Details for: FOS

Gene ID: 2353

Symbol: FOS

Ensembl ID: ENSG00000170345

Description: Fos proto-oncogene, AP-1 transcription factor subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 995.9804
    Cell Significance Index: -154.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 521.7167
    Cell Significance Index: -132.3300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 451.6108
    Cell Significance Index: -186.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 404.1283
    Cell Significance Index: -164.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 374.0342
    Cell Significance Index: -176.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 353.6843
    Cell Significance Index: -181.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 262.6739
    Cell Significance Index: -176.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 177.2310
    Cell Significance Index: -169.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 129.8830
    Cell Significance Index: -160.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 57.0088
    Cell Significance Index: -175.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 44.7258
    Cell Significance Index: -176.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.2177
    Cell Significance Index: -78.2700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 21.5148
    Cell Significance Index: 126.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 13.9301
    Cell Significance Index: 257.4700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.6174
    Cell Significance Index: 148.7800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.4521
    Cell Significance Index: 28.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 9.9403
    Cell Significance Index: 1274.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.3389
    Cell Significance Index: 215.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.4516
    Cell Significance Index: 149.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.2695
    Cell Significance Index: 237.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 6.5056
    Cell Significance Index: 460.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.2877
    Cell Significance Index: 2779.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.5984
    Cell Significance Index: 147.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.1693
    Cell Significance Index: 931.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.7179
    Cell Significance Index: 647.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.4264
    Cell Significance Index: 206.3800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.4108
    Cell Significance Index: 27.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.3446
    Cell Significance Index: 90.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.2521
    Cell Significance Index: 147.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0416
    Cell Significance Index: 2207.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7228
    Cell Significance Index: 174.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.7090
    Cell Significance Index: 456.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5964
    Cell Significance Index: 232.0200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 3.5386
    Cell Significance Index: 73.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 2.5991
    Cell Significance Index: 296.6900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.5237
    Cell Significance Index: 20.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4815
    Cell Significance Index: 67.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3006
    Cell Significance Index: 171.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9769
    Cell Significance Index: 255.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7592
    Cell Significance Index: 174.0200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.6980
    Cell Significance Index: 10.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5916
    Cell Significance Index: 83.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5890
    Cell Significance Index: 82.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3617
    Cell Significance Index: 36.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8876
    Cell Significance Index: 23.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8375
    Cell Significance Index: 756.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7288
    Cell Significance Index: 85.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4657
    Cell Significance Index: 5.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3270
    Cell Significance Index: 55.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2710
    Cell Significance Index: 205.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2599
    Cell Significance Index: 4.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1368
    Cell Significance Index: 13.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0131
    Cell Significance Index: -8.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0153
    Cell Significance Index: -23.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0166
    Cell Significance Index: -31.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0310
    Cell Significance Index: -22.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0726
    Cell Significance Index: -13.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0792
    Cell Significance Index: -146.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0847
    Cell Significance Index: -62.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0954
    Cell Significance Index: -59.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1039
    Cell Significance Index: -16.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1461
    Cell Significance Index: -198.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1782
    Cell Significance Index: -123.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2187
    Cell Significance Index: -123.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2248
    Cell Significance Index: -2.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3010
    Cell Significance Index: -32.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3092
    Cell Significance Index: -140.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3474
    Cell Significance Index: -15.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3715
    Cell Significance Index: -78.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.4833
    Cell Significance Index: -173.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4957
    Cell Significance Index: -142.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5635
    Cell Significance Index: -28.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5669
    Cell Significance Index: -8.6100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5826
    Cell Significance Index: -3.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6155
    Cell Significance Index: -25.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6450
    Cell Significance Index: -93.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6543
    Cell Significance Index: -33.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6641
    Cell Significance Index: -18.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.6668
    Cell Significance Index: -133.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.6861
    Cell Significance Index: -136.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7609
    Cell Significance Index: -24.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8951
    Cell Significance Index: -61.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9149
    Cell Significance Index: -54.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0377
    Cell Significance Index: -118.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.0452
    Cell Significance Index: -121.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.1213
    Cell Significance Index: -12.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.4006
    Cell Significance Index: -27.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.4785
    Cell Significance Index: -37.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.5413
    Cell Significance Index: -118.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5608
    Cell Significance Index: -21.3000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -1.5978
    Cell Significance Index: -7.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.6778
    Cell Significance Index: -174.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.1269
    Cell Significance Index: -119.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.1937
    Cell Significance Index: -173.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.2257
    Cell Significance Index: -33.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.4029
    Cell Significance Index: -151.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.4295
    Cell Significance Index: -149.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.4921
    Cell Significance Index: -152.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.5114
    Cell Significance Index: -168.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.7530
    Cell Significance Index: -79.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOS is a member of the AP-1 family of transcription factors, which play a key role in regulating gene expression in response to various cellular stimuli. Key characteristics of FOS include: 1. **Dimerization**: FOS forms a heterodimer with the JUN protein to form the AP-1 transcription factor complex. 2. **DNA binding**: FOS binds to specific DNA sequences, known as AP-1 consensus sequences, to regulate gene expression. 3. **Transcriptional activation**: FOS acts as a transcriptional activator, recruiting other transcription factors to regulate gene expression. 4. **Cellular localization**: FOS is primarily found in the nucleus, where it regulates gene expression. **Pathways and Functions** FOS is involved in various cellular pathways, including: 1. **Cellular responses to stimuli**: FOS regulates gene expression in response to growth factors, cytokines, stress, and immune responses. 2. **Immune system regulation**: FOS is involved in the regulation of immune responses, including inflammation, cytokine production, and immune cell development. 3. **Cancer development**: FOS is a potent oncogene that promotes cell proliferation, survival, and metastasis in various cancers. 4. **Stress response**: FOS regulates gene expression in response to oxidative stress, DNA damage, and other cellular stresses. **Clinical Significance** Dysregulation of FOS has been implicated in various diseases, including: 1. **Cancer**: FOS is overexpressed in various cancers, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: FOS is involved in the regulation of inflammatory responses, including rheumatoid arthritis and asthma. 3. **Autoimmune diseases**: FOS is implicated in the regulation of immune responses in autoimmune diseases, including multiple sclerosis and type 1 diabetes. 4. **Neurological disorders**: FOS is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FOS is a critical component of the AP-1 transcription factor complex, regulating gene expression in response to various cellular stimuli. Its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and autoimmune diseases. Further research is needed to fully understand the role of FOS in human disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 841333319

Symbol: FOS_HUMAN

Name: Cellular oncogene fos

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 6574479

Title: Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

PubMed ID: 6574479

DOI: 10.1073/pnas.80.11.3183

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1658710

Title: Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells.

PubMed ID: 1658710

PubMed ID: 2516827

Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

PubMed ID: 2516827

DOI: 10.1101/gad.3.12b.2083

PubMed ID: 2511004

Title: The basic region of Fos mediates specific DNA binding.

PubMed ID: 2511004

DOI: 10.1002/j.1460-2075.1989.tb08561.x

PubMed ID: 7588633

Title: The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.

PubMed ID: 7588633

DOI: 10.1002/j.1460-2075.1995.tb00187.x

PubMed ID: 9732876

Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

PubMed ID: 9732876

DOI: 10.1038/29814

PubMed ID: 12134156

Title: Molecular interpretation of ERK signal duration by immediate early gene products.

PubMed ID: 12134156

DOI: 10.1038/ncb822

PubMed ID: 16055710

Title: Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.

PubMed ID: 16055710

DOI: 10.1128/mcb.25.16.6964-6979.2005

PubMed ID: 17709345

Title: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.

PubMed ID: 17709345

DOI: 10.1093/nar/gkm617

PubMed ID: 17160021

Title: N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation.

PubMed ID: 17160021

DOI: 10.1038/sj.onc.1210137

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22105363

Title: The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity.

PubMed ID: 22105363

DOI: 10.1038/onc.2011.510

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 7816143

Title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.

PubMed ID: 7816143

DOI: 10.1038/373257a0

Sequence Information:

  • Length: 380
  • Mass: 40695
  • Checksum: 9E3B2969347C90C8
  • Sequence:
  • MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF 
    IPTVTAISTS PDLQWLVQPA LVSSVAPSQT RAPHPFGVPA PSAGAYSRAG VVKTMTGGRA 
    QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ 
    TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEV ATPESEEAFT 
    LPLLNDPEPK PSVEPVKSIS SMELKTEPFD DFLFPASSRP SGSETARSVP DMDLSGSFYA 
    ADWEPLHSGS LGMGPMATEL EPLCTPVVTC TPSCTAYTSS FVFTYPEADS FPSCAAAHRK 
    GSSSNEPSSD SLSSPTLLAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.