Details for: CYRIB

Gene ID: 51571

Symbol: CYRIB

Ensembl ID: ENSG00000153310

Description: CYFIP related Rac1 interactor B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 489.3111
    Cell Significance Index: -76.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 271.4638
    Cell Significance Index: -68.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 194.4665
    Cell Significance Index: -80.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 183.9458
    Cell Significance Index: -86.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 178.8522
    Cell Significance Index: -72.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 157.1390
    Cell Significance Index: -80.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 129.3773
    Cell Significance Index: -86.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 76.8898
    Cell Significance Index: -73.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.0294
    Cell Significance Index: -77.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.9760
    Cell Significance Index: -92.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.2050
    Cell Significance Index: -79.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.1820
    Cell Significance Index: -44.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.5785
    Cell Significance Index: 44.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.1604
    Cell Significance Index: 1133.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8843
    Cell Significance Index: 127.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8003
    Cell Significance Index: 561.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7855
    Cell Significance Index: 105.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3342
    Cell Significance Index: 179.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.3330
    Cell Significance Index: 1613.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1198
    Cell Significance Index: 59.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0578
    Cell Significance Index: 242.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9486
    Cell Significance Index: 386.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8520
    Cell Significance Index: 34.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.6843
    Cell Significance Index: 53.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1164
    Cell Significance Index: 181.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9777
    Cell Significance Index: 28.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8104
    Cell Significance Index: 52.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7537
    Cell Significance Index: 135.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7518
    Cell Significance Index: 92.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7126
    Cell Significance Index: 39.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5929
    Cell Significance Index: 323.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3144
    Cell Significance Index: 4.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3035
    Cell Significance Index: 134.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3011
    Cell Significance Index: 5.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2992
    Cell Significance Index: 14.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2111
    Cell Significance Index: 287.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1634
    Cell Significance Index: 31.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1274
    Cell Significance Index: 239.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1139
    Cell Significance Index: 5.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0689
    Cell Significance Index: 31.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0620
    Cell Significance Index: 39.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0526
    Cell Significance Index: 80.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0460
    Cell Significance Index: 5.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0454
    Cell Significance Index: 0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0314
    Cell Significance Index: 57.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0206
    Cell Significance Index: 0.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0033
    Cell Significance Index: -0.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0484
    Cell Significance Index: -1.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0594
    Cell Significance Index: -44.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0757
    Cell Significance Index: -55.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0985
    Cell Significance Index: -72.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1029
    Cell Significance Index: -14.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1127
    Cell Significance Index: -11.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1448
    Cell Significance Index: -81.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1532
    Cell Significance Index: -7.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1630
    Cell Significance Index: -101.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1836
    Cell Significance Index: -8.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2142
    Cell Significance Index: -4.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2498
    Cell Significance Index: -71.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2760
    Cell Significance Index: -47.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3171
    Cell Significance Index: -22.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3444
    Cell Significance Index: -39.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3648
    Cell Significance Index: -27.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3821
    Cell Significance Index: -52.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4283
    Cell Significance Index: -12.3400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4328
    Cell Significance Index: -5.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4563
    Cell Significance Index: -15.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4853
    Cell Significance Index: -102.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5413
    Cell Significance Index: -4.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6568
    Cell Significance Index: -17.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.6572
    Cell Significance Index: -84.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6597
    Cell Significance Index: -68.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6813
    Cell Significance Index: -35.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7158
    Cell Significance Index: -19.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7683
    Cell Significance Index: -9.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7768
    Cell Significance Index: -15.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7834
    Cell Significance Index: -20.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8257
    Cell Significance Index: -17.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9481
    Cell Significance Index: -75.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.0452
    Cell Significance Index: -48.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0526
    Cell Significance Index: -26.8900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.0807
    Cell Significance Index: -13.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0954
    Cell Significance Index: -69.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1045
    Cell Significance Index: -23.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2066
    Cell Significance Index: -38.4300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.2125
    Cell Significance Index: -17.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2429
    Cell Significance Index: -26.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2566
    Cell Significance Index: -41.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.2740
    Cell Significance Index: -18.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3799
    Cell Significance Index: -84.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.4604
    Cell Significance Index: -29.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.5183
    Cell Significance Index: -76.7300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.5735
    Cell Significance Index: -20.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6020
    Cell Significance Index: -56.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.6918
    Cell Significance Index: -49.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.7815
    Cell Significance Index: -38.4900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -1.7856
    Cell Significance Index: -15.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.8228
    Cell Significance Index: -45.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.8917
    Cell Significance Index: -20.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9126
    Cell Significance Index: -70.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CYRIB is a member of the CYFIP family, which is known for its involvement in the regulation of actin dynamics and small GTPase signaling pathways. The CYRIB protein is predicted to interact with Rac1, a small GTPase involved in various cellular processes, including cell migration, cytoskeleton reorganization, and immune response. CYRIB's ability to regulate actin filament polymerization and small GTPase-mediated signal transduction suggests its involvement in multiple cellular processes. **Pathways and Functions:** CYRIB's multifunctional nature is reflected in its involvement in various signaling pathways, including: 1. **Cellular response to bacterial molecules:** CYRIB's interaction with Rac1 and its role in regulating actin filament polymerization suggest its involvement in the cellular response to bacterial molecules. 2. **Cilium formation and function:** CYRIB's association with cilia, specialized microtubular structures involved in sensing and responding to environmental stimuli, highlights its role in cilium formation and function. 3. **Extracellular exosome regulation:** CYRIB's involvement in the regulation of extracellular exosome formation and function suggests its role in modulating intercellular communication. 4. **Immune response:** CYRIB's interaction with CD8+ alpha-beta regulatory T cells and its role in regulating T cell activation and cytokine production highlight its importance in immune response. 5. **Cell migration and chemotaxis:** CYRIB's involvement in regulating actin filament polymerization and small GTPase-mediated signal transduction suggests its role in cell migration and chemotaxis. **Clinical Significance:** The clinical significance of CYRIB lies in its potential role in various disease states, including: 1. **Immunodeficiency disorders:** CYRIB's involvement in regulating immune response and T cell activation suggests its potential role in immunodeficiency disorders, such as autoimmune diseases and immunosuppressive conditions. 2. **Cancer:** CYRIB's role in regulating cell migration and chemotaxis suggests its potential involvement in cancer progression and metastasis. 3. **Neurological disorders:** CYRIB's association with cilium formation and function highlights its potential role in neurological disorders, such as ciliopathies and neurodegenerative diseases. 4. **Hematological disorders:** CYRIB's involvement in regulating hematopoiesis and platelet function suggests its potential role in hematological disorders, such as anemia and thrombocytopenia. In conclusion, CYRIB is a multifunctional gene that plays a critical role in various cellular processes, including immune response, cell migration, and regulation of actin filament polymerization. Its clinical significance lies in its potential role in various disease states, including immunodeficiency disorders, cancer, neurological disorders, and hematological disorders. Further research is necessary to elucidate the mechanisms by which CYRIB influences these complex processes and to explore its potential therapeutic applications.

Genular Protein ID: 1807891724

Symbol: CYRIB_HUMAN

Name: L1

UniProtKB Accession Codes:

Q9NUQ9 Q96AZ5 Q9NW21 Q9NZE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 10 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 34 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 30250061

Title: Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

PubMed ID: 30250061

DOI: 10.1038/s41556-018-0198-9

PubMed ID: 29059164

Title: FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.

PubMed ID: 29059164

DOI: 10.1038/onc.2017.358

PubMed ID: 31285585

Title: CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.

PubMed ID: 31285585

DOI: 10.1038/s41564-019-0484-8

Sequence Information:

  • Length: 324
  • Mass: 36748
  • Checksum: EE370E3D170A6E38
  • Sequence:
    • MGNLLKVLTC TDLEQGPNFF LDFENAQPTE SEKEIYNQVN VVLKDAEGIL EDLQSYRGAG 
HEIREAIQHP ADEKLQEKAW GAVVPLVGKL KKFYEFSQRL EAALRGLLGA LTSTPYSPTQ 
HLEREQALAK QFAEILHFTL RFDELKMTNP AIQNDFSYYR RTLSRMRINN VPAEGENEVN 
NELANRMSLF YAEATPMLKT LSDATTKFVS ENKNLPIENT TDCLSTMASV CRVMLETPEY 
RSRFTNEETV SFCLRVMVGV IILYDHVHPV GAFAKTSKID MKGCIKVLKD QPPNSVEGLL 
NALRYTTKHL NDETTSKQIK SMLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.