Score: 3,302
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.59
Marker Score: 7,065
Cell Name: early promyelocyte (CL0002154)
Fold Change: 4.57
Marker Score: 3,658
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.33
Marker Score: 241,946
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.21
Marker Score: 11,641
Cell Name: theca cell (CL0000503)
Fold Change: 4.21
Marker Score: 3,015
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.09
Marker Score: 17,518
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 4.02
Marker Score: 2,264
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.95
Marker Score: 3,362
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.9
Marker Score: 132,747
Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.9
Marker Score: 3,371
Cell Name: blood cell (CL0000081)
Fold Change: 3.87
Marker Score: 44,978
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.82
Marker Score: 10,711
Cell Name: myelocyte (CL0002193)
Fold Change: 3.81
Marker Score: 1,645
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.76
Marker Score: 2,851
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.73
Marker Score: 8,500
Cell Name: supporting cell (CL0000630)
Fold Change: 3.73
Marker Score: 7,005
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.71
Marker Score: 19,490
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.65
Marker Score: 23,256
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.63
Marker Score: 4,148
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.62
Marker Score: 1,875
Cell Name: memory T cell (CL0000813)
Fold Change: 3.62
Marker Score: 1,557
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.52
Marker Score: 2,760
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.47
Marker Score: 2,722
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.42
Marker Score: 1,756
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.39
Marker Score: 4,092
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.36
Marker Score: 2,439
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.36
Marker Score: 4,639
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.35
Marker Score: 4,047
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.33
Marker Score: 8,462
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.32
Marker Score: 8,007
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.32
Marker Score: 6,625
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.3
Marker Score: 21,451
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.3
Marker Score: 3,109
Cell Name: naive T cell (CL0000898)
Fold Change: 3.29
Marker Score: 2,122
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.29
Marker Score: 2,829
Cell Name: mature T cell (CL0002419)
Fold Change: 3.28
Marker Score: 32,523
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.26
Marker Score: 3,124
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.24
Marker Score: 3,463
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.21
Marker Score: 8,402
Cell Name: basophil (CL0000767)
Fold Change: 3.16
Marker Score: 1,502
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.16
Marker Score: 20,602
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.15
Marker Score: 2,800
Cell Name: fibroblast (CL0000057)
Fold Change: 3.15
Marker Score: 3,039
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.14
Marker Score: 4,624
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.14
Marker Score: 6,572
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.13
Marker Score: 6,102
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.13
Marker Score: 2,290
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.11
Marker Score: 3,115
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.07
Marker Score: 6,973
Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.06
Marker Score: 768
Cell Name: neutrophil (CL0000775)
Fold Change: 3.04
Marker Score: 1,852
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.01
Marker Score: 1,850
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.95
Marker Score: 4,846
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.94
Marker Score: 101,798
Cell Name: naive B cell (CL0000788)
Fold Change: 2.92
Marker Score: 2,608
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.9
Marker Score: 9,111
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.9
Marker Score: 32,636
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.9
Marker Score: 38,202
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.88
Marker Score: 1,298
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.88
Marker Score: 8,413
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.87
Marker Score: 4,866
Cell Name: basal cell (CL0000646)
Fold Change: 2.87
Marker Score: 3,709
Cell Name: decidual cell (CL2000002)
Fold Change: 2.87
Marker Score: 12,384
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.87
Marker Score: 1,084
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.86
Marker Score: 1,428
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.86
Marker Score: 4,544
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.84
Marker Score: 1,663
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.83
Marker Score: 676
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.83
Marker Score: 2,317
Cell Name: immature B cell (CL0000816)
Fold Change: 2.81
Marker Score: 1,861
Cell Name: paneth cell (CL0000510)
Fold Change: 2.8
Marker Score: 1,949
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.78
Marker Score: 1,832
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.77
Marker Score: 956
Cell Name: club cell (CL0000158)
Fold Change: 2.76
Marker Score: 3,222
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.76
Marker Score: 1,185
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 2.74
Marker Score: 747
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.73
Marker Score: 16,201
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.73
Marker Score: 3,952
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.73
Marker Score: 3,784
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.72
Marker Score: 1,408
Cell Name: stromal cell (CL0000499)
Fold Change: 2.71
Marker Score: 3,173
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.71
Marker Score: 3,007
Cell Name: pericyte (CL0000669)
Fold Change: 2.7
Marker Score: 1,580
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.7
Marker Score: 2,941
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 2.69
Marker Score: 626
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.69
Marker Score: 68,822
Cell Name: enterocyte (CL0000584)
Fold Change: 2.68
Marker Score: 12,865
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.67
Marker Score: 1,114
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.67
Marker Score: 1,213
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.67
Marker Score: 1,151
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.66
Marker Score: 826
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.66
Marker Score: 1,244
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.66
Marker Score: 3,205
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.66
Marker Score: 26,916
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.63
Marker Score: 3,251
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.62
Marker Score: 3,812
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.62
Marker Score: 5,462
Cell Name: Unknown (CL0000548)
Fold Change: 2.61
Marker Score: 1,905

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** FOS is a member of the AP-1 family of transcription factors, which play a key role in regulating gene expression in response to various cellular stimuli. Key characteristics of FOS include: 1. **Dimerization**: FOS forms a heterodimer with the JUN protein to form the AP-1 transcription factor complex. 2. **DNA binding**: FOS binds to specific DNA sequences, known as AP-1 consensus sequences, to regulate gene expression. 3. **Transcriptional activation**: FOS acts as a transcriptional activator, recruiting other transcription factors to regulate gene expression. 4. **Cellular localization**: FOS is primarily found in the nucleus, where it regulates gene expression. **Pathways and Functions** FOS is involved in various cellular pathways, including: 1. **Cellular responses to stimuli**: FOS regulates gene expression in response to growth factors, cytokines, stress, and immune responses. 2. **Immune system regulation**: FOS is involved in the regulation of immune responses, including inflammation, cytokine production, and immune cell development. 3. **Cancer development**: FOS is a potent oncogene that promotes cell proliferation, survival, and metastasis in various cancers. 4. **Stress response**: FOS regulates gene expression in response to oxidative stress, DNA damage, and other cellular stresses. **Clinical Significance** Dysregulation of FOS has been implicated in various diseases, including: 1. **Cancer**: FOS is overexpressed in various cancers, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: FOS is involved in the regulation of inflammatory responses, including rheumatoid arthritis and asthma. 3. **Autoimmune diseases**: FOS is implicated in the regulation of immune responses in autoimmune diseases, including multiple sclerosis and type 1 diabetes. 4. **Neurological disorders**: FOS is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FOS is a critical component of the AP-1 transcription factor complex, regulating gene expression in response to various cellular stimuli. Its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune diseases. Further research is needed to fully understand the role of FOS in human disease and to develop therapeutic strategies to target its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cellular oncogene fos

Genular Protein ID: 841333319

Symbol: FOS_HUMAN

Name: Cellular oncogene fos

UniProtKB Accession Codes:

P01100 A8K4E2 B4DQ65 P18849

Database IDs:

Citations:

PubMed ID: 6574479

Title: Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

PubMed ID: 6574479

DOI: 10.1073/pnas.80.11.3183

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1658710

Title: Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells.

PubMed ID: 1658710

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 2511004

Title: The basic region of Fos mediates specific DNA binding.

PubMed ID: 2511004

DOI: 10.1002/j.1460-2075.1989.tb08561.x

PubMed ID: 7588633

Title: The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.

PubMed ID: 7588633

DOI: 10.1002/j.1460-2075.1995.tb00187.x

PubMed ID: 9732876

Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

PubMed ID: 9732876

DOI: 10.1038/29814

PubMed ID: 12134156

Title: Molecular interpretation of ERK signal duration by immediate early gene products.

PubMed ID: 12134156

DOI: 10.1038/ncb822

PubMed ID: 16055710

Title: Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.

PubMed ID: 16055710

DOI: 10.1128/mcb.25.16.6964-6979.2005

PubMed ID: 17709345

Title: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.

PubMed ID: 17709345

DOI: 10.1093/nar/gkm617

PubMed ID: 17160021

Title: N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation.

PubMed ID: 17160021

DOI: 10.1038/sj.onc.1210137

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22105363

Title: The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity.

PubMed ID: 22105363

DOI: 10.1038/onc.2011.510

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 7816143

Title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.

PubMed ID: 7816143

DOI: 10.1038/373257a0

Sequence Information:

Length: 380
Mass: 40695
Checksum: 9E3B2969347C90C8
Sequence:

MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF 
IPTVTAISTS PDLQWLVQPA LVSSVAPSQT RAPHPFGVPA PSAGAYSRAG VVKTMTGGRA 
QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ 
TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEV ATPESEEAFT 
LPLLNDPEPK PSVEPVKSIS SMELKTEPFD DFLFPASSRP SGSETARSVP DMDLSGSFYA 
ADWEPLHSGS LGMGPMATEL EPLCTPVVTC TPSCTAYTSS FVFTYPEADS FPSCAAAHRK 
GSSSNEPSSD SLSSPTLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FOS

Associated with

Cells (max top 100)

Other Information

Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. PubMed ID: 6574479

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells. PubMed ID: 1658710

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. PubMed ID: 2516827

The basic region of Fos mediates specific DNA binding. PubMed ID: 2511004

The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. PubMed ID: 7588633

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. PubMed ID: 9732876

Molecular interpretation of ERK signal duration by immediate early gene products. PubMed ID: 12134156

Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. PubMed ID: 16055710

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. PubMed ID: 17709345

N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation. PubMed ID: 17160021

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity. PubMed ID: 22105363

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. PubMed ID: 7816143