Details for: FOS

Gene ID: 2353

Symbol: FOS

Ensembl ID: ENSG00000170345

Description: Fos proto-oncogene, AP-1 transcription factor subunit

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.41
    Marker Score: 7,041
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.68
    Marker Score: 3,302
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.59
    Marker Score: 7,065
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.57
    Marker Score: 3,658
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.33
    Marker Score: 241,946
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.21
    Marker Score: 11,641
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.21
    Marker Score: 3,015
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.09
    Marker Score: 17,518
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 4.02
    Marker Score: 2,264
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.95
    Marker Score: 3,362
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.9
    Marker Score: 132,747
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.9
    Marker Score: 3,371
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.87
    Marker Score: 44,978
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.82
    Marker Score: 10,711
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.81
    Marker Score: 1,645
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.76
    Marker Score: 2,851
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.73
    Marker Score: 8,500
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.73
    Marker Score: 7,005
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.71
    Marker Score: 19,490
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.65
    Marker Score: 23,256
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.63
    Marker Score: 4,148
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.62
    Marker Score: 1,875
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.62
    Marker Score: 1,557
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.52
    Marker Score: 2,760
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.47
    Marker Score: 2,722
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.42
    Marker Score: 1,756
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.39
    Marker Score: 4,092
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.36
    Marker Score: 2,439
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.36
    Marker Score: 4,639
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.35
    Marker Score: 4,047
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.33
    Marker Score: 8,462
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.32
    Marker Score: 8,007
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.32
    Marker Score: 6,625
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.3
    Marker Score: 21,451
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.3
    Marker Score: 3,109
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.29
    Marker Score: 2,122
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.29
    Marker Score: 2,829
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.28
    Marker Score: 32,523
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.26
    Marker Score: 3,124
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.24
    Marker Score: 3,463
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.21
    Marker Score: 8,402
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.16
    Marker Score: 1,502
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.16
    Marker Score: 20,602
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.15
    Marker Score: 2,800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.15
    Marker Score: 3,039
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.14
    Marker Score: 4,624
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.14
    Marker Score: 6,572
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.13
    Marker Score: 6,102
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.13
    Marker Score: 2,290
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.11
    Marker Score: 3,115
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.07
    Marker Score: 6,973
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.06
    Marker Score: 768
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.04
    Marker Score: 1,852
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.01
    Marker Score: 1,850
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.95
    Marker Score: 4,846
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.94
    Marker Score: 101,798
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.92
    Marker Score: 2,608
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.9
    Marker Score: 9,111
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9
    Marker Score: 32,636
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.9
    Marker Score: 38,202
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.88
    Marker Score: 1,298
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.88
    Marker Score: 8,413
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.87
    Marker Score: 4,866
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.87
    Marker Score: 3,709
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.87
    Marker Score: 12,384
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.87
    Marker Score: 1,084
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.86
    Marker Score: 1,428
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.86
    Marker Score: 4,544
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.84
    Marker Score: 1,663
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.83
    Marker Score: 676
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.83
    Marker Score: 2,317
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.81
    Marker Score: 1,861
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.8
    Marker Score: 1,949
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.78
    Marker Score: 1,832
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.77
    Marker Score: 956
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.76
    Marker Score: 3,222
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.76
    Marker Score: 1,185
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 2.74
    Marker Score: 747
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.73
    Marker Score: 16,201
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.73
    Marker Score: 3,952
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.73
    Marker Score: 3,784
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.72
    Marker Score: 1,408
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.71
    Marker Score: 3,173
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.71
    Marker Score: 3,007
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.7
    Marker Score: 1,580
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.7
    Marker Score: 2,941
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.69
    Marker Score: 626
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.69
    Marker Score: 68,822
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.68
    Marker Score: 12,865
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.67
    Marker Score: 1,114
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.67
    Marker Score: 1,213
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.67
    Marker Score: 1,151
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.66
    Marker Score: 826
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.66
    Marker Score: 1,244
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.66
    Marker Score: 3,205
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.66
    Marker Score: 26,916
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.63
    Marker Score: 3,251
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.62
    Marker Score: 3,812
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.62
    Marker Score: 5,462
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.61
    Marker Score: 1,905

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOS is a member of the AP-1 family of transcription factors, which play a key role in regulating gene expression in response to various cellular stimuli. Key characteristics of FOS include: 1. **Dimerization**: FOS forms a heterodimer with the JUN protein to form the AP-1 transcription factor complex. 2. **DNA binding**: FOS binds to specific DNA sequences, known as AP-1 consensus sequences, to regulate gene expression. 3. **Transcriptional activation**: FOS acts as a transcriptional activator, recruiting other transcription factors to regulate gene expression. 4. **Cellular localization**: FOS is primarily found in the nucleus, where it regulates gene expression. **Pathways and Functions** FOS is involved in various cellular pathways, including: 1. **Cellular responses to stimuli**: FOS regulates gene expression in response to growth factors, cytokines, stress, and immune responses. 2. **Immune system regulation**: FOS is involved in the regulation of immune responses, including inflammation, cytokine production, and immune cell development. 3. **Cancer development**: FOS is a potent oncogene that promotes cell proliferation, survival, and metastasis in various cancers. 4. **Stress response**: FOS regulates gene expression in response to oxidative stress, DNA damage, and other cellular stresses. **Clinical Significance** Dysregulation of FOS has been implicated in various diseases, including: 1. **Cancer**: FOS is overexpressed in various cancers, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: FOS is involved in the regulation of inflammatory responses, including rheumatoid arthritis and asthma. 3. **Autoimmune diseases**: FOS is implicated in the regulation of immune responses in autoimmune diseases, including multiple sclerosis and type 1 diabetes. 4. **Neurological disorders**: FOS is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FOS is a critical component of the AP-1 transcription factor complex, regulating gene expression in response to various cellular stimuli. Its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune diseases. Further research is needed to fully understand the role of FOS in human disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 841333319

Symbol: FOS_HUMAN

Name: Cellular oncogene fos

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 6574479

Title: Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

PubMed ID: 6574479

DOI: 10.1073/pnas.80.11.3183

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1658710

Title: Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells.

PubMed ID: 1658710

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 2511004

Title: The basic region of Fos mediates specific DNA binding.

PubMed ID: 2511004

DOI: 10.1002/j.1460-2075.1989.tb08561.x

PubMed ID: 7588633

Title: The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.

PubMed ID: 7588633

DOI: 10.1002/j.1460-2075.1995.tb00187.x

PubMed ID: 9732876

Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

PubMed ID: 9732876

DOI: 10.1038/29814

PubMed ID: 12134156

Title: Molecular interpretation of ERK signal duration by immediate early gene products.

PubMed ID: 12134156

DOI: 10.1038/ncb822

PubMed ID: 16055710

Title: Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.

PubMed ID: 16055710

DOI: 10.1128/mcb.25.16.6964-6979.2005

PubMed ID: 17709345

Title: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.

PubMed ID: 17709345

DOI: 10.1093/nar/gkm617

PubMed ID: 17160021

Title: N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation.

PubMed ID: 17160021

DOI: 10.1038/sj.onc.1210137

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22105363

Title: The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity.

PubMed ID: 22105363

DOI: 10.1038/onc.2011.510

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 7816143

Title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.

PubMed ID: 7816143

DOI: 10.1038/373257a0

Sequence Information:

  • Length: 380
  • Mass: 40695
  • Checksum: 9E3B2969347C90C8
  • Sequence:
  • MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF 
    IPTVTAISTS PDLQWLVQPA LVSSVAPSQT RAPHPFGVPA PSAGAYSRAG VVKTMTGGRA 
    QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ 
    TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEV ATPESEEAFT 
    LPLLNDPEPK PSVEPVKSIS SMELKTEPFD DFLFPASSRP SGSETARSVP DMDLSGSFYA 
    ADWEPLHSGS LGMGPMATEL EPLCTPVVTC TPSCTAYTSS FVFTYPEADS FPSCAAAHRK 
    GSSSNEPSSD SLSSPTLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.