CYRIB | ENSG00000153310 | NCBI 51571

Details for: CYRIB

Gene ID: 51571

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CYRIB

Ensembl ID: ENSG00000153310

Description: CYFIP related Rac1 interactor B

Cell Significance Landscape

Display Count:

Associated with

Hemostasis
(R-HSA-109582)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Cellular response to molecule of bacterial origin
(GO:0071219)
Cilium
(GO:0005929)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Membrane
(GO:0016020)
Mhc class ib protein binding, via antigen binding groove
(GO:0023030)
Mitochondrion
(GO:0005739)
Negative regulation of actin filament polymerization
(GO:0030837)
Negative regulation of small gtpase mediated signal transduction
(GO:0051058)
Platelet alpha granule lumen
(GO:0031093)
Positive regulation of memory t cell activation
(GO:2000568)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Regulation of chemotaxis
(GO:0050920)
Regulation of establishment of cell polarity
(GO:2000114)
Regulation of mitochondrial fission
(GO:0090140)
Small gtpase binding
(GO:0031267)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

myeloid leukocyte CL0000766

CSI 79.37

rCSI 73.23%

PRS 12.03
pvalb GABAergic cortical interneuron CL4023018

CSI 78.47

rCSI 97.63%

PRS 6.42
sst GABAergic cortical interneuron CL4023017

CSI 72.04

rCSI 92.86%

PRS 7.26
VIP GABAergic cortical interneuron CL4023016

CSI 69.03

rCSI 82.46%

PRS 6.78
CD14-low, CD16-positive monocyte CL0002396

CSI 65.2

rCSI 50.23%

PRS 10.74
sncg GABAergic cortical interneuron CL4023015

CSI 56.33

rCSI 90.59%

PRS 7.66
lamp5 GABAergic cortical interneuron CL4023011

CSI 56.06

rCSI 94.09%

PRS 6.92
myeloid dendritic cell CL0000782

CSI 52.72

rCSI 76.37%

PRS 17.44
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 52.55

rCSI 92.81%

PRS 6.93
differentiation-committed oligodendrocyte precursor CL4023059

CSI 44.79

rCSI 81.39%

PRS 9.66
Hofbauer cell CL3000001

CSI 40.52

rCSI 76.49%

PRS 14.71
conventional dendritic cell CL0000990

CSI 40.41

rCSI 33.74%

PRS 34.81
intermediate monocyte CL0002393

CSI 38.82

rCSI 58.58%

PRS 11.68
common dendritic progenitor CL0001029

CSI 38.76

rCSI 48.64%

PRS 15.09
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 37.55

rCSI 91.25%

PRS 6.74
CD1c-positive myeloid dendritic cell CL0002399

CSI 36.72

rCSI 44.35%

PRS 13.89
central nervous system macrophage CL0000878

CSI 34.64

rCSI 100%

PRS 10.11
elicited macrophage CL0000861

CSI 31.87

rCSI 29.26%

PRS 13.54
neuron CL0000540

CSI 31.79

rCSI 84.66%

PRS 9.26
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 30.55

rCSI 95.54%

PRS 7.99
promonocyte CL0000559

CSI 29.36

rCSI 50.3%

PRS 15.85
L6b glutamatergic cortical neuron CL4023038

CSI 29.33

rCSI 91.65%

PRS 7.43
extravillous trophoblast CL0008036

CSI 29.09

rCSI 35.99%

PRS 10.41
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 28.63

rCSI 62.1%

PRS 6.17
plasmacytoid dendritic cell, human CL0001058

CSI 27.33

rCSI 19.08%

PRS 12.41
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 26.04

rCSI 93.69%

PRS 6.4
choroid plexus epithelial cell CL0000706

CSI 24.85

rCSI 40.7%

PRS 9.15
GABAergic amacrine cell CL4030027

CSI 24.25

rCSI 83.05%

PRS 10.67
near-projecting glutamatergic cortical neuron CL4023012

CSI 23.97

rCSI 90.58%

PRS 7.08
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 23.04

rCSI 55.11%

PRS 6.39
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 21.98

rCSI 72.23%

PRS 5.93
conjunctival epithelial cell CL1000432

CSI 21.92

rCSI 33.48%

PRS 11.85
retinal ganglion cell CL0000740

CSI 21.7

rCSI 47.93%

PRS 8.51
macrophage CL0000235

CSI 19.22

rCSI 34.97%

PRS 46.45
oligodendrocyte precursor cell CL0002453

CSI 18.38

rCSI 40.44%

PRS 6.4
microglial cell CL0000129

CSI 17.96

rCSI 72.29%

PRS 30.19
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 17.69

rCSI 11.79%

PRS 31.03
dendritic cell CL0000451

CSI 16.13

rCSI 19.87%

PRS 37.68
colon macrophage CL0009038

CSI 15.65

rCSI 72.27%

PRS 24.68
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 14.94

rCSI 87.99%

PRS 7.27
mature T cell CL0002419

CSI 14.7

rCSI 11.43%

PRS 17.1
Langerhans cell CL0000453

CSI 14.12

rCSI 21.56%

PRS 20.67
placental villous trophoblast CL2000060

CSI 13.66

rCSI 21.12%

PRS 11.11
kidney connecting tubule epithelial cell CL1000768

CSI 13.46

rCSI 34.14%

PRS 9.06
small intestine goblet cell CL1000495

CSI 13.3

rCSI 29.13%

PRS 15.87
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 12.56

rCSI 8.46%

PRS 14.21
basophil CL0000767

CSI 12.44

rCSI 26.31%

PRS 24.24
central nervous system neuron CL2000029

CSI 12.22

rCSI 89.78%

PRS 5.94
kidney interstitial alternatively activated macrophage CL1000695

CSI 11.95

rCSI 31.16%

PRS 11.05
monocyte CL0000576

CSI 11.33

rCSI 20.49%

PRS 31.91
large pre-B-II cell CL0000957

CSI 11.21

rCSI 32%

PRS 20.58
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 10.8

rCSI 14.72%

PRS 28.54
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 10.6

rCSI 27.39%

PRS 11.04
Kupffer cell CL0000091

CSI 10.59

rCSI 24.22%

PRS 11.44
fallopian tube secretory epithelial cell CL4030006

CSI 10.11

rCSI 9.74%

PRS 12.26
transit amplifying cell CL0009010

CSI 10.11

rCSI 15.46%

PRS 19.29
mature microglial cell CL0002629

CSI 10.07

rCSI 41.83%

PRS 16.4
brush cell of tracheobronchial tree CL0002075

CSI 9.9

rCSI 29.39%

PRS 17.7
alternatively activated macrophage CL0000890

CSI 9.69

rCSI 12.19%

PRS 18.14
inhibitory interneuron CL0000498

CSI 9.44

rCSI 21.78%

PRS 9.63
medium spiny neuron CL1001474

CSI 9.36

rCSI 80.62%

PRS 3.55
glutamatergic neuron CL0000679

CSI 9.34

rCSI 19.2%

PRS 12.11
neutrophil CL0000775

CSI 9.21

rCSI 51.55%

PRS 25.39
cardiac muscle cell CL0000746

CSI 9.2

rCSI 13.21%

PRS 9.32
hepatic stellate cell CL0000632

CSI 8.55

rCSI 32.05%

PRS 10.07
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 8.3

rCSI 50.22%

PRS 26.55
early lymphoid progenitor CL0000936

CSI 8.28

rCSI 7.27%

PRS 13.3
plasmacytoid dendritic cell CL0000784

CSI 8.14

rCSI 8.24%

PRS 59.11
starburst amacrine cell CL0004232

CSI 8.07

rCSI 67.9%

PRS 12.14
T follicular helper cell CL0002038

CSI 7.95

rCSI 5.95%

PRS 19.22
BEST4+ enteroycte CL4030026

CSI 7.43

rCSI 9.24%

PRS 12.53
GABAergic neuron CL0000617

CSI 7.32

rCSI 24.54%

PRS 8.36
double-positive, alpha-beta thymocyte CL0000809

CSI 6.92

rCSI 7.05%

PRS 16.93
glycinergic amacrine cell CL4030028

CSI 6.71

rCSI 17.47%

PRS 11.8
diffuse bipolar 3a cell CL4033029

CSI 6.7

rCSI 45.57%

PRS 11.96
ON parasol ganglion cell CL4033052

CSI 6.5

rCSI 92.3%

PRS 8.13
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 6.49

rCSI 8.92%

PRS 24.44
amacrine cell CL0000561

CSI 6.46

rCSI 18.71%

PRS 9.32
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 6.33

rCSI 4.75%

PRS 33.9
megakaryocyte-erythroid progenitor cell CL0000050

CSI 6.11

rCSI 5.51%

PRS 10.46
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 6.1

rCSI 3.6%

PRS 16.31
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 6.03

rCSI 4.23%

PRS 31.07
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 5.97

rCSI 8.46%

PRS 11.06
GABAergic interneuron CL0011005

CSI 5.92

rCSI 93.33%

PRS 5.7
memory B cell CL0000787

CSI 5.92

rCSI 5.84%

PRS 45.07
H2 horizontal cell CL0004218

CSI 5.88

rCSI 29.25%

PRS 13.04
enteroendocrine cell of small intestine CL0009006

CSI 5.8

rCSI 12.76%

PRS 18.18
myeloid dendritic cell, human CL0001057

CSI 5.79

rCSI 32.59%

PRS 37.32
adipocyte CL0000136

CSI 5.76

rCSI 7.39%

PRS 12.2
memory T cell CL0000813

CSI 5.63

rCSI 10.84%

PRS 26.5
renal alpha-intercalated cell CL0005011

CSI 5.61

rCSI 7.5%

PRS 15.79
non-classical monocyte CL0000875

CSI 5.52

rCSI 8.85%

PRS 36.43
mucosal invariant T cell CL0000940

CSI 5.52

rCSI 4.46%

PRS 19.91
naive T cell CL0000898

CSI 5.47

rCSI 3.8%

PRS 16.87
fraction A pre-pro B cell CL0002045

CSI 5.38

rCSI 6.16%

PRS 24.31
mature NK T cell CL0000814

CSI 5.36

rCSI 6.86%

PRS 47.53
renal beta-intercalated cell CL0002201

CSI 5.11

rCSI 12.18%

PRS 14.4
transitional stage B cell CL0000818

CSI 5.09

rCSI 16.67%

PRS 33.41
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 4.95

rCSI 5.72%

PRS 10.44
hematopoietic stem cell CL0000037

CSI 4.93

rCSI 3.28%

PRS 14.13

luminal cell of prostate epithelium CL0002340

CSI -4.4

rCSI -23.5%

PRS 21.4%
group 3 innate lymphoid cell CL0001071

CSI -2.2

rCSI -1.7%

PRS 12.3%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI -2.0

rCSI -4.6%

PRS 12.4%
alpha-beta T cell CL0000789

CSI -1.4

rCSI -1.6%

PRS 15.9%
retinal rod cell CL0000604

CSI -1.3

rCSI -2.2%

PRS 11.8%
squamous epithelial cell CL0000076

CSI -1.0

rCSI -2.4%

PRS 15.0%
endocardial cell CL0002350

CSI -0.9

rCSI -4.4%

PRS 15.5%
regular ventricular cardiac myocyte CL0002131

CSI -0.8

rCSI -4.9%

PRS 9.3%
enteric smooth muscle cell CL0002504

CSI -0.8

rCSI -1.1%

PRS 13.4%
exhausted T cell CL0011025

CSI -0.7

rCSI -11.3%

PRS 46.6%
mesodermal cell CL0000222

CSI -0.3

rCSI -0.4%

PRS 11.7%
late pro-B cell CL0002048

CSI -0.3

rCSI -0.7%

PRS 34.8%
intestinal crypt stem cell of colon CL0009043

CSI -0.1

rCSI -1.0%

PRS 21.9%
stromal cell CL0000499

CSI 0.0

rCSI 0.1%

PRS 17.0%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.1

rCSI 0.3%

PRS 19.4%
S cone cell CL0003050

CSI 0.1

rCSI 0.5%

PRS 8.7%
B-2 B cell CL0000822

CSI 0.2

rCSI 3.4%

PRS 58.3%
epithelial cell of urethra CL1000296

CSI 0.2

rCSI 4.1%

PRS 38.1%
colon goblet cell CL0009039

CSI 0.2

rCSI 0.4%

PRS 17.9%
mesenchymal cell CL0008019

CSI 0.2

rCSI 0.4%

PRS 12.1%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.2

rCSI 0.9%

PRS 15.4%
respiratory goblet cell CL0002370

CSI 0.2

rCSI 2.0%

PRS 22.9%
type EC enteroendocrine cell CL0000577

CSI 0.2

rCSI 0.7%

PRS 19.4%
decidual natural killer cell, human CL0002343

CSI 0.2

rCSI 2.0%

PRS 66.9%
syncytiotrophoblast cell CL0000525

CSI 0.2

rCSI 0.6%

PRS 23.1%
enterocyte of epithelium of large intestine CL0002071

CSI 0.2

rCSI 1.1%

PRS 21.3%
group 2 innate lymphoid cell CL0001069

CSI 0.2

rCSI 1.2%

PRS 39.7%
diffuse bipolar 2 cell CL4033028

CSI 0.2

rCSI 1.9%

PRS 12.0%
muscle cell CL0000187

CSI 0.3

rCSI 0.5%

PRS 27.9%
thymocyte CL0000893

CSI 0.3

rCSI 0.9%

PRS 37.0%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.3

rCSI 3.2%

PRS 46.0%
cerebellar neuron CL1001611

CSI 0.3

rCSI 2.7%

PRS 4.7%
transit amplifying cell of small intestine CL0009012

CSI 0.3

rCSI 1.4%

PRS 22.1%
podocyte CL0000653

CSI 0.3

rCSI 1.5%

PRS 11.7%
helper T cell CL0000912

CSI 0.4

rCSI 0.5%

PRS 16.6%
forebrain radial glial cell CL0013000

CSI 0.4

rCSI 1.2%

PRS 17.4%
paneth cell CL0000510

CSI 0.4

rCSI 0.5%

PRS 18.6%
pancreatic acinar cell CL0002064

CSI 0.4

rCSI 0.5%

PRS 13.0%
melanocyte of skin CL1000458

CSI 0.4

rCSI 0.5%

PRS 6.7%
diffuse bipolar 1 cell CL4033027

CSI 0.4

rCSI 3.1%

PRS 10.6%
colonocyte CL1000347

CSI 0.4

rCSI 0.6%

PRS 16.3%
IgG plasma cell CL0000985

CSI 0.4

rCSI 0.5%

PRS 20.3%
serotonergic neuron CL0000850

CSI 0.4

rCSI 2.0%

PRS 4.4%
type B pancreatic cell CL0000169

CSI 0.4

rCSI 1.0%

PRS 11.0%
cytotoxic T cell CL0000910

CSI 0.5

rCSI 2.6%

PRS 17.3%
H1 horizontal cell CL0004217

CSI 0.5

rCSI 1.9%

PRS 17.1%
tracheal goblet cell CL1000329

CSI 0.5

rCSI 1.1%

PRS 24.0%
erythroid progenitor cell CL0000038

CSI 0.5

rCSI 2.8%

PRS 18.4%
astrocyte of the cerebral cortex CL0002605

CSI 0.5

rCSI 1.2%

PRS 7.3%
ionocyte CL0005006

CSI 0.5

rCSI 0.6%

PRS 10.9%
flat midget bipolar cell CL4033033

CSI 0.5

rCSI 3.8%

PRS 11.3%
kidney epithelial cell CL0002518

CSI 0.5

rCSI 1.0%

PRS 28.0%
mature alpha-beta T cell CL0000791

CSI 0.6

rCSI 2.0%

PRS 20.3%
type L enteroendocrine cell CL0002279

CSI 0.6

rCSI 1.1%

PRS 23.4%
mesenchymal stem cell of adipose tissue CL0002570

CSI 0.6

rCSI 3.4%

PRS 35.1%
T-helper 17 cell CL0000899

CSI 0.6

rCSI 0.5%

PRS 20.8%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.6

rCSI 1.2%

PRS 25.8%
retina horizontal cell CL0000745

CSI 0.6

rCSI 0.9%

PRS 11.1%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 0.6

rCSI 5.4%

PRS 21.9%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 0.7

rCSI 3.7%

PRS 44.9%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.7

rCSI 1.6%

PRS 18.8%
respiratory suprabasal cell CL4033048

CSI 0.7

rCSI 0.9%

PRS 13.7%
common lymphoid progenitor CL0000051

CSI 0.7

rCSI 0.9%

PRS 22.6%
cardiac neuron CL0010022

CSI 0.7

rCSI 2.3%

PRS 8.5%
foveolar cell of stomach CL0002179

CSI 0.7

rCSI 1.5%

PRS 19.2%
myelocyte CL0002193

CSI 0.7

rCSI 4.8%

PRS 38.0%
renal principal cell CL0005009

CSI 0.8

rCSI 2.0%

PRS 16.0%
natural T-regulatory cell CL0000903

CSI 0.8

rCSI 1.5%

PRS 32.5%
basal cell of epidermis CL0002187

CSI 0.8

rCSI 1.4%

PRS 11.8%
class switched memory B cell CL0000972

CSI 0.8

rCSI 0.6%

PRS 19.9%
intestinal tuft cell CL0019032

CSI 0.8

rCSI 1.2%

PRS 13.6%
diffuse bipolar 6 cell CL4033032

CSI 0.9

rCSI 4.6%

PRS 14.1%
retinal pigment epithelial cell CL0002586

CSI 0.9

rCSI 1.8%

PRS 12.6%
neural crest cell CL0011012

CSI 0.9

rCSI 0.7%

PRS 8.2%
Bergmann glial cell CL0000644

CSI 0.9

rCSI 1.2%

PRS 12.1%
pulmonary ionocyte CL0017000

CSI 0.9

rCSI 1.1%

PRS 15.0%
invaginating midget bipolar cell CL4033034

CSI 0.9

rCSI 5.4%

PRS 12.6%
glandular epithelial cell CL0000150

CSI 0.9

rCSI 2.5%

PRS 23.2%
T-helper 1 cell CL0000545

CSI 1.0

rCSI 1.7%

PRS 31.7%
endothelial cell of placenta CL0009092

CSI 1.0

rCSI 4.7%

PRS 16.1%
suprabasal keratinocyte CL4033013

CSI 1.0

rCSI 1.6%

PRS 7.3%
small pre-B-II cell CL0000954

CSI 1.0

rCSI 0.9%

PRS 24.6%
eosinophil CL0000771

CSI 1.0

rCSI 6.4%

PRS 30.7%
mammary gland epithelial cell CL0002327

CSI 1.0

rCSI 3.5%

PRS 21.5%
diffuse bipolar 3b cell CL4033030

CSI 1.0

rCSI 6.8%

PRS 12.1%
mesothelial cell CL0000077

CSI 1.0

rCSI 4.0%

PRS 2.3%
CD4-positive helper T cell CL0000492

CSI 1.0

rCSI 0.8%

PRS 16.4%
lung ciliated cell CL1000271

CSI 1.0

rCSI 1.2%

PRS 8.7%
OFF-bipolar cell CL0000750

CSI 1.0

rCSI 1.4%

PRS 19.5%
diffuse bipolar 4 cell CL4033031

CSI 1.1

rCSI 12.0%

PRS 11.9%
centrilobular region hepatocyte CL0019029

CSI 1.1

rCSI 2.8%

PRS 19.3%
duct epithelial cell CL0000068

CSI 1.1

rCSI 1.6%

PRS 12.6%
myoepithelial cell CL0000185

CSI 1.1

rCSI 2.8%

PRS 14.7%
dopaminergic neuron CL0000700

CSI 1.2

rCSI 6.5%

PRS 4.6%
OFFx cell CL4033036

CSI 1.2

rCSI 5.5%

PRS 11.7%
basket cell CL0000118

CSI 1.2

rCSI 7.3%

PRS 4.9%
lung neuroendocrine cell CL1000223

CSI 1.2

rCSI 1.8%

PRS 13.7%
airway submucosal gland duct basal cell CL4033024

CSI 1.2

rCSI 7.9%

PRS 36.9%
vascular leptomeningeal cell CL4023051

CSI 1.2

rCSI 2.2%

PRS 8.6%
colon epithelial cell CL0011108

CSI 1.3

rCSI 1.3%

PRS 11.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary CYFIP related Rac1 interactor B ([CYRIB](/details-gene/51571)) is a protein-coding gene located on chromosome 8q24.21. It functions as a crucial negative regulator of the actin cytoskeleton by interacting with and inhibiting the small GTPase Rac1 [Link](https://doi.org/10.1038/s41556-018-0198-9). This regulatory role is central to its involvement in processes such as cell migration, chemotaxis, and the establishment of cell polarity. Expression data reveals a bimodal significance for [CYRIB](/details-gene/51571), with high expression in both the immune system, particularly in [myeloid leukocyte](/details-cell/CL0000766)s, and the central nervous system, where it is a prominent marker for various GABAergic cortical interneuron subtypes. Its function extends to mitochondrial dynamics, where it has been implicated in suppressing tumor metastasis [Link](https://doi.org/10.1038/onc.2017.358), and in host defense, where it helps protect against bacterial infection by modulating cytoskeletal responses [Link](https://doi.org/10.1038/s41564-019-0484-8). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [CYRIB](/details-gene/51571) highlights its specialized roles in the immune and nervous systems. It is most significantly expressed in [myeloid leukocyte](/details-cell/CL0000766)s (CSI: 79.37), including subsets like [CD14-low, CD16-positive monocyte](/details-cell/CL0002396)s and [myeloid dendritic cell](/details-cell/CL0000782)s. This suggests a primary function in regulating the migratory and phagocytic activities of these innate immune cells, which are heavily dependent on precise control of the actin cytoskeleton. Concurrently, [CYRIB](/details-gene/51571) demonstrates exceptionally high significance in several distinct populations of inhibitory neurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018)s (CSI: 78.47), [sst GABAergic cortical interneuron](/details-cell/CL4023017)s (CSI: 72.04), and [VIP GABAergic cortical interneuron](/details-cell/CL4023016)s (CSI: 69.03). This strong and specific expression pattern points towards a role in regulating neuronal morphology, dendritic spine dynamics, or axon guidance within cortical circuits. The specificity of [CYRIB](/details-gene/51571) function is further defined by the cell types where its expression is negligible. Its low significance in various epithelial cells (e.g., [luminal cell of prostate epithelium](/details-cell/CL0002340), [squamous epithelial cell](/details-cell/CL0000076)), muscle cells ([enteric smooth muscle cell](/details-cell/CL0002504)), and certain lymphoid lineages like [alpha-beta T cell](/details-cell/CL0000789)s underscores its specialized role, distinguishing it from a general housekeeping gene involved in cytoskeletal maintenance. ## Pathways and Molecular Function The molecular functions of [CYRIB](/details-gene/51571) are centered on protein-protein interactions, particularly its binding to small GTPases ([GO:0031267](https://www.ebi.ac.uk/QuickGO/term/GO:0031267)) like Rac1. This interaction is the mechanistic basis for its role as a negative regulator of Rac1-mediated signal transduction ([GO:0051058](https://www.ebi.ac.uk/QuickGO/term/GO:0051058)) and actin filament polymerization ([GO:0030837](https://www.ebi.ac.uk/QuickGO/term/GO:0030837)). These activities are fundamental to its ability to modulate cell migration ([GO:0030334](https://www.ebi.ac.uk/QuickGO/term/GO:0030334)) and chemotaxis ([GO:0050920](https://www.ebi.ac.uk/QuickGO/term/GO:0050920)). In the context of the immune system, [CYRIB](/details-gene/51571) is associated with the cellular response to bacteria ([GO:0071219](https://www.ebi.ac.uk/QuickGO/term/GO:0071219)). While GO annotations suggest it positively regulates T cell activation and cytotoxicity, its low expression in [alpha-beta T cell](/details-cell/CL0000789)s implies this role may be indirect, potentially occurring via its function in antigen-presenting cells like the [myeloid dendritic cell](/details-cell/CL0000782) where it is highly expressed. Furthermore, [CYRIB](/details-gene/51571) is implicated in platelet biology and hemostasis, as evidenced by its involvement in Reactome pathways such as [Platelet activation, signaling and aggregation](https://reactome.org/content/detail/R-HSA-76002) and [Hemostasis](https://reactome.org/content/detail/R-HSA-109582). This is consistent with its localization to the [platelet alpha granule lumen](https://www.ebi.ac.uk/QuickGO/term/GO:0031093) and the critical role of actin remodeling in platelet function. The gene also plays a role in organelle-level regulation, specifically in the regulation of mitochondrial fission ([GO:0090140](https://www.ebi.ac.uk/QuickGO/term/GO:0090140)), a function linked to its tumor-suppressive properties [Link](https://doi.org/10.1038/onc.2017.358). ## Research Directions The dual, high-specificity expression of [CYRIB](/details-gene/51571) in both myeloid and neuronal lineages, coupled with its known function as a Rac1 inhibitor, provides a foundation for several compelling research avenues. ### Proposed Hypotheses 1. **Immunology:** In myeloid cells, [CYRIB](/details-gene/51571) acts as a crucial rheostat for innate immune responses. Its constitutive expression maintains a quiescent state by suppressing Rac1-driven motility and phagocytosis, and its downregulation upon pathogen sensing is a required step for efficient myeloid cell activation and migration to sites of infection. 2. **Neuroscience:** In GABAergic interneurons, [CYRIB](/details-gene/51571) locally restricts Rac1 activity at dendritic spines or axonal growth cones. This spatial control is essential for maintaining the stability of inhibitory synapses and fine-tuning the connectivity of cortical microcircuits during development and learning. ### Suggested Experimental Approach To test the first hypothesis regarding its role in myeloid cell function, a definitive experiment would involve conditional knockout of [CYRIB](/details-gene/51571) in the myeloid lineage of mice (e.g., using a Lyz2-Cre driver). Bone marrow-derived macrophages (BMDMs) from these knockout mice and wild-type controls could be compared for key functions. Phagocytic capacity could be quantified by exposing the cells to fluorescently-labeled bacteria or zymosan particles and analyzing uptake via flow cytometry. Chemotactic migration towards stimuli like CCL2 could be measured using a transwell chamber assay. Finally, live-cell imaging of cells expressing an actin-GFP fusion protein would directly visualize differences in cytoskeletal dynamics, such as lamellipodia formation, upon stimulation. ### Therapeutic Potential Given that [CYRIB](/details-gene/51571) functions as a negative regulator of Rac1 and has been shown to suppress tumor metastasis [Link](https://doi.org/10.1038/onc.2017.358), its therapeutic potential lies in strategies that would **activate** its function or restore its expression. Rac1 is frequently hyperactivated in various cancers, driving invasion and metastasis. As an intracellular protein, [CYRIB](/details-gene/51571) is not a suitable target for monoclonal antibodies. However, it represents a candidate for novel therapeutic modalities. For example, in tumors with low [CYRIB](/details-gene/51571) expression, gene therapy to reintroduce the gene could be explored. Alternatively, the development of small-molecule drugs that stabilize the CYRIB-Rac1 complex, thereby enhancing its inhibitory effect, could serve as a novel anti-metastatic strategy.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1807891724

Symbol: CYRIB_HUMAN

Name: L1

UniProtKB Accession Codes:

Q9NUQ9 Q96AZ5 Q9NW21 Q9NZE7

Database IDs:

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 30250061

Title: Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

PubMed ID: 30250061

DOI: 10.1038/s41556-018-0198-9

PubMed ID: 29059164

Title: FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.

PubMed ID: 29059164

DOI: 10.1038/onc.2017.358

PubMed ID: 31285585

Title: CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.

PubMed ID: 31285585

DOI: 10.1038/s41564-019-0484-8

Sequence Information:

Length: 324
Mass: 36748
Checksum: EE370E3D170A6E38
Sequence:

MGNLLKVLTC TDLEQGPNFF LDFENAQPTE SEKEIYNQVN VVLKDAEGIL EDLQSYRGAG 
HEIREAIQHP ADEKLQEKAW GAVVPLVGKL KKFYEFSQRL EAALRGLLGA LTSTPYSPTQ 
HLEREQALAK QFAEILHFTL RFDELKMTNP AIQNDFSYYR RTLSRMRINN VPAEGENEVN 
NELANRMSLF YAEATPMLKT LSDATTKFVS ENKNLPIENT TDCLSTMASV CRVMLETPEY 
RSRFTNEETV SFCLRVMVGV IILYDHVHPV GAFAKTSKID MKGCIKVLKD QPPNSVEGLL 
NALRYTTKHL NDETTSKQIK SMLQ

Details for: CYRIB

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. PubMed ID: 30250061

FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. PubMed ID: 29059164

CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. PubMed ID: 31285585