Details for: WAC

Gene ID: 51322

Symbol: WAC

Ensembl ID: ENSG00000095787

Description: WW domain containing adaptor with coiled-coil

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 625.2522
    Cell Significance Index: -97.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 381.4016
    Cell Significance Index: -96.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 228.2086
    Cell Significance Index: -94.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 219.9640
    Cell Significance Index: -103.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 210.9009
    Cell Significance Index: -85.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 186.8833
    Cell Significance Index: -96.1300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 154.7192
    Cell Significance Index: -103.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 89.9614
    Cell Significance Index: -85.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 84.2974
    Cell Significance Index: -103.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.7965
    Cell Significance Index: -93.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 28.7291
    Cell Significance Index: -88.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.7825
    Cell Significance Index: -105.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.4574
    Cell Significance Index: -49.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.5757
    Cell Significance Index: 247.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.4766
    Cell Significance Index: 92.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.0641
    Cell Significance Index: 171.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4752
    Cell Significance Index: 491.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3819
    Cell Significance Index: 477.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0528
    Cell Significance Index: 57.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7759
    Cell Significance Index: 193.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7028
    Cell Significance Index: 610.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4642
    Cell Significance Index: 112.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3723
    Cell Significance Index: 82.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3472
    Cell Significance Index: 165.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3086
    Cell Significance Index: 25.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2518
    Cell Significance Index: 225.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1359
    Cell Significance Index: 155.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0720
    Cell Significance Index: 65.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9597
    Cell Significance Index: 524.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9585
    Cell Significance Index: 662.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8917
    Cell Significance Index: 22.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8491
    Cell Significance Index: 375.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8366
    Cell Significance Index: 24.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8048
    Cell Significance Index: 23.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6610
    Cell Significance Index: 42.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6217
    Cell Significance Index: 29.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6121
    Cell Significance Index: 116.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6051
    Cell Significance Index: 10.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5568
    Cell Significance Index: 1048.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5458
    Cell Significance Index: 88.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5000
    Cell Significance Index: 13.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4362
    Cell Significance Index: 671.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3943
    Cell Significance Index: 250.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3626
    Cell Significance Index: 24.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3354
    Cell Significance Index: 618.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3284
    Cell Significance Index: 15.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3093
    Cell Significance Index: 140.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2640
    Cell Significance Index: 5.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2616
    Cell Significance Index: 33.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2011
    Cell Significance Index: 181.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1860
    Cell Significance Index: 21.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1838
    Cell Significance Index: 249.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0991
    Cell Significance Index: 12.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0380
    Cell Significance Index: -27.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0415
    Cell Significance Index: -3.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0450
    Cell Significance Index: -3.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0638
    Cell Significance Index: -4.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0764
    Cell Significance Index: -13.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0960
    Cell Significance Index: -72.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1018
    Cell Significance Index: -75.3800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1026
    Cell Significance Index: -0.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1047
    Cell Significance Index: -1.2500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1283
    Cell Significance Index: -1.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1285
    Cell Significance Index: -12.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1641
    Cell Significance Index: -92.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1689
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1861
    Cell Significance Index: -116.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2096
    Cell Significance Index: -21.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2225
    Cell Significance Index: -7.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2761
    Cell Significance Index: -14.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2890
    Cell Significance Index: -15.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3016
    Cell Significance Index: -43.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3141
    Cell Significance Index: -90.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3334
    Cell Significance Index: -38.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3343
    Cell Significance Index: -12.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3939
    Cell Significance Index: -8.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4360
    Cell Significance Index: -22.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5189
    Cell Significance Index: -109.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5654
    Cell Significance Index: -13.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6015
    Cell Significance Index: -62.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6831
    Cell Significance Index: -78.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6970
    Cell Significance Index: -18.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7192
    Cell Significance Index: -12.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7971
    Cell Significance Index: -27.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8209
    Cell Significance Index: -11.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0013
    Cell Significance Index: -20.7700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.0595
    Cell Significance Index: -15.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0605
    Cell Significance Index: -83.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1165
    Cell Significance Index: -18.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1965
    Cell Significance Index: -54.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2162
    Cell Significance Index: -17.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2596
    Cell Significance Index: -23.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2831
    Cell Significance Index: -33.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3029
    Cell Significance Index: -41.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.4767
    Cell Significance Index: -42.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.4910
    Cell Significance Index: -13.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.5895
    Cell Significance Index: -10.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6466
    Cell Significance Index: -100.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6994
    Cell Significance Index: -42.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7528
    Cell Significance Index: -37.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Gene Summary: WAC (WW Domain Containing Adaptor with Coiled-Coil)** The WAC gene, also known as WW domain containing adaptor with coiled-coil (WAC), is a human gene that encodes a protein involved in various cellular processes including chromatin binding, DNA damage response, and regulation of autophagy. The gene is significantly expressed in multiple cell types, including hematopoietic stem cells, embryonic stem cells, and smooth muscle fibers, highlighting its role in tissue development and maintenance. **Key Characteristics of WAC** 1. **Structure**: The WAC protein contains a WW domain, a coiled-coil domain, and a ubiquitin-binding domain, which enables its interactions with various proteins and modifications. 2. **Cellular localization**: WAC is primarily localized to the nucleus and nucleoplasm, where it participates in chromatin remodeling and DNA damage response. 3. **Expression pattern**: WAC is expressed in a wide range of cell types, including hematopoietic stem cells, embryonic stem cells, smooth muscle fibers, and epithelial cells. **Pathways and Functions of WAC** 1. **Chromatin binding and remodeling**: WAC interacts with chromatin remodeling complexes to regulate gene expression and DNA replication. 2. **DNA damage response**: WAC is involved in the regulation of DNA damage response pathways, including the mitotic G1 DNA damage checkpoint signaling. 3. **Autophagy regulation**: WAC regulates autophagy by interacting with autophagy-related proteins and modulating the activity of the TORC1 signaling pathway. 4. **Protein modification and ubiquitination**: WAC is involved in the ubiquitination of target proteins, which regulates their degradation and function. 5. **Transcriptional regulation**: WAC regulates DNA-templated transcription by interacting with the RNA polymerase II complex and spliceosomal complexes. **Clinical Significance of WAC** 1. **Cancer**: WAC has been implicated in various cancers, including colorectal cancer, gastric cancer, and breast cancer, where it is often overexpressed or mutated. 2. **Autoimmune diseases**: WAC has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it is involved in the regulation of immune responses. 3. **Neurological disorders**: WAC has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates autophagy and protein degradation. 4. **Regenerative medicine**: WAC has potential applications in regenerative medicine, where it can be used to regulate tissue development and repair. In conclusion, the WAC gene plays a crucial role in various cellular processes, including chromatin binding, DNA damage response, and regulation of autophagy. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological disorders. Further research is needed to fully understand the functions of WAC and its potential applications in human disease and regenerative medicine.

Genular Protein ID: 2856430108

Symbol: WAC_HUMAN

Name: WW domain-containing adapter protein with coiled-coil

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22354037

Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

PubMed ID: 22354037

DOI: 10.1038/emboj.2012.36

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

PubMed ID: 26264232

Title: WAC loss-of-function mutations cause a recognisable syndrome characterised by dysmorphic features, developmental delay and hypotonia and recapitulate 10p11.23 microdeletion syndrome.

PubMed ID: 26264232

DOI: 10.1136/jmedgenet-2015-103069

PubMed ID: 26812014

Title: WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes.

PubMed ID: 26812014

DOI: 10.1016/j.devcel.2015.12.019

PubMed ID: 26757981

Title: De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila.

PubMed ID: 26757981

DOI: 10.1038/ejhg.2015.282

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21329877

Title: WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription.

PubMed ID: 21329877

DOI: 10.1016/j.molcel.2011.01.024

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 647
  • Mass: 70724
  • Checksum: 15C32DAAA3A94129
  • Sequence:
  • MVMYARKQQR LSDGCHDRRG DSQPYQALKY SSKSHPSSGD HRHEKMRDAG DPSPPNKMLR 
    RSDSPENKYS DSTGHSKAKN VHTHRVRERD GGTSYSPQEN SHNHSALHSS NSHSSNPSNN 
    PSKTSDAPYD SADDWSEHIS SSGKKYYYNC RTEVSQWEKP KEWLEREQRQ KEANKMAVNS 
    FPKDRDYRRE VMQATATSGF ASGMEDKHSS DASSLLPQNI LSQTSRHNDR DYRLPRAETH 
    SSSTPVQHPI KPVVHPTATP STVPSSPFTL QSDHQPKKSF DANGASTLSK LPTPTSSVPA 
    QKTERKESTS GDKPVSHSCT TPSTSSASGL NPTSAPPTSA SAVPVSPVPQ SPIPPLLQDP 
    NLLRQLLPAL QATLQLNNSN VDISKINEVL TAAVTQASLQ SIIHKFLTAG PSAFNITSLI 
    SQAAQLSTQA QPSNQSPMSL TSDASSPRSY VSPRISTPQT NTVPIKPLIS TPPVSSQPKV 
    STPVVKQGPV SQSATQQPVT ADKQQGHEPV SPRSLQRSSS QRSPSPGPNH TSNSSNASNA 
    TVVPQNSSAR STCSLTPALA AHFSENLIKH VQGWPADHAE KQASRLREEA HNMGTIHMSE 
    ICTELKNLRS LVRVCEIQAT LREQRILFLR QQIKELEKLK NQNSFMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.