FOS | ENSG00000170345 | NCBI 2353

Details for: FOS

Gene ID: 2353

Symbol: FOS

Ensembl ID: ENSG00000170345

Description: Fos proto-oncogene, AP-1 transcription factor subunit

Associated with

Activation of the ap-1 family of transcription factors
(R-HSA-450341)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cytokine signaling in immune system
(R-HSA-1280215)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-17 signaling
(R-HSA-448424)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Ngf-stimulated transcription
(R-HSA-9031628)
Npas4 regulates expression of target genes
(R-HSA-9768919)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Oxidative stress induced senescence
(R-HSA-2559580)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional regulation by npas4
(R-HSA-9634815)
Transcriptional regulation by tp53
(R-HSA-3700989)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to zinc ion starvation
(GO:0034224)
Cerebral cortex development
(GO:0021987)
Conditioned taste aversion
(GO:0001661)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Female pregnancy
(GO:0007565)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Myoblast proliferation
(GO:0051450)
Neural retina development
(GO:0003407)
Neuron differentiation
(GO:0030182)
Osteoclast differentiation
(GO:0030316)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
R-smad binding
(GO:0070412)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to activity
(GO:0014823)
Response to corticosterone
(GO:0051412)
Response to ethanol
(GO:0045471)
Response to gravity
(GO:0009629)
Response to immobilization stress
(GO:0035902)
Response to insulin
(GO:0032868)
Response to light stimulus
(GO:0009416)
Response to lipopolysaccharide
(GO:0032496)
Response to muscle stretch
(GO:0035994)
Response to progesterone
(GO:0032570)
Response to toxic substance
(GO:0009636)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle cell differentiation
(GO:0035914)
Skeletal muscle cell proliferation
(GO:0014856)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 995.9804
Cell Significance Index: -154.9200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 521.7167
Cell Significance Index: -132.3300
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 451.6108
Cell Significance Index: -186.0400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 404.1283
Cell Significance Index: -164.1800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 374.0342
Cell Significance Index: -176.5900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 353.6843
Cell Significance Index: -181.9300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 262.6739
Cell Significance Index: -176.2600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 177.2310
Cell Significance Index: -169.2100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 129.8830
Cell Significance Index: -160.1400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 57.0088
Cell Significance Index: -175.1000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 44.7258
Cell Significance Index: -176.4900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 29.2177
Cell Significance Index: -78.2700
Cell Name: theca cell (CL0000503)
Fold Change: 21.5148
Cell Significance Index: 126.4000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 13.9301
Cell Significance Index: 257.4700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 11.6174
Cell Significance Index: 148.7800
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 10.4521
Cell Significance Index: 28.0000
Cell Name: odontoblast (CL0000060)
Fold Change: 9.9403
Cell Significance Index: 1274.2900
Cell Name: peg cell (CL4033014)
Fold Change: 9.3389
Cell Significance Index: 215.7600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 8.4516
Cell Significance Index: 149.3500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 8.2695
Cell Significance Index: 237.0500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 6.5056
Cell Significance Index: 460.1000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 6.2877
Cell Significance Index: 2779.9500
Cell Name: granulosa cell (CL0000501)
Fold Change: 5.5984
Cell Significance Index: 147.2100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.1693
Cell Significance Index: 931.8600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.7179
Cell Significance Index: 647.9000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.4264
Cell Significance Index: 206.3800
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 4.4108
Cell Significance Index: 27.1500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.3446
Cell Significance Index: 90.9400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.2521
Cell Significance Index: 147.7600
Cell Name: cell in vitro (CL0001034)
Fold Change: 4.0416
Cell Significance Index: 2207.1900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.7228
Cell Significance Index: 174.9700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.7090
Cell Significance Index: 456.0600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.5964
Cell Significance Index: 232.0200
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 3.5386
Cell Significance Index: 73.8000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 2.5991
Cell Significance Index: 296.6900
Cell Name: kidney cell (CL1000497)
Fold Change: 2.5237
Cell Significance Index: 20.1500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.4815
Cell Significance Index: 67.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.3006
Cell Significance Index: 171.4600
Cell Name: lactocyte (CL0002325)
Fold Change: 1.9769
Cell Significance Index: 255.4000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.7592
Cell Significance Index: 174.0200
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.6980
Cell Significance Index: 10.5100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5916
Cell Significance Index: 83.5700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.5890
Cell Significance Index: 82.7700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.3617
Cell Significance Index: 36.4300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8876
Cell Significance Index: 23.7000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8375
Cell Significance Index: 756.2000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7288
Cell Significance Index: 85.9500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.4657
Cell Significance Index: 5.2900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3270
Cell Significance Index: 55.8300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2710
Cell Significance Index: 205.1200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.2599
Cell Significance Index: 4.3500
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.1368
Cell Significance Index: 13.9700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0131
Cell Significance Index: -8.3300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0153
Cell Significance Index: -23.4800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0166
Cell Significance Index: -31.2000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0310
Cell Significance Index: -22.7400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0726
Cell Significance Index: -13.8200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0792
Cell Significance Index: -146.1500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0847
Cell Significance Index: -62.7600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0954
Cell Significance Index: -59.5700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1039
Cell Significance Index: -16.9000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1461
Cell Significance Index: -198.5900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1782
Cell Significance Index: -123.2200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2187
Cell Significance Index: -123.3400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2248
Cell Significance Index: -2.0700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.3010
Cell Significance Index: -32.7500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.3092
Cell Significance Index: -140.3200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3474
Cell Significance Index: -15.7500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3715
Cell Significance Index: -78.2600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.4833
Cell Significance Index: -173.3600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4957
Cell Significance Index: -142.6300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5635
Cell Significance Index: -28.4800
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.5669
Cell Significance Index: -8.6100
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.5826
Cell Significance Index: -3.6200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.6155
Cell Significance Index: -25.2200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6450
Cell Significance Index: -93.7600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.6543
Cell Significance Index: -33.9900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.6641
Cell Significance Index: -18.5600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.6668
Cell Significance Index: -133.7600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.6861
Cell Significance Index: -136.1600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7609
Cell Significance Index: -24.3700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.8951
Cell Significance Index: -61.9000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.9149
Cell Significance Index: -54.9300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.0377
Cell Significance Index: -118.8900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0452
Cell Significance Index: -121.8100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -1.1213
Cell Significance Index: -12.1900
Cell Name: preadipocyte (CL0002334)
Fold Change: -1.4006
Cell Significance Index: -27.3400
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.4785
Cell Significance Index: -37.7700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.5413
Cell Significance Index: -118.2800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.5608
Cell Significance Index: -21.3000
Cell Name: supporting cell (CL0000630)
Fold Change: -1.5978
Cell Significance Index: -7.3800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.6778
Cell Significance Index: -174.7000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.1269
Cell Significance Index: -119.3500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -2.1937
Cell Significance Index: -173.7400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.2257
Cell Significance Index: -33.3500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.4029
Cell Significance Index: -151.4500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -2.4295
Cell Significance Index: -149.3300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.4921
Cell Significance Index: -152.7900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.5114
Cell Significance Index: -168.8700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -2.7530
Cell Significance Index: -79.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FOS is a member of the AP-1 family of transcription factors, which play a key role in regulating gene expression in response to various cellular stimuli. Key characteristics of FOS include: 1. **Dimerization**: FOS forms a heterodimer with the JUN protein to form the AP-1 transcription factor complex. 2. **DNA binding**: FOS binds to specific DNA sequences, known as AP-1 consensus sequences, to regulate gene expression. 3. **Transcriptional activation**: FOS acts as a transcriptional activator, recruiting other transcription factors to regulate gene expression. 4. **Cellular localization**: FOS is primarily found in the nucleus, where it regulates gene expression. **Pathways and Functions** FOS is involved in various cellular pathways, including: 1. **Cellular responses to stimuli**: FOS regulates gene expression in response to growth factors, cytokines, stress, and immune responses. 2. **Immune system regulation**: FOS is involved in the regulation of immune responses, including inflammation, cytokine production, and immune cell development. 3. **Cancer development**: FOS is a potent oncogene that promotes cell proliferation, survival, and metastasis in various cancers. 4. **Stress response**: FOS regulates gene expression in response to oxidative stress, DNA damage, and other cellular stresses. **Clinical Significance** Dysregulation of FOS has been implicated in various diseases, including: 1. **Cancer**: FOS is overexpressed in various cancers, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: FOS is involved in the regulation of inflammatory responses, including rheumatoid arthritis and asthma. 3. **Autoimmune diseases**: FOS is implicated in the regulation of immune responses in autoimmune diseases, including multiple sclerosis and type 1 diabetes. 4. **Neurological disorders**: FOS is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FOS is a critical component of the AP-1 transcription factor complex, regulating gene expression in response to various cellular stimuli. Its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune diseases. Further research is needed to fully understand the role of FOS in human disease and to develop therapeutic strategies to target its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cellular oncogene fos

Genular Protein ID: 841333319

Symbol: FOS_HUMAN

Name: Cellular oncogene fos

UniProtKB Accession Codes:

P01100 A8K4E2 B4DQ65 P18849

Database IDs:

Citations:

PubMed ID: 6574479

Title: Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

PubMed ID: 6574479

DOI: 10.1073/pnas.80.11.3183

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1658710

Title: Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells.

PubMed ID: 1658710

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 2511004

Title: The basic region of Fos mediates specific DNA binding.

PubMed ID: 2511004

DOI: 10.1002/j.1460-2075.1989.tb08561.x

PubMed ID: 7588633

Title: The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.

PubMed ID: 7588633

DOI: 10.1002/j.1460-2075.1995.tb00187.x

PubMed ID: 9732876

Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

PubMed ID: 9732876

DOI: 10.1038/29814

PubMed ID: 12134156

Title: Molecular interpretation of ERK signal duration by immediate early gene products.

PubMed ID: 12134156

DOI: 10.1038/ncb822

PubMed ID: 16055710

Title: Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.

PubMed ID: 16055710

DOI: 10.1128/mcb.25.16.6964-6979.2005

PubMed ID: 17709345

Title: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.

PubMed ID: 17709345

DOI: 10.1093/nar/gkm617

PubMed ID: 17160021

Title: N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation.

PubMed ID: 17160021

DOI: 10.1038/sj.onc.1210137

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22105363

Title: The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity.

PubMed ID: 22105363

DOI: 10.1038/onc.2011.510

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 7816143

Title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.

PubMed ID: 7816143

DOI: 10.1038/373257a0

Sequence Information:

Length: 380
Mass: 40695
Checksum: 9E3B2969347C90C8
Sequence:

MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF 
IPTVTAISTS PDLQWLVQPA LVSSVAPSQT RAPHPFGVPA PSAGAYSRAG VVKTMTGGRA 
QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ 
TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEV ATPESEEAFT 
LPLLNDPEPK PSVEPVKSIS SMELKTEPFD DFLFPASSRP SGSETARSVP DMDLSGSFYA 
ADWEPLHSGS LGMGPMATEL EPLCTPVVTC TPSCTAYTSS FVFTYPEADS FPSCAAAHRK 
GSSSNEPSSD SLSSPTLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FOS

Associated with

Cells (max top 100)

Other Information

Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. PubMed ID: 6574479

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells. PubMed ID: 1658710

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. PubMed ID: 2516827

The basic region of Fos mediates specific DNA binding. PubMed ID: 2511004

The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. PubMed ID: 7588633

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. PubMed ID: 9732876

Molecular interpretation of ERK signal duration by immediate early gene products. PubMed ID: 12134156

Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. PubMed ID: 16055710

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. PubMed ID: 17709345

N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation. PubMed ID: 17160021

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity. PubMed ID: 22105363

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. PubMed ID: 7816143