Details for: CL0002277

Cell ID: CL0002277

Cell Name: type I enteroendocrine cell

Marker Score Threshold: 249
(Derived using integrated single-cell and genomic data)

Description: An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile.

Synonyms: CCK cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.87
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.06
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.05
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.05
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.8
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.77
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.68
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.59
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.48
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.47
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.45
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.33
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.29
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.27
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.23
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.23
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.13
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.08
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.01
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.96
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.9
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.89
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.88
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.86
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.81
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.8
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.8
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.79
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.79
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.78
    Ensembl ID: ENSG00000085224
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.76
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.75
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.72
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.7
    Ensembl ID: ENSG00000026508
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.69
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.68
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.66
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.63
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.6
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.59
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.59
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.58
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.58
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.55
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.55
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.55
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.54
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.53
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.53
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.52
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.52
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.48
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.46
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.45
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.41
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.39
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.39
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.39
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.36
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.35
    Ensembl ID: ENSG00000110651
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.34
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.33
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.32
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.28
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.28
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.28
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.25
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.25
    Ensembl ID: ENSG00000172216
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.24
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.22
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.2
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.2
    Ensembl ID: ENSG00000115307
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.19
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.19
    Ensembl ID: ENSG00000109861
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.18
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.16
    Ensembl ID: ENSG00000159199
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.15
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143727
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.14
    Ensembl ID: ENSG00000107262
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.13
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.12
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.11
    Ensembl ID: ENSG00000145241
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.1
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.09
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.08
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.07
    Ensembl ID: ENSG00000131100
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.06
    Ensembl ID: ENSG00000183255
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.03
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.02
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177556
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1
    Ensembl ID: ENSG00000149823
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Cell Type**: Type I enteroendocrine cell 2. **Location**: Commonly found in the duodenum and jejunum, rare in the ileum 3. **Function**: Secretion of cholecystokinin (CCK) to regulate digestive enzymes and bile 4. **Genes**: ACTB (gene symbol) and B2M (gene symbol) 5. **Pathways/Ontology**: Actin cytoskeleton, Adherens junction, Apical junction complex, Chromatin, Cytoplasmic ribonucleoprotein granule, Cytoskeleton, Epigenetic regulation of gene expression, Gene expression (transcription), Immune system, Innate immune system, Protein binding, Protein localization to adherens junction, Regulation of actin dynamics for phagocytic cup formation, Regulation of apoptotic process, Regulation of cell cycle, Regulation of cyclin-dependent protein serine/threonine kinase activity, Regulation of double-strand break repair, Regulation of g0 to g1 transition, Regulation of g1/s transition of mitotic cell cycle, Regulation of mitotic metaphase/anaphase transition, Regulation of nucleotide-excision repair, Regulation of protein localization to plasma membrane, Regulation of synaptic vesicle endocytosis, Regulation of transcription by rna polymerase ii, Regulation of transepithelial transport, Regulation of transmembrane transporter activity 6. **Synonyms**: CCK cell 7. **Description**: Enteroendocrine cell involved in the regulation of digestive enzymes and bile through the secretion of cholecystokinin (CCK) **Clinical Significance** 1. **Digestive Disorders**: Type I enteroendocrine cells play a crucial role in the regulation of digestive enzymes and bile. Dysregulation of these cells can lead to various digestive disorders, such as pancreatitis, cholecystitis, and bile duct obstruction. 2. **Cancer**: Abnormal expression of cholecystokinin (CCK) has been linked to various cancers, including pancreatic cancer, breast cancer, and colon cancer. 3. **Gastrointestinal Diseases**: Type I enteroendocrine cells are involved in the regulation of gastrointestinal motility and secretion. Dysfunction of these cells can lead to gastrointestinal diseases, such as irritable bowel syndrome (IBS), functional dyspepsia, and gastroesophageal reflux disease (GERD). 4. **Infectious Diseases**: The immune system plays a crucial role in the regulation of type I enteroendocrine cells. Dysfunction of the immune system can lead to various infectious diseases, such as tuberculosis, malaria, and HIV/AIDS. 5. **Neurological Disorders**: Type I enteroendocrine cells are involved in the regulation of neurotransmitters and hormones. Dysfunction of these cells can lead to various neurological disorders, such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. In conclusion, type I enteroendocrine cells play a crucial role in the regulation of digestive enzymes and bile through the secretion of cholecystokinin (CCK). Dysfunction of these cells can lead to various digestive, gastrointestinal, infectious, and neurological disorders. Further research is needed to fully understand the role of type I enteroendocrine cells in human health and disease.