Details for: KCNA4

Gene ID: 3739

Symbol: KCNA4

Ensembl ID: ENSG00000182255

Description: potassium voltage-gated channel subfamily A member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.94
    Marker Score: 2737
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3175
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 3.08
    Marker Score: 3053
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.79
    Marker Score: 1995
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.44
    Marker Score: 1992
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.41
    Marker Score: 745
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.94
    Marker Score: 395
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14551
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.88
    Marker Score: 1667
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.87
    Marker Score: 7449
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.77
    Marker Score: 7252
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1109
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.69
    Marker Score: 42265
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1331
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.64
    Marker Score: 6090
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 491
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.57
    Marker Score: 2307
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 367
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 308
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.46
    Marker Score: 436
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.46
    Marker Score: 260
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.43
    Marker Score: 4462.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.37
    Marker Score: 1426
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.31
    Marker Score: 323.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 138
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.27
    Marker Score: 741
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.25
    Marker Score: 1051.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.25
    Marker Score: 701
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.24
    Marker Score: 1809
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.23
    Marker Score: 93
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.22
    Marker Score: 279
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 439
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.21
    Marker Score: 224
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.21
    Marker Score: 100
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.21
    Marker Score: 7839
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2
    Marker Score: 249
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.2
    Marker Score: 344
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.2
    Marker Score: 814
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.18
    Marker Score: 4109
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.18
    Marker Score: 171
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 80
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.17
    Marker Score: 1661
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 134
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.15
    Marker Score: 2283.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.15
    Marker Score: 232
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.15
    Marker Score: 208
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.14
    Marker Score: 602
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.14
    Marker Score: 2815
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.14
    Marker Score: 280
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.14
    Marker Score: 73
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.13
    Marker Score: 120
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.12
    Marker Score: 355
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.12
    Marker Score: 195
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.12
    Marker Score: 65
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.11
    Marker Score: 1929
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.11
    Marker Score: 131
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.11
    Marker Score: 105
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.09
    Marker Score: 147
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.08
    Marker Score: 61
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.08
    Marker Score: 306
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.08
    Marker Score: 20

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Other Information

**Key characteristics:** - It is a member of the potassium voltage-gated channel subfamily A. - It is expressed in a variety of cell types, including erythrocyte, blood vessel endothelial cell, type B pancreatic cell, plasma cell, double negative thymocyte, hematopoietic stem cell, goblet cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and absorptive cell. - It is a key component of the voltage-gated monoatomic and potassium channel complex. - It is involved in regulating presynaptic membrane potential through voltage-gated monoatomic and potassium channels. - It is involved in calcium signaling through voltage-gated calcium channels. **Pathways and functions:** - It is involved in the regulation of presynaptic membrane potential through voltage-gated monoatomic and potassium channels. - It is involved in the regulation of calcium signaling through voltage-gated calcium channels. - It is involved in the development and maintenance of the blood-brain barrier. **Clinical significance:** - Mutations in the KCNA4 gene have been linked to a number of human diseases, including epilepsy, stroke, and anxiety. - These mutations can lead to changes in the function of the KCNA4 protein, which can result in abnormal brain function. - Understanding the role of KCNA4 in health and disease could lead to the development of new treatments for these disorders.

Genular Protein ID: 4092909516

Symbol: KCNA4_HUMAN

Name: Potassium voltage-gated channel subfamily A member 4

UniProtKB Accession Codes:

P22459

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 4 Ensembl 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2263489

Title: Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4.

PubMed ID: 2263489

DOI: 10.1093/nar/18.23.7160

PubMed ID: 2001794

Title: Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle.

PubMed ID: 2001794

DOI: 10.1096/fasebj.5.3.2001794

PubMed ID: 19912772

Title: Human potassium channel genes: molecular cloning and functional expression.

PubMed ID: 19912772

DOI: 10.1016/1044-7431(90)90004-n

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 8495559

Title: Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?

PubMed ID: 8495559

DOI: 10.1161/01.res.72.6.1326

PubMed ID: 17156368

Title: Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2.

PubMed ID: 17156368

DOI: 10.1111/j.1460-9568.2006.05186.x

PubMed ID: 19968958

Title: Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.

PubMed ID: 19968958

DOI: 10.1016/j.bbrc.2009.11.143

PubMed ID: 27582084

Title: KCNA4 deficiency leads to a syndrome of abnormal striatum, congenital cataract and intellectual disability.

PubMed ID: 27582084

DOI: 10.1136/jmedgenet-2015-103637

PubMed ID: 9000078

Title: NMR structure of inactivation gates from mammalian voltage-dependent potassium channels.

PubMed ID: 9000078

DOI: 10.1038/385272a0

Sequence Information:

  • Length: 653
  • Mass: 73257
  • Checksum: 5E511DB704CCA013
  • Sequence:
    • MEVAMVSAES SGCNSHMPYG YAAQARARER ERLAHSRAAA AAAVAAATAA VEGSGGSGGG 
SHHHHQSRGA CTSHDPQSSR GSRRRRRQRS EKKKAHYRQS SFPHCSDLMP SGSEEKILRE 
LSEEEEDEEE EEEEEEEGRF YYSEDDHGDE CSYTDLLPQD EGGGGYSSVR YSDCCERVVI 
NVSGLRFETQ MKTLAQFPET LLGDPEKRTQ YFDPLRNEYF FDRNRPSFDA ILYYYQSGGR 
LKRPVNVPFD IFTEEVKFYQ LGEEALLKFR EDEGFVREEE DRALPENEFK KQIWLLFEYP 
ESSSPARGIA IVSVLVILIS IVIFCLETLP EFRDDRDLVM ALSAGGHGGL LNDTSAPHLE 
NSGHTIFNDP FFIVETVCIV WFSFEFVVRC FACPSQALFF KNIMNIIDIV SILPYFITLG 
TDLAQQQGGG NGQQQQAMSF AILRIIRLVR VFRIFKLSRH SKGLQILGHT LRASMRELGL 
LIFFLFIGVI LFSSAVYFAE ADEPTTHFQS IPDAFWWAVV TMTTVGYGDM KPITVGGKIV 
GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TENEEQTQLT QNAVSCPYLP SNLLKKFRSS 
TSSSLGDKSE YLEMEEGVKE SLCAKEEKCQ GKGDDSETDK NNCSNAKAVE TDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.