Details for: CL1000309

Cell ID: CL1000309

Cell Name: epicardial adipocyte

Marker Score Threshold: 486
(Derived using integrated single-cell and genomic data)

Description: An adipocyte that is part of the epicardial fat.

Synonyms: adipocyte of epicardial fat, epicardial fat cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: AQP7 (ENSG00000165269)
    Fold Change: 6.13
    Ensembl ID: ENSG00000165269
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 6.06
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 6
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 5.81
    Ensembl ID: ENSG00000278540
  • Gene Symbol: LAMA4 (ENSG00000112769)
    Fold Change: 5.41
    Ensembl ID: ENSG00000112769
  • Gene Symbol: LIPE (ENSG00000079435)
    Fold Change: 5.37
    Ensembl ID: ENSG00000079435
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 5.19
    Ensembl ID: ENSG00000100077
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 4.64
    Ensembl ID: ENSG00000263001
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 4.38
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 4.02
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 3.91
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 3.54
    Ensembl ID: ENSG00000131473
  • Gene Symbol: MEST (ENSG00000106484)
    Fold Change: 3.45
    Ensembl ID: ENSG00000106484
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 3.44
    Ensembl ID: ENSG00000091138
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 3.31
    Ensembl ID: ENSG00000122566
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 3.25
    Ensembl ID: ENSG00000167996
  • Gene Symbol: KCNE1 (ENSG00000180509)
    Fold Change: 3.24
    Ensembl ID: ENSG00000180509
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 3.14
    Ensembl ID: ENSG00000189403
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 3.05
    Ensembl ID: ENSG00000152601
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 2.96
    Ensembl ID: ENSG00000039537
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.91
    Ensembl ID: ENSG00000132475
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.9
    Ensembl ID: ENSG00000092199
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.77
    Ensembl ID: ENSG00000099622
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 2.76
    Ensembl ID: ENSG00000182326
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.72
    Ensembl ID: ENSG00000113712
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 2.7
    Ensembl ID: ENSG00000125730
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 2.7
    Ensembl ID: ENSG00000169045
  • Gene Symbol: CEACAM1 (ENSG00000079385)
    Fold Change: 2.7
    Ensembl ID: ENSG00000079385
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 2.62
    Ensembl ID: ENSG00000089280
  • Gene Symbol: CARS1 (ENSG00000110619)
    Fold Change: 2.58
    Ensembl ID: ENSG00000110619
  • Gene Symbol: AKR1C2 (ENSG00000151632)
    Fold Change: 2.56
    Ensembl ID: ENSG00000151632
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 2.56
    Ensembl ID: ENSG00000144674
  • Gene Symbol: COL3A1 (ENSG00000168542)
    Fold Change: 2.56
    Ensembl ID: ENSG00000168542
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 2.55
    Ensembl ID: ENSG00000135821
  • Gene Symbol: HIP1 (ENSG00000127946)
    Fold Change: 2.51
    Ensembl ID: ENSG00000127946
  • Gene Symbol: AFDN (ENSG00000130396)
    Fold Change: 2.5
    Ensembl ID: ENSG00000130396
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 2.47
    Ensembl ID: ENSG00000153187
  • Gene Symbol: DLAT (ENSG00000150768)
    Fold Change: 2.43
    Ensembl ID: ENSG00000150768
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: IARS1 (ENSG00000196305)
    Fold Change: 2.4
    Ensembl ID: ENSG00000196305
  • Gene Symbol: COL1A1 (ENSG00000108821)
    Fold Change: 2.38
    Ensembl ID: ENSG00000108821
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.36
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.34
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CD46 (ENSG00000117335)
    Fold Change: 2.33
    Ensembl ID: ENSG00000117335
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 2.33
    Ensembl ID: ENSG00000126777
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 2.32
    Ensembl ID: ENSG00000120129
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 2.31
    Ensembl ID: ENSG00000096060
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.31
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.3
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CRYAB (ENSG00000109846)
    Fold Change: 2.28
    Ensembl ID: ENSG00000109846
  • Gene Symbol: IGFBP5 (ENSG00000115461)
    Fold Change: 2.28
    Ensembl ID: ENSG00000115461
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.25
    Ensembl ID: ENSG00000167468
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 2.25
    Ensembl ID: ENSG00000134480
  • Gene Symbol: COL19A1 (ENSG00000082293)
    Fold Change: 2.24
    Ensembl ID: ENSG00000082293
  • Gene Symbol: MECP2 (ENSG00000169057)
    Fold Change: 2.23
    Ensembl ID: ENSG00000169057
  • Gene Symbol: DARS1 (ENSG00000115866)
    Fold Change: 2.23
    Ensembl ID: ENSG00000115866
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.23
    Ensembl ID: ENSG00000135298
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.23
    Ensembl ID: ENSG00000087086
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.21
    Ensembl ID: ENSG00000080824
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.19
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 2.19
    Ensembl ID: ENSG00000112297
  • Gene Symbol: LIMS1 (ENSG00000169756)
    Fold Change: 2.16
    Ensembl ID: ENSG00000169756
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.15
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.14
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 2.14
    Ensembl ID: ENSG00000120690
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.13
    Ensembl ID: ENSG00000156508
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.12
    Ensembl ID: ENSG00000087460
  • Gene Symbol: GPX3 (ENSG00000211445)
    Fold Change: 2.11
    Ensembl ID: ENSG00000211445
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.1
    Ensembl ID: ENSG00000156976
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.09
    Ensembl ID: ENSG00000072778
  • Gene Symbol: GSN (ENSG00000148180)
    Fold Change: 2.08
    Ensembl ID: ENSG00000148180
  • Gene Symbol: CYB5A (ENSG00000166347)
    Fold Change: 2.08
    Ensembl ID: ENSG00000166347
  • Gene Symbol: ITGB1 (ENSG00000150093)
    Fold Change: 2.07
    Ensembl ID: ENSG00000150093
  • Gene Symbol: JUNB (ENSG00000171223)
    Fold Change: 2.07
    Ensembl ID: ENSG00000171223
  • Gene Symbol: CIDEA (ENSG00000176194)
    Fold Change: 2.06
    Ensembl ID: ENSG00000176194
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.05
    Ensembl ID: ENSG00000077549
  • Gene Symbol: NR3C1 (ENSG00000113580)
    Fold Change: 2.05
    Ensembl ID: ENSG00000113580
  • Gene Symbol: JAK1 (ENSG00000162434)
    Fold Change: 2.03
    Ensembl ID: ENSG00000162434
  • Gene Symbol: KMT2A (ENSG00000118058)
    Fold Change: 2.02
    Ensembl ID: ENSG00000118058
  • Gene Symbol: LDHA (ENSG00000134333)
    Fold Change: 2.01
    Ensembl ID: ENSG00000134333
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2
    Ensembl ID: ENSG00000166710
  • Gene Symbol: UBE2K (ENSG00000078140)
    Fold Change: 1.99
    Ensembl ID: ENSG00000078140
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.99
    Ensembl ID: ENSG00000184009
  • Gene Symbol: NIPSNAP2 (ENSG00000146729)
    Fold Change: 1.98
    Ensembl ID: ENSG00000146729
  • Gene Symbol: MGST3 (ENSG00000143198)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143198
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.96
    Ensembl ID: ENSG00000116489
  • Gene Symbol: IL6ST (ENSG00000134352)
    Fold Change: 1.95
    Ensembl ID: ENSG00000134352
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.94
    Ensembl ID: ENSG00000142599
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.93
    Ensembl ID: ENSG00000100664
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.93
    Ensembl ID: ENSG00000172216
  • Gene Symbol: DECR1 (ENSG00000104325)
    Fold Change: 1.93
    Ensembl ID: ENSG00000104325
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.92
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 1.92
    Ensembl ID: ENSG00000044115
  • Gene Symbol: EWSR1 (ENSG00000182944)
    Fold Change: 1.91
    Ensembl ID: ENSG00000182944
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.91
    Ensembl ID: ENSG00000152518
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 1.9
    Ensembl ID: ENSG00000128585
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.9
    Ensembl ID: ENSG00000115361
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.89
    Ensembl ID: ENSG00000101384
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.89
    Ensembl ID: ENSG00000067560
  • Gene Symbol: MIA2 (ENSG00000150527)
    Fold Change: 1.88
    Ensembl ID: ENSG00000150527

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in epicardial adipocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in epicardial adipocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The epicardial adipocyte is characterized by the following key features: 1. **Location**: Epicardial adipocytes are found in the epicardial fat, a layer of adipose tissue surrounding the heart. 2. **Function**: Epicardial adipocytes play a crucial role in lipid metabolism, cell signaling, and immune responses. 3. **Gene Expression**: Epicardial adipocytes express a range of genes, including AQP7, DDX5, ADH1B, ACACA, LAMA4, LIPE, GRK3, and GTF2I, which are involved in various cellular functions. 4. **Cellular Processes**: Epicardial adipocytes are involved in various cellular processes, including glycerol transport, alternative splicing, alcohol dehydrogenase activity, acetyl-CoA carboxylase activity, and DNA binding transcription factor activity. 5. **Cardiovascular Health**: Epicardial adipocytes play a crucial role in maintaining cardiovascular health, and their dysregulation has been implicated in various cardiovascular diseases. **Clinical Significance** The epicardial adipocyte has significant clinical implications in the following areas: 1. **Cardiovascular Diseases**: Epicardial adipocytes have been implicated in various cardiovascular diseases, including atherosclerosis, hypertension, and heart failure. 2. **Metabolic Disorders**: Epicardial adipocytes play a role in lipid metabolism, and their dysregulation has been linked to metabolic disorders, such as obesity and type 2 diabetes. 3. **Inflammation**: Epicardial adipocytes produce pro-inflammatory cytokines, which can contribute to the development of cardiovascular diseases. 4. **Therapeutic Targets**: The epicardial adipocyte is a potential therapeutic target for the treatment of cardiovascular diseases and metabolic disorders. 5. **Pharmacological Interventions**: Pharmacological interventions, such as anti-inflammatory agents and lipid-lowering agents, may be effective in reducing the risk of cardiovascular diseases associated with epicardial adipocytes. In conclusion, the epicardial adipocyte is a complex cell type that plays a crucial role in maintaining cardiovascular health. Further research is needed to fully understand the mechanisms of epicardial adipocytes and their role in various diseases, in order to develop effective therapeutic strategies for the prevention and treatment of cardiovascular diseases and metabolic disorders.