Details for: WAC
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 625.2522
Cell Significance Index: -97.2600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 381.4016
Cell Significance Index: -96.7400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 228.2086
Cell Significance Index: -94.0100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 219.9640
Cell Significance Index: -103.8500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 210.9009
Cell Significance Index: -85.6800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 186.8833
Cell Significance Index: -96.1300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 154.7192
Cell Significance Index: -103.8200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 89.9614
Cell Significance Index: -85.8900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 84.2974
Cell Significance Index: -103.9400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 34.7965
Cell Significance Index: -93.2200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 28.7291
Cell Significance Index: -88.2400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 26.7825
Cell Significance Index: -105.6900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 22.4574
Cell Significance Index: -49.1500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.5757
Cell Significance Index: 247.2800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.4766
Cell Significance Index: 92.8300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.0641
Cell Significance Index: 171.9400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4752
Cell Significance Index: 491.2100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.3819
Cell Significance Index: 477.8100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.0528
Cell Significance Index: 57.3700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.7759
Cell Significance Index: 193.1600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.7028
Cell Significance Index: 610.7500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.4642
Cell Significance Index: 112.3600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3723
Cell Significance Index: 82.3900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.3472
Cell Significance Index: 165.6600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.3086
Cell Significance Index: 25.5400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2518
Cell Significance Index: 225.6700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1359
Cell Significance Index: 155.9900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.0720
Cell Significance Index: 65.8900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9597
Cell Significance Index: 524.1200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9585
Cell Significance Index: 662.9000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.8917
Cell Significance Index: 22.9200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8491
Cell Significance Index: 375.3900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8366
Cell Significance Index: 24.1100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8048
Cell Significance Index: 23.0700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6610
Cell Significance Index: 42.6500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6217
Cell Significance Index: 29.2200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6121
Cell Significance Index: 116.4900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.6051
Cell Significance Index: 10.3700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.5568
Cell Significance Index: 1048.4000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5458
Cell Significance Index: 88.7800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5000
Cell Significance Index: 13.6100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.4362
Cell Significance Index: 671.5400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3943
Cell Significance Index: 250.4400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3626
Cell Significance Index: 24.3800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.3354
Cell Significance Index: 618.5500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3284
Cell Significance Index: 15.3100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3093
Cell Significance Index: 140.4000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2640
Cell Significance Index: 5.7200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2616
Cell Significance Index: 33.5400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2011
Cell Significance Index: 181.5400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1860
Cell Significance Index: 21.9300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1838
Cell Significance Index: 249.8800 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0991
Cell Significance Index: 12.8100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0380
Cell Significance Index: -27.8300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0415
Cell Significance Index: -3.0900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0450
Cell Significance Index: -3.1900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0638
Cell Significance Index: -4.0200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0764
Cell Significance Index: -13.0500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0960
Cell Significance Index: -72.6400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1018
Cell Significance Index: -75.3800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1026
Cell Significance Index: -0.6200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1047
Cell Significance Index: -1.2500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1283
Cell Significance Index: -1.8500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1285
Cell Significance Index: -12.7100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1641
Cell Significance Index: -92.5700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1689
Cell Significance Index: -7.4700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1861
Cell Significance Index: -116.2000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2096
Cell Significance Index: -21.4100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2225
Cell Significance Index: -7.8200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2761
Cell Significance Index: -14.5000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2890
Cell Significance Index: -15.0200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3016
Cell Significance Index: -43.8400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3141
Cell Significance Index: -90.3800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3334
Cell Significance Index: -38.8500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3343
Cell Significance Index: -12.6600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3939
Cell Significance Index: -8.4200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4360
Cell Significance Index: -22.7100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5189
Cell Significance Index: -109.3000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5654
Cell Significance Index: -13.5600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6015
Cell Significance Index: -62.6300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6831
Cell Significance Index: -78.2600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6970
Cell Significance Index: -18.6800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.7192
Cell Significance Index: -12.1200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7971
Cell Significance Index: -27.7000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.8209
Cell Significance Index: -11.2000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.0013
Cell Significance Index: -20.7700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.0595
Cell Significance Index: -15.2200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0605
Cell Significance Index: -83.9900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.1165
Cell Significance Index: -18.6900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.1965
Cell Significance Index: -54.2400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.2162
Cell Significance Index: -17.9600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.2596
Cell Significance Index: -23.2800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.2831
Cell Significance Index: -33.7400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.3029
Cell Significance Index: -41.7300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.4767
Cell Significance Index: -42.1400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.4910
Cell Significance Index: -13.7300 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -1.5895
Cell Significance Index: -10.7700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.6466
Cell Significance Index: -100.9500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.6994
Cell Significance Index: -42.4800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.7528
Cell Significance Index: -37.3300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2856430108
Symbol: WAC_HUMAN
Name: WW domain-containing adapter protein with coiled-coil
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11347906
Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 11347906
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22354037
Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
PubMed ID: 22354037
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25356899
Title: De novo mutations in moderate or severe intellectual disability.
PubMed ID: 25356899
PubMed ID: 26264232
Title: WAC loss-of-function mutations cause a recognisable syndrome characterised by dysmorphic features, developmental delay and hypotonia and recapitulate 10p11.23 microdeletion syndrome.
PubMed ID: 26264232
PubMed ID: 26812014
Title: WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes.
PubMed ID: 26812014
PubMed ID: 26757981
Title: De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila.
PubMed ID: 26757981
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 21329877
Title: WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription.
PubMed ID: 21329877
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
Sequence Information:
- Length: 647
- Mass: 70724
- Checksum: 15C32DAAA3A94129
- Sequence:
MVMYARKQQR LSDGCHDRRG DSQPYQALKY SSKSHPSSGD HRHEKMRDAG DPSPPNKMLR RSDSPENKYS DSTGHSKAKN VHTHRVRERD GGTSYSPQEN SHNHSALHSS NSHSSNPSNN PSKTSDAPYD SADDWSEHIS SSGKKYYYNC RTEVSQWEKP KEWLEREQRQ KEANKMAVNS FPKDRDYRRE VMQATATSGF ASGMEDKHSS DASSLLPQNI LSQTSRHNDR DYRLPRAETH SSSTPVQHPI KPVVHPTATP STVPSSPFTL QSDHQPKKSF DANGASTLSK LPTPTSSVPA QKTERKESTS GDKPVSHSCT TPSTSSASGL NPTSAPPTSA SAVPVSPVPQ SPIPPLLQDP NLLRQLLPAL QATLQLNNSN VDISKINEVL TAAVTQASLQ SIIHKFLTAG PSAFNITSLI SQAAQLSTQA QPSNQSPMSL TSDASSPRSY VSPRISTPQT NTVPIKPLIS TPPVSSQPKV STPVVKQGPV SQSATQQPVT ADKQQGHEPV SPRSLQRSSS QRSPSPGPNH TSNSSNASNA TVVPQNSSAR STCSLTPALA AHFSENLIKH VQGWPADHAE KQASRLREEA HNMGTIHMSE ICTELKNLRS LVRVCEIQAT LREQRILFLR QQIKELEKLK NQNSFMV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.