Details for: FOS
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 995.9804
Cell Significance Index: -154.9200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 521.7167
Cell Significance Index: -132.3300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 451.6108
Cell Significance Index: -186.0400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 404.1283
Cell Significance Index: -164.1800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 374.0342
Cell Significance Index: -176.5900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 353.6843
Cell Significance Index: -181.9300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 262.6739
Cell Significance Index: -176.2600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 177.2310
Cell Significance Index: -169.2100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 129.8830
Cell Significance Index: -160.1400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 57.0088
Cell Significance Index: -175.1000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 44.7258
Cell Significance Index: -176.4900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 29.2177
Cell Significance Index: -78.2700 - Cell Name: theca cell (CL0000503)
Fold Change: 21.5148
Cell Significance Index: 126.4000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 13.9301
Cell Significance Index: 257.4700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 11.6174
Cell Significance Index: 148.7800 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 10.4521
Cell Significance Index: 28.0000 - Cell Name: odontoblast (CL0000060)
Fold Change: 9.9403
Cell Significance Index: 1274.2900 - Cell Name: peg cell (CL4033014)
Fold Change: 9.3389
Cell Significance Index: 215.7600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 8.4516
Cell Significance Index: 149.3500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 8.2695
Cell Significance Index: 237.0500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 6.5056
Cell Significance Index: 460.1000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 6.2877
Cell Significance Index: 2779.9500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 5.5984
Cell Significance Index: 147.2100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.1693
Cell Significance Index: 931.8600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.7179
Cell Significance Index: 647.9000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.4264
Cell Significance Index: 206.3800 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 4.4108
Cell Significance Index: 27.1500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.3446
Cell Significance Index: 90.9400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.2521
Cell Significance Index: 147.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 4.0416
Cell Significance Index: 2207.1900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.7228
Cell Significance Index: 174.9700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.7090
Cell Significance Index: 456.0600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.5964
Cell Significance Index: 232.0200 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 3.5386
Cell Significance Index: 73.8000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 2.5991
Cell Significance Index: 296.6900 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.5237
Cell Significance Index: 20.1500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.4815
Cell Significance Index: 67.5500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.3006
Cell Significance Index: 171.4600 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.9769
Cell Significance Index: 255.4000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.7592
Cell Significance Index: 174.0200 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.6980
Cell Significance Index: 10.5100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5916
Cell Significance Index: 83.5700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.5890
Cell Significance Index: 82.7700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.3617
Cell Significance Index: 36.4300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8876
Cell Significance Index: 23.7000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8375
Cell Significance Index: 756.2000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7288
Cell Significance Index: 85.9500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.4657
Cell Significance Index: 5.2900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3270
Cell Significance Index: 55.8300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2710
Cell Significance Index: 205.1200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.2599
Cell Significance Index: 4.3500 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.1368
Cell Significance Index: 13.9700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0131
Cell Significance Index: -8.3300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0153
Cell Significance Index: -23.4800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0166
Cell Significance Index: -31.2000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0310
Cell Significance Index: -22.7400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0726
Cell Significance Index: -13.8200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0792
Cell Significance Index: -146.1500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0847
Cell Significance Index: -62.7600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0954
Cell Significance Index: -59.5700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1039
Cell Significance Index: -16.9000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1461
Cell Significance Index: -198.5900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1782
Cell Significance Index: -123.2200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2187
Cell Significance Index: -123.3400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2248
Cell Significance Index: -2.0700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.3010
Cell Significance Index: -32.7500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.3092
Cell Significance Index: -140.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3474
Cell Significance Index: -15.7500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3715
Cell Significance Index: -78.2600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.4833
Cell Significance Index: -173.3600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4957
Cell Significance Index: -142.6300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5635
Cell Significance Index: -28.4800 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.5669
Cell Significance Index: -8.6100 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.5826
Cell Significance Index: -3.6200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.6155
Cell Significance Index: -25.2200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6450
Cell Significance Index: -93.7600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.6543
Cell Significance Index: -33.9900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.6641
Cell Significance Index: -18.5600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.6668
Cell Significance Index: -133.7600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.6861
Cell Significance Index: -136.1600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7609
Cell Significance Index: -24.3700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.8951
Cell Significance Index: -61.9000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.9149
Cell Significance Index: -54.9300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.0377
Cell Significance Index: -118.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0452
Cell Significance Index: -121.8100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -1.1213
Cell Significance Index: -12.1900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.4006
Cell Significance Index: -27.3400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.4785
Cell Significance Index: -37.7700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.5413
Cell Significance Index: -118.2800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.5608
Cell Significance Index: -21.3000 - Cell Name: supporting cell (CL0000630)
Fold Change: -1.5978
Cell Significance Index: -7.3800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.6778
Cell Significance Index: -174.7000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.1269
Cell Significance Index: -119.3500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -2.1937
Cell Significance Index: -173.7400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.2257
Cell Significance Index: -33.3500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.4029
Cell Significance Index: -151.4500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -2.4295
Cell Significance Index: -149.3300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.4921
Cell Significance Index: -152.7900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.5114
Cell Significance Index: -168.8700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -2.7530
Cell Significance Index: -79.3200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 841333319
Symbol: FOS_HUMAN
Name: Cellular oncogene fos
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6574479
Title: Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
PubMed ID: 6574479
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1658710
Title: Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells.
PubMed ID: 1658710
PubMed ID: 2516827
Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.
PubMed ID: 2516827
PubMed ID: 2511004
Title: The basic region of Fos mediates specific DNA binding.
PubMed ID: 2511004
PubMed ID: 7588633
Title: The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.
PubMed ID: 7588633
PubMed ID: 9732876
Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
PubMed ID: 9732876
DOI: 10.1038/29814
PubMed ID: 12134156
Title: Molecular interpretation of ERK signal duration by immediate early gene products.
PubMed ID: 12134156
DOI: 10.1038/ncb822
PubMed ID: 16055710
Title: Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.
PubMed ID: 16055710
PubMed ID: 17709345
Title: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.
PubMed ID: 17709345
DOI: 10.1093/nar/gkm617
PubMed ID: 17160021
Title: N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation.
PubMed ID: 17160021
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 22105363
Title: The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity.
PubMed ID: 22105363
DOI: 10.1038/onc.2011.510
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 7816143
Title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.
PubMed ID: 7816143
DOI: 10.1038/373257a0
Sequence Information:
- Length: 380
- Mass: 40695
- Checksum: 9E3B2969347C90C8
- Sequence:
MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF IPTVTAISTS PDLQWLVQPA LVSSVAPSQT RAPHPFGVPA PSAGAYSRAG VVKTMTGGRA QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEV ATPESEEAFT LPLLNDPEPK PSVEPVKSIS SMELKTEPFD DFLFPASSRP SGSETARSVP DMDLSGSFYA ADWEPLHSGS LGMGPMATEL EPLCTPVVTC TPSCTAYTSS FVFTYPEADS FPSCAAAHRK GSSSNEPSSD SLSSPTLLAL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.